“The knowledge becomes learning when pedagogy comes into play”. Taking this as our starting point, we can construct the paragraphs that sustain these guidelines, which try to serve as an instrument, a support tool when we attempt to transform knowledge into learning. The team, who has participated in its elaboration, has always aimed to design a real material suitable for different teaching realities. The goal of innovating application of teaching methodologies can be extrapolated to any reality in which the learning, formal, not formal or informal, can be carried out at any time in our life. They will be possible users of this guide: professional teachers who want to innovate and carry out new alternative teaching methods; company teachers who want to replace traditional methods and want to meet the needs required by the new business environment; organizations that want to incorporate e-learning as a way of learning innovation; university professors who stand for innovation as a way to adapt to Europe and the new knowledge society requests; institutions and organizations that use ICT’s for teaching learning. Finally for everybody that needs “learning to learn” the new rules of the 21th century environment.