Digital Health Funding 2014 Midyear Report by @Rock_Health

1. A R O C K R E P O R T B Y 2014MIDYEAR REVIEW DIGITAL HEALTH FUNDING 2014 JUN 30 Midyear Funding Report

2. N THE FIRST QUARTER OF 2014 WE FELT CONFIDENT STATING THAT it would be another record year for digital health funding. We were surprised however to see last year’s record funding total surpassed just three months later, reaching $2.3B. In our 2013 midyear report, we noted that digital health funding growth had slowed, and external observers questioned whether momentum in digital health would continue. There is no such question this year, with year-over-year growth exceeding 170%. These investments are coming from diverse healthcare, technology, and corporate venture firms, suggesting a wide-open space with multiple vectors of opportunity. Everyone who follows funding is naturally waiting for the liquidity events. We expect more multi-billion dollar exits over the coming years—in the meanwhile, we’ve created the first Digital Health Public Company Index to track the progress of our sector in the equity markets. Bring on the rest of 2014! A R O C K R E P O R T B Y WITH HELP FROM SONIA HAVELE MITCHELL MOM SHEILA SHAH HALLE TECCO ROCK HEALTH is powering the future of the digital health ecosystem, bringing together the brightest minds across disciplines to build better solutions. Rock Health funds and supports startups building the next generation of technologies transforming healthcare. ROCK HEALTH partners include Blue Shield of California, Deloitte, GE, Genentech, Harvard Medical School, Kaiser Permanente, Kleiner Perkins Caufield & Byers, Mayo Clinic, Mohr Davidow Ventures, Montreux Equity Partners, NEA, Qualcomm Life and UCSF. LEARN MORE AT rockhealth.com I AUTHORED BY MALAY GANDHI @mgxtro TERESA WANG @teresawang6

3. PRESENTATION © 2014 ROCK HEALTH 3 Dollars and deals Venture funding of digital health companies (2011-2014 YTD) Change in venture capital funding (2013 versus 2012 and H1 2014 versus H1 2013) Total venture funding and S&P 500 price by quarter (1995-2014 Q2) Deals by financing round (2013 vs. Q1-Q2 2014) Funding by geographic location of company (2014 YTD) 11 Investors Digital health deals announced by the most active digital health investors (2014 YTD) 12 Alternative funding Campaigns and dollars raised on crowdfunding platforms (2014 YTD) 13 Exits and public markets Notable M&A transactions (2014 YTD) Change relative to oﬀering price for digital health companies with a 2014 IPO (2014 YTD) Return performance of notable publicly-traded digital health companies (2014 YTD) Poll of digital health investors vs. Rock Weekly readers on next company to IPO 17 Summary Contents KEY FIGURESSECTION

4. PRESENTATION © 2014 ROCK HEALTH $0.0B $0.5B $1.0B $1.5B $2.0B $2.5B JAN FEB MAR APR MAY JUN JUL AUG SEP OCT NOV DEC Venture funding of digital health companies (2011-2014 YTD) Digital health funding in 2014 has broken previous records, with funding through the first half of the year exceeding the 2013 total Source: Rock Health funding database Note: Only includes deals >$2M OBLITERATING RECORDS 4 2013 2012 2011 2014 $2.3B

5. PRESENTATION © 2014 ROCK HEALTH 15% 28% 176% 123% 73% -17% 11% 39% 29% 8% Change in venture capital funding (2013 versus 2012 and H1 2014 versus H1 2013) Venture funding of digital health continues to significantly outpace traditional healthcare sectors PACESETTER 5 Source: PwC MoneyTree; digital health data based on Rock Health analysis Note: Digital health only includes deals >$2M ALL SECTORS SOFTWARE BIOTECH MED DEVICE TECHNOLOGY HEALTHCAREBENCHMARK DIGITAL HEALTH H1 2014 vs H1 2013 2013 vs 2012 LEGEND

6. PRESENTATION © 2014 ROCK HEALTH Total venture funding and S&P 500 price by quarter (1995-2014 Q2) Whether there is a bubble in venture or not depends entirely on where you’re sitting Source: PwC MoneyTree, Google Finance SPOT THE BUBBLE 6 $0.0B $10.0B $20.0B $30.0B $0 $500 $1,000 $1,500 $2,000 2000 Q11995 2014 Q22007 Q4 2011 Q2 S&P 500 VENTURE

7. PRESENTATION © 2014 ROCK HEALTHPRESENTATION © 2014 ROCK HEALTHPRESENTATION © 2014 ROCK HEALTH7 146 digital health companies each raised more than $ 2M IN 2014 SO FAR including eight Rock Health companies!

8. PRESENTATION © 2014 ROCK HEALTH Source: Rock Health funding database Note: Rock Health categorizes digital health companies into 24 separate categories The emerging themes of 2014 reflect a system shifting under healthcare reform and represent nearly 50% of all funding YTD ........ ........ ........ ........ ........ ........ ........ Management and administration tools for payers $ 211M PAYER ADMINISTRATION Software/hardware designed to treat a specific disease or condition $ 206M DIGITAL MEDICAL DEVICES Data aggregation and analysis to support a wide range of healthcare use cases $ 196M ANALYTICS AND BIG DATA Consumer tools for the purchasing of healthcare services or health insurance (B2B and B2C) $ 193M HEALTHCARE CONSUMER ENGAGEMENT Comprehensive platforms for managing the health of populations under the shift to risk- based payment models $ 162M POPULATION HEALTH MANAGEMENT Software platforms to support the delivery of medicine customized to an individual’s genetics $ 150M PERSONALIZED MEDICINE . 8

9. PRESENTATION © 2014 ROCK HEALTH Largest venture rounds for digital health companies (2014 YTD) The largest eight deals through the first half of 2014 make up more than one-third of all funding this year Source: Rock Health funding database ONE OF THESE THINGS IS NOT LIKE THE OTHER 9 SERIES B SERIES C D+ OR GROWTH EQUITY • • • • • • • •$54M $67M $71M $78M $120M $125M $130M $135M

10. PRESENTATION © 2014 ROCK HEALTH Deals by financing round (2013 vs. Q1-Q2 2014) Year-over-year deal growth reached 64% and continues to be driven by early stage deals Source: Rock Health funding database Note: Only includes deals >$2M with explicit deal stage announced EARLY STAGE FOCUS 10 2013 Q1-Q2 2014 SEED OR A 49% B 25% C 13% D+ 13% SEED OR A 57% B 18% C 12% D+ 13% 10 companies progressed from seed or A to B stage from 2013 to 2014 4 companies progressed from B to C stage from 2013 to 2014 6 companies progressed from C to D or D+ to further from 2013 to 2014

11. PRESENTATION © 2014 ROCK HEALTH The Bay Area remains the digital health hub, but New York City and Boston are coming along, doubling in size relative to 2013 Note: Digital health companies based in California raised $907M in total funding, representing almost 40% of all funding in 2014 YTD 11 Funding by geographic location of company (2014 YTD) GOLD RUSH 37 8 6 5 5 15 17 $500M+ $100-500M $50-100M $10-50M >$0-10M # of deals in metro area LEGEND

12. PRESENTATION © 2014 ROCK HEALTH Digital health deals announced by the most active digital health investors (2014 YTD) A growing number of technology and strategic investors are becoming the most active in digital health Note: Only includes announced deals >$2M; multiple investments in the same company in 2014 are considered a single deal for purposes of activity count PROLIFIC INVESTORS 12 DEAL 1 DEAL 2 DEAL 3 DEAL 4 QUALCOMM VENTURES ANDREESSEN HOROWITZ BESSEMER VENTURE PARTNERS EMERGENCE CAPITAL GOOGLE VENTURES MATRIX PARTNERS VENROCK

13. PRESENTATION © 2014 ROCK HEALTH Campaigns and dollars raised on crowdfunding platforms (2014 YTD) Source: Crowdfunding platform websites Note: Only includes campaigns which concluded in 2014 YTD SHY CROWDS .......................................................................... 13 ...... ..................CAMPAIGNS (SUCCESS RATE) $ RAISED CAMPAIGNS (SUCCESS RATE) $ RAISED CAMPAIGNS (SUCCESS RATE) $ RAISED $2.3M $66K $286K IN NUMBERS • 98 campaigns tracked • 16,575 individual backers contributing $2.6M across all campaigns • 21% success rate across all platforms • 41% of all crowdfunding dollars raised in 2014 YTD came from 1 blockbuster campaign (Healbe GoBe) 15% 22% 67% While Indiegogo remains the most popular crowdfunding platform, success rates are down almost 50% versus 2013

14. PRESENTATION © 2014 ROCK HEALTH ACQUIRER TARGET DESCRIPTION Biosensing wearable to detect and diagnose cardiac arrhythmias including atrial fibrillation Patient safety compliance software to prevent retained foreign objects during surgery Implantable pulmonary artery sensor paired with a wireless receiver to transmit data Biosensing wearable to detect heart rate and other physiological parameters in multiple form factors Medical device companies involved with M&A transactions (2014 YTD) Medical device companies have been busy acquiring digital health companies as their business models evolve Source: Company press releases Note: Medtronic announced its intended acquisition of Covidien on 6/15/2014 14 WEARABLE EXITS TYING THE KNOT Other notable acquisitions (2014 YTD) PRICE TARGET ACQUIRER $100M $100M $25M N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A N/A Basis Intel MedPage Today Everyday Health HealthPost The Advisory Board Company Altos Clinical Flatiron AmeriDoc Teladoc API Healthcare GE Audax Health Optum Clarus Health HealthSparq Mindbloom Welltok Moves Facebook RxAnte Millennium Laboratories Sense4Baby AirStrip Sessions MyFitnessPal Wello Weight Watchers $150M $120M $60M Undisclosed

15. PRESENTATION © 2014 ROCK HEALTH The public markets welcomed four digital health IPOs with mixed reception following the first day Source: NASDAQ, S-1 filings, company websites Note: Share price and market capitalization as of 6/30/2014 15 Change relative to oﬀering price for digital health companies with a 2014 IPO IPO DAY 1 CLOSE CSLT EVDY IMPR CRCM $ 0.5B MARKET CAP OFFERING: MAR 28 2014 $ 0.4B MARKET CAP OFFERING: JUN 25 2014 $ 1.4B MARKET CAP OFFERING: MAR 14 2014 $ 0.4B MARKET CAP OFFERING: JAN 24 2014 JUN 30 0% 150% 90% 30% -30% POP AND SIZZLE

16. PRESENTATION © 2014 ROCK HEALTH The Digital Health Public Company Index has underperformed in the public markets through the first half of 2014 16 -20% -10% 0% 10% 20% INDEXED COMPANIES Imprivata and IMS Health will be included starting Q3 2014 S&P 500 DIGITAL HEALTH INDEX JAN APR JUNFEB MAR MAR Note: “The Digital Health Index by Rock Health” on Motif Investing. Performance return as of 6/30/2014; Calculations based on split adjusted total returns of each individual component weighted by market cap; Available here: www.motifinvesting.com/motifs/the-digital-health-index-by-roc-O7xghiOF#/overview Return performance of notable publicly-traded digital health companies (2014 YTD) THE DIGITAL HEALTH PUBLIC COMPANY INDEX

17. PRESENTATION © 2014 ROCK HEALTH $155M $240M $130M $68M $66M $125M $138M $111M $82M $82M $108M Investors (and our readers) are anxious to see name brand digital health companies exit, given the amount of funding to date Source: 36 investors were polled on May 9; 264 Rock Weekly readers were polled on May 12 Note: Companies are selected—chart does not show all companies that have raised >$50M; ZocDoc funding includes $55M convertible note (2013) but not rumored new funding of $152M (2014) 17 3%4% 7%8% 2%2% 8% 3% 11% 6% 47% 0% 3%3%3%3% 6% 13%13%13% 16% 28% AGGREGATE FUNDS RAISED INVESTORS ROCK WEEKLY READERS Poll of investors at the Fenwick Digital Health Investor Summit vs. Rock Weekly readers WHAT DIGITAL HEALTH COMPANY WILL IPO NEXT?

18. PRESENTATION © 2014 ROCK HEALTH FUNDING AND DEAL VOLUME Digital health funding reached $2.3B in 2014 YTD alone, representing a year-over-year growth exceeding 170% and eclipsing the 2013 total. While 146 distinct companies raised over $2M, one-third of all funding is attributable to the eight largest deals of the year thus far. MAJOR THEMES OF THE YEAR The six themes (Rock Health tracks 24 categories) that emerged in 2014 YTD, representing nearly 50% of all funding included: payer administration, digital medical devices, analytics and big data, healthcare consumer engagement, population health management, and personalized medicine. Many of these themes are linked directly to healthcare reform and the related business model shifts within the industry. PROLIFIC INVESTORS EMERGE Seven separate investors (six of which are traditionally technology and strategic investors) have already made three or more digital health investments in 2014. ALTERNATIVE FUNDING FOR PRODUCTS There were 98 campaigns tracked but success rates across the three major platforms have fallen almost 50% compared to 2013. More than 40% of all funding raised came from a single blockbuster campaign (a campaign subsequently came into question related to its claims). EXIT ACTIVITY 2014 has been a big year for digital health IPOs—four new companies joined the public markets for the first time. M&A activity has also been abundant (we tracked 51 deals through the first half of the year), most notably medical device companies acquiring adjacent digital health businesses that can support their core oﬀerings. SUMMARY OF FINDINGS 18

19. SOURCES The Rock Health Funding Database is updated continuously by the Rock Health team using a wide range of sources, including company announcements and press releases, SEC filings (and websites that report SEC filings) and CrunchBase. CapIQ is not a primary source, but is used to reconcile and check for missed entries. We are grateful to all the folks who write about funding and make our lives a bit easier. DATA Our Funding Database is available for a fee on our website. The dataset encompasses individual deals back to 2011, provides details on each of the funded companies, and profiles investors based on deal volume. Updates are provided quarterly through the end of the calendar year of your purchase. Please visit rockhealth.com/research to learn more. research@rockhealth.org @rock_health PRESENTATION © 2014 ROCK HEALTH

Digital Health Funding 2014 Midyear Report by @Rock_Health

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