MUSCLE TISSUE
MUSCLE TISSUE   // AGGREGATES OF SPECIALIZED    ELONGATED CELLS, PRIMARY    FUNCTION IS CONTRACTION   INTERACTION OF MYO...
CLASSIFICATION   STRIATED    SKELETAL    VISCERAL STRIATED    CARDIAC   SMOOTH
SKELETL MUSCLE   MUSCLE FIBERS/CELLS   MESENCHYMAL, FUSION OF MYOBLAST   SIZE VARIABLE   ENDOMYSIUM   PERIMYSIUM, FAS...
MUSCLE FIBER   LONGITUDINAL   MULTINUCLEATED   CROSS STRIATIONS   TRANS. SECTION    POLYGGNOL WITH    FLAT NUCLEI   1...
MUSCLE FIBER   SARCOLEMMA   SARCOPLASM   MYOFIBRILS MYOFILAMENTS   SARCOPLASMIC REITCULUM
MYOFIBRILS   LONGITUDINALLY ARRANGED    SUBUNITS WITHIN A FIBER   COMPOSED OF BUNDLES OF    MYOFILAMENTS   ACTUAL CONTR...
CROSS STRIATIONS   STAINED UNSTAINED    PREPARATIONS   A BAND( DARK) I BAND    ( LIGHT)   A BAND MYOSIN FILAMENT    BIR...
THIN FILAMENT   F ACTIN TROPOMYOSIN &    TROPONIN   F ACTIN double stranded    polarized helix, polymers of G    ACTIN ...
Z LINE   ZIG ZAG   FILAMENTOUS +Z MATRIX   ANCHORS THIN FILAMENTS OF    ADJACENT SARCOMERE THRU ALPHA    ACTININ
THICK FILAMENTS   MYOSIN II   A BAND   2 HEAVY & 2PAIRS OF LIGHT CHAINS   HEAVY MYOSIN rod like part with globular hea...
SARCOPLASMIC RETICULUM   SER   AI------AI BAND   TERMINAL CISTERN Gated Ca channel   T TUBULES voltage sensor protein...
Muscle contraction   SARCOMERE SHORTENS   > OVERLAP b/w THICK & THIN    FILAMENTS   A BAND REMAINS SAME   IBAND SHORTENS
CONTRACTION   ATTACHMENT   RELEASE   BENDING   FORCE GENERATION   RE ATTACHMENT
MUSCLE FIBERS   RED, WHITE & INTERMEDIATE   MYOGLOBIN OXYGEN BINDING    PROTEIN   MITOCHONDRIA CYTOCHROMES    ELECTRON ...
RED                      WHITE   SMALL                 LARGE   SLOW TWITCH           FAST TWITCH   > MYOGLOBIN &     ...
CARDIAC MUSCLE
LIGHT MICROSCOPE   BRANCHING SYNCITIUM   10—14 micrometer   100 micrometer long   ENDOMYSIUM less well organized,    P...
ELECTRON MICROSCOPE   MYOFIBRILS not well demarcated   SARCOPLASM    Abundunt mitochondria    Sarcoplasmic reticulum    ...
SARCOPLASMIC RETICULUM   CISTERNS narrower with frequent    anastomosis   T tubules are wider, external lamina   T tubu...
INTERCALATED DISC   L/M Cross bands 0.5    —1 micrometer   Specialized areas of    cell junction   Step wise   Zonula ...
SMOOTH MUSCLE   SPINDLE SHAPED CELLS, SMALLER   // TO EACH OTHER (close packing & efficient transfer    of force)   BAS...
ELCTRON MICRSCOPEBASAL LAMINA, RETICULAR LAMINA Complete covering( nexus)   PLASMA MEMBRANE    alternnate areas of a) den...
SARCOPLASM   ORGANELLES at each end of nucleus   RUDIMENTRY S.E.R   NO T TUBULES   TWO CYTOPLASMIC DOMAINS   CYTOSKEL...
CYTOSKELETAL DOMAIN   LONGITUDINAL BUNDLES OF    INTERMEDIATE & THIN FILAMENTS    ASSOCIATED WITH DENSE BODIES   DENSE B...
Contractile domain   THIN & THICK FILAMENTS   1:15   THICK FILAMENTS ARE LABILE   OBLIQUE TO CYTOSKELETON   SUB MEMEB...
Muscle tissue
Muscle tissue
Muscle tissue
Muscle tissue
Muscle tissue
Muscle tissue
Muscle tissue
Muscle tissue
Muscle tissue
Muscle tissue
Muscle tissue
Muscle tissue
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Muscle tissue

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Muscle tissue

  1. 1. MUSCLE TISSUE
  2. 2. MUSCLE TISSUE // AGGREGATES OF SPECIALIZED ELONGATED CELLS, PRIMARY FUNCTION IS CONTRACTION INTERACTION OF MYOFILAMENTS
  3. 3. CLASSIFICATION STRIATED SKELETAL VISCERAL STRIATED CARDIAC SMOOTH
  4. 4. SKELETL MUSCLE MUSCLE FIBERS/CELLS MESENCHYMAL, FUSION OF MYOBLAST SIZE VARIABLE ENDOMYSIUM PERIMYSIUM, FASICLES EPIMYSIUM
  5. 5. MUSCLE FIBER LONGITUDINAL MULTINUCLEATED CROSS STRIATIONS TRANS. SECTION POLYGGNOL WITH FLAT NUCLEI 10—100 micrometer
  6. 6. MUSCLE FIBER SARCOLEMMA SARCOPLASM MYOFIBRILS MYOFILAMENTS SARCOPLASMIC REITCULUM
  7. 7. MYOFIBRILS LONGITUDINALLY ARRANGED SUBUNITS WITHIN A FIBER COMPOSED OF BUNDLES OF MYOFILAMENTS ACTUAL CONTRACTILE ELEMENTS ARRANGMENT CROSS STRIATIONS SARCOMERE
  8. 8. CROSS STRIATIONS STAINED UNSTAINED PREPARATIONS A BAND( DARK) I BAND ( LIGHT) A BAND MYOSIN FILAMENT BIREFRINGENT ANISOTROPIC CENTER OF SARCOMERE H ZONE & M LINE I BAND ACTIN FILAMENT MONOREFRINGENT & ISOTROPIC ADJACENT SARCOMERE Z LINE
  9. 9. THIN FILAMENT F ACTIN TROPOMYOSIN & TROPONIN F ACTIN double stranded polarized helix, polymers of G ACTIN Anchored to Z line alpha actinin I band, edges A band TROPOMYOSIN double helix, grooves,mask binding sites TROPONIN 3 subunits TnC___Ca TnT___troponin to tropomyosin TnI___actin
  10. 10. Z LINE ZIG ZAG FILAMENTOUS +Z MATRIX ANCHORS THIN FILAMENTS OF ADJACENT SARCOMERE THRU ALPHA ACTININ
  11. 11. THICK FILAMENTS MYOSIN II A BAND 2 HEAVY & 2PAIRS OF LIGHT CHAINS HEAVY MYOSIN rod like part with globular heads LIGHT CHAIN heads BINDING SITES ATP & ACTIN HEADS FORM CROSS BRIDGES b/w THICK & THIN H ZONE NARROW CENTRAL REGION WITHOUT HEADS ACESSORY PROTEINS
  12. 12. SARCOPLASMIC RETICULUM SER AI------AI BAND TERMINAL CISTERN Gated Ca channel T TUBULES voltage sensor protein TRIAD MITOCHONDRIA & GLYCOGEN GRANULES
  13. 13. Muscle contraction SARCOMERE SHORTENS > OVERLAP b/w THICK & THIN FILAMENTS A BAND REMAINS SAME IBAND SHORTENS
  14. 14. CONTRACTION ATTACHMENT RELEASE BENDING FORCE GENERATION RE ATTACHMENT
  15. 15. MUSCLE FIBERS RED, WHITE & INTERMEDIATE MYOGLOBIN OXYGEN BINDING PROTEIN MITOCHONDRIA CYTOCHROMES ELECTRON TRANSPORT COMPLEXES
  16. 16. RED WHITE SMALL  LARGE SLOW TWITCH  FAST TWITCH > MYOGLOBIN &  < MYOGLOBIN & MITOCHONDRIA MITOCHONDRIA RESISTANT TO  FATIGUE RAPIDLY FATIGUE  RAPID CONTRACTION SLOW CONTRACTION  > NEUROMUSCULAR < NEUROMUSCULAR JUNCTIIONS JUNCTIIONS  EXTRAOCULAR & LONG MUSCLES OF DIGITAL BACK
  17. 17. CARDIAC MUSCLE
  18. 18. LIGHT MICROSCOPE BRANCHING SYNCITIUM 10—14 micrometer 100 micrometer long ENDOMYSIUM less well organized, PERIMYSIUM SARCOLEMMA NUCLEUS single central SARCOPLASM perinuclear INTERCALATED DISC
  19. 19. ELECTRON MICROSCOPE MYOFIBRILS not well demarcated SARCOPLASM Abundunt mitochondria Sarcoplasmic reticulum Fat droplets Glycogen Lipofuscin pigment granules
  20. 20. SARCOPLASMIC RETICULUM CISTERNS narrower with frequent anastomosis T tubules are wider, external lamina T tubules at the level of Z band No dilated terminal cistern DIAD
  21. 21. INTERCALATED DISC L/M Cross bands 0.5 —1 micrometer Specialized areas of cell junction Step wise Zonula adherens, desmosomes, gap junction
  22. 22. SMOOTH MUSCLE SPINDLE SHAPED CELLS, SMALLER // TO EACH OTHER (close packing & efficient transfer of force) BASAL LAMINA, RETICULAR LAMINA DIAMETER LENGTH 20-500 micrmeter SINGLE CENTRAL NUCLEUS,(COCK SCREW) TRAN. Sect.
  23. 23. ELCTRON MICRSCOPEBASAL LAMINA, RETICULAR LAMINA Complete covering( nexus) PLASMA MEMBRANE alternnate areas of a) dense submembrane patches b) uncoated regions GAP JUNCTIONS BLOOD SUPPLY LESS EXTENSIVE
  24. 24. SARCOPLASM ORGANELLES at each end of nucleus RUDIMENTRY S.E.R NO T TUBULES TWO CYTOPLASMIC DOMAINS CYTOSKELETON & CONTRACTILE APPARATUS
  25. 25. CYTOSKELETAL DOMAIN LONGITUDINAL BUNDLES OF INTERMEDIATE & THIN FILAMENTS ASSOCIATED WITH DENSE BODIES DENSE BODIES alpha actinin
  26. 26. Contractile domain THIN & THICK FILAMENTS 1:15 THICK FILAMENTS ARE LABILE OBLIQUE TO CYTOSKELETON SUB MEMEBRANOUS DENSE BODIES TRANSMEMBRANE PROTEINS FBRONECTIN & LAMININ DISTRIBUTION & TRANSMISSION OF FORCE

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