Sistem limfatik

2,293 views

Published on

0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total views
2,293
On SlideShare
0
From Embeds
0
Number of Embeds
1
Actions
Shares
0
Downloads
283
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide

Sistem limfatik

  1. 1. SistemLimfatik M. Rasjad IndraLaboratorium Ilmu Faal FK. UNIBRAW
  2. 2. Berkaitan dengan: • Keseimbangan cairan tubuh • Pertahanan tubuh
  3. 3. Body Fluid Compartment
  4. 4. Body Fluid Volume Body fluid 60% (45-75) water Intracellular Extracellular 40 % 20 % (42 liter in 70 kg (14 liter in 70 kg young adult) young adult) Interstitial Plasma Transcellular 15 % 5% 1-3 % (10.5 liter in 70 kg (3.5 liter in 70 kg (Cerebrospinal) young adult) young adult) (Aqueous humor)
  5. 5. Electrolyte Composition of Body FluidElectrolytes Plasma Interstitial Fluid Intracellular (mEq/L) (mEq/Kg H2O) Fluid (mEq/Kg H2O)Cation:Na+ 142 145 10K+ 4 4 159Ca2+ 5 3 1Mg2+ 2 2 40Total 153 154 210Anion:Cl- 103 117 3HCO3- 25 28 7Protein 17 - 45Others 8 9 155Total 153 154 210
  6. 6. Daily Intake and Output of Water(in ml/day) Normal Prolonged Heavy Exercise Intake Fluid ingested 2100 ? From metabolism 200 200 Total intake 2300 ? Output Insensible-Skin 350 350 Insensible-Lungs 350 650 Sweat 100 5000 Feces 100 100 Urine 1400 500 Total output 2300 6600
  7. 7. Add pure water• Normal • Add pure water ICF ECF ICF ECF
  8. 8. Add isotonic saline• Normal • Add isotonic saline ICF ECF ICF ECF
  9. 9. Add pure NaCl• Normal • Add pure NaCl ICF ECF ICF ECF
  10. 10. Decreased ADH release from posterior pituitary Decreased plasma ADH Cardiovascular stretch receptor Osmoreceptor Decreased Increased collecting duct extracellular waterIngestion of 1L fluid volume permiabilityof water Decreased plasma osmolarity Decreased water Normal fluid reabsorption volume Increased water excretion
  11. 11. Increased ADH release from posterior pituitary Increased plasma ADH Cardiovascular stretch receptor Osmoreceptors Increased Decreased collecting duct extracellular water Thirst permiabilityDehydration fluid volume Increased plasma osmolarity Increased water intake Increased water reabsorption Normal fluid volume Decreased water excretion
  12. 12. Angiotensinogen Liver Kidney Renin Angiotensin IDecreasedeffectivearterial blood Lungsvolume Converting enzyme Angiotensin II Blood vessels Adrenal cortex Brain Vasoconstrictor Aldosteron secre. ADH secretion Thirst Blood pressure > Sodium reabs. H2O reabsorption Water intake Normal effective arterial blood volume
  13. 13. Increased plasma [K+] Increased [K+] in body cell Direct effect on adrenal (including kidney cells) cortex Increased Increased aldosteronePotasium intake secretionNormal potasium level Increased plasma aldosterone Increase luminal membrane permiablility to Na+ and K+ & Increase basolateral membrane Na+/K+-ATPase activity in collecting duct principal cells. Increased potasium secretion Increased potasium excretion
  14. 14. Starling HypothesisThe balance of hydrostatic and oncotic pressures acrossthe capillary endothelium Mean capillary hydrostatic pressure (Pc): 25 mmHg (40 10) Interstitial fluid hydrostatic pressure (P IF ): 0 mmHg Capillary oncotic pressure ( Пc): 28 mmHg Interstitial fluid oncotic pressure ( П IF ): 3 mmHgArterial end of capillary : Venous end of capillary:Pc= 40 mmHg; PIF= 0 mmHg Pc= 10 mmHg; PIF= 0 mmHgПc= 28 mmHg; ПIF= 3 mmHg Пc= 28 mmHg; ПIF= 3 mmHgNet Filtration= 40-0-28+3= 15 Net Absorption= 10-0-28+3= -15
  15. 15. Definition of Edema:An increase in the interstitial compartement of extracellularfluid volume (Harrison’s).Causes of Extracellular Edema 1. Increased capillary pressure 2. Decreased plasma proteins 3. Increased capillary permiability 4. Blockage of lymph return
  16. 16. • 1. Increased capillary pressure – Excessive kidney retention – High venous pressure – Decreased arteriole resistance
  17. 17. • 2. Decreased plasma proteins – Loss of protein in urine – Loss of protein from denuded skin – Failure of produce protein
  18. 18. • 3. Increased capillary permiability – Immune reaction – Toxin – Bacteria infection – Vitamin deficiency (exp. Vit C)
  19. 19. • 4. Blockage of lymph return – Cancer – Paracyte infection (Filaria) – Surgery – Congenital absence or abnormal of Lymphatic vessels

×