Connective tussue part 1

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  • MONOCYTE AND MACROPHAGES REPRESENT DIFFERENT STAGES OF MATURATION LANGERHAN CELLS ARE EXAMPLES OF ANTIGENPRESENTING
  • CART WHEEL NUCLEUS IS BECAUSE COMPACT PERIPHERAL HETROCHROMATIN ALTERNATES WITH EUCHROMATIN
  • DESMOSINE & ISODESMOSINE are two larone anotherge AArsponsible for covalent bonding of elastin molecules to Marfan syndrome is an autosomal dominant c.t disorder in which expression of fibrillin gene is abnormal
  • Connective tussue part 1

    1. 1. CONNECTIVE TUSSUE DIVERSE GROUP OF CELLS EMBEDDED IN A TISSUE SPECIFIC EXTRACELLULAR MATERIAL
    2. 2. COMPONENTS OF C.T. EXTRACELLULAR MATERIAL FIBERS GROUND SUBSTANCE TISSUE FLUID CELLS
    3. 3.  MESENCHYMAL ORIGIN STRUCTURAL & FUNCTIONAL DIVERSITY CLASSIFIED ON BASIS OF COMPOSITION & ORGANIZATION OF COMPONENTS
    4. 4. CLASSIFICATION EMBRYONIC MESENCHYMAL MUCOID C.T. PROPER GENERAL PROPERTIES SPECIAL PROPERTIES SPECIALIZED
    5. 5. MESENCHYMAL SPINDLE SHAPED CELLS WITH PROCESSES VISCOUS GROUND SUBSTANCE FINE COLLAGEN FIBER
    6. 6. MUCOID SPINDLE SHAPED CELLS WIDELY SEPARATED GELATINOUS GROUND SUBSTANCE WISPY COLLAGEN FIBERS ADULTS PULP OF TOOTH VITREOUS CHAMBER OF EYE NUCLEUS PULPOSUS
    7. 7. C.T. PROPER GENERAL PROPERTIES LOOSE DENSE REGULAR & IRREGULAR SPECIAL PROPERTIES ADIPOSE RETICULAR PIGMENTED
    8. 8. LOOSE C.T. CELLULAR WITH FEW FIBER GROUND SUBSTANCE SUPERFICIAL FACIA
    9. 9. CELLS OF CONNECTIVE TISSUE FIBROBLAST MACROPHAGES PLASMA CELLS MAST CELLS ADIPOSE CELLS WANDERING CELLS
    10. 10. FIBROBLAST PRINCIPAL CELLS ACTIVE & INACTIVE (FIBROBLAST OR FIBROCYTE) ABUNDUNT CYTOPLASM, PALE STAINING NUCLEUS WITH PROMINENT NUCLEOLUS LARGE FLATTENED OVOID CELLS, BRANCHING PROCESSES FLATTENED NUCLEI FIBERS & GROUND SUBSTANCE ( WOUND REPAIR)
    11. 11. MACROPHAGES PHAGOCYTIC CELLS DERIVED FROM MONOCYTES IRREGULAR, SHORT BLUNT PROCESSES & ECENTRIC KIDNEY SHAPED NUCLEUS LOCATIONS  KUPFFER, MICROGLIAL, LANGERHAN,OSTEOCLAST SUPRAVITAL STAINING FUNCTIONS PHAGOCYTOSIS,ANTIGEN PRESENTING, ENZYME PRODUCTION (COLLAGENASE) CYTOKINES (TUMOUR CELL KILLING CAPACITY)
    12. 12. PLASMA CELLS B LYMPHOCYTES OVOID IREGULAR,BASOPHILIC(r ER), CART WHEEL NUCLEUS & UNSTAINED AREA NEAR THE NUCLEUS MAJOR SOURCE OF CIRCULATING ANTIBODIES MUCOUS MEMBRANE, CHRONIC INFLAMMATION & RETICULAR C.T.
    13. 13. MAST CELLS LARGE CELLS WITH SMALL OVOID NUCLEUS & METACHROMATIC GRANULES B.V. MUCOUS MEMBRANE & SKIN ABSENT IN C.N.S. HEPARIN & HISTAMINE
    14. 14. FAT CELLS SIGNET RING APPEARANCE SPECIALIZED TO STORE NEUTRAL FAT UNILOCULAR MULTILOCULAR OSMIC ACID & SUDAN III
    15. 15. ADIPOSE CELLS
    16. 16. WANDERING CELLS WHITE BLOOD CELLS
    17. 17. FIBER COLLAGEN COLLAGEN RETICULAR COLLAGEN ELASTIC ELASTIN
    18. 18. COLLAGEN FIBER (L/M) PROTEIN COLLAGEN MOST ABUNDUNT FLEXIBLE WITH HIGH TENSILE STRENGTH WAVY BUNDLES VARIABLE LENGTH & DIAMETER ACIDIC DYES EOSIN PINK ANILINE BLUE BLUE MASSON TRICHROME GREEN
    19. 19. FIBRILS (E/M)VARIABLE68 nm CROSSBANDINGTROPOCOLLAGENSPECIFIC ARRANGEMENTCOVALENT BONDS
    20. 20. TROPOCOLLAGEN TRIPPLE HELIX HYDROXYPROLINE(LYSINE), GLYCINE PROLINE 300-6000 AA 27 TYPES OF CHAINS 19 DIFFERENT COLLAGEN
    21. 21. SYNTHESIS INTRACELLULAR RIBOSOMES POLYPEPTIDE CHAIN R.E.R POST TRANSLATIOAL MODIFICATION EXOCYTOSIS PROCOLLAGEN (VIT. C SCURVY) EXTRACELLULAR TROPOCOLLAGEN PEPTIDASE ALIGNMENT FIBRILS
    22. 22. COLLAGEN TYPES TYPE I LOOSE & DENSE C.T. TYPE II HYALINE & ELASTIC CARTILAGE TYPE III C.T. OF ORGANS RETICULAR FIBER TYPE IV BASAL LAMINA
    23. 23. RETICULAR FIBERS TYPE III FIBROBLAST THINNER, THREAD LIKE,68nm LOOSELY PACKED, INTERFIBRILLAR BRIDGES SUPPORTING FRAME WORK, SURROUNDS ADIPOSE & MUSCLE CELL, B.V. & NERVES ARGYROPHILLIC, PAS
    24. 24. ELASTIC FIBER THINNER BRANCHING FIBROBLAST, SMOOTH MUSCLE ELASTIN (PROLINE GLYCINE) FIBRILLIN GLYCOPROTEIN MICROFIBRILS DESMOSINE & ISODESMOSINE ELASTIC PROPERTY IS DUE TO RANDOM COILING OF ELASTIN MOLECULES VERTEBRAL LIGAMENTS, LARYNX & ELASTIC ARERIES ORCEIN RESORCEIN FUCHSIN MARFAN SYNDROME
    25. 25. GROUND SUBSTANCE COLOURLESS TRANSPARENT VISCOUS GEL PRESENT B/W CELLS & FIBERS OF CONNECTIVE TISSUE

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