SlideShare a Scribd company logo

analytical parameters of lepa & malahara.pptx

Dr Priyanka Patil
Dr Priyanka Patil
Dr Priyanka PatilDoctor at RKM ayurvedic medical college, Vijayapura

Ayurvedic ointment, lepa, malahara, gandhaka malahara, suppurative fomentation, ointment for skin diseases, cracked heels.

analytical parameters of lepa & malahara.pptx

1 of 37
Seminar on Analytical
Parameters of Lepa and
Malahara Kalpana
By
Dr.Gajendra.D.R
1st Yr Pg Scholar
RS&BK
Guide
Dr.Laxmi.B.Kurle
Asso Professor
Dept RS & BK
HOD
Dr.M.S.Doddamani
Professor & HOD
Dept RS & BK
Contents
• Introduction
• Concept of Lepa
• Concept of Malahara
• Analytical parameters of Lepa and Malahara
• Conclusion
Introduction
Topical applications are the main route of drug
administration on dermatological conditions.
Importance of these applications were
highlightened by ancient scholars, Lepa and
Malahara plays a major role in Twakgata
vikara's( skin disorders).
Lepa and Malahara treatment modality comes
under Bhahir parimarjana chikitsa.
CHIKITSA
ANTAR
PARIMARJANA
BAHIR
PARIMARJANA
LEPA
MALAHARA
Lepa Kalpana
Definition:
The Medicines in the form of a Paste used for external
application are called as lepas.
Synonyms:
Alepa, Lipta, Lepana,Lepa.
Malahara Kalpana
Malahara = Malham or Marham from Unani
Introduced in Ayurveda by Yogaratnakara
Usually with a base like Sarjarasa, Taila,
Ghrita, siktha.
Malahara are Considered as ointment, creams.

Recommended

API, AFI – AN OVERVIEW BY DR AJITH KUMAR
API, AFI – AN OVERVIEW BY DR AJITH KUMARAPI, AFI – AN OVERVIEW BY DR AJITH KUMAR
API, AFI – AN OVERVIEW BY DR AJITH KUMARDR AJITH KUMAR
 
Sandhan kalpana presentation
Sandhan  kalpana presentationSandhan  kalpana presentation
Sandhan kalpana presentationAngelTension
 
RASAMANIKYA FINAL.pptx
RASAMANIKYA FINAL.pptxRASAMANIKYA FINAL.pptx
RASAMANIKYA FINAL.pptxDR AJITH KUMAR
 
Sandhana kalpana by Dr.Bankimchandra
Sandhana kalpana by Dr.BankimchandraSandhana kalpana by Dr.Bankimchandra
Sandhana kalpana by Dr.BankimchandraBankimJ1
 
Sookshma Vyavayi Vikasi Karma acc Sharangadhara.pptx
Sookshma Vyavayi Vikasi Karma acc Sharangadhara.pptxSookshma Vyavayi Vikasi Karma acc Sharangadhara.pptx
Sookshma Vyavayi Vikasi Karma acc Sharangadhara.pptxMadhubala Gopinath
 
Dr.Lavanya.S.A - Analytical parameters of kshara kalpana
Dr.Lavanya.S.A -  Analytical parameters of kshara kalpanaDr.Lavanya.S.A -  Analytical parameters of kshara kalpana
Dr.Lavanya.S.A - Analytical parameters of kshara kalpanaDr.Lavanya .S.A
 

More Related Content

What's hot

Collection,cultivation and preservation
Collection,cultivation and preservation Collection,cultivation and preservation
Collection,cultivation and preservation AYURVEDA
 
The Concept of Pakshachedhana in Ayurveda Rasasastra
The Concept of Pakshachedhana in Ayurveda RasasastraThe Concept of Pakshachedhana in Ayurveda Rasasastra
The Concept of Pakshachedhana in Ayurveda RasasastraEbinuday
 
Critical appraisal of kshara kalpana
Critical appraisal of kshara kalpana Critical appraisal of kshara kalpana
Critical appraisal of kshara kalpana Seetaram Kishore
 
Controversy, adulteration and substitution
Controversy, adulteration and substitutionControversy, adulteration and substitution
Controversy, adulteration and substitutionPuneshwar Keshari
 
Concept of Agni in Rasa Shastra & Bhaishajya
Concept of Agni in Rasa Shastra & BhaishajyaConcept of Agni in Rasa Shastra & Bhaishajya
Concept of Agni in Rasa Shastra & BhaishajyaNitika Rattan
 
KSHARA VARGA-Dr.MEENU SWAMINATH
KSHARA VARGA-Dr.MEENU SWAMINATHKSHARA VARGA-Dr.MEENU SWAMINATH
KSHARA VARGA-Dr.MEENU SWAMINATHMeenu Swaminath
 
Importance of naamrupa vigyan
Importance of naamrupa vigyan Importance of naamrupa vigyan
Importance of naamrupa vigyan AYURVEDA
 
Concept of puta in rasa classics and its practical utility in present scenario
Concept of puta in rasa classics and its practical utility in present scenarioConcept of puta in rasa classics and its practical utility in present scenario
Concept of puta in rasa classics and its practical utility in present scenariosaumyagulati4
 
Chemistry of Satvapatana
Chemistry of SatvapatanaChemistry of Satvapatana
Chemistry of SatvapatanaSaranya Sasi
 
Rasa ratna samuchaya - 1st 11 chapters
Rasa ratna samuchaya - 1st 11 chaptersRasa ratna samuchaya - 1st 11 chapters
Rasa ratna samuchaya - 1st 11 chaptersShobhitha Madhur
 

What's hot (20)

Pottali Kalpas
Pottali KalpasPottali Kalpas
Pottali Kalpas
 
RASADRAVYA VARGEEKARANA
RASADRAVYA VARGEEKARANA RASADRAVYA VARGEEKARANA
RASADRAVYA VARGEEKARANA
 
Collection,cultivation and preservation
Collection,cultivation and preservation Collection,cultivation and preservation
Collection,cultivation and preservation
 
Rasasindura
RasasinduraRasasindura
Rasasindura
 
The Concept of Pakshachedhana in Ayurveda Rasasastra
The Concept of Pakshachedhana in Ayurveda RasasastraThe Concept of Pakshachedhana in Ayurveda Rasasastra
The Concept of Pakshachedhana in Ayurveda Rasasastra
 
Lavana varga
Lavana varga  Lavana varga
Lavana varga
 
Critical appraisal of kshara kalpana
Critical appraisal of kshara kalpana Critical appraisal of kshara kalpana
Critical appraisal of kshara kalpana
 
Lepa kalpana
Lepa kalpanaLepa kalpana
Lepa kalpana
 
Lavana kalpana
Lavana kalpanaLavana kalpana
Lavana kalpana
 
Bhaishjya kalpana
Bhaishjya  kalpana Bhaishjya  kalpana
Bhaishjya kalpana
 
Controversy, adulteration and substitution
Controversy, adulteration and substitutionControversy, adulteration and substitution
Controversy, adulteration and substitution
 
Review on Yogaratnakara
Review on YogaratnakaraReview on Yogaratnakara
Review on Yogaratnakara
 
Concept of Agni in Rasa Shastra & Bhaishajya
Concept of Agni in Rasa Shastra & BhaishajyaConcept of Agni in Rasa Shastra & Bhaishajya
Concept of Agni in Rasa Shastra & Bhaishajya
 
KSHARA VARGA-Dr.MEENU SWAMINATH
KSHARA VARGA-Dr.MEENU SWAMINATHKSHARA VARGA-Dr.MEENU SWAMINATH
KSHARA VARGA-Dr.MEENU SWAMINATH
 
churna kalpana.pptx
churna kalpana.pptxchurna kalpana.pptx
churna kalpana.pptx
 
Rasana controversy
Rasana controversyRasana controversy
Rasana controversy
 
Importance of naamrupa vigyan
Importance of naamrupa vigyan Importance of naamrupa vigyan
Importance of naamrupa vigyan
 
Concept of puta in rasa classics and its practical utility in present scenario
Concept of puta in rasa classics and its practical utility in present scenarioConcept of puta in rasa classics and its practical utility in present scenario
Concept of puta in rasa classics and its practical utility in present scenario
 
Chemistry of Satvapatana
Chemistry of SatvapatanaChemistry of Satvapatana
Chemistry of Satvapatana
 
Rasa ratna samuchaya - 1st 11 chapters
Rasa ratna samuchaya - 1st 11 chaptersRasa ratna samuchaya - 1st 11 chapters
Rasa ratna samuchaya - 1st 11 chapters
 

Similar to analytical parameters of lepa & malahara.pptx

Standardization of Unani Medicine -Parameters and Exigency
Standardization of Unani Medicine -Parameters and Exigency Standardization of Unani Medicine -Parameters and Exigency
Standardization of Unani Medicine -Parameters and Exigency Dr. NTR University
 
Preformulation and product development
Preformulation and product developmentPreformulation and product development
Preformulation and product developmentBishnu Koirala
 
Preformulation studies
Preformulation studiesPreformulation studies
Preformulation studiesSureshVijay7
 
Preformulation Power Point Presentation
Preformulation Power Point PresentationPreformulation Power Point Presentation
Preformulation Power Point PresentationBHAGYASHRI BHANAGE
 
Drug excepients compatability studies
Drug excepients compatability studiesDrug excepients compatability studies
Drug excepients compatability studieskinju19
 
Drug excipient interaction different method
Drug excipient interaction different methodDrug excipient interaction different method
Drug excipient interaction different methodROHIT
 
Analytical, toxicity, experimental and clinical validation of ayurvedic formu...
Analytical, toxicity, experimental and clinical validation of ayurvedic formu...Analytical, toxicity, experimental and clinical validation of ayurvedic formu...
Analytical, toxicity, experimental and clinical validation of ayurvedic formu...Nani Karnam Vinayakam
 
Standardization of herbal drugs
Standardization of herbal drugsStandardization of herbal drugs
Standardization of herbal drugsshveta arya
 
Evaluation of crude drug
Evaluation of crude drugEvaluation of crude drug
Evaluation of crude drugMohd Ehsan
 
evaluationofcrudedrug-190912112928.pptx pharmacognosy
evaluationofcrudedrug-190912112928.pptx pharmacognosyevaluationofcrudedrug-190912112928.pptx pharmacognosy
evaluationofcrudedrug-190912112928.pptx pharmacognosyAndrewSilungwe2
 
Preformulation Studies of Herbal Cosmetics
Preformulation Studies of Herbal CosmeticsPreformulation Studies of Herbal Cosmetics
Preformulation Studies of Herbal CosmeticsChhavi Singh
 
Test for active pharmaceutical raw materials in herbal drugs, Pharmacognostic...
Test for active pharmaceutical raw materials in herbal drugs, Pharmacognostic...Test for active pharmaceutical raw materials in herbal drugs, Pharmacognostic...
Test for active pharmaceutical raw materials in herbal drugs, Pharmacognostic...Md. Mohabbot Hossen
 
Preformulation 2020 Sakai.ppt
Preformulation 2020 Sakai.pptPreformulation 2020 Sakai.ppt
Preformulation 2020 Sakai.pptFakhrulAhsan2
 
Dissolution-method Development-PPT
Dissolution-method Development-PPTDissolution-method Development-PPT
Dissolution-method Development-PPTBhanu Prakash N
 
Preformulation/pharmaceutical preformulation
Preformulation/pharmaceutical preformulationPreformulation/pharmaceutical preformulation
Preformulation/pharmaceutical preformulationM R S
 
Detection identification characterization of degraded products
Detection identification characterization of degraded productsDetection identification characterization of degraded products
Detection identification characterization of degraded productsGnanabhaskar Danaboina
 

Similar to analytical parameters of lepa & malahara.pptx (20)

Standardization of Unani Medicine -Parameters and Exigency
Standardization of Unani Medicine -Parameters and Exigency Standardization of Unani Medicine -Parameters and Exigency
Standardization of Unani Medicine -Parameters and Exigency
 
Preformulation and product development
Preformulation and product developmentPreformulation and product development
Preformulation and product development
 
Preformulation studies
Preformulation studiesPreformulation studies
Preformulation studies
 
Preformulation Power Point Presentation
Preformulation Power Point PresentationPreformulation Power Point Presentation
Preformulation Power Point Presentation
 
Drug excepients compatability studies
Drug excepients compatability studiesDrug excepients compatability studies
Drug excepients compatability studies
 
Drug excipient interaction different method
Drug excipient interaction different methodDrug excipient interaction different method
Drug excipient interaction different method
 
Analytical, toxicity, experimental and clinical validation of ayurvedic formu...
Analytical, toxicity, experimental and clinical validation of ayurvedic formu...Analytical, toxicity, experimental and clinical validation of ayurvedic formu...
Analytical, toxicity, experimental and clinical validation of ayurvedic formu...
 
Standardization of herbal drugs
Standardization of herbal drugsStandardization of herbal drugs
Standardization of herbal drugs
 
Preformulation Guide
Preformulation GuidePreformulation Guide
Preformulation Guide
 
Preformulation
PreformulationPreformulation
Preformulation
 
Evaluation of crude drug
Evaluation of crude drugEvaluation of crude drug
Evaluation of crude drug
 
evaluationofcrudedrug-190912112928.pptx pharmacognosy
evaluationofcrudedrug-190912112928.pptx pharmacognosyevaluationofcrudedrug-190912112928.pptx pharmacognosy
evaluationofcrudedrug-190912112928.pptx pharmacognosy
 
Preformulation Studies of Herbal Cosmetics
Preformulation Studies of Herbal CosmeticsPreformulation Studies of Herbal Cosmetics
Preformulation Studies of Herbal Cosmetics
 
Herbal drug
Herbal drugHerbal drug
Herbal drug
 
W.H.O Guidelines.ppt by Dr.U.Srinivasa
W.H.O Guidelines.ppt by  Dr.U.SrinivasaW.H.O Guidelines.ppt by  Dr.U.Srinivasa
W.H.O Guidelines.ppt by Dr.U.Srinivasa
 
Test for active pharmaceutical raw materials in herbal drugs, Pharmacognostic...
Test for active pharmaceutical raw materials in herbal drugs, Pharmacognostic...Test for active pharmaceutical raw materials in herbal drugs, Pharmacognostic...
Test for active pharmaceutical raw materials in herbal drugs, Pharmacognostic...
 
Preformulation 2020 Sakai.ppt
Preformulation 2020 Sakai.pptPreformulation 2020 Sakai.ppt
Preformulation 2020 Sakai.ppt
 
Dissolution-method Development-PPT
Dissolution-method Development-PPTDissolution-method Development-PPT
Dissolution-method Development-PPT
 
Preformulation/pharmaceutical preformulation
Preformulation/pharmaceutical preformulationPreformulation/pharmaceutical preformulation
Preformulation/pharmaceutical preformulation
 
Detection identification characterization of degraded products
Detection identification characterization of degraded productsDetection identification characterization of degraded products
Detection identification characterization of degraded products
 

More from Dr Priyanka Patil

basic principles of aushadi yoga.pptx
basic principles of aushadi yoga.pptxbasic principles of aushadi yoga.pptx
basic principles of aushadi yoga.pptxDr Priyanka Patil
 
AVARTANA TECHNOLOGY IN PHARMACEUTICAL PREPARATIONS.pptx
AVARTANA TECHNOLOGY IN PHARMACEUTICAL PREPARATIONS.pptxAVARTANA TECHNOLOGY IN PHARMACEUTICAL PREPARATIONS.pptx
AVARTANA TECHNOLOGY IN PHARMACEUTICAL PREPARATIONS.pptxDr Priyanka Patil
 
Analytical parameters in Avaleha kalpana
Analytical parameters in Avaleha kalpanaAnalytical parameters in Avaleha kalpana
Analytical parameters in Avaleha kalpanaDr Priyanka Patil
 
Arka kalpana and its modern aspect.pptx
Arka kalpana and its modern aspect.pptxArka kalpana and its modern aspect.pptx
Arka kalpana and its modern aspect.pptxDr Priyanka Patil
 
asava aristha in bruhatrayee.pptx
asava aristha in bruhatrayee.pptxasava aristha in bruhatrayee.pptx
asava aristha in bruhatrayee.pptxDr Priyanka Patil
 
analytical tests of bhaishajya kalpana.pptx
analytical tests of bhaishajya kalpana.pptxanalytical tests of bhaishajya kalpana.pptx
analytical tests of bhaishajya kalpana.pptxDr Priyanka Patil
 
adharabhuta siddanta of BK.pptx
adharabhuta siddanta of BK.pptxadharabhuta siddanta of BK.pptx
adharabhuta siddanta of BK.pptxDr Priyanka Patil
 
Mahagandhakam: essential boon for mahasrotas
Mahagandhakam: essential boon for mahasrotasMahagandhakam: essential boon for mahasrotas
Mahagandhakam: essential boon for mahasrotasDr Priyanka Patil
 
Kasisa drava basti in arshas
Kasisa drava basti in arshasKasisa drava basti in arshas
Kasisa drava basti in arshasDr Priyanka Patil
 
Role of ayurvedic drugs in immunomodulation
Role of ayurvedic drugs in immunomodulationRole of ayurvedic drugs in immunomodulation
Role of ayurvedic drugs in immunomodulationDr Priyanka Patil
 
Determination of extractives
Determination of extractivesDetermination of extractives
Determination of extractivesDr Priyanka Patil
 

More from Dr Priyanka Patil (18)

bio availability.pptx
bio availability.pptxbio availability.pptx
bio availability.pptx
 
Basti kalpana.pptx
Basti kalpana.pptxBasti kalpana.pptx
Basti kalpana.pptx
 
basic principles of aushadi yoga.pptx
basic principles of aushadi yoga.pptxbasic principles of aushadi yoga.pptx
basic principles of aushadi yoga.pptx
 
AVARTANA TECHNOLOGY IN PHARMACEUTICAL PREPARATIONS.pptx
AVARTANA TECHNOLOGY IN PHARMACEUTICAL PREPARATIONS.pptxAVARTANA TECHNOLOGY IN PHARMACEUTICAL PREPARATIONS.pptx
AVARTANA TECHNOLOGY IN PHARMACEUTICAL PREPARATIONS.pptx
 
Analytical parameters in Avaleha kalpana
Analytical parameters in Avaleha kalpanaAnalytical parameters in Avaleha kalpana
Analytical parameters in Avaleha kalpana
 
Arka kalpana and its modern aspect.pptx
Arka kalpana and its modern aspect.pptxArka kalpana and its modern aspect.pptx
Arka kalpana and its modern aspect.pptx
 
ARJUNA KSHEERA PAAKA.pptx
ARJUNA KSHEERA PAAKA.pptxARJUNA KSHEERA PAAKA.pptx
ARJUNA KSHEERA PAAKA.pptx
 
asava aristha in bruhatrayee.pptx
asava aristha in bruhatrayee.pptxasava aristha in bruhatrayee.pptx
asava aristha in bruhatrayee.pptx
 
analytical tests of bhaishajya kalpana.pptx
analytical tests of bhaishajya kalpana.pptxanalytical tests of bhaishajya kalpana.pptx
analytical tests of bhaishajya kalpana.pptx
 
adharabhuta siddanta of BK.pptx
adharabhuta siddanta of BK.pptxadharabhuta siddanta of BK.pptx
adharabhuta siddanta of BK.pptx
 
Mahagandhakam: essential boon for mahasrotas
Mahagandhakam: essential boon for mahasrotasMahagandhakam: essential boon for mahasrotas
Mahagandhakam: essential boon for mahasrotas
 
Kasisa drava basti in arshas
Kasisa drava basti in arshasKasisa drava basti in arshas
Kasisa drava basti in arshas
 
Role of ayurvedic drugs in immunomodulation
Role of ayurvedic drugs in immunomodulationRole of ayurvedic drugs in immunomodulation
Role of ayurvedic drugs in immunomodulation
 
Determination of extractives
Determination of extractivesDetermination of extractives
Determination of extractives
 
Cohort study
Cohort studyCohort study
Cohort study
 
Distillation & evaporation
Distillation & evaporationDistillation & evaporation
Distillation & evaporation
 
Ekangaveera rasa
Ekangaveera rasaEkangaveera rasa
Ekangaveera rasa
 
Kottumchukkadi taila
Kottumchukkadi tailaKottumchukkadi taila
Kottumchukkadi taila
 

Recently uploaded

odontogenic keratocyst a developmental cyst
odontogenic keratocyst  a developmental cystodontogenic keratocyst  a developmental cyst
odontogenic keratocyst a developmental cystJani253068
 
Seminario BioMol- Aura Cristina Peña Santos
Seminario BioMol- Aura Cristina Peña SantosSeminario BioMol- Aura Cristina Peña Santos
Seminario BioMol- Aura Cristina Peña SantosAuraCristinaPeaSanto
 
Seminario Biomol- Gwyneth Lorena Serna Salazar
Seminario Biomol- Gwyneth Lorena Serna SalazarSeminario Biomol- Gwyneth Lorena Serna Salazar
Seminario Biomol- Gwyneth Lorena Serna SalazarLorenasernasalazar
 
Target pain receptors with essential oils
Target pain receptors with essential oilsTarget pain receptors with essential oils
Target pain receptors with essential oilsKevin KF Ng
 
SEMINARIO VIH BIOLOGIA MOLECULAR PDF.pdf
SEMINARIO VIH BIOLOGIA MOLECULAR PDF.pdfSEMINARIO VIH BIOLOGIA MOLECULAR PDF.pdf
SEMINARIO VIH BIOLOGIA MOLECULAR PDF.pdfmarlonduqueupb
 
Seminario biología molecular Kevin Duque
Seminario biología molecular Kevin DuqueSeminario biología molecular Kevin Duque
Seminario biología molecular Kevin Duquekevinestebanduque
 
Renal Regulation of Potassium, Calcium, Magnesium and Phosphorus
Renal Regulation of Potassium, Calcium, Magnesium and PhosphorusRenal Regulation of Potassium, Calcium, Magnesium and Phosphorus
Renal Regulation of Potassium, Calcium, Magnesium and PhosphorusMedicoseAcademics
 
Seminario Biología Molecular - Susana Cano V.pdf
Seminario Biología Molecular - Susana Cano V.pdfSeminario Biología Molecular - Susana Cano V.pdf
Seminario Biología Molecular - Susana Cano V.pdfsusiedapp
 
Emergency-First-Aid-Made-Easy-Training-Presentation.pptx
Emergency-First-Aid-Made-Easy-Training-Presentation.pptxEmergency-First-Aid-Made-Easy-Training-Presentation.pptx
Emergency-First-Aid-Made-Easy-Training-Presentation.pptxDrSathishMS1
 
USG,CT AND MR IMAGING OF HEPATIC MASS LESIONS.
USG,CT AND MR IMAGING OF HEPATIC MASS LESIONS.USG,CT AND MR IMAGING OF HEPATIC MASS LESIONS.
USG,CT AND MR IMAGING OF HEPATIC MASS LESIONS.vrchk912
 
Seminario Biología Molecular Manuela Álvarez Ramírez
Seminario Biología Molecular Manuela Álvarez RamírezSeminario Biología Molecular Manuela Álvarez Ramírez
Seminario Biología Molecular Manuela Álvarez Ramírezmanuelaalvarezr
 
AI in Healthcare a hands on workshop resource
AI in Healthcare a hands on workshop resourceAI in Healthcare a hands on workshop resource
AI in Healthcare a hands on workshop resourceVaikunthan Rajaratnam
 
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdf
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdfABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdf
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdfAbdurahmanRafeeq
 
Introducing amazing Healthy habits and fitness
Introducing amazing Healthy habits and fitnessIntroducing amazing Healthy habits and fitness
Introducing amazing Healthy habits and fitnessFredrick Amos
 
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...bkling
 
GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing...
GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing...GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing...
GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing...Abhinav S
 
Peripheral Vascular Disease (PVD): Physiotherapy assessment and management
Peripheral Vascular Disease (PVD): Physiotherapy assessment and managementPeripheral Vascular Disease (PVD): Physiotherapy assessment and management
Peripheral Vascular Disease (PVD): Physiotherapy assessment and managementTushar Sharma
 
pediatrics. epilepsy and seizures in children 8.ppt
pediatrics. epilepsy and seizures in children 8.pptpediatrics. epilepsy and seizures in children 8.ppt
pediatrics. epilepsy and seizures in children 8.pptArun170190
 
Cell cytoskeleton and molecular motors.pdf
Cell cytoskeleton and molecular motors.pdfCell cytoskeleton and molecular motors.pdf
Cell cytoskeleton and molecular motors.pdfMedicoseAcademics
 

Recently uploaded (20)

odontogenic keratocyst a developmental cyst
odontogenic keratocyst  a developmental cystodontogenic keratocyst  a developmental cyst
odontogenic keratocyst a developmental cyst
 
Seminario BioMol- Aura Cristina Peña Santos
Seminario BioMol- Aura Cristina Peña SantosSeminario BioMol- Aura Cristina Peña Santos
Seminario BioMol- Aura Cristina Peña Santos
 
Seminario Biomol- Gwyneth Lorena Serna Salazar
Seminario Biomol- Gwyneth Lorena Serna SalazarSeminario Biomol- Gwyneth Lorena Serna Salazar
Seminario Biomol- Gwyneth Lorena Serna Salazar
 
Target pain receptors with essential oils
Target pain receptors with essential oilsTarget pain receptors with essential oils
Target pain receptors with essential oils
 
Nasal Decongestants.pdf
Nasal Decongestants.pdfNasal Decongestants.pdf
Nasal Decongestants.pdf
 
SEMINARIO VIH BIOLOGIA MOLECULAR PDF.pdf
SEMINARIO VIH BIOLOGIA MOLECULAR PDF.pdfSEMINARIO VIH BIOLOGIA MOLECULAR PDF.pdf
SEMINARIO VIH BIOLOGIA MOLECULAR PDF.pdf
 
Seminario biología molecular Kevin Duque
Seminario biología molecular Kevin DuqueSeminario biología molecular Kevin Duque
Seminario biología molecular Kevin Duque
 
Renal Regulation of Potassium, Calcium, Magnesium and Phosphorus
Renal Regulation of Potassium, Calcium, Magnesium and PhosphorusRenal Regulation of Potassium, Calcium, Magnesium and Phosphorus
Renal Regulation of Potassium, Calcium, Magnesium and Phosphorus
 
Seminario Biología Molecular - Susana Cano V.pdf
Seminario Biología Molecular - Susana Cano V.pdfSeminario Biología Molecular - Susana Cano V.pdf
Seminario Biología Molecular - Susana Cano V.pdf
 
Emergency-First-Aid-Made-Easy-Training-Presentation.pptx
Emergency-First-Aid-Made-Easy-Training-Presentation.pptxEmergency-First-Aid-Made-Easy-Training-Presentation.pptx
Emergency-First-Aid-Made-Easy-Training-Presentation.pptx
 
USG,CT AND MR IMAGING OF HEPATIC MASS LESIONS.
USG,CT AND MR IMAGING OF HEPATIC MASS LESIONS.USG,CT AND MR IMAGING OF HEPATIC MASS LESIONS.
USG,CT AND MR IMAGING OF HEPATIC MASS LESIONS.
 
Seminario Biología Molecular Manuela Álvarez Ramírez
Seminario Biología Molecular Manuela Álvarez RamírezSeminario Biología Molecular Manuela Álvarez Ramírez
Seminario Biología Molecular Manuela Álvarez Ramírez
 
AI in Healthcare a hands on workshop resource
AI in Healthcare a hands on workshop resourceAI in Healthcare a hands on workshop resource
AI in Healthcare a hands on workshop resource
 
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdf
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdfABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdf
ABDULRAHMAN AL RAFIQ UPDATED MANAGEMENT OF ACUTE PULMONARY EMBOLISM .pdf
 
Introducing amazing Healthy habits and fitness
Introducing amazing Healthy habits and fitnessIntroducing amazing Healthy habits and fitness
Introducing amazing Healthy habits and fitness
 
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...
Report Back from San Antonio Breast Cancer Symposium (SABCS) 2023: Spotlight ...
 
GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing...
GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing...GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing...
GERIATRIC PHARMACOLOGY Geriatric pharmacology is a specialized field focusing...
 
Peripheral Vascular Disease (PVD): Physiotherapy assessment and management
Peripheral Vascular Disease (PVD): Physiotherapy assessment and managementPeripheral Vascular Disease (PVD): Physiotherapy assessment and management
Peripheral Vascular Disease (PVD): Physiotherapy assessment and management
 
pediatrics. epilepsy and seizures in children 8.ppt
pediatrics. epilepsy and seizures in children 8.pptpediatrics. epilepsy and seizures in children 8.ppt
pediatrics. epilepsy and seizures in children 8.ppt
 
Cell cytoskeleton and molecular motors.pdf
Cell cytoskeleton and molecular motors.pdfCell cytoskeleton and molecular motors.pdf
Cell cytoskeleton and molecular motors.pdf
 

analytical parameters of lepa & malahara.pptx

  • 1. Seminar on Analytical Parameters of Lepa and Malahara Kalpana By Dr.Gajendra.D.R 1st Yr Pg Scholar RS&BK Guide Dr.Laxmi.B.Kurle Asso Professor Dept RS & BK HOD Dr.M.S.Doddamani Professor & HOD Dept RS & BK
  • 2. Contents • Introduction • Concept of Lepa • Concept of Malahara • Analytical parameters of Lepa and Malahara • Conclusion
  • 3. Introduction Topical applications are the main route of drug administration on dermatological conditions. Importance of these applications were highlightened by ancient scholars, Lepa and Malahara plays a major role in Twakgata vikara's( skin disorders). Lepa and Malahara treatment modality comes under Bhahir parimarjana chikitsa.
  • 5. Lepa Kalpana Definition: The Medicines in the form of a Paste used for external application are called as lepas. Synonyms: Alepa, Lipta, Lepana,Lepa.
  • 6. Malahara Kalpana Malahara = Malham or Marham from Unani Introduced in Ayurveda by Yogaratnakara Usually with a base like Sarjarasa, Taila, Ghrita, siktha. Malahara are Considered as ointment, creams.
  • 7. Analytical Parameters As the demand of various Ayurvedic preparations is going on increasing in market, manufactures are tempted to or actually compromising with the quality of the product in urge of fulfilling all demands. Here to judge the quality of the raw material or finished product purchased from market we need some standards for each product and for these standards we need on analytical study. Analytical study provides us the objective parameters for standardization. It helps in understanding and interpretation of a drug and its structure. It assists us to conduct the comparative study among various samples during drug manufacturing, by offering objective parameter to judge the exact status of the drug and to decide the future work plan. By advanced analytical techniques, now one can also deduce the volatile content or organic content of a Herbo- mineral drug.
  • 8. Analytical Specifications of Lepa and Malahara… acc to PLIM • Organoleptic characters • Uniformity of Content • Microscopic • Rancidity Test • Identifications. TLC / HPLC/GLC • Assay • Viscosity • pH • Particle size (mesh size 125-150) • Total fatty matter • Loss on drying at 1050c • Spreadability. • Test for heavy metals: Lead, Cadmium , Mercury, Arsenic. • Microbial contamination:- Total Bacterial Count Total Fungal Count • Test for specific pathogen:- E. coli Salmonella spp S.aureus Pseudomonas aeruginosa
  • 9. Organoleptic characters  Colour:- This represents the Colour of the lepa. It is mainly depends on ingredients which are used in that. Change in colour indicates improper preparation of lepa or detoriation of lepa. ex:- Rasadi lepa -Black colour  Smell:- This shows smell of the product. ex:- Rasadi lepa- Sarshapa Gandha.  Texture :- This percives surface quality of the product . It is Soft for lepa's and Malahara .
  • 10. Content Uniformity Most important parameter governing product stability and process control of the disperse system. In ointment/cream formulation are more dependent on particle size, shear rate, and mixing efficiency in order to attain and maintain uniformity of the active drug component(usually the internal phase).
  • 11. Method : Drug content -1gm of lepa was accurately weighed, in a 50ml of volumetric flask to which 20ml purified water was added with continuous shaking. Volume was adjusted with a mixture of 10% methanol in water. Absorbance of the solution with the blank was measured at 360nm using UV-spectrophotometer. Homogeneity of drug content -For homogeneity of drug contents, six tubes were taken randomly and assayed for the drug content as stated above. The usual sample size for testing ranges between 0.5 and 1.5 g per sample assay.
  • 12. Microscopic Microscopic identification of the botonical ingradients is a standard for statutory purposes in several solid and semisolid composed formulations. Microscopic identification tests are confined to those formulations where the botonical ingradients are not more then ten and where they are added in situ in power form as prakshepa dravys. such comminuted ingradients land themselves for microscopic identification as they are not drastically changed in cell structure or content while processing and appear intact in microscopic slide preparation after proper treatement. Method of preparing specimens of crude materials of vegetable drugs for microscopical studies vary, depending on the morphological groups of drugs to be examined and also on the natures of the materials i.e entire cut or powdered.
  • 13. Rancidity Test Rancidity testing determines the level of oxidation in a sample. when lipids (fats and oils ) go rancid, its nutritional values is compromised, and the lipids will taken on a rancid taste and odour. Proper rancidity testing is an essential component in determining the shelf life of the product. The test depends upon the formation of a red colour when oxidized fat is treated with con. HCl and a solution of phloroglucinol in ether. The compound of Rancid fats responsible for the colour reaction is epihydrin aldehyde. All oxidised fats responds to the kreis test and the intensity of the colour produced is roughly proportional to the degree of oxidative rancidity.
  • 14. TLC Thin-layer chromatography (TLC) is a chromatography technique used to separate non-volatile mixtures. Thin layer chromatography is done exactly as it says –  using a thin uniform layer of silica gel or  Alumina coated onto a piece of glass, metal or rigid plastic.
  • 15. TLC (Thin Layer Chromatography) TLC in which a solute undergoes distribution between two phases, a stationary phase acting through adsorption and a mobile phase in the form of a liquid. The adsorbent is a relatively thin, uniform layer of dry finely powdered material applied to a glass, plastic or metal sheet or plate. Glass plates are most commonly used. Separation may also be achieved on the basis of partition or a combination of partition and adsorption, depending on the particular type of support , its preparation and its use with different solvent. Identification can be effected by observation of spots of identical Rf value and about equal magnitude obtained, respectively with an unknown and a reference sample chromatographed on the same plate. A visual comparison of the spot usually serves for semi-quantitative estimation.
  • 16. TLC Applications  Thin-layer chromatography can be used to monitor the progress of a reaction, identify compounds present in a given mixture.  To determine the purity of a substance.  TLC assays are done as general screening for group of drugs like steroids, amphetamines & other stimulants , NSAIDS, antihistamines, anti depressants, barbiturates.  For quantitative analysis of drugs  For separation of active ingredients present in the drugs  For fingerprinting of drugs.  For quantification of compound drug.  For standardization of compound drugs.  To research adulterants present in the drug.  For identification of drug.
  • 17. Assays • Drugs which cannot be assayed by chemical, or physical means are evaluated by biological methods. • A crude drug may be assayed for a particular group of constituents(e.g. The total alkaloids in belladonna or the total glycosides of digitalis) or specific components ( e.g. reserpine content of Rauwolfia spp.)
  • 18. Bio - Assays When the estimation of crude drug or its preparation is done by means of its effect on living organism like bacteria, fungi, or animal tissue or entire animal it is known as BIOASSAY. Indication For Bio Assay Evaluation • This is true for the substances having an Interfering obstacles • When quantity is too small. • No specific chemical test is available • When the action of drug is due to a mixture of substance • Purification of drug is not possible
  • 19. VISCOSITY Viscosity is the property of a fluid that resists deformation. It is a property of a resistance offered by the fluid material to a movement.  Viscosity of liquid may be determined by any method that will measure the resistance to shear offered by the liquid.  Absolute Vicosity can be measured directly if accurate dimensions of the measuring instruments are known but it is more common practice to calibrate the instrument with a liquid of known viscosity and to determine the viscosity of the unknown fluid by comparison with that of the known.  Choice of Viscometer: ostwald viscometer  Eg. Castor Oil 1000 cp
  • 21. Method : The Viscometer- Calibrated to measure the apparent viscosity of the disperse system at equilibrium at a given temperature to establish system reproducibility. Consistency type Approximate viscosity in cps at 25°C Pharmaceutical example Soft, spreadable 100,000-300,000 W/O, O/W CREAM Plastic flow, spreadable 300,000-1,000,000 Ointment Application : It is a resistance of a liquid to flow. Higher the value indicates more the solute or more concentration of substance. Thus viscosity of lepa and malahara should be more .
  • 22. pH determination Topically applied drug products should be tested of pH at the time of batch release and at designated stability time points for batch to batch monitoring. Because some topically applied drug products contain very limited quantities of water or aqueous phase, pH measurements may not always be warranted. This test is generally firnulation dependent. Therefore it is not included in compendial drug product monograph but is part of the manufacturer's specification for the drug product.
  • 23. Conti…… The pH value of an aqueous liquid may be defined as the common logarithm of the reciprocal of the hydrogen ion concentration expressed in g/l . Although this definition provides a useful practical means for the quantitative indication of the acidity or alkalinity of the solution, it is less satisfactory from a strictly theoretical point of view. No definition of pH as a measurable quantity can have a simple meaning. which is also fundamental and exact. The pH value of a liquid is determined potentially by means of glass, electrode and a suitable pH meter. Eg:- pH of Darvyadi Malahara is :- 3.7 to 4.2
  • 24. Importance of pH  To determine the Physical, chemical and biological stability of crude drugs.  Qualitative and quantitative analysis of the samples.  Solubility of the drug:- pH of the solution affects its solubility. solubility of weak acids increase (to a limit) as pH increase and solubility of weak bases increase (to a limit) as pH decrease.  Stability of the drug :-The pH of the solution can affect the degradation rate of the drug. pH of stability varies from drug to drug. Example, aspirin is most stable (has lowest degradation rate) at pH = 2.5.  Permeability of the drug through biological membranes:-This depends on the extent of ionization of the drug. The pH of the solution can affect the extent of ionization of weak acidic or weak basic drugs.  Tissue irritation -pH of a solution can’t be too acidic or too basic. Greater the pH than the physiological pH greater the irritation.
  • 25. pH Meter Potentiometric ph meter Digital ph meter
  • 26. Particle size Consideration Control of particle morphology and particle size are important parameters to attain high quality drug product manufacture and control procedure. Particle size distribution for most disperse system should be in the range of 0.2-20 microns.
  • 27. Conti…. Applications - Size and surface area of a particle can be related in a significant way to the physical, chemical, and pharmacological properties of a drug. -Clinically, the particle size of a drug can affect its release from dosage forms that are administered orally, parenterally, rectally and topically.
  • 28. FAT CONTENT To estimate fatty content present in the product Method :- • Extract accurately weighed air dried sample ,with petroleum ether (40-600C) in Soxhlet apparatus. • Dry the extract over anhydrous sodium sulphate and remove solvent under vacuum at 400C. • Weigh residue and calculate percentage with reference to the weight of sample material used.
  • 29. Loss on drying Method is used to measure the amount of water content and other volatile material in a sample upon drying or heat treatement. method :- Weigh accurately about 2gm of drug in a nickel or silica crucible . if the sample is large crystal or lump, promptly crush it into particles not larger than 2mm in diameter. Spread the sample on the crucible so that the layer is not thicker than 5mm, and weigh it accurately. Dry in an air over at 1050 till a constant weight is obtained. If the sample melts at a temperature lower than the specified drying temperature, dry it at a tempereture 5-100 lower than the melting temperature for 1to2 hours and dry it under the specified conditions. The difference in the two weighing gives loss on drying . Calculate the % of loss on drying
  • 30. Spreadability The efficasy of a topical therapy depends on the patient spreading the drug formulation in an even layer to administer a standard dose. Spreadability is therefore an important characteristic of these formulations and is responsible for currect dosage transfer to the currect target site, ease of application on the substrate, excrudability from the package and most important, consumer prefarence.
  • 31. Spreadability method Determined by an apparatus suggested by Muttimer (1999) Consist of a wooden block having a pulley at one end with fixed glass slide on block. Spreadability was expressed in terms of time in seconds taken by two slides to slip of from the cream/ ointment, place in b/w the slides under certain load. Lesser the time taken for separation of the two slides, better the spreadability.
  • 32. A shorter interval indicates better spreadability. Spreadability is measured as S = m × l /t. S:- Spreadability, m:- weight placed over the upper glass plate. l:- length of the glass, t:-Time for spreading in seconds.
  • 33. Test for Heavy Metals The test for Heavy Meatals is designed to determine the content of metallic impurities that are coloured by sulphide ion, under specified conditions. The limit for Heavy metal is indicated in the individual monographs in terms of the parts of lead per million parts of the substance ( by weight), as determined by visual comparision of the colour prodused by the substance with that of a control prepared from a standard lead solution.
  • 34. Microbial limits The following tests are designed for the estimation of the number of visible aerobic micro-organisms present and for detecting the presence of designated microbial species in phamaceutical substances. The term 'growth' is used to designate the presence and presumed proliferation of viable micro-organisms.
  • 35. Limits for ASU products Parameter Specifications Total bacterial count 1 X 105 CFU/gm Yeast & mould 1 X 103 CFU/gm E.Coli Absent Salmonella Absent P. Aeruginosa Absent S. Aureus Absent 2. Pesticide residue – organo-chloro group Less than 1 ppm 3.Heavy metals Lead 10 ppm Mercury 01 ppm Arsenic 03 ppm Cadmium 0.3 ppm 4.Aflatoxin B1 – 0.5 ppm G1 – 0.5 ppm B2 – 0.1 ppm G2 – 0.1 ppm
  • 36. Conclusion • No doubt that Analytical Parameters play vital role in standardization of lepa and malahara kalpana. • Ayurvedic drugs are comes under the drug and cosmetic act, the need for the quality control methods for the Ayurvedic drugs has become very necessary. • Many classical preparations of Lepa and Malahara are yet to be standardized which are used in day to day practice.

Editor's Notes

  1. Deduce :- coclude or conclusion .
  2. Detoration :- deccay Texture:-the feel, appearance, or consistency of a surface or a substance.
  3. Shear rate:- Shear rate is the rate of change of velocity at which one layer of fluid passes over an adjacent layer. As an example, consider that a fluid is placed between two parallel plates that are 1.0 cm apart, the upper plate moving at a velocity of 1.0 cm/sec and the lower plate fixed.
  4. Statutory:- required, permitted, or enacted by statute. Situ :-The words situ and situs are Latin for "site" (or location). They also have other meanings (Situmeans "lake" in Sundanese).
  5. Kreis test:- Quality evaluation of edible oils is tested by different methods. Among the chemical methods, Kreis test is a promising one for early detection of rancidity, particularly aldehydes with a characteristic odor impact. Positive relationship of these breakdown products with perceived deterioration in quality evoked interest in re-examining the Kreis test. The color development in the test is critical and requires optimization. In continuation of studies in edible oils, the present investigation deals with sunflower and mustard oils. Through central composite rotatable design, response surface was fit as a function of oil quantity (0.3–3.3 mL) 1% phloroglucinol (0.08 mol) in acetic acid (0.3–3.3 mL) and incubation period (10–90 min). The polynomial fits were excellent with multiple correlation of >0.90. Optimized conditions were obtained for the two oils. Thus, use of 1 mL oil, 1 mL of 1% phloroglucinol, incubation time of 20 min and absorbance readings at 545 nm is derived and found applicable to all edible oils for routine tests.
  6. Retardation Factor:-dext top Adsorption is the adhesion of molecules of gas, liquid, or dissolved solids to a surface. This process creates a film of the adsorbate (the molecules or atoms being accumulated) on the surface of the adsorbent. It differs from absorption, in which a fluid permeates or is dissolved by a liquid or solid. Adsorbent:- a substance which adsorbs another.
  7. Resist:- withstand the action or effect of.
  8. cps :- centipoise w/o :- water in oil, o/w : oil in water .
  9. compendial :-pharmacopeial
  10. Degraded:-the condition or process of degrading or being degraded.
  11. Ex:- loss on drying of avalgunjadi lepa is not more than 5.2% and not more than 6.2 % w/w.
  12. Presumed:- assumed Proliferation:- rapid increase in the number or amount of something.
  13. CFU-GM:- is a colony forming unit. It is derived from CFU-GEMM. The "GM" stands for "granulocyte, monocyte". It is the precursor for monoblasts and myeloblasts. Production is stimulated by granulocyte macrophage colony-stimulating factor.  Ppm :- is an abbreviation of parts per million weight, a subunit of ppm that is used for part of weights like milligrams per kilogram (mg/kg). ... The concentration C in ppm is calculated from the solute mass msolute in milligrams and the solution mass msolution in milligrams .