Laure Rittié, Ph.D.

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Laure Rittié, Ph.D.

  1. 1. Laure Rittié, Ph.D. 04/15/2010 1 Laure Rittié, Ph.D. Research Investigator Department of Dermatology Medical Science I, Rm 6447 1301 E. Catherine Ann Arbor, MI 48109 Phone: (734) 647-7957 Email: lrittie@umich.edu EDUCATION 1995 B.S. (Biochemistry), Université de Reims Champagne-Ardenne, France. 1996 M.S. (Cell Biology), Université de Reims Champagne-Ardenne, France. 1997 DEA [i.e. Pre-graduate Research Degree] (Clinical Pharmacology – Drug Metabolism and Mechanisms of Action), Universités de Reims Champagne- Ardenne & Nancy I-Lorraine, France. 2001 Ph.D. Summa cum Laude (Biochemistry and Molecular Biology) Université de Reims Champagne-Ardenne, France. TRAINING Sep 1994 - Aug 1995 Research Assistant, Université de Reims Champagne-Ardenne, France, Department of Immunology. Sep 1996 - Jul 1997 Pre-graduate research training [DEA], Université de Reims Champagne-Ardenne, France, Department of Biochemistry and Molecular Biology. Aug 1997 - Feb 2001 Ph.D. thesis, Université de Reims Champagne-Ardenne, France, Department of Biochemistry and Molecular Biology. Feb - Nov 2001 Post-doctoral fellow, Université de Reims Champagne-Ardenne, France, Department of Biochemistry and Molecular Biology (Mentor: William Hornebeck, Ph.D.) Jan 2002 - Mar 2006 Post-doctoral fellow, University of Michigan, Department of Dermatology (Mentor: Gary J. Fisher, Ph.D.) ACADEMIC APPOINTMENTS 2006 - Research Investigator, University of Michigan, Department of Dermatology. RESEARCH INTERESTS  Cutaneous wound healing  Regulation of epidermal growth and differentiation  Keratin proteins  Cell-matrix interactions  Collagen homeostasis MEMBERSHIP IN PROFESSIONAL SOCIETIES 2006 - Society for Investigative Dermatology
  2. 2. Laure Rittié, Ph.D. 04/15/2010 2 FUNDING Pending  Mechanisms of Altered Skin Re-Epithelialization in Aging (role: PI) NIH Mentored Research Scientist Development Award (K01) (Period: 07/2010 - 06/2014, Direct Costs: $391,685) Current  Molecular and Cellular Basis for Impaired Wound Healing in Aged Human Skin in vivo (role: PI) Dermatology Foundation (Period: 07/2009 - 06/2010, Direct Costs: $20,000). Previous  Effects of Aging on Follicular Stem Cell Functions in Human Skin (role: PI) American Skin Association (Period: 04/2007 - 03/2008, Direct Costs: $50,000) HONORS AND AWARDS 2001 Ph.D. Suma cum Laude, Université de Reims Champagne Ardenne 2007 American Skin Association Research Scholar Award TEACHING Positions 1998-99 Teacher Assistant, Biochemistry Lab Classes to first-year medical students, Faculté de Médecine, Université de Reims Champagne-Ardenne, France. 1998-00 Biochemistry Laboratory Training to Medical Residents, University of Reims Champagne- Ardenne, France. Mentoring 2003 Mentor of Naomi Simon (M4 Individual Elective) 2003 Mentor of Suzan Tosh (M4 Individual Elective) 2004 Mentor of Hillary Alpert (Student Biomedical Research Program) 2005 Mentor of Marcus Williams (Summer Clinical Research Apprenticeship Program) 2005-06 Mentor of Emily J Matthias (Undergraduate Student) 2006 Mentor of Jessica McPherson (Student Biomedical Research Program) 2007 Mentor of Victoria Min (Student Biomedical Research Program) 2009 Mentor of Savina Aneja (Medical student Case Western Reserve University) Intramural Lectures 2003 “In vitro models to study hormone action in skin”, Dermatology Research Conference 2004 “Estrogen actions in human skin”, Dermatology Research Conference 2006 “Effects of topical estrogens on aged human skin in vivo”, Dermatology Research Conference 2008 “Skin Stem Cells and Aging – Implications for Wound Healing”, Surgery Department, Burn- Trauma - Wound Healing Seminars. 2009 “Skin Stem Cells, Aging, and Wound Healing”, Dermatology Research Conference Courses 2007- UM Dermatology, Basic Science Journal Club: Intermediate filaments (08/2007), Elastic fibers (09/2007), Connexins (11/2007), Basement Membranes (07/2008), Melanogenesis (11/2008), Epidermal stem cells (01/2009), Hereditary
  3. 3. Laure Rittié, Ph.D. 04/15/2010 3 periodic fever syndromes (03/2009), Mast cells (06/2009), Hair Cycle (11/2009), Melanogenesis (01/2010), Keratins (02/2010). PEER-REVIEW SERVICE 2004- Journal of Investigative Dermatology, Reviewer 2006- Experimental Dermatology, Reviewer 2006 Biochimica et Biophysica Acta – Molecular Cell Research, Reviewer 2006- Archives of Dermatological Research, Reviewer 2007- The American Journal of Pathology, Reviewer 2008- Clinical and Experimental Dermatology, Reviewer 2008- Journal of Dermatological Science, Reviewer 2008- Journal of the European Academy of Dermatology and Venereology, Reviewer 2008 Journal of Cell Communication and Signaling, Reviewer 2010 Journal of Food Science, Reviewer NATIONAL AND INTERNATIONAL COMMUNICATIONS “About the in vitro interactions between human monocytes and type I collagen”. Journée des Jeunes Chercheurs, Société de Biologie de Reims, Reims, France, 1998. “Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin binding-EGF and amphiregulin in human skin in vivo”. The 65th Meeting of the Society for Investigative Dermatology, Providence, RI, 2004. “Human skin expresses both estrogen receptor alpha and beta, and responds to topical estradiol by production of type I procollagen expression”. The 66th Meeting of the Society for Investigative Dermatology, St-Louis, MO, 2005. “Topical 17 -estradiol stimulates collagen synthesis in sun-protected aged skin, but not in photoaged human skin in vivo”. The 68th Meeting of the Society for Investigative Dermatology, Los Angeles, CA, 2007. “Expression of CCN proteins in normal human skin in vivo and during wound healing”. The 5th International Workshop on the CCN family of genes, Toronto, Canada, 2008. BIBLIOGRAPHY Peer-Reviewed Publications in Scientific Journals (Chronological order) 1. Rittié L, Berton A, Monboisse JC, Hornebeck W, Gillery P. Decreased contraction of glycated collagen lattices coincides with impaired matrix metalloproteinase production (1999). Biochem Biophys Res Commun, 264 (2):488-492. 2. Garnotel R, Rittié L, Poitevin S, Monboisse JC, Nguyen P, Potron G, Maquart FX, Randoux A, Gillery P. Human blood monocytes interact with type I collagen through alpha x beta 2 integrin (CD11c-CD18, gp150-95) (2000). J Immunol, 164 (11):5928-5934. 3. Monboisse JC, Rittié L, Lamfarraj H, Garnotel R, Gillery P. In vitro glycoxidation alters the interactions between collagens and human polymorphonuclear leucocytes (2000). Biochem J, 350 (Pt 3):777-783, 2000. 4. Rittié L, Monboisse JC, Gorisse MC, Gillery P. Malondialdehyde binding to proteins dramatically alters fibroblast functions (2002). J Cell Physiol, 191 (2):227-236. 5. Rittié L, Fisher GJ. UV-light-induced signal cascades and skin aging (2002). Ageing Res Rev, 1 (4):705-720. Review.
  4. 4. Laure Rittié, Ph.D. 04/15/2010 4 6. Rittié L, Fisher GJ. Isolation and culture of skin fibroblasts (2005). Methods Mol Med, 117:83- 98. Review. 7. Rittié L, Varani J, Kang S, Voorhees JJ, Fisher GJ. Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin binding-EGF and amphiregulin in human skin in vivo (2006). J Invest Dermatol, 126 (4):732-739. 8. Varani J, Dame MK, Rittié L, Fligiel SEG, Kang S, Fisher GJ, Voorhees JJ. Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation (2006). Am J Pathol, 168 (6):1861-1868. 9. Rittié L, Kansra S, Stoll SW, Li Y, Gudjonsson JE, Shao Y, Michael LE, Fisher GJ, Johnson TM, Elder JT. Differential ErbB1 Signaling in Squamous Cell versus Basal Cell Carcinoma of the Skin (2007). Am J Pathol, 170 (6):2089-2099. 10. Rittié L, Perbal B. Enzymes used in molecular biology: a useful guide (2008). J Cell Commun Signal, 2 (1-2):25-45. Review. 11. Rittié L, Kang S, Voorhees JJ, Fisher GJ. Induction of collagen by estradiol: difference between sun-protected and photodamaged human skin in vivo (2008). Arch Dermatol, 144 (9):1129- 1140. 12. Karimipour DJ, Rittié L, Hammerberg C, Min VK, Voorhees JJ, Orringer JS, Sachs DL, Hamilton T, Fisher GJ. Molecular analysis of aggressive microdermabrasion in photoaged skin (2009). Arch Dermatol, 145 (10):1114-1122. 13. Rittié L, Stoll SW, Kang S, Voorhees JJ, Fisher GJ. Hedgehog Signaling Maintains Hair Follicle Stem Cell Phenotype in Young and Aged Human Skin (2009). Aging Cell, 8 (6): 738-751. 14. Stoll SW, Johnson JL, Bhasin A, Gudjonsson JE, Johnston A, Rittié L, Elder JT. Metalloproteinase- mediated, context-dependent function of EGF-like growth factors in human keratinocytes and skin (2010). J Invest Dermatol, 130 (1), 295-304. 15. Pasmant E, Ortonne N, Rittié L, Laurendeau I, Lévy P, Lazar V, Parfait B, Leroy K, Dessen P, Valeyrie-Allanore L, Perbal B, Wolkenstein P, Vidaud M, Vidaud D, Bièche I. Differential Expression of CCN1/CYR61, CCN3/NOV, CCN4/WISP1, and CCN5/WISP2 in Neurofibromatosis Type 1 Tumorigenesis (2010). J Neuropathol Exp Neurol, 69 (1):60-69. Accepted/In Press Publications 16. Orringer JS, Rittié L, Hamilton T, Karimipour DJ, Voorhees JJ, Fisher GJ. Intraepidermal Erbium:YAG Laser Resurfacing: Impact on the Dermal Matrix. J Am Acad Dermatol, Accepted for publication 02/14/2010. 17. Stoll SW, Johnson JL, Li Y, Rittié L, Elder JT. Amphiregulin Carboxy-Terminal Domain is Required for Autocrine Keratinocyte Growth. J Invest Dermatol, Accepted for publication 03/06/2010. Academic Publications (Peer-Reviewed) 1. Rittié L: DEA Report. Interactions monocytes - collagène de type I : rôle de la matrice extracellulaire dans l'inflammation [Monocytes - type I collagen interactions: role of the extracellular matrix in inflammation], Universités Henri Poincaré, Nancy I - Reims Champagne- Ardenne, France, 1997. 2. Rittié L: Ph.D. Thesis. Influence des modifications post-traductionnelles des protéines sur les interactions cellules - matrice extracellulaire et le métabolisme des fibroblastes [Effects of proteins’ post-translational modifications on cell-matrix interactions & fibroblast metabolism]. Université de Reims Champagne-Ardenne, France, 2001.
  5. 5. Laure Rittié, Ph.D. 04/15/2010 5 Book Chapters 1. Rittié L, Fisher GJ. Isolation and culture of skin fibroblasts. In: Fibrosis Research: Methods and Protocols (Varga J, Brenner SA, Phan SH, eds), Humana Press Inc., Totowa, NJ, pp 83-98, 2005. 2. Rittié L, Fisher GJ, Voorhees JJ. Retinoid therapy for photoaging. In: Skin Ageing (Gilchrest BA, Krutman J, eds), Springer-Verlag, Berlin-Heidelberg-New York, pp 143-156, 2006. 3. Rittié L, Fisher GJ, Griffiths CEM. Anti-aging effects of retinoids and mechanisms of action. In: Retinoids and Carotenoids in Dermatology (Vahlquist A, Duvic M, eds), Informa Healthcare USA Inc., New York, NY, pp 77-102, 2007. 4. Rittié L, Fisher GJ, Voorhees JJ. Aging and Photoaging of the Skin. In: Therapy of Skin Diseases (eds: Krieg T, Bickers DR, Miyachi Y), Springer-Verlag, Berlin-Heidelberg-New York, pp 705-716, 2010. Abstracts & Poster presentations -- * Indicates selection for Oral presentation-- 1.* Rittié L, Varani J, Fisher GJ, Voorhees JJ. Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin binding- EGF and amphiregulin in human skin in vivo. J Invest Dermatol, 122: A49, 2004. (the 65th Meeting of the Society for Investigative Dermatology, Providence, RI, 2004). 2.*Rittié L, Shao Y, Kang S, Voorhees JJ, Fisher GJ. Human skin expresses both estrogen receptor alpha and beta, and responds to topical estradiol by production of type I procollagen expression. J Invest Dermatol, 124: A43, 2005. (the 66th Meeting of the Society for Investigative Dermatology, St-Louis, MO, 2005). 3. Rittié L, Kansra S, Li Y, Stoll SW, Michael LE, Shao Y, Boyd C, Johnson TM, Fisher GJ, Elder JT. Differential autocrine ErbB signaling in SCC vs. BCC. J Invest Dermatol, 124: A21, 2005. (the 66th Meeting of the Society for Investigative Dermatology, St-Louis, MO, 2005). 4. Rittié L, Voorhees JJ, Fisher GJ. Genomic actions of estrogen receptors-alpha and beta are limited by their low levels of expression in primary human dermal fibroblasts. J Invest Dermatol, 126: 81, 2006. (the 67th Meeting of the Society for Investigative Dermatology, Philadelphia, PA, 2006). 5. Stoll SW, Johnson JL, Rittié L, Elder JT. Differential expression and function of EGF receptor ligands influence autocrine keratinocyte proliferation and morphology. J Invest Dermatol, 126: 95, 2006. (the 67th Meeting of the Society for Investigative Dermatology, Philadelphia, PA, 2006). 6.*Rittié L, Kang S, Voorhees JJ, Fisher GJ. Topical 17-β-estradiol stimulates collagen synthesis in sun-protected aged skin, but not in photoaged human skin in vivo. J Invest Dermatol, 127: S51, 2007. (the 68th Meeting of the Society for Investigative Dermatology, Los Angeles, CA, 2007). 7. Rittié L, Orringer JS, Voorhees JJ, Fisher GJ. Hair follicle stem cells and upper follicular keratinocytes reconstitute the epidermis after wounding in human skin in vivo. J Invest Dermatol, 128: S106, 2008. (the 5th Joint Meeting of the European Society for Dermatological Research, Japanese Society for Investigative Dermatology, and Society for Investigative Dermatology, Kyoto, Japan, 2008). 8. Stoll SW, Rittié L, Elder JT. Inhibition of human keratinocyte growth by AREG-specific shRNA cannot be reversed by EGFR ligands. J Invest Dermatol, 129: S96, 2009. (the 69th Meeting of the Society for Investigative Dermatology, Montréal, Canada, 2009). 9. Rittié L, Stoll SW, Kang S, Dlugosz AA, Voorhees JJ, Fisher GJ. Hedgehog signaling maintains hair follicle stem cell phenotype in young and aged human skin in vivo. J Invest Dermatol, 129: S102, 2009. (the 69th Meeting of the Society for Investigative Dermatology, Montréal, Canada, 2009).
  6. 6. Laure Rittié, Ph.D. 04/15/2010 6 10. Lin ZY, Natesan V, Shi H, Hamik A, Kawanami D, Hao C, Mahabaleshwar GH, Atkins GB, Rittié L, Firth SM, Perbal B, Jain MK. A Novel Role of CCN3 in Regulating Endothelial Inflammation. Circulation, 120: S1029, 2009. (the 82nd Scientific Session of the American-Heart- Association, Orlando, FL, 2009). 11. Rittié L, Orringer JS, Baker D, Voorhees JJ, Fisher GJ. Fractional photothermolysis treatment triggers a wound healing response and dermal remodeling in photoaged human skin in vivo. J Invest Dermatol, 130: S52, 2010. (the 70th Meeting of the Society for Investigative Dermatology, Atlanta, GA, 2010). 12. Stoll SW, Rittié L, Elder JT. Amphiregulin carboxy-terminal domain regulates autocrine keratinocyte growth and differentiation. J Invest Dermatol, 130: S101, 2010. (the 70th Meeting of the Society for Investigative Dermatology, Atlanta, GA, 2010). .

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