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Alström syndrome

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Alström syndrome

  1. 1. Alström syndromeClinical studies and research<br />R B Paisey on behalf of:<br />National clinical advisory Group<br />Alström syndrome UK<br />Cardiology,endocrinology,vascular medicine, biochemistry, radiology, dietetics, respiratory medicine, urology,audiology, orthopaedics and rheumatology.<br />
  2. 2. National Clinical Advisory Team<br />Major organ transplantation<br />Rare disease diagnosis and treatment<br />“ EU Rules” Alström UK<br />
  3. 3.
  4. 4. Alström Syndrome<br />Carl Henry Alström 1959<br />Deaf blind syndrome<br />Preserved intelligence<br />Obesity<br />Insulin resistance<br />Type 2 diabetes<br />? 30 in world-now 600+<br />
  5. 5. Alström friends<br />
  6. 6. Noncarrier individual<br />Non-affected carrier<br />Affected individual<br />Autosomal Recessive Inheritance<br /><ul><li>Two germline mutations (one from each parent) to develop disease
  7. 7. Equally transmitted by men and women</li></ul>ASCO<br />
  8. 8. Alström syndrome human chromosomes<br />
  9. 9. Alström syndrome chromosome 2<br />
  10. 10. Alström syndrome location of the gene<br />The ALMS1 gene is located on the short (p) arm of chromosome 2 at position 13.<br />More precisely, the ALMS1 gene is located from base pair 73,612,885 to base pair 73,837,045 on chromosome 2<br />
  11. 11. Alström syndrome-gene translation<br />
  12. 12. Alström syndrome-ALMS protein function<br />
  13. 13. Alström syndromemicrotubules<br />
  14. 14. Alström syndrome cilia in photoreceptors<br />
  15. 15. The cilium in the eye<br />Found inside photoreceptors<br />“Connecting cilium”<br />Connects inner segment to <br />outer segment<br />Carries proteins made in the inner segment, to outer segment<br />Malfunction stops transport of vital proteins, photoreceptors die<br />
  16. 16. Alström syndrome<br />
  17. 17. Alstrom adult clinics 1998 to 2008<br />Alström families conference UK <br />
  18. 18. Alström Syndrome<br />Further features identified:<br />Congestive heart failure secondary to cardiomyopathy<br />Sensorineural hearing loss <br />Short stature / advanced bone age / scolosis<br />Progressive, chronic nephropathy<br />Liver fibrosis<br />
  19. 19. Check list for exclusion of Alström syndrome in visually impaired young people<br />
  20. 20. Alström Syndrome is one <br />of many “ciliopathies”<br />Primary Cilia Dyskinesia (PCD)<br />Polycystic Kidney Disease (PKD)<br />Joubert Syndrome (JS)<br />Orofaciodigital Syndrome type I (OFD1)<br />Meckel-Gruber Syndrome (MKS)<br />Laurence-Moon-Bardet-Biedl Syndrome (LMBBS/BBS)<br />In most cases there is blindness, kidney disease, obesity<br />In all cases it is thought that the cilium is not working, <br />in a number of organs<br />
  21. 21. Alström syndrome<br />histology<br />
  22. 22. Overview of studies in AS<br />But:-<br />Cardiomyopathy, diabetes, lipid disorders,liver, kidney, waterworks problems are variable in extent.<br />Suggests influence of other genetic and environmental factors:-<br /> Are these modifiable?<br />
  23. 23. Cause and effect<br />?<br />
  24. 24. CARNITINE<br />ACYL TRANSFERASE<br /> TCA<br />CYCLE<br />INSULIN EFFECTS ON INTERMEDIARY METABOLISM<br />PLASMA<br />HEPATOCYTE<br />PLASMA<br />LACTATE<br />GLYCOGEN<br />PYRUVATE<br />PHOSPHORYLASE<br />GLYCOGEN<br /> SYNTH<br />రర<br />GLUCONEOGENESIS<br />GLUCOSE<br />GLUCOKINASE<br />FRUCTOSE 6 PHOS<br /> GLYCOLYSIS<br /> INSULIN<br /> SENSITIVE<br />LIPOPROTEIN<br /> LIPASE<br /> GLUT<br />RECEPTOR<br />PYRUVATE<br />VLDL<br />CHOLESTEROL<br /> FA +<br />GLYCEROL<br />LDL<br />MELONYL<br />FATTY<br /> ACIDS<br /> HMG CoA<br />ACETYL CoA<br />CoA<br />MEVALONIC <br /> ACID<br />REDUCTASE<br />TG<br />VLDL<br />HDL<br />TRIGLYCERIDE<br />KETONE<br />BODIES<br />ADIPOCYTE<br /> OXIDATIVE<br />PHOSPHORYLATION<br />30ATP<br /> INSULIN<br />SENSITIVE<br />MITOCHONDRION<br />
  25. 25. Could it all be this?<br />
  26. 26. Overview of studies in AS<br />Metabolic treatments<br />Control of diabetes<br />Control of serum lipids<br />Testosterone<br />Thyroxine<br />Diet and exercise<br />Early detection of major organ damage<br />Kidneys<br />Heart<br />Liver<br />Musculoskeletal<br />urological<br />
  27. 27. Alström syndrome<br />Tertiary prevention:<br />Control diabetes low carb,Metformin,incretin<br />Control lipids-Niaspan<br />Slow heart and renal failure<br />Detect liver fibrosis early<br />Treat hormone deficiencies<br />Refine audiology intervention<br />
  28. 28. A hopeful sign<br />Neuropathy-amongst 58 Alström subjects with up to 25 yrs of diabetes none had neuropathy compared with young onset non- genetic type 2 diabetic subjects who had 30% neuropathy and 16% foot ulceration. <br />
  29. 29. Proportion of A.S patients with severe cardiomyopathy<br />
  30. 30. Alström syndrome and stem cells<br />
  31. 31. Alström syndrome and stem cells<br />
  32. 32. Procedure for Producing Inducible Pluripotent Stem Cells from a Small Punch Skin Biopsy<br />Freeze and Store<br />Freeze and Store<br />Liver Cells<br />Heart Cells<br />Muscle Cells<br />Nerve Cells<br />Many more...<br />Skin biopsy:<br />LA<br />4mm biopsy<br />10 mins<br />Pluripotent Stem Cells<br />Cultured Dermal Fibroblasts<br />
  33. 33. Alström syndrome<br />?Hope for the future<br />Genotype phenotype correlation<br />Reprogramming of cells in culture to assess cause of dysfunction<br />Correction of cell defect and transplantation of cardiomyocytes.<br />Insight into more common diabetic, cardiac, hepatic and renal disease. <br />
  34. 34. Staff involved<br />Alstrom adult clinics 1998 to 2008<br />AS UK: Torbay Hospital:<br /> Kay Parkinson Cathy Carey Mary Costelloe<br /> John Parkinson Richard Paisey Claire Rockett<br /> Kevin Goodwin Lee Dobson Kimberley Vogler<br /> Sean Waiting Jamie Smith Chrissie Rowe<br /> Charlotte Parkinson Kathleen Williams Mark Clemence<br /> Kerry Leeson Debbie Hodge Kirsten Mackay<br /> Mike Hales Lynne Bower Sue Bunce<br /> Mark McCarthy Alison White<br /> Sarah Mills Richard Seymour<br />

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  • JingweiJiang

    Dec. 16, 2017
  • bakthamd

    Feb. 12, 2020

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