SlideShare a Scribd company logo

Determination of extractives

Dr Priyanka Patil
Dr Priyanka Patil
Dr Priyanka PatilDoctor at RKM ayurvedic medical college, Vijayapura

determination of extractives, acid soluble extractive, acid insoluble ash, water soluble extractive, ether soluble extractives, ash value.

Determination of extractives

1 of 14
DETERMINATION OF
EXTRACTIVES
determination of extractives TGAMC Ballari.
1
PRESENTER
DR.PRIYANKA.PATIL
1ST YR P.G. SCHOLAR
Guide
Dr Ravi.R.Chavan
Dept of RS&BK
Asst. Professor
TGAMC, Ballari.
HOD
Dr. shankaragouda
Dept of RS & BK
Professor and HOD
TGAMC, Ballari
INTRODUCTION
• Extractives are the natural chemical products of biomass
that are capable of being extracted by some solvents.
• It comes under physical parameter of the drug evaluation.
• It helps to indicate the nature of chemical constituents
present in the drug.
determination of extractives TGAMC Ballari.
2
TYPES
1.
• Alcohol
soluble
extractive
2.
• Water
soluble
extractive
3.
• Ether
soluble
extractive
determination of extractives TGAMC Ballari.
3
Water soluble extractives
• Is applied for the drugs which contain water soluble constituents such as tannins,
sugars, plant acids and mucilage.
Alcohol soluble extractives
• For drugs which contain alcohol soluble constituents such as tannins, resins, and
alkaloids.
Ether soluble extractives
• For extraction of volatile oil, fixed oils and resins.
• volatile ether soluble extractive
• non volatile ether soluble extractive.
determination of extractives TGAMC Ballari.
4
DETERMINATION
WATER SOLUBLE EXTRACTIVE VALUE
1) Macerate about 5gm of the accurately weighed coarse powder(air dried drug) with 100ml of
water in a 100ml volumetric flask for 24hrs.
2) Shake frequently for first 6 hrs.
3) Filter rapidly, through filter paper and evaporate 25ml of water extract (water bath) to dryness
in a tared flat bottomed shallow dish.
4) Dry the residue at 105 (muffle furnace) and weigh. Keep it in a desiccator.
5) Dry the extract to constant weight, finally calculate the % of W/W of water soluble extractive
value with reference to the air dried drug.
determination of extractives TGAMC Ballari.
5
Weigh dry empty
crucible
Frequently stir 1st
6hrs
100ml water + 5gm
drug
Heat in muffle furnace Keep on water bath and evaporate add Filtrate to crucible
Filter rapidly Take 25ml filtrate
Dry in desiccator
Weigh crucible
again
determination of extractives TGAMC Ballari.
6

More Related Content

What's hot

Isolation, Identification and Analysis of Phytoconstituents
Isolation, Identification and Analysis of PhytoconstituentsIsolation, Identification and Analysis of Phytoconstituents
Isolation, Identification and Analysis of PhytoconstituentsDr. Siddhi Upadhyay
 
Isolation,identification and analysis of phytoconstituents .Dr.U.Srinivasa, P...
Isolation,identification and analysis of phytoconstituents .Dr.U.Srinivasa, P...Isolation,identification and analysis of phytoconstituents .Dr.U.Srinivasa, P...
Isolation,identification and analysis of phytoconstituents .Dr.U.Srinivasa, P...Srinivas college of pharmacy, Mangalore
 
Industrial production, estimation and utilization of phytoconstituents
Industrial production, estimation and utilization of phytoconstituentsIndustrial production, estimation and utilization of phytoconstituents
Industrial production, estimation and utilization of phytoconstituentsMahewash Sana Pathan
 
Drugs and Cosmetics act, 1940
Drugs and Cosmetics act, 1940Drugs and Cosmetics act, 1940
Drugs and Cosmetics act, 1940Payal Mundada
 
Accelerated stability studes
Accelerated stability studesAccelerated stability studes
Accelerated stability studesSunil Boreddy Rx
 
Stability testing of herbal natural products and its
Stability testing of herbal natural products and itsStability testing of herbal natural products and its
Stability testing of herbal natural products and itsSudhindraKini
 
Isolation Extraction Estimation of Artemisinin
Isolation Extraction Estimation of ArtemisininIsolation Extraction Estimation of Artemisinin
Isolation Extraction Estimation of ArtemisininAFSATH
 
Extraction of volatile oils
Extraction of volatile oilsExtraction of volatile oils
Extraction of volatile oilsSajeenaCH
 
Basic of phytochemistry
Basic of phytochemistryBasic of phytochemistry
Basic of phytochemistryTulsi Nimbekar
 

What's hot (20)

Tannins drugs
Tannins   drugsTannins   drugs
Tannins drugs
 
Senna
SennaSenna
Senna
 
HDT Practical Exp.1
HDT Practical Exp.1HDT Practical Exp.1
HDT Practical Exp.1
 
Isolation, Identification and Analysis of Phytoconstituents
Isolation, Identification and Analysis of PhytoconstituentsIsolation, Identification and Analysis of Phytoconstituents
Isolation, Identification and Analysis of Phytoconstituents
 
Isolation,identification and analysis of phytoconstituents .Dr.U.Srinivasa, P...
Isolation,identification and analysis of phytoconstituents .Dr.U.Srinivasa, P...Isolation,identification and analysis of phytoconstituents .Dr.U.Srinivasa, P...
Isolation,identification and analysis of phytoconstituents .Dr.U.Srinivasa, P...
 
Industrial production, estimation and utilization of phytoconstituents
Industrial production, estimation and utilization of phytoconstituentsIndustrial production, estimation and utilization of phytoconstituents
Industrial production, estimation and utilization of phytoconstituents
 
Vinca
VincaVinca
Vinca
 
Drugs and Cosmetics act, 1940
Drugs and Cosmetics act, 1940Drugs and Cosmetics act, 1940
Drugs and Cosmetics act, 1940
 
Accelerated stability studes
Accelerated stability studesAccelerated stability studes
Accelerated stability studes
 
Stability testing of herbal natural products and its
Stability testing of herbal natural products and itsStability testing of herbal natural products and its
Stability testing of herbal natural products and its
 
Castor oil
Castor oilCastor oil
Castor oil
 
Natural Colorants
Natural ColorantsNatural Colorants
Natural Colorants
 
Isolation Extraction Estimation of Artemisinin
Isolation Extraction Estimation of ArtemisininIsolation Extraction Estimation of Artemisinin
Isolation Extraction Estimation of Artemisinin
 
Bitter almond
Bitter almondBitter almond
Bitter almond
 
Bio assays of insulin
Bio assays of insulinBio assays of insulin
Bio assays of insulin
 
Herbal excipients
Herbal excipientsHerbal excipients
Herbal excipients
 
Extraction of volatile oils
Extraction of volatile oilsExtraction of volatile oils
Extraction of volatile oils
 
Basic of phytochemistry
Basic of phytochemistryBasic of phytochemistry
Basic of phytochemistry
 
Herbal drug technology unit 1
Herbal drug technology unit 1Herbal drug technology unit 1
Herbal drug technology unit 1
 
Basics of Phytochemistry
Basics of PhytochemistryBasics of Phytochemistry
Basics of Phytochemistry
 

Similar to Determination of extractives

Physical and biological method of drug evaluation by Dr.U.Srinivasa
Physical and biological method of drug evaluation by Dr.U.SrinivasaPhysical and biological method of drug evaluation by Dr.U.Srinivasa
Physical and biological method of drug evaluation by Dr.U.Srinivasaummanabadsrinivas
 
Physical evaluation of crude drugs
Physical evaluation of crude drugsPhysical evaluation of crude drugs
Physical evaluation of crude drugsArslan Tahir
 
analytical methods of Diuretics
analytical methods of Diureticsanalytical methods of Diuretics
analytical methods of DiureticsAlekya Chinki
 
Phytochemical investigation of lawsonia inermis linn and its
Phytochemical investigation of lawsonia inermis linn and itsPhytochemical investigation of lawsonia inermis linn and its
Phytochemical investigation of lawsonia inermis linn and itsMamoona Nigha
 
extraction of important phytodrug
extraction of important phytodrugextraction of important phytodrug
extraction of important phytodrugMilantirtha Mete
 
Introduction and scope of pharmacognosy by Dr.U.Srinivasa, Professor, Sriniv...
Introduction  and scope of pharmacognosy by Dr.U.Srinivasa, Professor, Sriniv...Introduction  and scope of pharmacognosy by Dr.U.Srinivasa, Professor, Sriniv...
Introduction and scope of pharmacognosy by Dr.U.Srinivasa, Professor, Sriniv...Srinivas college of pharmacy, Mangalore
 
Standardisation of hd by pooja
Standardisation of hd by poojaStandardisation of hd by pooja
Standardisation of hd by poojaPOOJA KHANPARA
 
Compendial evaluation for evaluation of crude and herbal drugs
Compendial evaluation for evaluation of crude and herbal drugsCompendial evaluation for evaluation of crude and herbal drugs
Compendial evaluation for evaluation of crude and herbal drugsShruti Patel
 
Phytochemical and acute toxicity study of leaves of artocarpus heterophyllus lam
Phytochemical and acute toxicity study of leaves of artocarpus heterophyllus lamPhytochemical and acute toxicity study of leaves of artocarpus heterophyllus lam
Phytochemical and acute toxicity study of leaves of artocarpus heterophyllus lampharmaindexing
 
Standardization of herbal drug Ppt
Standardization  of herbal drug PptStandardization  of herbal drug Ppt
Standardization of herbal drug Pptinder makhija
 
tooba shafi presentation.pptx
tooba shafi presentation.pptxtooba shafi presentation.pptx
tooba shafi presentation.pptxToobaNoor29
 
Standardization of herbal drugs
Standardization of herbal drugsStandardization of herbal drugs
Standardization of herbal drugsshveta arya
 

Similar to Determination of extractives (20)

Dr.U.Srinivasa
Dr.U.SrinivasaDr.U.Srinivasa
Dr.U.Srinivasa
 
Physical and biological method of drug evaluation by Dr.U.Srinivasa
Physical and biological method of drug evaluation by Dr.U.SrinivasaPhysical and biological method of drug evaluation by Dr.U.Srinivasa
Physical and biological method of drug evaluation by Dr.U.Srinivasa
 
Physical evaluation of crude drugs
Physical evaluation of crude drugsPhysical evaluation of crude drugs
Physical evaluation of crude drugs
 
Lecture 4
Lecture 4Lecture 4
Lecture 4
 
analytical methods of Diuretics
analytical methods of Diureticsanalytical methods of Diuretics
analytical methods of Diuretics
 
Phytochemical investigation of lawsonia inermis linn and its
Phytochemical investigation of lawsonia inermis linn and itsPhytochemical investigation of lawsonia inermis linn and its
Phytochemical investigation of lawsonia inermis linn and its
 
extraction of important phytodrug
extraction of important phytodrugextraction of important phytodrug
extraction of important phytodrug
 
Introduction and scope of pharmacognosy by Dr.U.Srinivasa, Professor, Sriniv...
Introduction  and scope of pharmacognosy by Dr.U.Srinivasa, Professor, Sriniv...Introduction  and scope of pharmacognosy by Dr.U.Srinivasa, Professor, Sriniv...
Introduction and scope of pharmacognosy by Dr.U.Srinivasa, Professor, Sriniv...
 
Standardisation of hd by pooja
Standardisation of hd by poojaStandardisation of hd by pooja
Standardisation of hd by pooja
 
alkaloids.pptx
alkaloids.pptxalkaloids.pptx
alkaloids.pptx
 
Antihelmenthic activity
Antihelmenthic activityAntihelmenthic activity
Antihelmenthic activity
 
ALKALOIDAL DRUG ASSAY.pptx
ALKALOIDAL DRUG ASSAY.pptxALKALOIDAL DRUG ASSAY.pptx
ALKALOIDAL DRUG ASSAY.pptx
 
Resin
ResinResin
Resin
 
Compendial evaluation for evaluation of crude and herbal drugs
Compendial evaluation for evaluation of crude and herbal drugsCompendial evaluation for evaluation of crude and herbal drugs
Compendial evaluation for evaluation of crude and herbal drugs
 
Phytochemical and acute toxicity study of leaves of artocarpus heterophyllus lam
Phytochemical and acute toxicity study of leaves of artocarpus heterophyllus lamPhytochemical and acute toxicity study of leaves of artocarpus heterophyllus lam
Phytochemical and acute toxicity study of leaves of artocarpus heterophyllus lam
 
Standardization of herbal drug Ppt
Standardization  of herbal drug PptStandardization  of herbal drug Ppt
Standardization of herbal drug Ppt
 
tooba shafi presentation.pptx
tooba shafi presentation.pptxtooba shafi presentation.pptx
tooba shafi presentation.pptx
 
Extraction updated
Extraction updatedExtraction updated
Extraction updated
 
FOOD ADDITIVES
FOOD ADDITIVESFOOD ADDITIVES
FOOD ADDITIVES
 
Standardization of herbal drugs
Standardization of herbal drugsStandardization of herbal drugs
Standardization of herbal drugs
 

More from Dr Priyanka Patil

basic principles of aushadi yoga.pptx
basic principles of aushadi yoga.pptxbasic principles of aushadi yoga.pptx
basic principles of aushadi yoga.pptxDr Priyanka Patil
 
AVARTANA TECHNOLOGY IN PHARMACEUTICAL PREPARATIONS.pptx
AVARTANA TECHNOLOGY IN PHARMACEUTICAL PREPARATIONS.pptxAVARTANA TECHNOLOGY IN PHARMACEUTICAL PREPARATIONS.pptx
AVARTANA TECHNOLOGY IN PHARMACEUTICAL PREPARATIONS.pptxDr Priyanka Patil
 
Analytical parameters in Avaleha kalpana
Analytical parameters in Avaleha kalpanaAnalytical parameters in Avaleha kalpana
Analytical parameters in Avaleha kalpanaDr Priyanka Patil
 
Arka kalpana and its modern aspect.pptx
Arka kalpana and its modern aspect.pptxArka kalpana and its modern aspect.pptx
Arka kalpana and its modern aspect.pptxDr Priyanka Patil
 
asava aristha in bruhatrayee.pptx
asava aristha in bruhatrayee.pptxasava aristha in bruhatrayee.pptx
asava aristha in bruhatrayee.pptxDr Priyanka Patil
 
analytical tests of bhaishajya kalpana.pptx
analytical tests of bhaishajya kalpana.pptxanalytical tests of bhaishajya kalpana.pptx
analytical tests of bhaishajya kalpana.pptxDr Priyanka Patil
 
analytical parameters of lepa & malahara.pptx
analytical parameters of lepa & malahara.pptxanalytical parameters of lepa & malahara.pptx
analytical parameters of lepa & malahara.pptxDr Priyanka Patil
 
adharabhuta siddanta of BK.pptx
adharabhuta siddanta of BK.pptxadharabhuta siddanta of BK.pptx
adharabhuta siddanta of BK.pptxDr Priyanka Patil
 
Mahagandhakam: essential boon for mahasrotas
Mahagandhakam: essential boon for mahasrotasMahagandhakam: essential boon for mahasrotas
Mahagandhakam: essential boon for mahasrotasDr Priyanka Patil
 
Kasisa drava basti in arshas
Kasisa drava basti in arshasKasisa drava basti in arshas
Kasisa drava basti in arshasDr Priyanka Patil
 
Role of ayurvedic drugs in immunomodulation
Role of ayurvedic drugs in immunomodulationRole of ayurvedic drugs in immunomodulation
Role of ayurvedic drugs in immunomodulationDr Priyanka Patil
 

More from Dr Priyanka Patil (19)

bio availability.pptx
bio availability.pptxbio availability.pptx
bio availability.pptx
 
Basti kalpana.pptx
Basti kalpana.pptxBasti kalpana.pptx
Basti kalpana.pptx
 
basic principles of aushadi yoga.pptx
basic principles of aushadi yoga.pptxbasic principles of aushadi yoga.pptx
basic principles of aushadi yoga.pptx
 
AVARTANA TECHNOLOGY IN PHARMACEUTICAL PREPARATIONS.pptx
AVARTANA TECHNOLOGY IN PHARMACEUTICAL PREPARATIONS.pptxAVARTANA TECHNOLOGY IN PHARMACEUTICAL PREPARATIONS.pptx
AVARTANA TECHNOLOGY IN PHARMACEUTICAL PREPARATIONS.pptx
 
Analytical parameters in Avaleha kalpana
Analytical parameters in Avaleha kalpanaAnalytical parameters in Avaleha kalpana
Analytical parameters in Avaleha kalpana
 
Arka kalpana and its modern aspect.pptx
Arka kalpana and its modern aspect.pptxArka kalpana and its modern aspect.pptx
Arka kalpana and its modern aspect.pptx
 
ARJUNA KSHEERA PAAKA.pptx
ARJUNA KSHEERA PAAKA.pptxARJUNA KSHEERA PAAKA.pptx
ARJUNA KSHEERA PAAKA.pptx
 
asava aristha in bruhatrayee.pptx
asava aristha in bruhatrayee.pptxasava aristha in bruhatrayee.pptx
asava aristha in bruhatrayee.pptx
 
analytical tests of bhaishajya kalpana.pptx
analytical tests of bhaishajya kalpana.pptxanalytical tests of bhaishajya kalpana.pptx
analytical tests of bhaishajya kalpana.pptx
 
analytical parameters of lepa & malahara.pptx
analytical parameters of lepa & malahara.pptxanalytical parameters of lepa & malahara.pptx
analytical parameters of lepa & malahara.pptx
 
adharabhuta siddanta of BK.pptx
adharabhuta siddanta of BK.pptxadharabhuta siddanta of BK.pptx
adharabhuta siddanta of BK.pptx
 
Mahagandhakam: essential boon for mahasrotas
Mahagandhakam: essential boon for mahasrotasMahagandhakam: essential boon for mahasrotas
Mahagandhakam: essential boon for mahasrotas
 
Kasisa drava basti in arshas
Kasisa drava basti in arshasKasisa drava basti in arshas
Kasisa drava basti in arshas
 
Role of ayurvedic drugs in immunomodulation
Role of ayurvedic drugs in immunomodulationRole of ayurvedic drugs in immunomodulation
Role of ayurvedic drugs in immunomodulation
 
Cohort study
Cohort studyCohort study
Cohort study
 
Distillation & evaporation
Distillation & evaporationDistillation & evaporation
Distillation & evaporation
 
Ekangaveera rasa
Ekangaveera rasaEkangaveera rasa
Ekangaveera rasa
 
Avaleha kalpana
Avaleha  kalpanaAvaleha  kalpana
Avaleha kalpana
 
Kottumchukkadi taila
Kottumchukkadi tailaKottumchukkadi taila
Kottumchukkadi taila
 

Recently uploaded

TRANSPORT PROCESS ACROSS CELL MEMBRANE.pptx
TRANSPORT PROCESS ACROSS CELL MEMBRANE.pptxTRANSPORT PROCESS ACROSS CELL MEMBRANE.pptx
TRANSPORT PROCESS ACROSS CELL MEMBRANE.pptxPoojaDahale3
 
Target pain receptors with essential oils
Target pain receptors with essential oilsTarget pain receptors with essential oils
Target pain receptors with essential oilsKevin KF Ng
 
Renal Regulation of Potassium, Calcium, Magnesium and Phosphorus
Renal Regulation of Potassium, Calcium, Magnesium and PhosphorusRenal Regulation of Potassium, Calcium, Magnesium and Phosphorus
Renal Regulation of Potassium, Calcium, Magnesium and PhosphorusMedicoseAcademics
 
Indian Best Pharmaceutical Company - Solace biotech limited
Indian Best Pharmaceutical Company - Solace biotech limitedIndian Best Pharmaceutical Company - Solace biotech limited
Indian Best Pharmaceutical Company - Solace biotech limitedSBL DIGITAL
 
ANTI-HYPERTENSIVE DRUG - RAUWOLFIA ROOT.
ANTI-HYPERTENSIVE DRUG - RAUWOLFIA ROOT.ANTI-HYPERTENSIVE DRUG - RAUWOLFIA ROOT.
ANTI-HYPERTENSIVE DRUG - RAUWOLFIA ROOT.Divya Kanojiya
 
Feel and Look Years Younger With Nutra IGF 1 Supplement
Feel and Look Years Younger With Nutra IGF 1 SupplementFeel and Look Years Younger With Nutra IGF 1 Supplement
Feel and Look Years Younger With Nutra IGF 1 SupplementWintersBiotechnology
 
pediatrics. epilepsy and seizures in children 8.ppt
pediatrics. epilepsy and seizures in children 8.pptpediatrics. epilepsy and seizures in children 8.ppt
pediatrics. epilepsy and seizures in children 8.pptArun170190
 
Peripheral Vascular Disease (PVD): Physiotherapy assessment and management
Peripheral Vascular Disease (PVD): Physiotherapy assessment and managementPeripheral Vascular Disease (PVD): Physiotherapy assessment and management
Peripheral Vascular Disease (PVD): Physiotherapy assessment and managementTushar Sharma
 
https://getneurozoom.cc/welcome#aff=musvi5
https://getneurozoom.cc/welcome#aff=musvi5https://getneurozoom.cc/welcome#aff=musvi5
https://getneurozoom.cc/welcome#aff=musvi5Hussain Syed
 
The EMA and Glucagon-Like Peptide-1 Agonists: A Wake-Up Call
The EMA and Glucagon-Like Peptide-1 Agonists: A Wake-Up CallThe EMA and Glucagon-Like Peptide-1 Agonists: A Wake-Up Call
The EMA and Glucagon-Like Peptide-1 Agonists: A Wake-Up Callsemualkaira
 
Dental Hygiene Library session Searching - 2nd class
Dental Hygiene Library session Searching - 2nd classDental Hygiene Library session Searching - 2nd class
Dental Hygiene Library session Searching - 2nd classHVCClibrary
 
Scanning electron microscope - SEM , Its applicability in rasashastra
Scanning electron microscope - SEM , Its applicability in rasashastraScanning electron microscope - SEM , Its applicability in rasashastra
Scanning electron microscope - SEM , Its applicability in rasashastraDr. Madduru Muni Haritha
 
Tolerance Hydra10P Avene trainings blink
Tolerance Hydra10P Avene trainings blinkTolerance Hydra10P Avene trainings blink
Tolerance Hydra10P Avene trainings blinkClinicians
 
Presentation on Cerebral Palsy and its orthotic management
Presentation on Cerebral Palsy and its orthotic managementPresentation on Cerebral Palsy and its orthotic management
Presentation on Cerebral Palsy and its orthotic managementeshasmalik27
 
Epidemiological Study Design, Research Design, Clinical Research
Epidemiological Study Design, Research Design, Clinical ResearchEpidemiological Study Design, Research Design, Clinical Research
Epidemiological Study Design, Research Design, Clinical ResearchDr KHALID B.M
 
Seminario Biología Molecular - Susana Cano V.pdf
Seminario Biología Molecular - Susana Cano V.pdfSeminario Biología Molecular - Susana Cano V.pdf
Seminario Biología Molecular - Susana Cano V.pdfsusiedapp
 
Different Export Prices of Medicinal Drugs.pdf
Different Export Prices of Medicinal Drugs.pdfDifferent Export Prices of Medicinal Drugs.pdf
Different Export Prices of Medicinal Drugs.pdfAsmaa Khalil
 
Anatomy and Physiology of Optic Nerve Dr.PrabhatDevkota.pptx
Anatomy and Physiology of Optic Nerve Dr.PrabhatDevkota.pptxAnatomy and Physiology of Optic Nerve Dr.PrabhatDevkota.pptx
Anatomy and Physiology of Optic Nerve Dr.PrabhatDevkota.pptxDr. Prabhat Devkota, MD
 
FEBRUARY 2024 ONCOLOGY CARTOON /95TH VOLUME
FEBRUARY 2024 ONCOLOGY CARTOON /95TH VOLUMEFEBRUARY 2024 ONCOLOGY CARTOON /95TH VOLUME
FEBRUARY 2024 ONCOLOGY CARTOON /95TH VOLUMEKanhu Charan
 

Recently uploaded (20)

TRANSPORT PROCESS ACROSS CELL MEMBRANE.pptx
TRANSPORT PROCESS ACROSS CELL MEMBRANE.pptxTRANSPORT PROCESS ACROSS CELL MEMBRANE.pptx
TRANSPORT PROCESS ACROSS CELL MEMBRANE.pptx
 
Target pain receptors with essential oils
Target pain receptors with essential oilsTarget pain receptors with essential oils
Target pain receptors with essential oils
 
Renal Regulation of Potassium, Calcium, Magnesium and Phosphorus
Renal Regulation of Potassium, Calcium, Magnesium and PhosphorusRenal Regulation of Potassium, Calcium, Magnesium and Phosphorus
Renal Regulation of Potassium, Calcium, Magnesium and Phosphorus
 
Indian Best Pharmaceutical Company - Solace biotech limited
Indian Best Pharmaceutical Company - Solace biotech limitedIndian Best Pharmaceutical Company - Solace biotech limited
Indian Best Pharmaceutical Company - Solace biotech limited
 
ANTI-HYPERTENSIVE DRUG - RAUWOLFIA ROOT.
ANTI-HYPERTENSIVE DRUG - RAUWOLFIA ROOT.ANTI-HYPERTENSIVE DRUG - RAUWOLFIA ROOT.
ANTI-HYPERTENSIVE DRUG - RAUWOLFIA ROOT.
 
Feel and Look Years Younger With Nutra IGF 1 Supplement
Feel and Look Years Younger With Nutra IGF 1 SupplementFeel and Look Years Younger With Nutra IGF 1 Supplement
Feel and Look Years Younger With Nutra IGF 1 Supplement
 
Expectorants and Antitussives.pdf
Expectorants and Antitussives.pdfExpectorants and Antitussives.pdf
Expectorants and Antitussives.pdf
 
pediatrics. epilepsy and seizures in children 8.ppt
pediatrics. epilepsy and seizures in children 8.pptpediatrics. epilepsy and seizures in children 8.ppt
pediatrics. epilepsy and seizures in children 8.ppt
 
Peripheral Vascular Disease (PVD): Physiotherapy assessment and management
Peripheral Vascular Disease (PVD): Physiotherapy assessment and managementPeripheral Vascular Disease (PVD): Physiotherapy assessment and management
Peripheral Vascular Disease (PVD): Physiotherapy assessment and management
 
https://getneurozoom.cc/welcome#aff=musvi5
https://getneurozoom.cc/welcome#aff=musvi5https://getneurozoom.cc/welcome#aff=musvi5
https://getneurozoom.cc/welcome#aff=musvi5
 
The EMA and Glucagon-Like Peptide-1 Agonists: A Wake-Up Call
The EMA and Glucagon-Like Peptide-1 Agonists: A Wake-Up CallThe EMA and Glucagon-Like Peptide-1 Agonists: A Wake-Up Call
The EMA and Glucagon-Like Peptide-1 Agonists: A Wake-Up Call
 
Dental Hygiene Library session Searching - 2nd class
Dental Hygiene Library session Searching - 2nd classDental Hygiene Library session Searching - 2nd class
Dental Hygiene Library session Searching - 2nd class
 
Scanning electron microscope - SEM , Its applicability in rasashastra
Scanning electron microscope - SEM , Its applicability in rasashastraScanning electron microscope - SEM , Its applicability in rasashastra
Scanning electron microscope - SEM , Its applicability in rasashastra
 
Tolerance Hydra10P Avene trainings blink
Tolerance Hydra10P Avene trainings blinkTolerance Hydra10P Avene trainings blink
Tolerance Hydra10P Avene trainings blink
 
Presentation on Cerebral Palsy and its orthotic management
Presentation on Cerebral Palsy and its orthotic managementPresentation on Cerebral Palsy and its orthotic management
Presentation on Cerebral Palsy and its orthotic management
 
Epidemiological Study Design, Research Design, Clinical Research
Epidemiological Study Design, Research Design, Clinical ResearchEpidemiological Study Design, Research Design, Clinical Research
Epidemiological Study Design, Research Design, Clinical Research
 
Seminario Biología Molecular - Susana Cano V.pdf
Seminario Biología Molecular - Susana Cano V.pdfSeminario Biología Molecular - Susana Cano V.pdf
Seminario Biología Molecular - Susana Cano V.pdf
 
Different Export Prices of Medicinal Drugs.pdf
Different Export Prices of Medicinal Drugs.pdfDifferent Export Prices of Medicinal Drugs.pdf
Different Export Prices of Medicinal Drugs.pdf
 
Anatomy and Physiology of Optic Nerve Dr.PrabhatDevkota.pptx
Anatomy and Physiology of Optic Nerve Dr.PrabhatDevkota.pptxAnatomy and Physiology of Optic Nerve Dr.PrabhatDevkota.pptx
Anatomy and Physiology of Optic Nerve Dr.PrabhatDevkota.pptx
 
FEBRUARY 2024 ONCOLOGY CARTOON /95TH VOLUME
FEBRUARY 2024 ONCOLOGY CARTOON /95TH VOLUMEFEBRUARY 2024 ONCOLOGY CARTOON /95TH VOLUME
FEBRUARY 2024 ONCOLOGY CARTOON /95TH VOLUME
 

Determination of extractives

  • 1. DETERMINATION OF EXTRACTIVES determination of extractives TGAMC Ballari. 1 PRESENTER DR.PRIYANKA.PATIL 1ST YR P.G. SCHOLAR Guide Dr Ravi.R.Chavan Dept of RS&BK Asst. Professor TGAMC, Ballari. HOD Dr. shankaragouda Dept of RS & BK Professor and HOD TGAMC, Ballari
  • 2. INTRODUCTION • Extractives are the natural chemical products of biomass that are capable of being extracted by some solvents. • It comes under physical parameter of the drug evaluation. • It helps to indicate the nature of chemical constituents present in the drug. determination of extractives TGAMC Ballari. 2
  • 3. TYPES 1. • Alcohol soluble extractive 2. • Water soluble extractive 3. • Ether soluble extractive determination of extractives TGAMC Ballari. 3
  • 4. Water soluble extractives • Is applied for the drugs which contain water soluble constituents such as tannins, sugars, plant acids and mucilage. Alcohol soluble extractives • For drugs which contain alcohol soluble constituents such as tannins, resins, and alkaloids. Ether soluble extractives • For extraction of volatile oil, fixed oils and resins. • volatile ether soluble extractive • non volatile ether soluble extractive. determination of extractives TGAMC Ballari. 4
  • 5. DETERMINATION WATER SOLUBLE EXTRACTIVE VALUE 1) Macerate about 5gm of the accurately weighed coarse powder(air dried drug) with 100ml of water in a 100ml volumetric flask for 24hrs. 2) Shake frequently for first 6 hrs. 3) Filter rapidly, through filter paper and evaporate 25ml of water extract (water bath) to dryness in a tared flat bottomed shallow dish. 4) Dry the residue at 105 (muffle furnace) and weigh. Keep it in a desiccator. 5) Dry the extract to constant weight, finally calculate the % of W/W of water soluble extractive value with reference to the air dried drug. determination of extractives TGAMC Ballari. 5
  • 6. Weigh dry empty crucible Frequently stir 1st 6hrs 100ml water + 5gm drug Heat in muffle furnace Keep on water bath and evaporate add Filtrate to crucible Filter rapidly Take 25ml filtrate Dry in desiccator Weigh crucible again determination of extractives TGAMC Ballari. 6
  • 7. CALCULATION % of water soluble extract weight of residue weight of drug 100 determination of extractives TGAMC Ballari. 7
  • 8. WATER SOLUBLE EXTRACTIVE VALUE. S.No DRUG Water soluble extractive (% W/W) 1. Aloe vera NLT 25.0 2. Linseed NLT 20.0 3. Senna leaves NLT 30.0 4. Ginger NLT 10.0 5. Glycyrrhiza NLT 20.0 determination of extractives TGAMC Ballari. 8
  • 9. DETERMINATION ALCOHOL SOLUBLE EXTRACTIVE VALUE 1) Macerate about 5gm of the accurately weighed coarse powder(air dried drug) with 100ml of 90% alcohol in a 100ml volumetric flask for 24hrs 2) Shake frequently for first 6 hrs. 3) Filter rapidly, through filter paper and evaporate 25ml of alcohol extract (steam bath) to dryness in a tared flat bottomed shallow dish. 4) Dry the residue at 105 (muffle furnace) and weigh. Keep it in a desiccator. 5) Dry the extract to constant weight, finally calculate the % of W/W of alcohol soluble extractive value with reference to the air dried drug. determination of extractives TGAMC Ballari. 9
  • 10. Weigh dry empty crucible Frequently shake first 6hrs 100ml alcohol + 5gm drug Heat in muffle furnace Keep on water bath and evaporate add Filter to crucible Filter rapidly Take 25ml filtrate Dry in desiccator Weigh crucible again determination of extractives TGAMC Ballari. 10
  • 11. ALCOHOL SOLUBLE EXTRACTIVE VALUE. Sl. No. Drug. Alcohol soluble Extractive % W/W. 1. Aloevera NLT 10.0 2. Benzoin NLT 90.0 3. Asafoetida NLT 50.0 4. Ginger NLT 04.0 5. Myrrh NLT 24.0 determination of extractives TGAMC Ballari. 11
  • 12. ETHER SOLUBLE EXTRACTIVE VALUE. Follows same method as previous. 1. Volatile ether soluble extract - volatile oil, clove oil. 2. Non volatile ether soluble extract – resin, fixed oils coloring matter. Sl. No Drug Non volatile ether soluble extract 1. Capsicum NLT 12.0 2. Male fern NLT 01.0 3. Linseed NLT 25.0 determination of extractives TGAMC Ballari. 12
  • 13. SIGNIFICANCE Extractive values are primarily useful for the determination of exhausted or adulterated drugs. Helps to indicate the nature of chemical constituents present in the drug. The extractive value of crude drug determines the quality as well as purity of the drug. Useful in evaluation when the constituents of the drugs can not be readily estimated by any other means. determination of extractives TGAMC Ballari. 13
  • 14. determination of extractives TGAMC Ballari. 14