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Molecule making machine - A 3D Printer for Chemicals


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Breakthrough Molecular 3D Printer Can Print Billions of Possible Compounds
Molecule making machine - A 3D Printer for Chemicals

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Molecule making machine - A 3D Printer for Chemicals

  1. 1. Molecule-Making Machine A 3D printer for Chemicals Presented by Raja Wajahat
  2. 2. A group of chemists led by medical doctor Martin D. Burke at the University of Illinois may have already taken a major step in that direction. Burke, who joined the Department of Chemistry at the university in 2005, heads up Burke Laboratories where he studies and synthesizes small molecules with protein-like structures. 2Presented by Raja Wajahat
  3. 3. The machine can break down very complex molecules into their basic chemical building blocks To put things into perspective, imagine each chemical building block as a different LEGO brick. They all share the same connectors, but may be totally different from one another 3Presented by Raja Wajahat
  4. 4. The machine is able to use a catch-and-release method to automate the process of connecting these building blocks together, one brick at a time, while releasing the byproducts of each chemical reaction. 4Presented by Raja Wajahat
  5. 5. 5Presented by Raja Wajahat
  6. 6. It was this technique of releasing the unwanted byproducts which made this breakthrough a reality. Using this process the machine can utilize over 200 different building blocks along with thousands of other molecules To ‘print’ billions of different organic compounds, many of which make up 14 classes of small molecules, including the ratanhine molecule family 6Presented by Raja Wajahat
  7. 7. Also, according to Burke, it can even synthesize chemicals which were never before created 7Presented by Raja Wajahat
  8. 8. BURKE AND HIS TEAM 8Presented by Raja Wajahat
  9. 9. “The vision for the future is that anyone who needs a specific small molecule can essentially print it out from their computer,” explained Burke “We are really excited about the immediate impacts that this will have on drug discovery.” 9Presented by Raja Wajahat
  10. 10. 10Presented by Raja Wajahat
  11. 11. REVOLUTION Medicines, Inc. has already licensed the technology and is investing heavily in developing next generation molecule-making machines which will be much more powerful and easier to scale 11Presented by Raja Wajahat
  12. 12. If things go as planned, these machines have the potential to do to chemistry what 3D printing has done to engineering; making it fast, less complicated and accessible to pretty much anyone 12Presented by Raja Wajahat
  13. 13. “Perhaps most exciting, this work has opened up an actionable road map to a general and automated way to make most small molecules,” stated Burke 13Presented by Raja Wajahat
  14. 14. 14Presented by Raja Wajahat
  15. 15. “If that goal can be realized, it will help shift the bottleneck from synthesis to function and bring the power of making small molecules to nonspecialists…. A 3D printer for molecules could allow us to harness all the creativity, innovation, and outside-the-box thinking that comes when non-experts start to use technology that used to only be in the hands of a select few.” 15Presented by Raja Wajahat
  16. 16. Imagine a website like Thingiverse, where instead of open sourcing 3D design files for printing, you could open source medications and other chemicals 16Presented by Raja Wajahat
  17. 17. Presented by Raja Wajahat