Lower-body fat loss is not associated with elevations in diabetes and cardiovascular disease risk factors <ul><li>Peter M....
Abdominal Fat and Health Risk Android/ Abdominal Obesity <ul><li>BMI = 35 kg/m 2 </li></ul><ul><li>BP = 170/90 mm Hg </li>...
Lower Body Fat and Health Risk Gynoid/ Lower Body Obesity <ul><li>BMI = 41 kg/m 2 </li></ul><ul><li>BP = 130/70 mm Hg </li...
Abdominal and Lower Body Fat Loss and Changes in Health Risk: Longitudinal Observations From:  Fujioka et al. 1991, Ross e...
Objective During weight loss, is the reduction of lower body fat for a given amount of abdominal (visceral and subcutaneou...
<ul><li>Study Sample </li></ul>Current Investigation Janiszewski et al. Diabetologia (2008) 51:1475-1482 47 57 BMI ≥ 25 kg...
Body Composition by MRI Janiszewski et al. Diabetologia (2008) 51:1475-1482
Body Composition by MRI Janiszewski et al. Diabetologia (2008) 51:1475-1482
Body Composition by MRI Janiszewski et al. Diabetologia (2008) 51:1475-1482
Effects of Treatment: Anthropometric   Body Weight (kg) Men Women Pre Post Janiszewski et al. Diabetologia (2008) 51:1475-...
Effects of Treatment: Abdominal AT   Visceral AT (kg) Men Women Pre Post Janiszewski et al. Diabetologia (2008) 51:1475-14...
Effects of Treatment: Lower Body AT   Lower body SAT (kg) Men Women Pre Post Janiszewski et al. Diabetologia (2008) 51:147...
Effects of Treatment: Cardiometabolic Risk Factors OGTT Glucose AUC (mmol/L  •2Hr ) Men Women Pre Post Janiszewski et al. ...
Abdominal AT Loss and Changes in Cardiometabolic Risk Abdominal Fat Loss Controlled for: age, gender, treatment group, and...
Abdominal AT Loss and Changes in Cardiometabolic Risk Abdominal Fat Loss Good Controlled for: age, gender, treatment group...
Lower Body AT Loss and Changes in Cardiometabolic Risk Janiszewski et al. Diabetologia (2008) 51:1475-1482 Δ   Health Risk...
Lower Body AT Loss and Changes in Cardiometabolic Risk Δ   OGTT Insulin AUC Lower Body SAT Loss Good Controlled for: age, ...
Lower Body AT Loss and Changes in Cardiometabolic Risk Δ   Cardiometabolic Risk Factors Lower Body SAT Loss Controlled for...
Conclusions <ul><li>The reduction of lower body SAT consequent to weight loss is not associated with deterioration in card...
Thank You
Energy Surplus Dysfunctional adipokine secretion FFA spillover ↑  Glucose production ↑  VLDL ↑  Lipolysis ↑ ‘ Bad’ adipoki...
Protective Lower-body Fat: Possible Mechanism (Lemieux, 2004)
‘ Protective’ Thigh Fat in the media
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Lower-body fat loss is not associated with elevations in diabetes and cardiovascular disease risk factors

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Dr. Peter Janiszewski's presentation from the 2008 Annual Meeting of the Canadian Society for Exercise Physiology

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Lower-body fat loss is not associated with elevations in diabetes and cardiovascular disease risk factors

  1. 1. Lower-body fat loss is not associated with elevations in diabetes and cardiovascular disease risk factors <ul><li>Peter M. Janiszewski, Jennifer L. Kuk, and Robert Ross. </li></ul><ul><li>Diabetologia (2008) 51:1475-1482 </li></ul>School of Kinesiology and Health Studies
  2. 2. Abdominal Fat and Health Risk Android/ Abdominal Obesity <ul><li>BMI = 35 kg/m 2 </li></ul><ul><li>BP = 170/90 mm Hg </li></ul><ul><li>Diabetic </li></ul>From: Vague 1956 Health Risk Abdominal Fat < Good Bad =
  3. 3. Lower Body Fat and Health Risk Gynoid/ Lower Body Obesity <ul><li>BMI = 41 kg/m 2 </li></ul><ul><li>BP = 130/70 mm Hg </li></ul><ul><li>Blood sugar normal </li></ul>From: Vague 1956 Health Risk Lower Body Fat = < Bad Good
  4. 4. Abdominal and Lower Body Fat Loss and Changes in Health Risk: Longitudinal Observations From: Fujioka et al. 1991, Ross et al. 2000 Δ Health Risk Abdominal Fat Loss Δ Health Risk Lower Body Fat Loss Good Bad ?
  5. 5. Objective During weight loss, is the reduction of lower body fat for a given amount of abdominal (visceral and subcutaneous) fat reduction associated with an exacerbation in cardiometabolic profile? Janiszewski et al. Diabetologia (2008) 51:1475-1482
  6. 6. <ul><li>Study Sample </li></ul>Current Investigation Janiszewski et al. Diabetologia (2008) 51:1475-1482 47 57 BMI ≥ 25 kg/m 2 + 3 or more risk factors (%) 100 100 BMI ≥ 25 kg/m 2 + 1 or more risk factors (%) 99.4 ± 9.3 108.8 ± 7.9 Waist circumference (cm) 33.1 ± 4.3 32.1 ± 3.0 BMI (kg/m 2 ) 39.9 ± 6.8 43.9 ± 9.1 Age (yr) Women (n=49) Men (n= 58) <ul><li>Treatments </li></ul>- 3 months of one of the following: - Exercise - Diet - Exercise + Diet
  7. 7. Body Composition by MRI Janiszewski et al. Diabetologia (2008) 51:1475-1482
  8. 8. Body Composition by MRI Janiszewski et al. Diabetologia (2008) 51:1475-1482
  9. 9. Body Composition by MRI Janiszewski et al. Diabetologia (2008) 51:1475-1482
  10. 10. Effects of Treatment: Anthropometric Body Weight (kg) Men Women Pre Post Janiszewski et al. Diabetologia (2008) 51:1475-1482 * * * Significantly different from baseline (P < 0.05) Waist Circumference (cm) Men Women * *
  11. 11. Effects of Treatment: Abdominal AT Visceral AT (kg) Men Women Pre Post Janiszewski et al. Diabetologia (2008) 51:1475-1482 * * * Significantly different from baseline (P < 0.05)
  12. 12. Effects of Treatment: Lower Body AT Lower body SAT (kg) Men Women Pre Post Janiszewski et al. Diabetologia (2008) 51:1475-1482 * * * Significantly different from baseline (P < 0.05)
  13. 13. Effects of Treatment: Cardiometabolic Risk Factors OGTT Glucose AUC (mmol/L •2Hr ) Men Women Pre Post Janiszewski et al. Diabetologia (2008) 51:1475-1482 * * Significantly different from baseline (P < 0.05) * Triglycerides (mmol/L) Men Women * * LDL-cholesterol (mmol/L) Men Women * * Fasting Insulin (pmol/L) Men Women * *
  14. 14. Abdominal AT Loss and Changes in Cardiometabolic Risk Abdominal Fat Loss Controlled for: age, gender, treatment group, and change in VO 2 max Janiszewski et al. Diabetologia (2008) 51:1475-1482 Δ Glucose Δ OGTT glucose Δ OGTT insulin Δ Cholesterol Δ LDL-C Good β = 0.21 to 0.24, p < 0.05
  15. 15. Abdominal AT Loss and Changes in Cardiometabolic Risk Abdominal Fat Loss Good Controlled for: age, gender, treatment group, and change in VO 2 max + Δ lower body SAT β = 0.19 to 0.24, p < 0.05 Δ OGTT glucose Δ Cholesterol Δ LDL-C Janiszewski et al. Diabetologia (2008) 51:1475-1482 =
  16. 16. Lower Body AT Loss and Changes in Cardiometabolic Risk Janiszewski et al. Diabetologia (2008) 51:1475-1482 Δ Health Risk Lower Body Fat Loss Bad ?
  17. 17. Lower Body AT Loss and Changes in Cardiometabolic Risk Δ OGTT Insulin AUC Lower Body SAT Loss Good Controlled for: age, gender, treatment group, and change in VO 2 max β = 0.23, p < 0.05 Janiszewski et al. Diabetologia (2008) 51:1475-1482
  18. 18. Lower Body AT Loss and Changes in Cardiometabolic Risk Δ Cardiometabolic Risk Factors Lower Body SAT Loss Controlled for: age, gender, treatment group, and change in VO 2 max + Δ in abdominal VAT and SAT = β = -0.07 to 0.19, p > 0.05 Not Bad Janiszewski et al. Diabetologia (2008) 51:1475-1482
  19. 19. Conclusions <ul><li>The reduction of lower body SAT consequent to weight loss is not associated with deterioration in cardiometabolic risk factors </li></ul><ul><li>Thus, among overweight and obese men and women, the reduction of excess AT is likely to convey health benefit, regardless of origin </li></ul>Janiszewski et al. Diabetologia (2008) 51:1475-1482
  20. 20. Thank You
  21. 21. Energy Surplus Dysfunctional adipokine secretion FFA spillover ↑ Glucose production ↑ VLDL ↑ Lipolysis ↑ ‘ Bad’ adipokines ↓ Insulin Clearance ↓ Glucose Uptake ↓ Insulin Secretion ↑ β -cell death ↑ heart cell death Cardiometabolic Risk Healthy adipokine secretion FFA buffering (no spillover) Healthy Cardiometabolic Profile Functional SAT Dysfunctional SAT
  22. 22. Protective Lower-body Fat: Possible Mechanism (Lemieux, 2004)
  23. 23. ‘ Protective’ Thigh Fat in the media

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