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Nefropatía diabetica

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Nefropatía diabetica

  1. 1. Nefropatía Diabetica<br />Jorge Arturo Bustos Martinez<br />Residente de primer año medicina interna UN <br />
  2. 2. Contenido<br />Epidemiologia<br />Definición<br />Fisiopatologia<br />Historia Natural<br />Clasificación<br />Screening y tratamiento<br />
  3. 3. Epidemiologia <br />Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11<br />
  4. 4. Definición<br />Lesiones microangiopaticas renales<br />Complicación vascular crónica especifica de la diabetes<br />Alteraciones funcionales y estructurales.<br />Proliferación de la matriz y celularidadmesangial-> aumento del grosor de la MB glomerular -> esclerosis glomerular.<br />Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11<br />
  5. 5. Definicion<br />Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11<br />
  6. 6. Histopatología<br />Hipertrofia glomerular:<br />Celularidadmesangial:<br />Kimmelstiel-Wilson:<br />Engrosamiento mesangial:<br />Suma Dronavalli, Irena Duka and George L Bakris. The pathogenesis of diabetic nephropathy. nature clinical practice ENDOCRINOLOGY & METABOLISM. AUGUST 2008 vol 4 no 8<br />
  7. 7. Fisiopatologia<br />Suma Dronavalli, Irena Duka and George L Bakris. The pathogenesis of diabetic nephropathy. nature clinical practice ENDOCRINOLOGY & METABOLISM. AUGUST 2008 vol 4 no 8<br />
  8. 8. Fisiopatologia<br />Suma Dronavalli, Irena Duka and George L Bakris. The pathogenesis of diabetic nephropathy. nature clinical practice ENDOCRINOLOGY & METABOLISM. AUGUST 2008 vol 4 no 8<br />
  9. 9. Fisiopatologia<br />Prorrenina-> Proteincinasas activadas por mitogenos (MAPK)<br />Citoquinas.<br />Estrés oxidativo<br />Susceptibilidad genetica.<br />Suma Dronavalli, Irena Duka and George L Bakris. The pathogenesis of diabetic nephropathy. nature clinical practice ENDOCRINOLOGY & METABOLISM. AUGUST 2008 vol 4 no 8<br />
  10. 10. Historia Natural.<br /> <br />Richard J. MacIsaac and George Jerums. Diabetic kidney disease with and without albuminuria. CurrentOpinion in Nephrologyand Hypertension2011, 20:000–000<br />
  11. 11. Historia Natural<br /> <br />Richard J. MacIsaac and George Jerums. Diabetic kidney disease with and without albuminuria. CurrentOpinion in Nephrologyand Hypertension2011, 20:000–000<br />
  12. 12. Riesgo de Muerte<br />Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11<br />
  13. 13. Clasificación<br />Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11<br />
  14. 14. Clasificación<br />Mogenssen:<br />Catalá M, Rosalén R. Nefropatía diabética. Medicine 1993;6(34):1442-61<br />
  15. 15. Screening y Tratamiento<br />Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11<br />
  16. 16. Screening y Tratamiento<br />Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11<br />
  17. 17. Screening y Tratamiento<br />Albuminuria:<br /> - DM tipo 1: después de 5 años del diagnostico.<br /> - DM tipo 2: en todos a partir del diagnostico.<br />Creatinina:<br /> - En todos los diabeticos<br />Anualmente<br />Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11<br />
  18. 18. Tratamiento<br />(A)<br />Robert G. Nelson, MD, Katherine R. Tuttle. Clinical Practice Guidelines and Clinical Practice Recommendations for DIABETES AND CHRONIC KIDNEY DISEASE. American Journal of Kidney Diseases, Vol 49, No 2, Suppl 2 (February), 2007: pp S10-S11<br />
  19. 19. Conclusiones<br />Prevención primaria<br />Detección temprana<br />Tratamiento optimo<br />
  20. 20. Tequila<br />http://micro.magnet.fsu.edu/cocktails/pages/tequila.html<br />

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