PharmARC SMMAInsights from Social Media DataJan 2011 to July 2011 – Twitter data for rheumatoid arthritisTanmay SaraykarMa...
Every Sunday, RA patients chat on Twitter using #rheum on        various topics related to rheumatoid arthritis           ...
RA Activities on Twitter – Overview      Twitter hashtag Definition: Words or phrases prefixed with a # sign,      used as...
Sample tweets from patients of rheumatoid arthritis      mouth sores from                                                 ...
Chat Topics – January 2011        (Sundays – 2nd, 9th, 16th, 23rd and 30th)                         Chat Topics from Chats...
Social media data reveals valuable insights about        critical parameters of prescription drugs                        ...
Social media reveals – Drug Consumption data for        various drug classes                   #1                         ...
Analysis of tweets reveals buzz around rheumatoid        arthritis brand names – Tag clouds for brand names               ...
Methotrexate is by far the most discussed, amongst        drugs (not surprising)                                          ...
Social media reveals – Comments about efficacy        of drugs                   #2                         Drug efficacy ...
Tweets by patients of rheumatoid arthritis reveal        insights regarding efficacy of biologics           25            ...
Social media data contains patients’ comments about side        effects of various drugs (methotrexate example)           ...
Side effects of various biologics as mentioned by the        patients who are consuming them            Side effects - Enb...
Side effects of various biologics as mentioned by the        patients who are consuming them         Side effects - Remica...
Social media reveals – comments on switch-overs                   #3                         Drug switch-overs        When...
For patients of rheumatoid arthritis, social media data reveals switch-        overs from one drug class to another (From ...
Summary of switch-overs between RA brands (38) –        Combining insights from all social media platforms should        r...
Analysis of 38 switch-overs mentioned in tweets indicate        that efficacy is a significant reason for switch over     ...
Social media reveals – what drug combinations the        patients are on                   #4                         Drug...
Methotrexate is used in combination with various        biologics for treatment of rheumatoid arthritis                   ...
Social media reveals – comments on convenience        of dosage for RA drugs                   #5                         ...
RA patients post comments about convenience of dosage for        DMARDs and biologic drugs                          DMARD ...
Trends from social media data - Conversations about rheumatoid        arthritis on social media platforms revolve around t...
Conclusion  Continuous monitoring and analysis of healthcare-related social   media data reveals insights into critical as...
For further information on this document, please contact:        Tanmay Saraykar        Manager, Social Media Analytics   ...
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PharmARC SMMA Insights About Rheumatoid Arthritis from Twitter Data

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This presentations outlines how health related data posted by patients on popular social networks such as Twitter, can be analysed and used for deriving specific insights about prescription drugs. Insights can be around consumption of drugs used for treatment of rheumatoid arthritis such as DMARDs and biologics, their efficacy and side effects, swtich-overs and convenience of dosage. This data can be used by patients as well as physicians to make better informed decisions about treatment of rheumatoid arthritis.

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PharmARC SMMA Insights About Rheumatoid Arthritis from Twitter Data

  1. 1. PharmARC SMMAInsights from Social Media DataJan 2011 to July 2011 – Twitter data for rheumatoid arthritisTanmay SaraykarManager, Social Media Analytics www.pharmarc.com
  2. 2. Every Sunday, RA patients chat on Twitter using #rheum on various topics related to rheumatoid arthritis Daily count of tweets – Jan 2011 to July 2011 600 Sunday, March 06, Sunday, July 24, 2011 500 2011 400 Sunday, January 09, Sunday, June 05, 2011 2011 300 Sunday, January 30, Sunday, April 17, 2011 2011 200 100 0© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 2
  3. 3. RA Activities on Twitter – Overview Twitter hashtag Definition: Words or phrases prefixed with a # sign, used as text indicators to organize around an idea, tweet about certain subjects, group posts around topics Popular Twitter hashtag for rheumatoid arthritis: #rheum #rheum - Chats on Rheumatology topics: Sundays at 3pm EST/8pm GMT. Use the hashtag #rheum for rheumatology tweets This hashtag is a Tweet Chat Duration: January 2, 2011 to July 31, 2011 Total no. of tweets using #rheum – 16,524 Total tweeting accounts – 1160 No. of tweets for top 10% accounts – 13,049 (80%) Top 10 % accounts are the most influential.© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 3
  4. 4. Sample tweets from patients of rheumatoid arthritis mouth sores from #Rheum doc appt So far Ive been on Methotrexate went well. Switching to Plaquenil, MTX, commented on #rheum // if folic injection & upping Arava and Enbrel. your Humira post; acid doesnt work, dose of Methotrexate. My rheumy has I had no luck with try folinic acid. A Go back in 2mths; 2 now prescribed it either, but rhubarb extract consider Remicade in Humira. #rheum Rituximab has may help healing. place of Enbrel. changed my life, so there is hope #rheum MTX: 3 years, Uggity. Rituximab: 3 years, Painsomnia stinks. Perfect post today. I Prednisolone: 6 Been up 5 hrs have PsA and P Enbrel works for years. Tried after sleep for 3. #rheum just put me me! Humira gave everything from This is gonna be a on Methotrexate me headache all Anti-TNF to JOY of a day. And recently since my day everyday for plaquenil in- Enbrel delivery! Enbrel stopped entire 2 mos. I between #rheum #rheum working. Need used it. #rheum positives.© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 4
  5. 5. Chat Topics – January 2011 (Sundays – 2nd, 9th, 16th, 23rd and 30th) Chat Topics from Chats on Twitter with #rheum Standard Twitter Chat Rules 1. How many RA patients manage to work full time, part time? For 1. Tweets assumed to be your how many years? How about working from home? own opinion 2. Do not sell 2. New year resolutions for RA patients 3. Politely stay on topics 3. Patients bringing in information about RA, does it bother doctors? What about writing to doctors or commenting on blogs? Social Essence 4. Favorite stress relievers for patients, rewards and comforts 1. Professional life of RA patients 5. Do you do what the doctor says? If not, do you tell the doctor? 2. Pain management 3. Stress relief and hobbies 6. Are online support groups better than local support groups? 4. Compliance to prescription Why? drugs 7. Annual RA meet-up 5. Social information sharing and support groups 8. Depression from chronic pain 6. Annual events • Suggestions to avoid or combat depression 7. Emotional issues related to chronic pain from RA • What can friends, family members, doctor do to help 8. Helping newly diagnosed depression from chronic pain? patients 9. Most important suggestions to patients newly diagnosed with RA© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 5
  6. 6. Social media data reveals valuable insights about critical parameters of prescription drugs  Drug consumption/Comments about Drug Brands The insights revealed through  Drug efficacy, Side effects social media monitoring and  Switch-overs analysis can act as decision-  Combination with other medication making points for consumers  Convenience of dosage© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 6
  7. 7. Social media reveals – Drug Consumption data for various drug classes #1 Drug consumption Which prescription drugs are being consumed by patients of rheumatoid arthritis? Drug Class Brands  DMARDs Enbrel, Humira,  Biologics Remicade, Rituxan,  NSAIDs Orencia, Actemra, Cimzia, Simponi, etc.© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 7
  8. 8. Analysis of tweets reveals buzz around rheumatoid arthritis brand names – Tag clouds for brand names Methotrexate Orencia Enbrel Cimzia Simponi Rituxan Remicade Humira Actemra© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 8
  9. 9. Methotrexate is by far the most discussed, amongst drugs (not surprising) Total Mentions Methotrexate 517 Enbrel (etanercept) 226 Humira (adalimumab) 189 Remicade (infliximab) 86 Orencia (abatacept) 54 Actemra (tocilizumab) 50 Rituxan (Rituximab) 45 Simponi (golimumab) 22 Cimzia (certolizumab) 11 0 100 200 300 400 500 600© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 9
  10. 10. Social media reveals – Comments about efficacy of drugs #2 Drug efficacy and Side effects Which prescription drugs work better than others? How do drugs compare on efficacy as mentioned by patients? Efficacy  Biologics - Half life of the drug  Positive efficacy  Negative efficacy© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 10
  11. 11. Tweets by patients of rheumatoid arthritis reveal insights regarding efficacy of biologics 25 22 20 18 15 10 9 9 5 3 3 2 2 2 2 0 0 0 Enbrel Remicade Humira Orencia Actemra Rituxan Drug works for me Doesn’t work/worsened condition© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 11
  12. 12. Social media data contains patients’ comments about side effects of various drugs (methotrexate example) Side effects of methotrexate from Twitter data 12 10 10 10 9 8 6 6 6 4 4 3 3 2 2 2 2 2 2 0 Fatigue Nausea Vomiting Fever Stomach Ache/Issues Sickness Flares Insomnia Bizzare dreams Abdominal cramps Hair loss/thinning hair Breathing difficulty Allergic reaction© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 12
  13. 13. Side effects of various biologics as mentioned by the patients who are consuming them Side effects - Enbrel Side effects - Humira Side effects - Rituxan  Cough/Chronic respiratory  Flu like symptoms infection  Burning sensation (2)  Painsomnia  Lowers ability to fight infection  Sickness (1)  Joint and muscle pain (3)  Upper respiratory problems  Burning sensation (2)  Headache (2)  Fatigue  Nerve shock and numbness?  Flares (2)  Lupus like and MS like symptoms  Fever  Inflammation  Gastrointestinal symptoms  Sickness  Thinning hair  Excessive was build-up in ears (3)  Nausea  Flares (2)  Paleness  Lightheadedness, hot flashings,  Mouth sores (2) chills  Fever  Rashes and bruising© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 13
  14. 14. Side effects of various biologics as mentioned by the patients who are consuming them Side effects - Remicade Side effects - Orencia Side effects - Actemra  Hangover  Cough (4, with one  Hives (2)  Headache (2) mentioning persistent, severe  Allergic reaction (1)  Ill feeling, fatigue cough)  Allergic reaction (3)  Queasy and crackly feeling  Drop in blood pressure  Itch and bruises© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 14
  15. 15. Social media reveals – comments on switch-overs #3 Drug switch-overs When one biologic drug or DMARD stops working for an RA patient, which one do they switch to? Switch-overs  Reasons for switching drug class  Reasons for switching brands within a drug class© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 15
  16. 16. For patients of rheumatoid arthritis, social media data reveals switch- overs from one drug class to another (From DMARDs to Biologics) as well as within a certain drug class (within biologics) Switchover to Enbrel from Switchover from Enbrel to Methotrexate Methotrexate 1 3 5 Humira Humira 1 1 2 Orencia Remicade 2 1 Unspecified Unspecified© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 16
  17. 17. Summary of switch-overs between RA brands (38) – Combining insights from all social media platforms should reveal substantial insights (example below is from twitter)© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 17
  18. 18. Analysis of 38 switch-overs mentioned in tweets indicate that efficacy is a significant reason for switch over Helps with other Side effect indication 5% 3% Previous drug stops working 24% Not specified 68%© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 18
  19. 19. Social media reveals – what drug combinations the patients are on #4 Drug combinations For treatment of RA, which combinations of drugs are taken by patients? Switch-overs  DMARDs and Biologics  NSAIDs and Pain Killers  Anti-depressants© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 19
  20. 20. Methotrexate is used in combination with various biologics for treatment of rheumatoid arthritis Combinations of methotrexate with biologics MTX and Enbrel 18 NSAIDs/Pain Killers/Others MTX and Humira 12  Sulfasalazine  Prednisone MTX and Orencia 3  Mobic  Ibuprofen MTX and Rituximab 2  Naproxen  Anti-acidity MTX and Cimzia 1  Anti-depressant  Folic Acid MTX and Actemra 1 0 5 10 15 20© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 20
  21. 21. Social media reveals – comments on convenience of dosage for RA drugs #5 Convenience of dosage What are the issues associated with administering biologics to RA patients? Convenience  DMARDs  Biologics© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 21
  22. 22. RA patients post comments about convenience of dosage for DMARDs and biologic drugs DMARD - methotrexate Biologic - Enbrel Positives Negatives Positives Negatives  Methotrexate stays  Methotrexate takes  Enbrel can sustain  Often causes longer in the body time to become in good condition swelling at the  Methotrexate active in the body for 4 days at room injection site injections cause  Methotrexate oral temperature, easy  If injected in the less stomach medication causes to carry during stomach, leaves problems nausea travel bruises  Patients need to put ice at the injection site which is inconvenient  Doesn’t stay for long in the body  Needed in more volumes and frequent injections© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 22
  23. 23. Trends from social media data - Conversations about rheumatoid arthritis on social media platforms revolve around three main topics Drugs/Brands for treating RA Pain/inflammation management Emotional issues • Parameters of RA drugs • Patients discuss the drugs • Patients show strong (such as DMARDs and consumed for managing empathy and concern on Biologics), on the basis of chronic pain and social networks about which, patients take inflammation such as fellow RA patients decisions, e.g. NSAIDs and pain killers • They encourage sharing • Efficacy • Discussions around issues relating to family, • Side effects household therapies and livelihood, friends, • Switch-overs alternative therapies for important events (e.g. • Convenience of relieving pain undergoing some surgery, dosage • Patients share tips for pregnancy, etc.) to gain • Costs managing the emotional and social • Discussions around inconvenience during support reasons for switching over biologic infusions • RA patients express between drug classes as • Patients share information depression due to chronic well as switching brands about precautions to be pain and immobility as a within a drug class taken against major concern • Discussions around pain/inflammation during medication and alternative different seasons, as therapies needed to treat severe weather conditions the side effects of RA may elevate RA-related drugs symptoms© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 23
  24. 24. Conclusion Continuous monitoring and analysis of healthcare-related social media data reveals insights into critical aspects of prescription drugs, and helps understand the consumers better© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved. Slide 24
  25. 25. For further information on this document, please contact: Tanmay Saraykar Manager, Social Media Analytics +91 7829909766 tanmay.saraykar@pharmarc.com Corporate Headquarters Europe USA PharmARC Analytic Solutions Pvt. Ltd. PharmARC Consulting Services GmbH PharmARC Inc. Mercury 2B Block, 6th Floor Passage 6 100 Overlook Center Prestige Technology Park 4104 Oberwil (BL) 2nd Floor, Princeton, NJ 08540 Sarjapur - Marathahalli Outer Ring Road Switzerland USA Bangalore 560 103, India T +41 (61) 261 8900 T +91 (80) 4123 8900 F +41 (61) 261 8901 T +1 (609) 450 1880 F +91 (80) 4123 8999 F +1 (609) 895 2666© PharmARC Analytic Solutions Pvt. Ltd., 2011. All Rights Reserved.

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