An entirely new concept in a filtering facepiece respirator that can be used, for example, in medical and surgical procedures as well as in public health settings. The outer shell is reusable, and includes a novel face seal design that custom fits to the user's face. The result, scientifically proven and published, is the highest possible face seal efficiency that can be achieved in such a device. The inhalation and exhalation filters are reusable/disposable and can be custom selected based upon the specific aerosol challenge.