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People talk about a Moore's Law for gene sequencing, a Moore's Law for software, etc. This is talk is about *the* Moore's Law, the bull that the other "Laws" ride; and how Python-powered ML helps drive it. How do we keep making ever-smaller devices? How do we harness atomic-scale physics? Large-scale machine learning is key. The computation drives new chip designs, and those new chip designs are used for new computations, ad infinitum. High-dimensional regression, classification, active learning, optimization, ranking, clustering, density estimation, scientific visualization, massively parallel processing -- it all comes into play, and Python is powering it all.