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Category of blood variation in shape "POIKILOCYTOSIS"

  1. 1. CATEGORY OF BLOOD VARIATION IN SHAPE “POIKILOCYTOSIS” PRINCESS ALEN AGUILAR
  2. 2. OVAL MACROCYTES (OVALOCYTES) • Inc. MCV • CS= Megaloblas tic Anemia most popular for this cell • No cental pallor
  3. 3. SPHEROCYTES  Dec. surface volume to ratio  Defects on RBC membrane CHONs  Spectrin deficiency  CS= Hereditary spherocytosis, AIHA, G6PD, ABOHDN, RC ENZYME DEF.  Microcytic Hyperchromic anemia
  4. 4. ELLIPTOCYTES “ciggar shape cell”  CS= IDA, Pernicious Anemia, Hereditary elliptocytosis, Myelofibrosis w/ myeloid dysplasia, Megaloblastic Anemia, SCA, Thalassemia, Congenital disorder of diserythropoiesis
  5. 5. ECHINOCYTES (CRENATED RBC)  Short equally spaced projections, regular spicules  Present in prolonged standing artifacts  Resembles to Burr Cells  CS= pyruvate kinase def. , uremia, hepatic therapy, renal insufficiency, suddend change in pH
  6. 6. Burr cells “sea urchin”  Irregular spicules, less pointed  Also seen in Renal failure and uremia
  7. 7. Acanthocytes “Spur cells or thorn cells”  Very spiny irregular projections  CS= Abetalipoproteinemia, cirrhosis, HUS, post splenectomy, HA, PKD  Lysine: Sphingomyosin def.
  8. 8. Stomatocytes “Mouth Cell”  w/ slit like or mouth like central pallor  CS=Rh null Disease, Renal Dse, Liver Dse  Due to osmotic changes
  9. 9. TARGET CELLS/CODOCYTES  MEXICAN HAT CELLS, LEPTOCYTES, PLATYCYTES, BULL’S EYE, GREEK HELMET CELLS  INC. VOLUME RATIO  CS= Liver Dse, Hemoglobinopathies, Thalassemia, IDA
  10. 10. SCHISTOCYTES “Fragmentocytes or Egg shells”  Cell fragments  CS= Microangiopathic anemia, thermal injury, renal transplantation rejection, G6PD def, heart velve replacement, HA, severe burns, mechanical destruction due to TTP or DIC  Fragmenting/disintegrating RBC
  11. 11. KERATOCYTES (HELMET CELLS) Horn like projections Red cell caught in fibrin strands Triangle cell, keratocytes of Bessis Fragile CS= Hemolytic Anemia
  12. 12. DACROCYTES (TEAR DROP)  Round cell wth elongated tail  Cells are squeezed into small opening  CS= Myelofibrosis, Megaloblastic Anemia, Thalassemia, Pernicous Anemia
  13. 13. MICROSPHEROCYTES/ PYROPOIKILOCYTES  Occurs in severe burns  Low MCV  2-3um
  14. 14. SICKLE CELL/ DREPANOCYTES/ MENISCOCYTES  THIN, ELONGATED, POINTED ENDS,  APPEAR CRESCENT SHAPE RBC  LACK CENTRAL PALLOR  Hgbinopathies SS, SC, SD
  15. 15. Hgb CC Crystal  Rhomboid, tetragonal or rod shaped, crystals of dense staining  After splenectomy  CS= Homozygous Hb SC Dse
  16. 16. BLISTER CELL  Red cell w/ single or multiple vacuoles or markedly thinned areas at the periphery  Pre-cursor of helmet cells  Microangiopathic Hemolytic Anemia
  17. 17. DEGMACYTE (BITE CELL)  Drug-induced anemias  G6PD Def., Thalassemia,  Happened due to passing through the blood vessels of the spleen some parts of the cell remains
  18. 18. BASOPHILIC STIPPLING  Fine= Inc. polychromatophilia  Blueberry bagel appearance  CS= Lead poisoning (Plumbism), Impaired Hgb synthesis, MA  Remnants of RBC RNA
  19. 19. HOWELL JOLLY BODIES  Single: nuclear chromatic remnants, MA, HA  Double: MA, Abnormal Erythropoiesis  Large single inclusions  Related to DNA remnants
  20. 20. PAPPENHEIMER BODIES  SIDEROTIC GRANULES  SMALL DARK BLUE PURPLE  PRUSSIAN BLUE= Staining non-heme iron granules  WRIGHTS STAIN= Faint blue  Granules clumped together  CS= Sideroblastic anemia, Hgbinoathies, Thalassemia, MA, myelodysplatic syndrome
  21. 21. CABOT RINGS  Ring shape, figure of 8  Double or several concentrics  Microtubules remnants or mitotic spindle  Rarely seen in PA, lead poisoning  Abnormal erythropoiesis
  22. 22. HEINZ BODIES  Denatured Hgb  Residues of oxidized Hgb  Presence in indicative of RBC injury  w/ alcoholism  G6PD def, unstable Hgb
  23. 23. Hb H INCLUSIONS “GOLF BALL DENTS” Multiple blue green spherical inclusins stained with Brilliant Cresyl Blue (BCB)
  24. 24. MALARIAL INCLUSIONS

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