TB in SL: Thinking Big about the Very Small


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Presentation for non-science audience on the educational use of the virtual world Second Life in the context of an ongoing pilot build themed on the bacterium Mycobacterium tuberculosis.

TB in SL: Thinking Big about the Very Small

  1. 1. http://tidalblog.blogspot.com/<br />http://bit.ly/listfaq <br />Graham Mills<br />TBinSL:Thinking Big about the Very Small<br />
  2. 2. Visualization: molecules, gene data, cells...<br />Max Chatnoir demonstrates her giant cellon Elucian Isles<br />
  3. 3. Context: TB (tuberculosis)<br /> Downsides<br />Bacterial infection <br />Kills 4500 people daily<br />Antibiotic-resistant strains<br />Vaccines of limited use<br />Rapidly lethal in HIV/AIDS<br />Hard to do labwork<br />Upsides<br /><ul><li>Major research initiatives aimed at developing new drugs and vaccines and eliminating TB by 2020</li></li></ul><li>Molecules<br />Small molecules (metabolites, drugs)<br /><ul><li>Hiro Sheridan: molecule rezzer (ACS), Orac [1]
  4. 4. Incorporated into metabolic browser </li></ul> <br />Large molecules: proteins, etc<br /><ul><li>Prim-intensive: Troy McLuhan [2]
  5. 5. Added interactivity
  6. 6. Sculpted: HiroSheridan [3]
  7. 7. Added interactivity
  8. 8. Also: animated [4] and static textures [5], particles
  9. 9. SL Molecular Structures Group (AsorelTodriya)
  10. 10. Lang & Bradley (2009)http://journal.chemistrycentral.com/content/3/1/14</li></ul> <br />
  11. 11. Molecules in Second Life<br />1<br />2<br />5<br />3<br />4<br />
  12. 12. Metabolic browser<br />Molecules by Hiro Sheridan’s Oracand stored inTroy McLuhan’s holoemitter<br />
  13. 13. Prim-intensive protein models (backbone only)<br />M. tuberculosis<br />cellulase<br />
  14. 14. Student work on A2M in the E. coli cell wall (2008)<br />A2M<br />
  15. 15. Sculpted protein (+ particle)<br />
  16. 16. Student group work (2009)<br />Students work on different genes<br />Groups work on different species<br />Link by teleport to giant TB genome<br />
  17. 17. Datascape: Giant TB genome<br />Genes encode proteins<br />>4000 TB genes, alltouch-sensitive<br />
  18. 18. Individual genes and their products<br />Associations withother proteins (STRING)<br />Contextual sub-map<br />SLV 2.0 texture on marker<br />
  19. 19. Take your analytical tools with you: shared media dashboard<br />Follower is a mashup of<br />Puppeteer and Scratch4SL<br />
  20. 20. Cellscape: porins, alveolus, macrophage<br />
  21. 21. Cityscape: The Cure<br />
  22. 22. Robert Koch’s lab<br />
  23. 23. TB timeline maze (under construction)<br />TB started here<br />And is a major problem here<br />
  24. 24. Conclusions<br />Progress has been made so let’s share it!<br />It’s not content, it’s collaboration<br />Reasons to be cheerful<br />Some students (not all) like this!!<br />Groupwork works<br />Shared media (meshes next?)<br />