Healthy and Harmful HalogensHealthy and Harmful Halogens
IodineIodine andand FluorideFluoride
LewRockwell.com ConferenceLe...
HalogensHalogens
Atomic Wt. DiscoveredAtomic Wt. Discovered
FluorineFluorine 1919 18861886
ChlorineChlorine 3535 18091809
...
IodineIodine BromineBromine ChlorineChlorine FluorideFluoride IodineIodine
FluorideFluoride
Halogens in WarHalogens in War
Elements that Compose the Human BodyElements that Compose the Human Body
Periodic Table of ElementsPeriodic Table of Eleme...
Origin of FluoridationOrigin of Fluoridation
Manhattan ProjectManhattan Project
Edward BernaysEdward Bernays
Fluoride inFluoride in Dr. StrangeloveDr. Strangelove
“Have you ever seen a commie drink a glass of water?”
Capt. Jack D. ...
Dental FluorosisDental Fluorosis
Cosmetic Correction of FluorosisCosmetic Correction of Fluorosis
$14,000 later
Lead, Fluoride and ArsenicLead, Fluoride and Arsenic
Toxicity Maximum ContaminantToxicity Maximum Contaminant
LevelsLevels
Manifestations of Fluoride PoisoningManifestations of Fluoride Poisoning
• Skeletal FluorosisSkeletal Fluorosis
– Arthriti...
Manifestations of Fluoride PoisoningManifestations of Fluoride Poisoning
• Increases risk for cancerIncreases risk for can...
Water Filters that Remove FluorideWater Filters that Remove Fluoride
Reverse Osmosis DistillerReverse Osmosis Distiller
Water Fluoridation in U.S.Water Fluoridation in U.S.
Goal (Objective 21-9):Goal (Objective 21-9): Increase proportionIncre...
Iodine in Thyroid HormonesIodine in Thyroid Hormones
Iodine atomIodine atom
Actions of Triiodothyronine (TActions of Triiodothyronine (T33))
 Regulate cellular oxidationRegulate cellular oxidation
...
Iodine Deficiency DisordersIodine Deficiency Disorders
Goiter Mental RetardationGoiter Mental Retardation
CretinismCretini...
Reference Daily IntakeReference Daily Intake
(RDI) for Iodine(RDI) for Iodine
According to the AMA, NIH National ResearchA...
Worldwide Iodine NutritionWorldwide Iodine Nutrition
Median urinary iodine concentration of 100-199 ug/L with
correspondin...
Iodine Intake in JapanIodine Intake in Japan
Nutrition in Japan, 1964. Nutrition Section, Bureau of Public Health,Nutritio...
Iodine Intake in the United StatesIodine Intake in the United States
Urinary iodine levels (Urinary iodine levels (µµg/L) ...
Health Comparisons:Health Comparisons:
United States and JapanUnited States and Japan
United States JapanUnited States Jap...
The Earth’s 3The Earth’s 3rdrd
Atmosphere, from 2.2 GaAtmosphere, from 2.2 Ga
OxygenOxygen
Level inLevel in
AtmosphereAtmo...
Iodine as an AntioxidantIodine as an Antioxidant
II--
+ H+ H22OO22 HIO + OHHIO + OH--
HIO +HIO + II--
+ H+ H++
II22 + H+ H...
Function of Iodine in HumansFunction of Iodine in Humans
and Other Animalsand Other Animals
Thyroidal -- OrganicThyroidal ...
Zhang, L. et al. Nonradioactive Iodide Effectively Induces Apoptosis in GeneticallyZhang, L. et al. Nonradioactive Iodide ...
Effect of Iodine on Tumor Growth in MiceEffect of Iodine on Tumor Growth in Mice
Genetically Modified TumorGenetically Mod...
Organs with Iodine Concentrating AbilityOrgans with Iodine Concentrating Ability
Via the Sodium/Iodine Symporter PumpVia t...
The Real Truth on IodineThe Real Truth on Iodine
Dose-Related BenefitsDose-Related Benefits
In microgram (In microgram (μμ...
Different Kinds of IodineDifferent Kinds of Iodine
 Inorganic, Nonradioactive (Inorganic, Nonradioactive (127127
I)I)
– K...
Forms of Inorganic, NonradioactiveForms of Inorganic, Nonradioactive
IodineIodine
• KIKI (Potassium Iodide)(Potassium Iodi...
Iodine PoisoningIodine Poisoning
IngestedIngested 15 gm15 gm of Iodine –of Iodine – 100,000 x100,000 x
the RDA of 0.00015 ...
Iodine in DermatologyIodine in Dermatology
PyodermaPyoderma
GangrenosumGangrenosum
NodularNodular
VasculitisVasculitis
Spo...
Fibrocystic Breast DiseaseFibrocystic Breast Disease
CystCyst
FibrousFibrous
tissuetissue
EpithelialEpithelial
andand
apoc...
Iodine Prevents Breast CancerIodine Prevents Breast Cancer
Animal StudiesAnimal Studies
Reduces incidence in rats given ca...
The Iodine ProjectThe Iodine Project
Hypothesis:Hypothesis: Whole body sufficiencyWhole body sufficiency
of iodine require...
Health Benefits of mg-DoseHealth Benefits of mg-Dose
Iodine atIodine at 100x the RDI100x the RDI
 Feel HealthierFeel Heal...
Healthy and Harmful Halogens Iodine and Fluoride
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Healthy and Harmful Halogens Iodine and Fluoride

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Healthy and Harmful Halogens Iodine and Fluoride

  1. 1. Healthy and Harmful HalogensHealthy and Harmful Halogens IodineIodine andand FluorideFluoride LewRockwell.com ConferenceLewRockwell.com Conference Be Healthy, Wealthy, and WiseBe Healthy, Wealthy, and Wise Center for Libertarian StudiesCenter for Libertarian Studies Foster City, CAFoster City, CA December 2, 2006December 2, 2006 Donald W. Miller, Jr., M.DDonald W. Miller, Jr., M.D.. Professor of SurgeryProfessor of Surgery Division of Cardiothoracic SurgeryDivision of Cardiothoracic Surgery University of Washington School of MedicineUniversity of Washington School of Medicine
  2. 2. HalogensHalogens Atomic Wt. DiscoveredAtomic Wt. Discovered FluorineFluorine 1919 18861886 ChlorineChlorine 3535 18091809 BromineBromine 8080 18261826 IodineIodine 127127 18111811 AstatineAstatine 210210 19401940
  3. 3. IodineIodine BromineBromine ChlorineChlorine FluorideFluoride IodineIodine FluorideFluoride Halogens in WarHalogens in War
  4. 4. Elements that Compose the Human BodyElements that Compose the Human Body Periodic Table of ElementsPeriodic Table of Elements IodineIodine ChlorineChlorine
  5. 5. Origin of FluoridationOrigin of Fluoridation
  6. 6. Manhattan ProjectManhattan Project
  7. 7. Edward BernaysEdward Bernays
  8. 8. Fluoride inFluoride in Dr. StrangeloveDr. Strangelove “Have you ever seen a commie drink a glass of water?” Capt. Jack D. Ripper
  9. 9. Dental FluorosisDental Fluorosis
  10. 10. Cosmetic Correction of FluorosisCosmetic Correction of Fluorosis $14,000 later
  11. 11. Lead, Fluoride and ArsenicLead, Fluoride and Arsenic Toxicity Maximum ContaminantToxicity Maximum Contaminant LevelsLevels
  12. 12. Manifestations of Fluoride PoisoningManifestations of Fluoride Poisoning • Skeletal FluorosisSkeletal Fluorosis – ArthritisArthritis – Osteoporosis/FractureOsteoporosis/Fracture – Crippling deformitiesCrippling deformities • NeurotoxicityNeurotoxicity – Abnormal brain developmentAbnormal brain development – Alzheimer’s diseaseAlzheimer’s disease • HypothyroidismHypothyroidism
  13. 13. Manifestations of Fluoride PoisoningManifestations of Fluoride Poisoning • Increases risk for cancerIncreases risk for cancer – OsteosarcomaOsteosarcoma – HepatocholangiocarcinomaHepatocholangiocarcinoma • Early onset of pubertyEarly onset of puberty – Due to impaired melatonin productionDue to impaired melatonin production • Reduced male fertilityReduced male fertility
  14. 14. Water Filters that Remove FluorideWater Filters that Remove Fluoride Reverse Osmosis DistillerReverse Osmosis Distiller
  15. 15. Water Fluoridation in U.S.Water Fluoridation in U.S. Goal (Objective 21-9):Goal (Objective 21-9): Increase proportionIncrease proportion of U.S. population served by fluoridatedof U.S. population served by fluoridated community water systems to 75 percentcommunity water systems to 75 percent
  16. 16. Iodine in Thyroid HormonesIodine in Thyroid Hormones Iodine atomIodine atom
  17. 17. Actions of Triiodothyronine (TActions of Triiodothyronine (T33))  Regulate cellular oxidationRegulate cellular oxidation  CalorigenesisCalorigenesis  ThermoregulationThermoregulation  Intermediary MetabolismIntermediary Metabolism  Necessary for protein synthesisNecessary for protein synthesis  PromotesPromotes  Nitrogen retentionNitrogen retention  GlycogenolysisGlycogenolysis  Intestinal absorption of glucose and galactoseIntestinal absorption of glucose and galactose  LipolysisLipolysis  Uptake of glucose by adipocytesUptake of glucose by adipocytes
  18. 18. Iodine Deficiency DisordersIodine Deficiency Disorders Goiter Mental RetardationGoiter Mental Retardation CretinismCretinism
  19. 19. Reference Daily IntakeReference Daily Intake (RDI) for Iodine(RDI) for Iodine According to the AMA, NIH National ResearchAccording to the AMA, NIH National Research Council, Joint UN FAO/WHO Expert CommitteeCouncil, Joint UN FAO/WHO Expert Committee on Food Additives, and the EU IPCSon Food Additives, and the EU IPCS RDI:RDI: 100-150100-150 μμg/dayg/day
  20. 20. Worldwide Iodine NutritionWorldwide Iodine Nutrition Median urinary iodine concentration of 100-199 ug/L with corresponding approximate iodine intake 150-299 ug/day International Council for the Control of Iodine Deficiency Disorders.International Council for the Control of Iodine Deficiency Disorders. Current IDD Status Database, 2003Current IDD Status Database, 2003
  21. 21. Iodine Intake in JapanIodine Intake in Japan Nutrition in Japan, 1964. Nutrition Section, Bureau of Public Health,Nutrition in Japan, 1964. Nutrition Section, Bureau of Public Health, Ministry of Health and Welfare, Tokyo, Japan, March 1965Ministry of Health and Welfare, Tokyo, Japan, March 1965 Iodine Intake 1950-1963:Iodine Intake 1950-1963: 13.8 mg/per capita/day13.8 mg/per capita/day (average 4.5 gm seaweed(average 4.5 gm seaweed a day. Measured Iodinea day. Measured Iodine content 0.3mg/gm)content 0.3mg/gm) Seaweed consumption in 2001:Seaweed consumption in 2001: 14.6 gm (dry weight)14.6 gm (dry weight) Iodine Intake 2001:Iodine Intake 2001: 43.8 mg43.8 mg If Iodine content theIf Iodine content the same (was notsame (was not measured)measured)
  22. 22. Iodine Intake in the United StatesIodine Intake in the United States Urinary iodine levels (Urinary iodine levels (µµg/L) ing/L) in the United States, age 6-74the United States, age 6-74 NHANES I, 1971-741 NHANES III, 1988-911 NHANES 2000 Median 32.00 14.5 16.1 SE 0.6 0.3 0.7 1 Hollowell, JE et al. Iodine nutrition in the United States. Trends and public health implications: Iodine excretion data from National Health and Nutrition Examination Surveys I and III (1971-74 and 1988-94). J Clin Endocrinol Metab 83:3401-3408. 1998. Current Average DailyCurrent Average Daily Intake of Iodine:Intake of Iodine: 240 µg (0.24 mg)240 µg (0.24 mg) Iodine Intake in 1970s:Iodine Intake in 1970s: 480 µg (0.48 mg)480 µg (0.48 mg) 320 145 161
  23. 23. Health Comparisons:Health Comparisons: United States and JapanUnited States and Japan United States JapanUnited States Japan Incidence of BreastIncidence of Breast Highest in World LowestHighest in World Lowest CancerCancer Life ExpectancyLife Expectancy 77.85 years 81.25 years77.85 years 81.25 years (48(48thth /226 countries) (No. 6)/226 countries) (No. 6) Infant Mortality RateInfant Mortality Rate 7.0 3.57.0 3.5 (deaths under age 1 per (Lowest in World)(deaths under age 1 per (Lowest in World) 1,000 live births)1,000 live births)
  24. 24. The Earth’s 3The Earth’s 3rdrd Atmosphere, from 2.2 GaAtmosphere, from 2.2 Ga OxygenOxygen Level inLevel in AtmosphereAtmosphere (Percent)(Percent) 4.6 3.6 2.6 1.6 0.64.6 3.6 2.6 1.6 0.6 Billion Years AgoBillion Years Ago Photosynthesis first done byPhotosynthesis first done by Cyanobacteria:Cyanobacteria: 6CO6CO22 + 6H+ 6H22OO →→ CC 66HH1212 OO66 + 6O+ 6O22 CyanobacteriaCyanobacteria are also the first life forms to tolerate andare also the first life forms to tolerate and use……………………...use……………………... IODINEIODINE
  25. 25. Iodine as an AntioxidantIodine as an Antioxidant II-- + H+ H22OO22 HIO + OHHIO + OH-- HIO +HIO + II-- + H+ H++ II22 + H+ H22OO Reactive Oxygen SpeciesReactive Oxygen Species Kupper FC, et al. Iodine uptake in Laminariales involves extracellular,Kupper FC, et al. Iodine uptake in Laminariales involves extracellular, haloperoxidase-mediated oxidation of iodide.haloperoxidase-mediated oxidation of iodide. PlantaPlanta 1998;207:163-171.1998;207:163-171.
  26. 26. Function of Iodine in HumansFunction of Iodine in Humans and Other Animalsand Other Animals Thyroidal -- OrganicThyroidal -- Organic  A Component of Thyroxine and T3A Component of Thyroxine and T3 Extrathyroidal -- InorganicExtrathyroidal -- Inorganic  An AntioxidantAn Antioxidant  Triggers ApoptosisTriggers Apoptosis  OtherOther • Detoxify chemicals and biological toxinsDetoxify chemicals and biological toxins • Anti-allergic, coat external proteins rendering themAnti-allergic, coat external proteins rendering them non allergicnon allergic • Suppess auto-immunitySuppess auto-immunity • Strengthen immune systemStrengthen immune system • Provide antisepsis in the stomachProvide antisepsis in the stomach
  27. 27. Zhang, L. et al. Nonradioactive Iodide Effectively Induces Apoptosis in GeneticallyZhang, L. et al. Nonradioactive Iodide Effectively Induces Apoptosis in Genetically Modified Lung Cancer Cells.Modified Lung Cancer Cells. Cancer ResearchCancer Research 2003;63:5065-50722003;63:5065-5072 Iodine-Induced Apoptosis in Lung CancerIodine-Induced Apoptosis in Lung Cancer Iodine Sensitive Lung Cancer Cells Parent (unmodified) Lung Cancer CellsIodine Sensitive Lung Cancer Cells Parent (unmodified) Lung Cancer Cells
  28. 28. Effect of Iodine on Tumor Growth in MiceEffect of Iodine on Tumor Growth in Mice Genetically Modified TumorGenetically Modified Tumor Xenograft ControlsXenograft Controls Genetically Modified TumorGenetically Modified Tumor XenograftXenograft with Iodinewith Iodine Zhang, L. et al. Nonradioactive Iodide Effectively Induces Apoptosis inZhang, L. et al. Nonradioactive Iodide Effectively Induces Apoptosis in Genetically Modified Lung Cancer Cells.Genetically Modified Lung Cancer Cells. Cancer ResearchCancer Research 2003;63:5065-50722003;63:5065-5072
  29. 29. Organs with Iodine Concentrating AbilityOrgans with Iodine Concentrating Ability Via the Sodium/Iodine Symporter PumpVia the Sodium/Iodine Symporter Pump Stomach MucosaStomach Mucosa Mammary GlandsMammary Glands Salivary GlandsSalivary Glands Other:Other: OvariesOvaries ThymusThymus EpidermisEpidermis Choroid PlexusChoroid Plexus Articular, Arterial, andArticular, Arterial, and Skeletal SystemsSkeletal Systems 125125 I total-body scintiscansI total-body scintiscans 30 min 6 hr 20 hr30 min 6 hr 20 hr Venturi S, et al. Role of Iodine in Evolution and Carcinogenesis ofVenturi S, et al. Role of Iodine in Evolution and Carcinogenesis of Thyroid, Breast and Stomach.Thyroid, Breast and Stomach. Adv Clin PathAdv Clin Path 2000;4:11-17.2000;4:11-17.
  30. 30. The Real Truth on IodineThe Real Truth on Iodine Dose-Related BenefitsDose-Related Benefits In microgram (In microgram (μμg)g) amounts:amounts: In milligram (mg)In milligram (mg) amounts:amounts: In gram (g)In gram (g) amounts:amounts: For thyroid hormoneFor thyroid hormone Achieve optimal healthAchieve optimal health Prevent (and treat) fibrocysticPrevent (and treat) fibrocystic disease of the breastdisease of the breast Prevent cancerPrevent cancer Civil DefenseCivil Defense Treat multiple diseases:Treat multiple diseases: dermatologic, pulmonary,dermatologic, pulmonary, cardiovascular, fungalcardiovascular, fungal
  31. 31. Different Kinds of IodineDifferent Kinds of Iodine  Inorganic, Nonradioactive (Inorganic, Nonradioactive (127127 I)I) – KI, SSKI, Lugol’s Solution, Iodoral,KI, SSKI, Lugol’s Solution, Iodoral, – Tincture of Iodine, Povidone-Iodine)Tincture of Iodine, Povidone-Iodine)  OrganicOrganic – EndogenousEndogenous • Thyroid hormonesThyroid hormones – SyntheticSynthetic • AmiodaroneAmiodarone • Radiocontrast mediaRadiocontrast media – Iopanoic acid, Meglumine Iotroxate, Propyliodone, etc.Iopanoic acid, Meglumine Iotroxate, Propyliodone, etc.  (Inorganic) Radioactive Isotopes(Inorganic) Radioactive Isotopes
  32. 32. Forms of Inorganic, NonradioactiveForms of Inorganic, Nonradioactive IodineIodine • KIKI (Potassium Iodide)(Potassium Iodide) – A 130 mg tablet contains 100 mg of iodideA 130 mg tablet contains 100 mg of iodide • SSKISSKI (Saturated Solution of Potassium Iodide)(Saturated Solution of Potassium Iodide) – 38 mg/drop iodide (760 mg/ml)38 mg/drop iodide (760 mg/ml) • 19 mg/drop in Tahoma Clinic’s SSKI Tri-Quench19 mg/drop in Tahoma Clinic’s SSKI Tri-Quench • Lugol’s SolutionLugol’s Solution ---- 5% iodine (I5% iodine (I22) and 10% KI) and 10% KI – 6.5 mg/drop blend of iodine and iodide (130 mg/ml)6.5 mg/drop blend of iodine and iodide (130 mg/ml) • Iodoral --Iodoral -- 5% iodine and 10% KI5% iodine and 10% KI – One tablet = 12.5 mg blend of iodine and iodideOne tablet = 12.5 mg blend of iodine and iodide
  33. 33. Iodine PoisoningIodine Poisoning IngestedIngested 15 gm15 gm of Iodine –of Iodine – 100,000 x100,000 x the RDA of 0.00015 gm (150the RDA of 0.00015 gm (150 μμg)g) Serum Iodide level wasSerum Iodide level was 2,950 ug/dL2,950 ug/dL (normal is 3.5(normal is 3.5 μμg/dL with daily intakeg/dL with daily intake of 150 ug Iodine)of 150 ug Iodine) Salivary Iodide LevelSalivary Iodide Level 60,000 ug/dL60,000 ug/dL (normal 105(normal 105 μμg/dL)g/dL)
  34. 34. Iodine in DermatologyIodine in Dermatology PyodermaPyoderma GangrenosumGangrenosum NodularNodular VasculitisVasculitis SporotrichosisSporotrichosis Sterling JB, Heymann WR. Potassium IodideSterling JB, Heymann WR. Potassium Iodide In Dermatology: A 19In Dermatology: A 19thth Century Drug for the 21Century Drug for the 21stst Century—Uses, Pharmacology, Adverse Effects,Century—Uses, Pharmacology, Adverse Effects, and Contraindications.and Contraindications. J Am Acad DermatolJ Am Acad Dermatol 2000;43:691-697.2000;43:691-697.
  35. 35. Fibrocystic Breast DiseaseFibrocystic Breast Disease CystCyst FibrousFibrous tissuetissue EpithelialEpithelial andand apocrineapocrine hyperplasiahyperplasia ElementalElemental Iodine, IIodine, I22, more, more effective thaneffective than Iodide, IIodide, I-- Ghent WR, Eskin BA, Low DA, Hill LP. Iodine Replacement inGhent WR, Eskin BA, Low DA, Hill LP. Iodine Replacement in Fibrocystic Disease of the Breast.Fibrocystic Disease of the Breast. Can J SurgCan J Surg 1993;36:453-1993;36:453-
  36. 36. Iodine Prevents Breast CancerIodine Prevents Breast Cancer Animal StudiesAnimal Studies Reduces incidence in rats given carcinogensReduces incidence in rats given carcinogens Human StudiesHuman Studies Kills cancer cells grownKills cancer cells grown in vitroin vitro Absorbed by cancer-prone ductal epitheliumAbsorbed by cancer-prone ductal epithelium Epidemiological StudiesEpidemiological Studies Increased incidence with goiterIncreased incidence with goiter Lower incidence in people who eat seaweed andLower incidence in people who eat seaweed and fishfish
  37. 37. The Iodine ProjectThe Iodine Project Hypothesis:Hypothesis: Whole body sufficiencyWhole body sufficiency of iodine requires mg (12.5 mg),of iodine requires mg (12.5 mg), notnot μμg (150g (150 μμg ) daily amountsg ) daily amounts Principle InvestigatorsPrinciple Investigators Guy Abraham MD, 1997: Optimox Corp., Torrance, CAGuy Abraham MD, 1997: Optimox Corp., Torrance, CA Jorge Flechas MD, 2000 (1,000 pts.): Flechas FamilyJorge Flechas MD, 2000 (1,000 pts.): Flechas Family Practice, Hendersonville, NCPractice, Hendersonville, NC David Brownstein MD, 2003 (3,000 pts.): Center for HolisticDavid Brownstein MD, 2003 (3,000 pts.): Center for Holistic Medicine, West Bloomfield, MIMedicine, West Bloomfield, MI Iodine Loading TestIodine Loading Test Take 50 mg iodine, urine collected for 24 hoursTake 50 mg iodine, urine collected for 24 hours Less than 90 % excretion indicates iodine insufficiencyLess than 90 % excretion indicates iodine insufficiency
  38. 38. Health Benefits of mg-DoseHealth Benefits of mg-Dose Iodine atIodine at 100x the RDI100x the RDI  Feel HealthierFeel Healthier  Sense of Well-BeingSense of Well-Being  Lifting of Brain FogLifting of Brain Fog  Increased Energy –Increased Energy – Achieve More in Less TimeAchieve More in Less Time  Feel Warmer in ColdFeel Warmer in Cold EnvironmentsEnvironments  Need Less SleepNeed Less Sleep  Regular Bowel MovementsRegular Bowel Movements  Improved Skin ComplexionImproved Skin Complexion  Strengthens Immune SystemStrengthens Immune System  Prevents CancerPrevents Cancer  BlocksBlocks 131131 I Absorption from Radioactive FalloutI Absorption from Radioactive Fallout

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