SlideShare a Scribd company logo
1 of 22
Download to read offline
Mucosal Drug Delivery System
Presented By:
Pranali M. Palandurkar
University department of
Pharmaceutical Sciences R.
T.M.N.U nagur
Contents
 Introduction
 Principle of bioadhesion
 Concept of mucosal delivery system
 Advantages & Disadvantages
 Transmucosal permeability
 Formulation & consideration of buccal drug delivery system
2
INTRODUCTION
 Delivery of drugs via the absorptive mucosa in various easily accessible body cavities, like
the ocular, nasal, buccal, rectal and vaginal mucosae, has the advantage of bypassing the
hepato-gastrointestinal first-pass elimination associated with oral administration.
 Mucosal membranes can be useful sites with good accessibility for easy application of
drug delivery systems, especially for those with bio(muco)adhesive properties.
 Mucoadhesive drug delivery systems utilize the property of bioadhesion of certain
polymers which become adhesive on hydration and hence can be used for targeting a
drug to a particular region of the body for extended periods of time and can be exploited
for the noninvasive systemic delivery of organic- and peptide-based drugs, with rapid
absorption as well as sustained drug action
3
PRINCIPLE OF BIOADHESION
There are six classical theories adapted which explain the phenomenon of adhesion.
1.Electronic theory- When both mucoadhesive and biological materials come into contact, they
transfer electrons leading to the building of a double electronic layer at the interface, where the
attractive forces within this electronic double layer determines the mucoadhesive strength.
2.Adsorption theory- The mucoadhesive device adheres to the mucus by secondary chemical
interactions, such as in van der Waals and hydrogen bonds, electrostatic attraction or hydrophobic
interactions. Such forces have been considered the most important in the adhesive interaction
phenomenon because, although they are individually weak, a great number of interactions can result
in an intense global adhesion
4
3.Wetting theory-The wetting theory applies to liquid systems which present affinity to the surface in
order to spread over it. This affinity can be measure by contact angle. The general rule states that the
lower the contact angle then the greater the affinity The contact angle should be equal or close to
zero to provide adequate spreadability
The spreadability coefficient, SAB, can be calculated from the difference between the surface
energies γB and γA and the interfacial energy γAB, as indicated in equation
SAB= γB- γA- γAB
The greater the individual surface energy of mucus and device in relation to the interfacial energy, the
greater the adhesion work, WA, i.e. the greater the energy needed to separate the two phases
WA=γA+γB-γAB
5
4.Diffusion theory-Diffusion theory describes the interpenetration of both polymer and mucin chains
to a sufficient depth to create a semi-permanent adhesive bond. It is believed that the adhesion force
increases with the degree of penetration of the polymer chains. This penetration rate depends on the
diffusion coefficient, flexibility and nature of the mucoadhesive chains, mobility and contact time. This
interpenetration depth of polymer and mucin chains can be estimated by the following equation
l = (tDb)½
Where, t - contact time
Db -diffusion coefficient of the mucoadhesive material in the mucus.
The adhesion strength for a polymer is reached when the depth of penetration is approximately
equivalent to the polymer chain size.
6
5.Fracture theory-It analyses the force required to separate two surfaces after adhesion is
established . The force Sm is frequently calculated in tests of resistance to rupture by the ratio of
the maximal detachment force,Fm and the total surface area A0
Sm=Fm/A0
6.Mechanical theory-This theory consider adhesion to be due to the filling of the irregularities
on a rough surface by a mucoadhesive liquid. Moreover ,such roughness increases the interfacial
area available to interactions thereby aiding dissipating energy and can be considered the most
important phenomenon of the process.
7
CONCEPT OF BIOADHESION
 Bioadhesion is the state in which two materials ,(at least one of which is biological in nature), are
held together for a extended period of time by interfacial forces.
 The term bioadhesion implies attachment of drug-carrier system of specific biological location. This
biological surface can be epithelial tissue or the biological surface can be epithelial tissue or the
mucous coat on the surface of tissue.
 If adhesive attachment is to mucous coat then phenomenon is referred as mucoadesion.
 These drug delivery system utilize property of bioadhesion of certain water soluble polymers which
become adhesive on hydration and hence can be used for targeting particular sites.
8
 Mechanisms of Bioadhesion – The mechanism responsible in the formation of bioadhesive
bonds are not fully known ,however most research has described bioadhesive bond formulation
as a three step process .
Step 1- Wetting and swelling of polymer
Step 2-Interpenetration between the polymer chains and the mucosal membrane
Step 3- Formation of chemical bonds between the entangled chains.
9
Mucosal drug delivery offers several advantages over other controlled release systems :
 High drug flux at the absorbing tissue.
 Painless and ease of administration.
 Low enzymatic activity and avoid of first pass metabolism.
 Targeting and localization of the dosage form at a specific site.
 Termination of therapy is possible.
 drugs which are unstable in acidic environment of stomach or destroyed by the alkaline
environment of intestine can be given other mucosal route .
 Drug shows poor bioavailability by oral route can be administered by other mucosal route .
ADVANTAGES
10
 It follows passive diffusion , and does not require any activation.
 The presence of saliva ensures large amount of water for dissolution of drug unlike in case of
rectal and transdermal route.
 Thin mucin film exist on the surface of oral cavity provides opportunity to retain delivery system
in contact with mucosa for prolonged period of time with the help of mucoadhesive compounds
 The buccal membrane is sufficiently large to allow delivery system to be placed at different
sites on the same membrane for different occasion , if the drug or other excipients cause
reversible damage or irritate mucosa .
11
DISADVANTAGES
 Over hydration may lead to formulation slippery surface and structural integrity of the formulation
may get disrupted by the swelling and hydration of the bioadhesion polymer.
 Eating and drinking may become restricted
 Drug which irritate mucosa or have a bitter or unpleasant taste or an obnoxious odour cannot be
administered by this route .
 Only drug which are absorbed by passive diffusion can be administered by this route .
 Only small dose drug can be administered .
 In case of ,buccal tablet there is possibility that patient may swallow the tablet.
 Costly drug delivery system.
 Unfortunately , the lack of standardized techniques often leads to unclear result. 12
TRANSMUCOSAL PERMEABILITY
 Mucosal routes provide the potential pathways to bypass hepatogastrointestinal first-pass
elimination following oral administration. Transmucosal drug delivery has the potential to
achieve greater systemic bioavailability for orally metabolized drugs, including organic- and
peptide-based pharmaceuticals.
 There are two routes potentially involved in drug permeation across epithelial membranes:
a) Transcellular route
b)Paracellular route
13
1)Paracellular route: For hydrophilic compounds
 This compound is difficult to penetrate into the lipophilic cell membrane .
 Intercellular space is preferred route for drug transport
 Drug movement in this route (JH)can be written as
(JH)=DH Є CD
hH
Where Є= fraction of surface area of paracellular route
DH= diffusion coefficient
hH= pathlength of paracellular route
CD=donar side drug concentration
14
2)Transcellular route:
For lipophilic compound.
Drug molecule move across both lipophilic cell membrane and hydrophilic cytoplasm as well
as intercellular space.
The permeability of lipophilic compound across the epithelial cell membrane is typically high .
Drug flux is transcellular route (JL) can be expressed as:
JL=(1-Є)DH KP CD
hL
Where , KP =partition coefficient between lipophilic and hydrophilic region
hL= pathlength of transcellular route
15
Various potential mucosal pathways for systemic delivery of therapeutic agents.
16
Buccal Delivery: Drugs are delivered through mucosal membrane into systemic circulation by placing
drug in between cheeks and gums.
Classification of Buccal Bioadhesive Dosage Forms
 Buccal Bioadhesive Tablets.
 Buccal Bioadhesive semisolids.
 Buccal Bioadhesive patch and films.
 Buccal Bioadhesive Powders.
Formulation consideration of Buccal drug
delivery system
17
Advantages of Buccal Drug Delivery System
 The residence time of dosage form at the site of absorption is prolong, hence increases
the bioavailability.
 Rapid onset of action.
 High blood supply and good blood flow rate cause rapid absorption.
 In the acidic medium of git drug is protected from degradation.
 Improved patient compliance.
 Nor painful neither irritations.
Disadvantages of Buccal Drug Delivery System:
 Prolonged contact of the drug possessing ulcerogenic property.
 For the in vitro screening of drugs the oral mucosal delivery is lack of good model. This is the
major drawback of this drug delivery.
 Patient acceptability in terms to taste, irritancy and mouth feel is to be checked.
 As compared to the sublingual membrane the buccal membrane is low permeability.
 Also has smaller surface area.
 The dissolution of drug due to continuous secretion of saliva (0.5-2 l/day).
18
The basic components of buccal bioadhesive drug delivery system are :
 Drug substance -Drug used for rapid release/prolonged release and for local/systemic effect is a
suitable candidate for buccal delivery
 Bioadhesive polymers-Bioadhesive polymers play a major role in buccoadesive drug delivery
systems of drugs. Polymers are also used in matrix devices in which the drug is embedded in the
polymer matrix, which controls the duration of release of drugs.
 Backing membrane-Backing membrane plays a major role in the attachment of bioadhesive
devices to the mucus membrane.
 Penetration enhancers- To increases the permeation rate of the membrane of co-administrated
drug penetration enhancer are added. Without causing toxicity and damaging the membrane they
improve the bioavailability of drugs that have poor membrane penetration
19
Components Examples
Bioadhesive polymers Agarose, chitosan, gelatin, Hyaluronic acid,
Poly(acrylic acid)-based polymers, Hydroxyethyl
starch ,PVA, PVP, scleroglucan
Backing membrane Carbopol, Magnesium separate, HPMC, HPC,
CMC, Polycarbophil
Penetration enhancers Sodium lauryl, Cetylpyridinium chloride,
Poloxamer, Sodium gylcodeoxycholate, Oleic
acid, Ceprylic acid, Trimethyl chitosan, EDTA
,sodium citrate.
20
Marketed Formulation
Product Company Bioadhesive agent Dosage Form
Buccastem Reckitt Benckiser PVP, Xanthum Gum Buccal Tablet
Corlan Pellets Celtech Acacia gum Oromucosal Pellets
Suscard Forest HPMC Buccal Tablet
Orabase Convatech Pectin ,Gelatin Oral Paste
Corsodyl Gel Glaxosmith Kline HPMC Oromucosal Gel
21
22

More Related Content

What's hot

Approaches Of Gastro-Retentive Drug Delivery System or GRDDS
Approaches Of Gastro-Retentive Drug Delivery System or GRDDSApproaches Of Gastro-Retentive Drug Delivery System or GRDDS
Approaches Of Gastro-Retentive Drug Delivery System or GRDDSAkshayPatane
 
Buccal drug delivery system
Buccal drug delivery systemBuccal drug delivery system
Buccal drug delivery systemshivamthakore
 
Intrauterine drug delivery system
Intrauterine drug delivery systemIntrauterine drug delivery system
Intrauterine drug delivery systemAloysiatreslyn
 
Controlled Release Drug Delivery Systems - Types, Methods and Applications
Controlled Release Drug Delivery Systems - Types, Methods and ApplicationsControlled Release Drug Delivery Systems - Types, Methods and Applications
Controlled Release Drug Delivery Systems - Types, Methods and ApplicationsSuraj Choudhary
 
ocular barriers and methods to overcome barriers
ocular barriers and methods to overcome barriersocular barriers and methods to overcome barriers
ocular barriers and methods to overcome barriersTarun Gollapudi
 
Controlled drug delivery systems
Controlled drug delivery systemsControlled drug delivery systems
Controlled drug delivery systemsTheabhi.in
 
Implantable Drug Delivery System
Implantable Drug Delivery SystemImplantable Drug Delivery System
Implantable Drug Delivery SystemSourav Kar
 
Regulatory requirements for drug approval
Regulatory requirements for drug approval Regulatory requirements for drug approval
Regulatory requirements for drug approval Namdeo Shinde
 
buccal drug delivery system
buccal drug delivery systembuccal drug delivery system
buccal drug delivery systemrasikawalunj
 
Mucoadhesive drug delivery system
Mucoadhesive drug delivery systemMucoadhesive drug delivery system
Mucoadhesive drug delivery systemJamia Hamdard
 
Mucoadhesive drug delivery system
Mucoadhesive drug delivery systemMucoadhesive drug delivery system
Mucoadhesive drug delivery systemAnita Duduskar
 
Non clinical drug development. ppt
Non clinical drug development. pptNon clinical drug development. ppt
Non clinical drug development. pptPRABU12345678
 
formulation of Buccal Drug Delivery System.pptx
formulation of Buccal Drug Delivery System.pptxformulation of Buccal Drug Delivery System.pptx
formulation of Buccal Drug Delivery System.pptxPawanDhamala1
 
gastro retentive drug delivery system advantages and approaches
gastro retentive drug delivery system advantages and approachesgastro retentive drug delivery system advantages and approaches
gastro retentive drug delivery system advantages and approachesmangasrinivas37
 
Industrial Pharmacy-II (IP-II) Unit 2:- chapter:- 2 Technology Development an...
Industrial Pharmacy-II (IP-II) Unit 2:- chapter:- 2 Technology Development an...Industrial Pharmacy-II (IP-II) Unit 2:- chapter:- 2 Technology Development an...
Industrial Pharmacy-II (IP-II) Unit 2:- chapter:- 2 Technology Development an...Audumbar Mali
 
Floating drug delivery system ppt
Floating drug delivery system ppt Floating drug delivery system ppt
Floating drug delivery system ppt Shireen Zeba
 

What's hot (20)

Gastroretentive Drug Delivery System
Gastroretentive Drug Delivery SystemGastroretentive Drug Delivery System
Gastroretentive Drug Delivery System
 
Approaches Of Gastro-Retentive Drug Delivery System or GRDDS
Approaches Of Gastro-Retentive Drug Delivery System or GRDDSApproaches Of Gastro-Retentive Drug Delivery System or GRDDS
Approaches Of Gastro-Retentive Drug Delivery System or GRDDS
 
Microencapsulation
MicroencapsulationMicroencapsulation
Microencapsulation
 
Buccal drug delivery system
Buccal drug delivery systemBuccal drug delivery system
Buccal drug delivery system
 
Intrauterine drug delivery system
Intrauterine drug delivery systemIntrauterine drug delivery system
Intrauterine drug delivery system
 
Controlled Release Drug Delivery Systems - Types, Methods and Applications
Controlled Release Drug Delivery Systems - Types, Methods and ApplicationsControlled Release Drug Delivery Systems - Types, Methods and Applications
Controlled Release Drug Delivery Systems - Types, Methods and Applications
 
ocular barriers and methods to overcome barriers
ocular barriers and methods to overcome barriersocular barriers and methods to overcome barriers
ocular barriers and methods to overcome barriers
 
Controlled drug delivery systems
Controlled drug delivery systemsControlled drug delivery systems
Controlled drug delivery systems
 
Implantable Drug Delivery System
Implantable Drug Delivery SystemImplantable Drug Delivery System
Implantable Drug Delivery System
 
Regulatory requirements for drug approval
Regulatory requirements for drug approval Regulatory requirements for drug approval
Regulatory requirements for drug approval
 
buccal drug delivery system
buccal drug delivery systembuccal drug delivery system
buccal drug delivery system
 
Mucoadhesive drug delivery system
Mucoadhesive drug delivery systemMucoadhesive drug delivery system
Mucoadhesive drug delivery system
 
Mucoadhesive drug delivery system
Mucoadhesive drug delivery systemMucoadhesive drug delivery system
Mucoadhesive drug delivery system
 
osmotic pump
osmotic pumposmotic pump
osmotic pump
 
Non clinical drug development. ppt
Non clinical drug development. pptNon clinical drug development. ppt
Non clinical drug development. ppt
 
formulation of Buccal Drug Delivery System.pptx
formulation of Buccal Drug Delivery System.pptxformulation of Buccal Drug Delivery System.pptx
formulation of Buccal Drug Delivery System.pptx
 
gastro retentive drug delivery system advantages and approaches
gastro retentive drug delivery system advantages and approachesgastro retentive drug delivery system advantages and approaches
gastro retentive drug delivery system advantages and approaches
 
Industrial Pharmacy-II (IP-II) Unit 2:- chapter:- 2 Technology Development an...
Industrial Pharmacy-II (IP-II) Unit 2:- chapter:- 2 Technology Development an...Industrial Pharmacy-II (IP-II) Unit 2:- chapter:- 2 Technology Development an...
Industrial Pharmacy-II (IP-II) Unit 2:- chapter:- 2 Technology Development an...
 
Polymers in controlled release Drug Delivery System
Polymers in controlled release Drug Delivery SystemPolymers in controlled release Drug Delivery System
Polymers in controlled release Drug Delivery System
 
Floating drug delivery system ppt
Floating drug delivery system ppt Floating drug delivery system ppt
Floating drug delivery system ppt
 

Similar to Mucosal drug delivery system

Mucosal drug delivery system novel drug delivery system
Mucosal drug delivery system novel drug delivery systemMucosal drug delivery system novel drug delivery system
Mucosal drug delivery system novel drug delivery systemShubhangiKhade7
 
Mucosal Drug Delivery System.pptx
Mucosal Drug Delivery System.pptxMucosal Drug Delivery System.pptx
Mucosal Drug Delivery System.pptxAkshataJain17
 
Buccal Drug Delivery System
Buccal Drug Delivery SystemBuccal Drug Delivery System
Buccal Drug Delivery SystemSwatiAbat
 
Mucosal Drug Delivery System
Mucosal Drug Delivery SystemMucosal Drug Delivery System
Mucosal Drug Delivery SystemSwatiSen3
 
mucoadhesive drug delivery system.pptx
mucoadhesive drug delivery system.pptxmucoadhesive drug delivery system.pptx
mucoadhesive drug delivery system.pptxRevathykrishnan13
 
MUCOADHESIIVE DRUG DELIVERY SYSTEM
MUCOADHESIIVE DRUG DELIVERY SYSTEMMUCOADHESIIVE DRUG DELIVERY SYSTEM
MUCOADHESIIVE DRUG DELIVERY SYSTEMDr Gajanan Sanap
 
Buccal drug delivery system
Buccal drug delivery systemBuccal drug delivery system
Buccal drug delivery systemSiddu K M
 
Mucosal-Drug-Delivery-system.pdf
Mucosal-Drug-Delivery-system.pdfMucosal-Drug-Delivery-system.pdf
Mucosal-Drug-Delivery-system.pdfVaibhav92934
 
Mucosal drug delivery system.pdf
Mucosal drug delivery system.pdfMucosal drug delivery system.pdf
Mucosal drug delivery system.pdfAkankshaPatel55
 
Buccal drug delivery systems
Buccal drug delivery systemsBuccal drug delivery systems
Buccal drug delivery systemshardik dhiman
 
Buccal drug delivery systems
Buccal drug delivery systemsBuccal drug delivery systems
Buccal drug delivery systemshardik dhiman
 
Development And Evaluation Of Buccal Drug Delivery System For Anti-Anginal Dr...
Development And Evaluation Of Buccal Drug Delivery System For Anti-Anginal Dr...Development And Evaluation Of Buccal Drug Delivery System For Anti-Anginal Dr...
Development And Evaluation Of Buccal Drug Delivery System For Anti-Anginal Dr...ASHISHKUMARTUDU1
 
Buccal drug delivery system
Buccal drug delivery system Buccal drug delivery system
Buccal drug delivery system Samatha Jajala
 
Buccal drug delivery system.
Buccal drug delivery system.Buccal drug delivery system.
Buccal drug delivery system.Manish Rajput
 
Buccal drug delivery pptx
Buccal drug delivery pptxBuccal drug delivery pptx
Buccal drug delivery pptxSreedhar Reddy
 
Mucoadhesive Drug delivery system
Mucoadhesive Drug delivery systemMucoadhesive Drug delivery system
Mucoadhesive Drug delivery systemsahebrao Boraste
 
Buccal drug delivery system
Buccal drug delivery system Buccal drug delivery system
Buccal drug delivery system Priyanka Tambe
 
2103313001_dhavalkumar H rathod_MPH102T.pptx
2103313001_dhavalkumar H rathod_MPH102T.pptx2103313001_dhavalkumar H rathod_MPH102T.pptx
2103313001_dhavalkumar H rathod_MPH102T.pptxMariyambibiMandarawa1
 
buccal drug delivery how to deliver drug
buccal drug delivery how to deliver drugbuccal drug delivery how to deliver drug
buccal drug delivery how to deliver drugamartya2087
 
Oral mucosal drug delivery systems
Oral mucosal drug delivery systemsOral mucosal drug delivery systems
Oral mucosal drug delivery systemsMEENAL VERMA
 

Similar to Mucosal drug delivery system (20)

Mucosal drug delivery system novel drug delivery system
Mucosal drug delivery system novel drug delivery systemMucosal drug delivery system novel drug delivery system
Mucosal drug delivery system novel drug delivery system
 
Mucosal Drug Delivery System.pptx
Mucosal Drug Delivery System.pptxMucosal Drug Delivery System.pptx
Mucosal Drug Delivery System.pptx
 
Buccal Drug Delivery System
Buccal Drug Delivery SystemBuccal Drug Delivery System
Buccal Drug Delivery System
 
Mucosal Drug Delivery System
Mucosal Drug Delivery SystemMucosal Drug Delivery System
Mucosal Drug Delivery System
 
mucoadhesive drug delivery system.pptx
mucoadhesive drug delivery system.pptxmucoadhesive drug delivery system.pptx
mucoadhesive drug delivery system.pptx
 
MUCOADHESIIVE DRUG DELIVERY SYSTEM
MUCOADHESIIVE DRUG DELIVERY SYSTEMMUCOADHESIIVE DRUG DELIVERY SYSTEM
MUCOADHESIIVE DRUG DELIVERY SYSTEM
 
Buccal drug delivery system
Buccal drug delivery systemBuccal drug delivery system
Buccal drug delivery system
 
Mucosal-Drug-Delivery-system.pdf
Mucosal-Drug-Delivery-system.pdfMucosal-Drug-Delivery-system.pdf
Mucosal-Drug-Delivery-system.pdf
 
Mucosal drug delivery system.pdf
Mucosal drug delivery system.pdfMucosal drug delivery system.pdf
Mucosal drug delivery system.pdf
 
Buccal drug delivery systems
Buccal drug delivery systemsBuccal drug delivery systems
Buccal drug delivery systems
 
Buccal drug delivery systems
Buccal drug delivery systemsBuccal drug delivery systems
Buccal drug delivery systems
 
Development And Evaluation Of Buccal Drug Delivery System For Anti-Anginal Dr...
Development And Evaluation Of Buccal Drug Delivery System For Anti-Anginal Dr...Development And Evaluation Of Buccal Drug Delivery System For Anti-Anginal Dr...
Development And Evaluation Of Buccal Drug Delivery System For Anti-Anginal Dr...
 
Buccal drug delivery system
Buccal drug delivery system Buccal drug delivery system
Buccal drug delivery system
 
Buccal drug delivery system.
Buccal drug delivery system.Buccal drug delivery system.
Buccal drug delivery system.
 
Buccal drug delivery pptx
Buccal drug delivery pptxBuccal drug delivery pptx
Buccal drug delivery pptx
 
Mucoadhesive Drug delivery system
Mucoadhesive Drug delivery systemMucoadhesive Drug delivery system
Mucoadhesive Drug delivery system
 
Buccal drug delivery system
Buccal drug delivery system Buccal drug delivery system
Buccal drug delivery system
 
2103313001_dhavalkumar H rathod_MPH102T.pptx
2103313001_dhavalkumar H rathod_MPH102T.pptx2103313001_dhavalkumar H rathod_MPH102T.pptx
2103313001_dhavalkumar H rathod_MPH102T.pptx
 
buccal drug delivery how to deliver drug
buccal drug delivery how to deliver drugbuccal drug delivery how to deliver drug
buccal drug delivery how to deliver drug
 
Oral mucosal drug delivery systems
Oral mucosal drug delivery systemsOral mucosal drug delivery systems
Oral mucosal drug delivery systems
 

More from Pranali Palandurkar

More from Pranali Palandurkar (7)

Gastroretentive drug delivery System
Gastroretentive drug delivery SystemGastroretentive drug delivery System
Gastroretentive drug delivery System
 
Polymers
PolymersPolymers
Polymers
 
Therapeutic goods adminstration
Therapeutic goods adminstration   Therapeutic goods adminstration
Therapeutic goods adminstration
 
Orodispersible liquisolid compacts
Orodispersible liquisolid compactsOrodispersible liquisolid compacts
Orodispersible liquisolid compacts
 
Ocular drug delivery system
Ocular drug delivery systemOcular drug delivery system
Ocular drug delivery system
 
3 d printing of pharmaceuticals
3 d printing  of  pharmaceuticals 3 d printing  of  pharmaceuticals
3 d printing of pharmaceuticals
 
Master formula record
Master formula recordMaster formula record
Master formula record
 

Recently uploaded

Rabies ,a deadly viral disease transmitted by the most beautiful beings. by ...
Rabies ,a deadly viral disease transmitted by the most beautiful beings.  by ...Rabies ,a deadly viral disease transmitted by the most beautiful beings.  by ...
Rabies ,a deadly viral disease transmitted by the most beautiful beings. by ...uzmashireenmbe01
 
Presentation about adversarial image attacks
Presentation about adversarial image attacksPresentation about adversarial image attacks
Presentation about adversarial image attacksKoshinKhodiyar
 
Environmental acoustics- noise criteria.pptx
Environmental acoustics- noise criteria.pptxEnvironmental acoustics- noise criteria.pptx
Environmental acoustics- noise criteria.pptxpriyankatabhane
 
Think Science: What Are Eclipses (101), by Craig Bobchin
Think Science: What Are Eclipses (101), by Craig BobchinThink Science: What Are Eclipses (101), by Craig Bobchin
Think Science: What Are Eclipses (101), by Craig BobchinNathan Cone
 
Anatomy of Duodenum- detailed ppt presentation for science students
Anatomy of Duodenum- detailed ppt presentation for science studentsAnatomy of Duodenum- detailed ppt presentation for science students
Anatomy of Duodenum- detailed ppt presentation for science studentsgargipatil3210
 
Environmental Acoustics- Speech interference level, acoustics calibrator.pptx
Environmental Acoustics- Speech interference level, acoustics calibrator.pptxEnvironmental Acoustics- Speech interference level, acoustics calibrator.pptx
Environmental Acoustics- Speech interference level, acoustics calibrator.pptxpriyankatabhane
 
Understanding Nutrition, 16th Edition pdf
Understanding Nutrition, 16th Edition pdfUnderstanding Nutrition, 16th Edition pdf
Understanding Nutrition, 16th Edition pdfHabibouKarbo
 
Think Science: What Are Eclipses, by Craig Bobchin
Think Science: What Are Eclipses, by Craig BobchinThink Science: What Are Eclipses, by Craig Bobchin
Think Science: What Are Eclipses, by Craig BobchinNathan Cone
 
Interpreting SDSS extragalactic data in the era of JWST
Interpreting SDSS extragalactic data in the era of JWSTInterpreting SDSS extragalactic data in the era of JWST
Interpreting SDSS extragalactic data in the era of JWSTAlexander F. Mayer
 
chapter 28 Reproductive System Power Point
chapter 28 Reproductive System Power Pointchapter 28 Reproductive System Power Point
chapter 28 Reproductive System Power Pointchelseakland
 
SANDAL SPIKE MYCOPLASMAL DISEASE K R ppt
SANDAL SPIKE MYCOPLASMAL DISEASE K R pptSANDAL SPIKE MYCOPLASMAL DISEASE K R ppt
SANDAL SPIKE MYCOPLASMAL DISEASE K R pptKARTHIK REDDY C A
 
Mycobacterium Mycobacterium tuberculosis
Mycobacterium Mycobacterium tuberculosisMycobacterium Mycobacterium tuberculosis
Mycobacterium Mycobacterium tuberculosisKARTHIK REDDY C A
 
Fungal Sex Hormones SIRENIN ANTHERIDIOL.
Fungal Sex Hormones SIRENIN ANTHERIDIOL.Fungal Sex Hormones SIRENIN ANTHERIDIOL.
Fungal Sex Hormones SIRENIN ANTHERIDIOL.KARTHIK REDDY C A
 
ULTRA STRUCTURE OF FUNGAL CELL AND GROWTH
ULTRA STRUCTURE OF FUNGAL CELL AND GROWTHULTRA STRUCTURE OF FUNGAL CELL AND GROWTH
ULTRA STRUCTURE OF FUNGAL CELL AND GROWTHKARTHIK REDDY C A
 
Mycoplasma Mycoplasma pneumoniae K R.pptx
Mycoplasma Mycoplasma pneumoniae  K R.pptxMycoplasma Mycoplasma pneumoniae  K R.pptx
Mycoplasma Mycoplasma pneumoniae K R.pptxKARTHIK REDDY C A
 
ISOLATION OF ALGAE (INDOOR) AND PHOTOBIOREACTOR K R.ppt
ISOLATION OF ALGAE (INDOOR) AND PHOTOBIOREACTOR K R.pptISOLATION OF ALGAE (INDOOR) AND PHOTOBIOREACTOR K R.ppt
ISOLATION OF ALGAE (INDOOR) AND PHOTOBIOREACTOR K R.pptKARTHIK REDDY C A
 
6.1 Pests of Groundnut_Binomics_Identification_Dr.UPR
6.1 Pests of Groundnut_Binomics_Identification_Dr.UPR6.1 Pests of Groundnut_Binomics_Identification_Dr.UPR
6.1 Pests of Groundnut_Binomics_Identification_Dr.UPRPirithiRaju
 

Recently uploaded (20)

Rabies ,a deadly viral disease transmitted by the most beautiful beings. by ...
Rabies ,a deadly viral disease transmitted by the most beautiful beings.  by ...Rabies ,a deadly viral disease transmitted by the most beautiful beings.  by ...
Rabies ,a deadly viral disease transmitted by the most beautiful beings. by ...
 
Presentation about adversarial image attacks
Presentation about adversarial image attacksPresentation about adversarial image attacks
Presentation about adversarial image attacks
 
Environmental acoustics- noise criteria.pptx
Environmental acoustics- noise criteria.pptxEnvironmental acoustics- noise criteria.pptx
Environmental acoustics- noise criteria.pptx
 
Think Science: What Are Eclipses (101), by Craig Bobchin
Think Science: What Are Eclipses (101), by Craig BobchinThink Science: What Are Eclipses (101), by Craig Bobchin
Think Science: What Are Eclipses (101), by Craig Bobchin
 
Bioenergetics and the role of ATP to drive the beats of life.
Bioenergetics and the role of ATP to drive the beats of life.Bioenergetics and the role of ATP to drive the beats of life.
Bioenergetics and the role of ATP to drive the beats of life.
 
Anatomy of Duodenum- detailed ppt presentation for science students
Anatomy of Duodenum- detailed ppt presentation for science studentsAnatomy of Duodenum- detailed ppt presentation for science students
Anatomy of Duodenum- detailed ppt presentation for science students
 
Environmental Acoustics- Speech interference level, acoustics calibrator.pptx
Environmental Acoustics- Speech interference level, acoustics calibrator.pptxEnvironmental Acoustics- Speech interference level, acoustics calibrator.pptx
Environmental Acoustics- Speech interference level, acoustics calibrator.pptx
 
Understanding Nutrition, 16th Edition pdf
Understanding Nutrition, 16th Edition pdfUnderstanding Nutrition, 16th Edition pdf
Understanding Nutrition, 16th Edition pdf
 
Think Science: What Are Eclipses, by Craig Bobchin
Think Science: What Are Eclipses, by Craig BobchinThink Science: What Are Eclipses, by Craig Bobchin
Think Science: What Are Eclipses, by Craig Bobchin
 
Interpreting SDSS extragalactic data in the era of JWST
Interpreting SDSS extragalactic data in the era of JWSTInterpreting SDSS extragalactic data in the era of JWST
Interpreting SDSS extragalactic data in the era of JWST
 
TISSUE TYPING .pptx
TISSUE TYPING                       .pptxTISSUE TYPING                       .pptx
TISSUE TYPING .pptx
 
chapter 28 Reproductive System Power Point
chapter 28 Reproductive System Power Pointchapter 28 Reproductive System Power Point
chapter 28 Reproductive System Power Point
 
SANDAL SPIKE MYCOPLASMAL DISEASE K R ppt
SANDAL SPIKE MYCOPLASMAL DISEASE K R pptSANDAL SPIKE MYCOPLASMAL DISEASE K R ppt
SANDAL SPIKE MYCOPLASMAL DISEASE K R ppt
 
Mycobacterium Mycobacterium tuberculosis
Mycobacterium Mycobacterium tuberculosisMycobacterium Mycobacterium tuberculosis
Mycobacterium Mycobacterium tuberculosis
 
Fungal Sex Hormones SIRENIN ANTHERIDIOL.
Fungal Sex Hormones SIRENIN ANTHERIDIOL.Fungal Sex Hormones SIRENIN ANTHERIDIOL.
Fungal Sex Hormones SIRENIN ANTHERIDIOL.
 
ULTRA STRUCTURE OF FUNGAL CELL AND GROWTH
ULTRA STRUCTURE OF FUNGAL CELL AND GROWTHULTRA STRUCTURE OF FUNGAL CELL AND GROWTH
ULTRA STRUCTURE OF FUNGAL CELL AND GROWTH
 
Battery Reasearch Reagents from TCI Chemicals
Battery Reasearch Reagents from TCI ChemicalsBattery Reasearch Reagents from TCI Chemicals
Battery Reasearch Reagents from TCI Chemicals
 
Mycoplasma Mycoplasma pneumoniae K R.pptx
Mycoplasma Mycoplasma pneumoniae  K R.pptxMycoplasma Mycoplasma pneumoniae  K R.pptx
Mycoplasma Mycoplasma pneumoniae K R.pptx
 
ISOLATION OF ALGAE (INDOOR) AND PHOTOBIOREACTOR K R.ppt
ISOLATION OF ALGAE (INDOOR) AND PHOTOBIOREACTOR K R.pptISOLATION OF ALGAE (INDOOR) AND PHOTOBIOREACTOR K R.ppt
ISOLATION OF ALGAE (INDOOR) AND PHOTOBIOREACTOR K R.ppt
 
6.1 Pests of Groundnut_Binomics_Identification_Dr.UPR
6.1 Pests of Groundnut_Binomics_Identification_Dr.UPR6.1 Pests of Groundnut_Binomics_Identification_Dr.UPR
6.1 Pests of Groundnut_Binomics_Identification_Dr.UPR
 

Mucosal drug delivery system

  • 1. Mucosal Drug Delivery System Presented By: Pranali M. Palandurkar University department of Pharmaceutical Sciences R. T.M.N.U nagur
  • 2. Contents  Introduction  Principle of bioadhesion  Concept of mucosal delivery system  Advantages & Disadvantages  Transmucosal permeability  Formulation & consideration of buccal drug delivery system 2
  • 3. INTRODUCTION  Delivery of drugs via the absorptive mucosa in various easily accessible body cavities, like the ocular, nasal, buccal, rectal and vaginal mucosae, has the advantage of bypassing the hepato-gastrointestinal first-pass elimination associated with oral administration.  Mucosal membranes can be useful sites with good accessibility for easy application of drug delivery systems, especially for those with bio(muco)adhesive properties.  Mucoadhesive drug delivery systems utilize the property of bioadhesion of certain polymers which become adhesive on hydration and hence can be used for targeting a drug to a particular region of the body for extended periods of time and can be exploited for the noninvasive systemic delivery of organic- and peptide-based drugs, with rapid absorption as well as sustained drug action 3
  • 4. PRINCIPLE OF BIOADHESION There are six classical theories adapted which explain the phenomenon of adhesion. 1.Electronic theory- When both mucoadhesive and biological materials come into contact, they transfer electrons leading to the building of a double electronic layer at the interface, where the attractive forces within this electronic double layer determines the mucoadhesive strength. 2.Adsorption theory- The mucoadhesive device adheres to the mucus by secondary chemical interactions, such as in van der Waals and hydrogen bonds, electrostatic attraction or hydrophobic interactions. Such forces have been considered the most important in the adhesive interaction phenomenon because, although they are individually weak, a great number of interactions can result in an intense global adhesion 4
  • 5. 3.Wetting theory-The wetting theory applies to liquid systems which present affinity to the surface in order to spread over it. This affinity can be measure by contact angle. The general rule states that the lower the contact angle then the greater the affinity The contact angle should be equal or close to zero to provide adequate spreadability The spreadability coefficient, SAB, can be calculated from the difference between the surface energies γB and γA and the interfacial energy γAB, as indicated in equation SAB= γB- γA- γAB The greater the individual surface energy of mucus and device in relation to the interfacial energy, the greater the adhesion work, WA, i.e. the greater the energy needed to separate the two phases WA=γA+γB-γAB 5
  • 6. 4.Diffusion theory-Diffusion theory describes the interpenetration of both polymer and mucin chains to a sufficient depth to create a semi-permanent adhesive bond. It is believed that the adhesion force increases with the degree of penetration of the polymer chains. This penetration rate depends on the diffusion coefficient, flexibility and nature of the mucoadhesive chains, mobility and contact time. This interpenetration depth of polymer and mucin chains can be estimated by the following equation l = (tDb)½ Where, t - contact time Db -diffusion coefficient of the mucoadhesive material in the mucus. The adhesion strength for a polymer is reached when the depth of penetration is approximately equivalent to the polymer chain size. 6
  • 7. 5.Fracture theory-It analyses the force required to separate two surfaces after adhesion is established . The force Sm is frequently calculated in tests of resistance to rupture by the ratio of the maximal detachment force,Fm and the total surface area A0 Sm=Fm/A0 6.Mechanical theory-This theory consider adhesion to be due to the filling of the irregularities on a rough surface by a mucoadhesive liquid. Moreover ,such roughness increases the interfacial area available to interactions thereby aiding dissipating energy and can be considered the most important phenomenon of the process. 7
  • 8. CONCEPT OF BIOADHESION  Bioadhesion is the state in which two materials ,(at least one of which is biological in nature), are held together for a extended period of time by interfacial forces.  The term bioadhesion implies attachment of drug-carrier system of specific biological location. This biological surface can be epithelial tissue or the biological surface can be epithelial tissue or the mucous coat on the surface of tissue.  If adhesive attachment is to mucous coat then phenomenon is referred as mucoadesion.  These drug delivery system utilize property of bioadhesion of certain water soluble polymers which become adhesive on hydration and hence can be used for targeting particular sites. 8
  • 9.  Mechanisms of Bioadhesion – The mechanism responsible in the formation of bioadhesive bonds are not fully known ,however most research has described bioadhesive bond formulation as a three step process . Step 1- Wetting and swelling of polymer Step 2-Interpenetration between the polymer chains and the mucosal membrane Step 3- Formation of chemical bonds between the entangled chains. 9
  • 10. Mucosal drug delivery offers several advantages over other controlled release systems :  High drug flux at the absorbing tissue.  Painless and ease of administration.  Low enzymatic activity and avoid of first pass metabolism.  Targeting and localization of the dosage form at a specific site.  Termination of therapy is possible.  drugs which are unstable in acidic environment of stomach or destroyed by the alkaline environment of intestine can be given other mucosal route .  Drug shows poor bioavailability by oral route can be administered by other mucosal route . ADVANTAGES 10
  • 11.  It follows passive diffusion , and does not require any activation.  The presence of saliva ensures large amount of water for dissolution of drug unlike in case of rectal and transdermal route.  Thin mucin film exist on the surface of oral cavity provides opportunity to retain delivery system in contact with mucosa for prolonged period of time with the help of mucoadhesive compounds  The buccal membrane is sufficiently large to allow delivery system to be placed at different sites on the same membrane for different occasion , if the drug or other excipients cause reversible damage or irritate mucosa . 11
  • 12. DISADVANTAGES  Over hydration may lead to formulation slippery surface and structural integrity of the formulation may get disrupted by the swelling and hydration of the bioadhesion polymer.  Eating and drinking may become restricted  Drug which irritate mucosa or have a bitter or unpleasant taste or an obnoxious odour cannot be administered by this route .  Only drug which are absorbed by passive diffusion can be administered by this route .  Only small dose drug can be administered .  In case of ,buccal tablet there is possibility that patient may swallow the tablet.  Costly drug delivery system.  Unfortunately , the lack of standardized techniques often leads to unclear result. 12
  • 13. TRANSMUCOSAL PERMEABILITY  Mucosal routes provide the potential pathways to bypass hepatogastrointestinal first-pass elimination following oral administration. Transmucosal drug delivery has the potential to achieve greater systemic bioavailability for orally metabolized drugs, including organic- and peptide-based pharmaceuticals.  There are two routes potentially involved in drug permeation across epithelial membranes: a) Transcellular route b)Paracellular route 13
  • 14. 1)Paracellular route: For hydrophilic compounds  This compound is difficult to penetrate into the lipophilic cell membrane .  Intercellular space is preferred route for drug transport  Drug movement in this route (JH)can be written as (JH)=DH Є CD hH Where Є= fraction of surface area of paracellular route DH= diffusion coefficient hH= pathlength of paracellular route CD=donar side drug concentration 14
  • 15. 2)Transcellular route: For lipophilic compound. Drug molecule move across both lipophilic cell membrane and hydrophilic cytoplasm as well as intercellular space. The permeability of lipophilic compound across the epithelial cell membrane is typically high . Drug flux is transcellular route (JL) can be expressed as: JL=(1-Є)DH KP CD hL Where , KP =partition coefficient between lipophilic and hydrophilic region hL= pathlength of transcellular route 15
  • 16. Various potential mucosal pathways for systemic delivery of therapeutic agents. 16
  • 17. Buccal Delivery: Drugs are delivered through mucosal membrane into systemic circulation by placing drug in between cheeks and gums. Classification of Buccal Bioadhesive Dosage Forms  Buccal Bioadhesive Tablets.  Buccal Bioadhesive semisolids.  Buccal Bioadhesive patch and films.  Buccal Bioadhesive Powders. Formulation consideration of Buccal drug delivery system 17
  • 18. Advantages of Buccal Drug Delivery System  The residence time of dosage form at the site of absorption is prolong, hence increases the bioavailability.  Rapid onset of action.  High blood supply and good blood flow rate cause rapid absorption.  In the acidic medium of git drug is protected from degradation.  Improved patient compliance.  Nor painful neither irritations. Disadvantages of Buccal Drug Delivery System:  Prolonged contact of the drug possessing ulcerogenic property.  For the in vitro screening of drugs the oral mucosal delivery is lack of good model. This is the major drawback of this drug delivery.  Patient acceptability in terms to taste, irritancy and mouth feel is to be checked.  As compared to the sublingual membrane the buccal membrane is low permeability.  Also has smaller surface area.  The dissolution of drug due to continuous secretion of saliva (0.5-2 l/day). 18
  • 19. The basic components of buccal bioadhesive drug delivery system are :  Drug substance -Drug used for rapid release/prolonged release and for local/systemic effect is a suitable candidate for buccal delivery  Bioadhesive polymers-Bioadhesive polymers play a major role in buccoadesive drug delivery systems of drugs. Polymers are also used in matrix devices in which the drug is embedded in the polymer matrix, which controls the duration of release of drugs.  Backing membrane-Backing membrane plays a major role in the attachment of bioadhesive devices to the mucus membrane.  Penetration enhancers- To increases the permeation rate of the membrane of co-administrated drug penetration enhancer are added. Without causing toxicity and damaging the membrane they improve the bioavailability of drugs that have poor membrane penetration 19
  • 20. Components Examples Bioadhesive polymers Agarose, chitosan, gelatin, Hyaluronic acid, Poly(acrylic acid)-based polymers, Hydroxyethyl starch ,PVA, PVP, scleroglucan Backing membrane Carbopol, Magnesium separate, HPMC, HPC, CMC, Polycarbophil Penetration enhancers Sodium lauryl, Cetylpyridinium chloride, Poloxamer, Sodium gylcodeoxycholate, Oleic acid, Ceprylic acid, Trimethyl chitosan, EDTA ,sodium citrate. 20
  • 21. Marketed Formulation Product Company Bioadhesive agent Dosage Form Buccastem Reckitt Benckiser PVP, Xanthum Gum Buccal Tablet Corlan Pellets Celtech Acacia gum Oromucosal Pellets Suscard Forest HPMC Buccal Tablet Orabase Convatech Pectin ,Gelatin Oral Paste Corsodyl Gel Glaxosmith Kline HPMC Oromucosal Gel 21
  • 22. 22