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Resourcd File

  1. 1. Use 2 highlighters to sort these into evidence for or against the monoamine hypothesis of unipolar depression:  Thase et al. (2002) found that depressed patients (especially those with severe depression) had increased levels of noradrenaline.  By-product compounds of the enzymes that act upon noradrenaline and serotonin were lower than normal in the urine of people with depression(Teuting, Rosen, & Hirschfeld, 1981  SSRIs inhibit the re-uptake of serotonin and the resulting increase in the level of serotonin is linked to improved mood.  Post-mortem studies of patients who committed suicide show reduced levels of serotonin and an increased number of serotonin receptor sites.  Antidepressant drugs do not work for all patients. (about 60%)  Abnormalities in serotonin function continue after recovery from depression  The drugs increase the levels of the biochemicals immediately but can take weeks before they alleviate the depression.  Antidepressant drugs such as the monoamine oxidase inhibitors (MAOIs) increase the levels of noradrenaline and serotonin and alleviate the symptoms of depression  Rampello, Nicoletti, and Nicoletti (2000) found that patients with major depressive disorder had an imbalance in several neurotransmitters, including noradrenaline, serotonin, dopamine, and acetylcholine.

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