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UK Center for Clinical and Translational Science

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Stephen W. Wyatt

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UK Center for Clinical and Translational Science

  1. 1. University of Kentucky Center for Clinical and Translational Science (CCTS) November 2015 Stephen W. Wyatt, DMD, MPH Senior Associate Director Center for Clinical and Translational Science University of Kentucky
  2. 2. CCTS History 1985 General Clinical Research Center Initial Award: 5 Competing Renewals, ending March 2008 2002 University of Kentucky Clinical Research Organization 2005 RFA for Clinical and Translational Science Awards (CTSA) released 2006 Center for Clinical and Translational Science (CCTS) formed, reporting to the Provost 2006 – 2010 CCTS Growth, Consolidation, Transitions: 2006: CTSA Planning Grant funded (9/2006 - 9/2008) 2009: Consolidation of GCRC/CRO → CR-DOC 2007-10: CTSA Submissions – Jan 07, Nov 07, Oct 08, Oct 09, Oct 10 2011 Funded CTSA 2015 New Submission CTSA U54
  3. 3.  Champion innovation in the full spectrum of clinical & translational research  Educate the workforce of the future  Engage our communities in biomedical science to improve quality of life of the populace of Central Appalachia UK has 16 colleges, with 11 involved in the UK CCTS (including six biomedical colleges) on one central campus. This creates a closely knit unifies academic community and positions the UK CCTS to demonstrate the impact of collaborative translational research and leadership in team science Goals as a CTSA Hub
  4. 4. Specific Aims of the CCTS Aim 1 Lead institutional innovation in the delivery of efficient, effective clinical and translational research Aim 2 Develop a diverse workforce across multiple disciplines that advances translational research and excels in team-based science Aim 3 Meet the unique needs of Central Appalachian residents by extensively engaging and collaborating with our regional, rural, and community-based partners
  5. 5. Aim 4 Catalyze innovative research, including novel drug development and informatics methodologies, with particular focus on bringing innovation to special populations and across the lifespan. Aim 5 Create an efficient clinical trials network centered at UK and extending to our partnering medical centers in order to serve as an essential, leading component of the CTSA consortium for engaging with participants from rural Central Appalachia Specific Aims of the CCTS
  6. 6. Major Accomplishments to Date  Created integrated home for clinical & translational research to promote scientific progress & discoveries at every phase of the translational continuum  Recognized locally and regionally for catalyzing change  Fundamentally transformed the research environment at UK and throughout Central Appalachia  Development of robust Appalachian Translational Research Network across four states, with integrated research partnerships including other CTSA hubs  Positions CCTS to lead local, regional and national research efforts to address the significant health disparities in this population
  7. 7. CCTS Functions • Administrative Core • Organization, Governance, Collaboration and Communication • Diversity • Evaluation and Continuous Improvement • Quality and Efficiency Goals • Informatics • Community and Collaboration • Community Engagement • Collaboration and Multi-Disciplinary Team Science • Translational Endeavors • Translational Workforce Development (TWD) • Pilot and Translational Clinical Studies (PTC)
  8. 8. Appalachian Translational Research Network (ATRN) Connecting Central Appalachian institutions and communities with national CTSA network resources to facilitate their active engagement in multi-center research studies.
  9. 9. ATRN Aims Aim 1 Promote collaborative clinical and translational research (CTR), team science and workforce development among the ATRN partner institutions with an overall goal to benefit the health of residents in Central Appalachia Aim 2 Enhance UK CCTS Network Capacity to recruit study participants and to deliver clinical trials in Central Appalachia Aim 3 Develop the translational workforce at Marshal University with a focus on informatics, regulatory systems and regulatory administration, resulting in a strong partnership for multi-center clinical trials
  10. 10. Regional Reach Map
  11. 11. UK: 16 colleges on one campus
  12. 12. Community Engagement Aims Aim 1 Develop new innovative strategies to engage Kentucky and Central Appalachian communities and partners in the full spectrum of CTR, enhancing responsiveness to community needs, while addressing the region’s health challenges Aim 2 Catalyze the development and dissemination of best practices for engaging communities in CTR and fostering team science, in cooperation with our Appalachian Translational Research Network (ATRN) partners, including other CTSA hubs
  13. 13. Community Engagement Aims Aim 3 Implement strategies for developing and sustaining diverse, multi-disciplinary research teams to more effectively address the health disparities prevalent in Kentucky and Central Appalachia Aim 4 Transform our institutional culture so that collaborative team science is valued and recognized during the promotion and tenure process as essential to the success of translational science and discovery
  14. 14. Community Champions Cabinet
  15. 15. Community Leadership Institute of Kentucky (CLIK) A rigorous research training program for Appalachian Kentucky community leaders to bolster local capacities and solutions Established in 2014 with guidance from CTSA hubs at Washington University, UCLA, and the University of Cincinnati
  16. 16. Community Leadership Institute of Kentucky (CLIK)  Applications for CLIK are solicited from diverse constituencies including public health departments, FQHCs, school systems, social service agencies, hospitals, etc.  Selected individuals ( apprx. 50% were accepted) attend a 60-hour CTR training program designed to enhance: • use of evidence-based programs • research skills • awareness and use of logic models and data mining • presentation development, public speaking, grant writing, and program evaluation skills
  17. 17. Questions?

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