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Sympathomimmetic agents

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Sympathomimmetic agents

  1. 1. : SYMPHATHOMIMETIC AGENT 19/6/2018 By-Cadet.Rajkumar Kumawat
  2. 2. Sympathomimetic agent 9/6/2018 2By-Cadet.Rajkumar Kumawat
  3. 3. • Sympathomimetic drugs are stimulants compound which mimic the effect of endogenous agonist of the sympathetic nervous system. • Drug can make the action partially or completely or it may also be defined as the substance which sympathetic system is known as sympathomimetic agent or sympathomimetic drugs Sympathomimetic agent 9/6/2018 3By-Cadet.Rajkumar Kumawat
  4. 4. Classification of sympathomimetic agent 1. Direct acting 2. Indirect acting 3. Mixed acting 9/6/2018 4By-Cadet.Rajkumar Kumawat
  5. 5.  Nor-epinephrine  Epinephrine  Phenylephrine  Dopamine  Methyldopa  Salbutamol Hydroxyamphetamine Pseudoephedrine Propylhexedrine Ephedrine MetaAraminol Direct acting Mixed actingIndirect acting 9/6/2018 5By-Cadet.Rajkumar Kumawat
  6. 6. Direct acting sympathomimetic agent • They act through complexation with specific receptors they are represented by nor- adrenaline for the activation of beta receptor phenolic hydroxy function in meta at the catechol nucleus and at the side chain Hydroxide in beta and Amine especially the phenolic hydroxyl seems to be relatively more critical for activation of beta receptors. 9/6/2018 6By-Cadet.Rajkumar Kumawat
  7. 7. Nor-epinephrine • Chemical formula: C8H11NO3 • Mol. Mass : 169.18 g/mol Uses: Norepinephrine is similar to adrenaline. It works by constricting (narrowing) theblood vessels and increasing blood pressure and blood glucose (sugar) levels.9/6/2018 7By-Cadet.Rajkumar Kumawat
  8. 8. Epinephrine • Chemical formula: C9H13NO3 • Mol. Mass : 183.204 g/mol Uses : This medication is used in emergencies to treat very serious allergic reactions to insect stings/bites, foods, drugs, or other substances. Epinephrine acts quickly to improve breathing, stimulate the heart, raise a dropping blood pressure, reverse hives, and reduce swelling of the face, lips, and throat.9/6/2018 8By-Cadet.Rajkumar Kumawat
  9. 9. Salbutamol • Chemical formula: C13H21NO3 • Mol. Mass : 239.311 g/mol Uses : This drug relaxes the smooth muscle in the lungs and opens airways to improve breathing. It is used to treat asthma, chronic bronchitis, emphysema and to prevent exercise-related asthma.9/6/2018 9By-Cadet.Rajkumar Kumawat
  10. 10. Dopamine • Chemical formula: C8H11NO2 • Mol. Mass : 153.18 g/mol Uses : It works by improving the pumping strength of the heart and improves blood flow to the kidneys. Dopamine is used to treat certain conditions that occur when you are in shock, which may be caused by heart attack, trauma, surgery, heart failure, kidney failure, and other serious medical conditions. 9/6/2018 10By-Cadet.Rajkumar Kumawat
  11. 11. Methyldopa • Chemical formula: C10H13NO4 • Mol. Mass : 211.215 g/mol Uses : This medication is used alone or with other medications to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Methyldopa works byrelaxing blood vessels so blood can flow more easily. 9/6/2018 11By-Cadet.Rajkumar Kumawat
  12. 12. Indirect acting 9/6/2018 12By-Cadet.Rajkumar Kumawat
  13. 13. Hydroxyamphetamine • Chemical formula: C9H13NO • Mol. Mass : 151.206 g/mol Uses : Hydroxyamphetamine/tropicamide is a sympathomimetic and anticholinergic combination eye drop. It works by relaxing the muscles of the eye to cause the pupil to dilate or widen (mydriasis).9/6/2018 13By-Cadet.Rajkumar Kumawat
  14. 14. Pseudoephedrine • Chemical formula: C10H15NO • Mol. Mass : 165.23 g/mol Uses : Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose). Pseudoephedrine is used to treat nasal and sinus congestion, or congestion of the tubes that drain fluid from your inner ears,9/6/2018 14By-Cadet.Rajkumar Kumawat
  15. 15. Propylhexedrine • Chemical formula: C10H21N • Mol. Mass : 155.29 g/mol Uses : It is an analogue of methamphetamine that is used medicinally for relief of congestion due to colds, allergies and allergic rhinitis and recreationally for its euphoric effects. 9/6/2018 15By-Cadet.Rajkumar Kumawat
  16. 16. Mixed Action… 9/6/2018 16By-Cadet.Rajkumar Kumawat
  17. 17. Ephedrine • Chemical formula: C10H15NO • Mol. Mass : 165.24 g/mol Uses : Ephedrine is a central nervous system stimulant used to treat breathing problems (as a bronchodilator), nasal congestion (as a decongestant), low blood pressureproblems (orthostatic hypotension), or myasthenia gravis. 9/6/2018 17By-Cadet.Rajkumar Kumawat
  18. 18. Metaraminol • Chemical formula: C9H13NO3 • Mol. Mass : 167.205 g/mol Uses : It is a potent sympathomimetic amine used in the prevention and treatment of hypotension, particularly as a complication of anesthesia. 9/6/2018 18By-Cadet.Rajkumar Kumawat
  19. 19. 9/6/2018 19By-Cadet.Rajkumar Kumawat

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