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IN DEPTH EFFICACY CHARACTERIZATION CRO
SYNCROSOME
In Depth Efficacy Characterization CRO
IN DEPTH EFFICACY CHARACTERIZATION CRO
Animal models Manipulation Read-outs
- ASTHMA
- COPD
- PULMONARY FIBROSIS
- COUGH
-...
IN DEPTH EFFICACY CHARACTERIZATION CRO
ASTHMA DISEASE MODEL
IN DEPTH EFFICACY CHARACTERIZATION CRO
ASTHMA MODEL: ANTIGEN-INDUCED LUNG EOSINOPHILIA
MODELS : Immunization
SPECIES : mou...
IN DEPTH EFFICACY CHARACTERIZATION CRO
COPD DISEASE MODEL
IN DEPTH EFFICACY CHARACTERIZATION CRO
COPD MODEL: LPS-INDUCED LUNG NEUTROPHILIA
MODELS : LPS
SPECIES : Mouse, rat
TECHNIQ...
IN DEPTH EFFICACY CHARACTERIZATION CRO
PULMONARY FIBROSIS MODEL
IN DEPTH EFFICACY CHARACTERIZATION CRO
PULMONARY FIBROSIS MODEL
MODELS : Bleomycin
SPECIES : Rats
PARAMETERS : IHC
Fibrosi...
IN DEPTH EFFICACY CHARACTERIZATION CRO
PULMONARY ARTERIAL HYPERTENSION
IN DEPTH EFFICACY CHARACTERIZATION CRO
PAH : 3 DIFFERENT INDUCTION
MODELS : Pharmacological, Hypoxia, and others…
SPECIES ...
IN DEPTH EFFICACY CHARACTERIZATION CRO
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Syncrosome: Respiratory disease models for efficacy characterization

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You will find our preclinical in vivo models for your compounds in pneumology.
Syncrosome is a preclinical CRo running in vivo experiments in its own labs with its own animal facilities, working in GLP like conditions

Published in: Science
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Syncrosome: Respiratory disease models for efficacy characterization

  1. 1. IN DEPTH EFFICACY CHARACTERIZATION CRO SYNCROSOME In Depth Efficacy Characterization CRO
  2. 2. IN DEPTH EFFICACY CHARACTERIZATION CRO Animal models Manipulation Read-outs - ASTHMA - COPD - PULMONARY FIBROSIS - COUGH - Pulmonary Arterial Hypertension (PAH) - All type of treatments - Small molecules - Immunization - Nutraceuticals - All routes of administration - Ip, iv, sc, im - Intranasal - Intra-Tracheal (Penn Century Device) - Oral (gavage, food, water) - Sample collection - Lung – blood – organs - Tissue preparation - Lung - Preparation for histology in paraffin or liquid nitrogen - Biochemistry - Cell counting on Bronchoalveolar Lavage (BAL) - Cytokine monitoring (IL1, IL8, IL6, TNF-α…) - Immunohistochemistry - Cardiac parameters and functiun - Biomarkers - Plethysmography - Tidal Volume - Respiratory Rate OVERVIEW OF SYNCROSOME’S RESPIRATORY MODELS
  3. 3. IN DEPTH EFFICACY CHARACTERIZATION CRO ASTHMA DISEASE MODEL
  4. 4. IN DEPTH EFFICACY CHARACTERIZATION CRO ASTHMA MODEL: ANTIGEN-INDUCED LUNG EOSINOPHILIA MODELS : Immunization SPECIES : mouse, rat TECHNIQUE : Cell counting Plethysmography PARAMETERS : Inflammation Respiratory parameters Cytokines REF. CPDS : Roflumilast, Budesonide, Dexamethasone
  5. 5. IN DEPTH EFFICACY CHARACTERIZATION CRO COPD DISEASE MODEL
  6. 6. IN DEPTH EFFICACY CHARACTERIZATION CRO COPD MODEL: LPS-INDUCED LUNG NEUTROPHILIA MODELS : LPS SPECIES : Mouse, rat TECHNIQUE : Cell counting Plethysmography PARAMETERS : Inflammation Respiratory parameters Cytokines REF. CPDS : Roflumilast, Budesonide, Dexamethasone
  7. 7. IN DEPTH EFFICACY CHARACTERIZATION CRO PULMONARY FIBROSIS MODEL
  8. 8. IN DEPTH EFFICACY CHARACTERIZATION CRO PULMONARY FIBROSIS MODEL MODELS : Bleomycin SPECIES : Rats PARAMETERS : IHC Fibrosis Histological evaluation Biochemical markers REF. CPDS : Cortisone
  9. 9. IN DEPTH EFFICACY CHARACTERIZATION CRO PULMONARY ARTERIAL HYPERTENSION
  10. 10. IN DEPTH EFFICACY CHARACTERIZATION CRO PAH : 3 DIFFERENT INDUCTION MODELS : Pharmacological, Hypoxia, and others… SPECIES : mouse, rat TECHNIQUE : Cell counting, plexiform lesions Plethysmography Cardiac parameters, Doppler PARAMETERS : Inflammation, vascular remodeling Respiratory parameters Cytokines…. REF. CPDS : PDE5 inhibitor, Bosentan, Tadalafil, Vardenafil
  11. 11. IN DEPTH EFFICACY CHARACTERIZATION CRO

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