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Nucleic Acid Drug Delivery Technologies: Players, products & prospects to 2018 (Volume III)

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Nucleic Acid DeliveryThe nucleic acid delivery market is maturing with over 1,450 clinical trials underway worldwide. The majority of these are in early clinical development (approximately 60%) with just over 3% in Phase III trials. Our analysis indicates that up to 35 novel nucleic acid products could reach the market within our forecasting period (2008-2018). However the harsh economic environment may force companies to place promising drugs on hold as they focus on lead projects rather than multiple programmes. To date, only a handful of nucleic acid-based products have been approved for human prescription and these products rely on delivery technologies in one shape or form. We estimate the nucleic acid market was worth just over US$80 million globally in 2008.By 2018 we anticipate the nucleic acid technology market will have matured as many of the late-stage clinical programmes come to fruition and drug delivery companies continue to overcome issues surrounding its safety and efficiency. The development of nucleic acid delivery systems will help to improve specificity whilst the development of novel polymers and lipopolymer complexes will help to carry larger DNA payloads in order to target cells and make multigene targeting a reality. We forecast that nucleic acid products in development from 11 key companies could generate additional sales of nearly US$2.3 billion by 2018. These products utilise a range of delivery platforms including viral to non-viral delivery systems, and cover gene therapies, gene agents and DNA vaccines for a variety of targets including cancer, cardiovascular and infectious diseases.Catalysts for changeImprovements in our understanding into the underlying genetic causes of disease as well as the uptake of new mechanisms of modulating DNA such as RNA interference which will help to fuel market growth.The development of a new generation of DNA vaccines that will provoke strong immunogenic responses and will help to determine whether this has been a sound investment for the pharma industry.Launch of the first siRNA-based therapeutics (although progress has been dampened following the recent termination of Opko Health's leading eye treatment at the Phase III development stage). We anticipate companies will pursue other conditions such as infectious diseases and cancer where robust preclinical studies have already been performed and where drug delivery platforms have been adopted rather than the use of naked siRNAs.This report is part of a major new 4-volume strategic analysisDrug Delivery Technologies:Players, Products & Prospects to 2018Focusing on the sectors that are driving growthVOLUME ICONTROLLED- RELEASEVOLUME IINANOTECHNOLOGYVOLUME IIINUCLEIC ACID DELIVERYVOLUME IVTARGETED DELIVERYClick here for details of the full report >> CONTENTSEXECUTIVE SUMMARY & INTRODUCTION - Overview of delivery technologies for genetic material: past, present & future - Leading technology platforms for the delivery of genetic material - Nucleic acid delivery: motivators & resistorsADVANCED NUCLEIC ACID DELIVERY TECHNOLOGIES - Types of nucleic acid-based products under development by the pharma industry - Viral vector delivery of nucleic acids - Bacterial vector delivery of nucleic acids - Non-viral vector delivery of nucleic acids - Chemical Technologies - Physical Technologies - Current therapeutic applications for the viral and non-viral delivery of nucleic acids - Leading nucleic acid-based products in development - Future commercial applications & opportunitiesSTRATEGIES OF DRUG DELIVERY COMPANIES - Leading nucleic acid drug delivery companies - Strategic developmental & commercialisation partnerships - Mergers, acquisitions & joint ventures - Intellectual PropertyTHE VIRAL AND NON-VIRAL VECTOR DELIVERY MARKET - Now 2009: Approved nucleic acid product sales - Future 2018: Novel nucleic acid product sales and Global nucleic acid product sales COMPETITOR ANALYSISDetailed analysis of leading companies cove

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Nucleic Acid Drug Delivery Technologies: Players, products & prospects to 2018 (Volume III)

  1. 1. Find Industry reports, Company profilesReportLinker and Market Statistics >> Get this Report Now by email!Nucleic Acid Drug Delivery Technologies: Players, products &prospects to 2018 (Volume III)Published on June 2009 Report SummaryNucleic Acid DeliveryThe nucleic acid delivery market is maturing with over 1,450 clinical trials underway worldwide. The majority of these are in earlyclinical development (approximately 60%) with just over 3% in Phase III trials. Our analysis indicates that up to 35 novel nucleic acidproducts could reach the market within our forecasting period (2008-2018). However the harsh economic environment may forcecompanies to place promising drugs on hold as they focus on lead projects rather than multiple programmes. To date, only a handfulof nucleic acid-based products have been approved for human prescription and these products rely on delivery technologies in oneshape or form. We estimate the nucleic acid market was worth just over US$80 million globally in 2008.By 2018 we anticipate the nucleic acid technology market will have matured as many of the late-stage clinical programmes come tofruition and drug delivery companies continue to overcome issues surrounding its safety and efficiency. The development of nucleicacid delivery systems will help to improve specificity whilst the development of novel polymers and lipopolymer complexes will help tocarry larger DNA payloads in order to target cells and make multigene targeting a reality. We forecast that nucleic acid products indevelopment from 11 key companies could generate additional sales of nearly US$2.3 billion by 2018. These products utilise a rangeof delivery platforms including viral to non-viral delivery systems, and cover gene therapies, gene agents and DNA vaccines for avariety of targets including cancer, cardiovascular and infectious diseases.Catalysts for changeImprovements in our understanding into the underlying genetic causes of disease as well as the uptake of new mechanisms ofmodulating DNA such as RNA interference which will help to fuel market growth.The development of a new generation of DNA vaccines that will provoke strong immunogenic responses and will help to determinewhether this has been a sound investment for the pharma industry.Launch of the first siRNA-based therapeutics (although progress has been dampened following the recent termination of OpkoHealths leading eye treatment at the Phase III development stage). We anticipate companies will pursue other conditions such asinfectious diseases and cancer where robust preclinical studies have already been performed and where drug delivery platforms havebeen adopted rather than the use of naked siRNAs.This report is part of a major new 4-volume strategic analysisDrug Delivery Technologies:Players, Products & Prospects to 2018Focusing on the sectors that are driving growthVOLUME ICONTROLLED- RELEASEVOLUME IINANOTECHNOLOGYNucleic Acid Drug Delivery Technologies: Players, products & prospects to 2018 (Volume III) Page 1/7
  2. 2. Find Industry reports, Company profilesReportLinker and Market StatisticsVOLUME IIINUCLEIC ACID DELIVERYVOLUME IVTARGETED DELIVERYClick here for details of the full report >>CONTENTSEXECUTIVE SUMMARY & INTRODUCTION- Overview of delivery technologies for genetic material: past, present & future- Leading technology platforms for the delivery of genetic material- Nucleic acid delivery: motivators & resistorsADVANCED NUCLEIC ACID DELIVERY TECHNOLOGIES- Types of nucleic acid-based products under development by the pharma industry- Viral vector delivery of nucleic acids- Bacterial vector delivery of nucleic acids- Non-viral vector delivery of nucleic acids- Chemical Technologies- Physical Technologies- Current therapeutic applications for the viral and non-viral delivery of nucleic acids- Leading nucleic acid-based products in development- Future commercial applications & opportunitiesSTRATEGIES OF DRUG DELIVERY COMPANIES- Leading nucleic acid drug delivery companies- Strategic developmental & commercialisation partnerships- Mergers, acquisitions & joint ventures- Intellectual PropertyTHE VIRAL AND NON-VIRAL VECTOR DELIVERY MARKET- Now 2009: Approved nucleic acid product sales- Future 2018: Novel nucleic acid product sales and Global nucleic acid product salesCOMPETITOR ANALYSISDetailed analysis of leading companies covering:- Proprietary delivery technology- Applications in the pharma industry- Management/technical expertise- Competition within the delivery technology sector- Products in development/approved utilising the delivery technology- Sales forecasts of products utilising the delivery technology- Competitor ratio analysisCompanies analysed- Alnylam Pharmaceuticals, Inc.- AlphaVax, Inc.- Altea Therapeutics, Inc.- AP Pharma, Inc.- ArmaGen Technologies, Inc.- BioDelivery Sciences International, Inc.- Calando Pharmaceuticals, Inc.- Cequent Pharmaceuticals, Inc.- Copernicus Therapeutics, Inc.Nucleic Acid Drug Delivery Technologies: Players, products & prospects to 2018 (Volume III) Page 2/7
  3. 3. Find Industry reports, Company profilesReportLinker and Market Statistics- Diatos SA, Inc.- DOR BioPharma, Inc- Expression Genetics, Inc- Inovio Biomedical Corporation- MaxCyte, Inc- Nanotherapeutics, Inc.- NeoPharm, Inc.- Novagali Pharma, S.A.- Oxford Biomedica, Plc.- PCI Biotech ASA.- Silence Therapeutics, Plc.- Targeted Genetics Corporation- TissueGene, Inc.- Vical, Inc.- Zosano Pharma, Inc.APPENDICIES- Global nucleic acid approved drug sales 2008-2018- Global nucleic acid development drug sales 2008-2018- Key nucleic acid delivery companies by 2018Unique company & technology evaluationIt is vital that management information is reliable, current and insightful. Today, product and company assessment must be seen in awider competitive and market environment.In this report we present a précis on each of the leading delivery specialists and potential new delivery platforms and have identifiedtheir key attributes, based on a number of criteria including:Proprietary delivery technologyApplications of the delivery technology within the pharmaceutical industryManagement/technical expertise of the delivery specialistCompetition within the delivery technology sectorProducts in development/approved utilising the delivery technologyWe have established a competitor ratio analysis based on each of the criteria mentioned above. Each criterion attracts an award of upto 10 points, with a maximum score of 50, thus enabling the establishment of an Espicom ranking table in each segment of themarket, dependent on their relative attributes.Multi-point evaluation and scoring assessmentPharma drugs that utilise drug delivery systems have been evaluated based on a number of parameters, including:The technologyComparison of delivery platforms within each area including: activated, degradation or diffusion for controlled-release systems;nano-engineered (nanocrystals, nanoparticle, nanosuspension) or nanocarriers (carbon/ceramic, dendrimer, liposome, micelle,polymeric nanoparticles) for nano-enabled delivery; viral or non-viral platforms for nucleic acid delivery and active or passive platformsfor targeted delivery systemsThe application of the technology within a number of therapy areasRoute of delivery (oral, parenteral, transdermal, implantable), delivery of small molecules/macromolecules and vaccines, additionalfeatures such as bioerodible materials etcThe current status of the technology in clinical development or following approvalNumber of approved and marketed products, clinical or preclinical development candidates, single or multiple products.Nucleic Acid Drug Delivery Technologies: Players, products & prospects to 2018 (Volume III) Page 3/7
  4. 4. Find Industry reports, Company profilesReportLinker and Market StatisticsCompetition within the technology arenaAlternative drug delivery systems to technologies under evaluation, advantages and disadvantages over competitors.The drug delivery specialists expertiseNumber of drug delivery systems in development, strategic alliances, financial position, marketing presence.The product portfolioDrug delivery systems under evaluation, products in development, commercialisation/development partnerships.Potential drug salesBased on key events such as market, competition, patent expiry, time of entry into the market.About the AuthorDr Cheryl Barton is a highly regarded independent consultant with over 16 years research and business analysis experience.Following her senior research positions in academia and seven years with Merck, in which she was responsible for research projectsranging from Alzheimers disease to schizophrenia. Dr Barton subsequently joined Dutch investment bank ABN Amro NV as a seniorequity analyst where she was lead analyst on major pharmaceutical companies such as Roche and Sanofi-Synthélabo, and assessedthe potential impact of new drug development on European Stocks.In 2002, Dr Barton founded a consulting business (www.Pharmavision.co.uk) to provide independent, tailor-made, pharmaceuticalthematic research to investment houses and pharmaceutical companies. The research reports combine independent scientificanalysis with patient-based models to forecast the potential sales growth of key drugs in clinical development. Table of ContentCONTENTSEXECUTIVE SUMMARY & INTRODUCTION- Overview of delivery technologies for genetic material: past, present & future- Leading technology platforms for the delivery of genetic material- Nucleic acid delivery: motivators & resistorsADVANCED NUCLEIC ACID DELIVERY TECHNOLOGIES- Types of nucleic acid-based products under development by the pharma industry- Viral vector delivery of nucleic acids- Bacterial vector delivery of nucleic acids- Non-viral vector delivery of nucleic acids- Chemical Technologies- Physical Technologies- Current therapeutic applications for the viral and non-viral delivery of nucleic acids- Leading nucleic acid-based products in development- Future commercial applications & opportunitiesSTRATEGIES OF DRUG DELIVERY COMPANIES- Leading nucleic acid drug delivery companies- Strategic developmental & commercialisation partnerships- Mergers, acquisitions & joint ventures- Intellectual PropertyTHE VIRAL AND NON-VIRAL VECTOR DELIVERY MARKET- Now 2009: Approved nucleic acid product sales- Future 2018: Novel nucleic acid product sales and Global nucleic acid product salesNucleic Acid Drug Delivery Technologies: Players, products & prospects to 2018 (Volume III) Page 4/7
  5. 5. Find Industry reports, Company profilesReportLinker and Market StatisticsCOMPETITOR ANALYSISDetailed analysis of leading companies covering:- Proprietary delivery technology- Applications in the pharma industry- Management/technical expertise- Competition within the delivery technology sector- Products in development/approved utilising the delivery technology- Sales forecasts of products utilising the delivery technology- Competitor ratio analysisCompanies analysed- Alnylam Pharmaceuticals, Inc.- AlphaVax, Inc.- Altea Therapeutics, Inc.- AP Pharma, Inc.- ArmaGen Technologies, Inc.- BioDelivery Sciences International, Inc.- Calando Pharmaceuticals, Inc.- Cequent Pharmaceuticals, Inc.- Copernicus Therapeutics, Inc.- Diatos SA, Inc.- DOR BioPharma, Inc- Expression Genetics, Inc- Inovio Biomedical Corporation- MaxCyte, Inc- Nanotherapeutics, Inc.- NeoPharm, Inc.- Novagali Pharma, S.A.- Oxford Biomedica, Plc.- PCI Biotech ASA.- Silence Therapeutics, Plc.- Targeted Genetics Corporation- TissueGene, Inc.- Vical, Inc.- Zosano Pharma, Inc.APPENDICIES- Global nucleic acid approved drug sales 2008-2018- Global nucleic acid development drug sales 2008-2018- Key nucleic acid delivery companies by 2018Nucleic Acid Drug Delivery Technologies: Players, products & prospects to 2018 (Volume III) Page 5/7
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