Glioblastoma multiforme (GBM) is the most common and deadliest of malignant primary brain tumors in adults and is one of the groups of tumors referred to as gliomas. Glioblastoma is a type of astrocytoma, cancer that forms from star-shaped cells in the brain called astrocytes. In adults, this cancer usually starts in the cerebrum, the largest part of your brain.

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Parijatak Ayurveda
Treatment Center, Nagpur
“GLIOBLASTOMA MULTIFORME
TREATMENT USING AYURVEDA”
Dr. Nitesh Khonde
Parijatak Ayurveda Treatment Center Nagpur
Shankar Nagar Branch :
154, Shankar Nagar, Near Garden,
Nagpur-440010(INDIA)
Phone No :- +91-9607957777, 7263807777
+91-9923200007
info@parijatak.com , ayurveda@parijatak.com

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Glioblastoma Multiforme
Treatment Using Ayurveda

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Glioblastoma multiforme (GBM) is the most common and deadliest of
malignant primary brain tumors in adults and is one of the groups of tumors referred to
as gliomas.
Glioblastoma is a type of astrocytoma, cancer that forms from star-shaped cells in
the brain called astrocytes. In adults, this cancer usually starts in the cerebrum, the
largest part of your brain.
Classified as a grade IV astrocytoma, GBM develops from the lineage of star- shaped
gilal cells, called astrocytes, that support nerve cells.
GBM develops primarily in the cerebral hemisphere but can develop in other parts of the
brain, brainstem, or spinal cord.
Glioblastoma usually affects adults.
There is no reasonable method to keep the infection. Normally, treatment includes
medical procedure, after which chemotherapy and radiation treatment are utilized. The
pharmaceutical temozolomide is utilized as often as possible as a major aspect of
chemotherapy.
High measurements steroids might be utilized to help lessen swelling and diminishing
indications. It is misty in the case of endeavoring to evacuate all or just the greater part
of the malignancy is better.
In spite of most extreme treatment, disease generally repeats. The most widely
recognized length of survival following analysis is 12 to 15 months, with less than 3% to
5% of individuals surviving longer than five years. Without treatment, survival is
regularly three months.
It is the most widely recognized growth that starts inside the mind and the second most
normal cerebrum tumor, after meningioma. Around 3 for every 100,000 individuals build
up the malady a year. It frequently starts around 64 years old and happens more
ordinarily in guys than females. Immunotherapy is being considered in glioblastoma with
promising outcomes.

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Characteristics of Glioblastoma Multiforme
Common symptoms include seizure, headaches, nausea and vomiting, memory
loss, changes to personality, mood or concentration; and localized neurological
problems.
The kind of symptoms produced depends more on the location of the tumor than on its
pathological properties. The tumor can start producing symptoms quickly, but
occasionally is an asymptomatic condition until it reaches an enormous size.

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1. Can be composed of several different cell types.
2. Can develop directly or evolve from lower grade astrocytoma or oligodendroglioma
3. Most common in older individuals and more common in men than women
4. Less common in children
Causes:
The cause is unknown, but research is pointing substantially towards genetic mutations
Symptoms of Glioblastoma Multiforme
Symptoms of glioblastoma vary depending on the location of the tumor, but they may
include:
• Persistent headaches
• Double or blurred vision
• Nausea
• Vomiting
• Loss of appetite
• Changes in mood or personality
• Changes in ability to think and learn
• Memory loss
• New onset of seizures
• Muscle weakness
• Speech difficulty

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Ayurvedic Treatment For Glioblastoma
Multiforme At Central India, Nagpur at
Parijatak
In Ayurveda, There are various Treatment method availble to treat Glioblastoma
Multiforme
It is very difficult to treat glioblastoma due to several complicating factors:
• The tumor cells are very resistant to conventional therapies.
• The brain is susceptible to damage due to conventional therapy.
• The brain has a very limited capacity to repair itself.
• Many drugs cannot cross the blood–brain barrier to act on the tumor.
Treatment of primary brain tumors and brain metastases consists of both symptomatic
therapies, palliative therapies, Vatakapha Haram and Medo Haram
Symptomatic therapy
Supportive treatment focuses on relieving symptoms and improving the patient’s
neurologic function.
The primary supportive agents are anticonvulsants and corticosteroids.

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Historically, around 90% of patients with glioblastoma underwent anticonvulsant
treatment, although it has been estimated that only approximately 40% of patients
required this treatment. Recently, it has been recommended that neurosurgeons not
administer anticonvulsants prophylactically, and should wait until a seizure occurs
before prescribing this medication. Those receiving phenytoin concurrent with radiation
may have serious skin reactions such as erythema multiforme and Stevens–Johnson
syndrome.
Corticosteroids, usually dexamethasone given 4 to 8 mg every 4 to 6 h, can reduce
peritumoral edema (through rearrangement of the blood–brain barrier), diminishing
mass effect and lowering intracranial pressure, with a decrease in headache or
drowsiness.
Palliative therapy
Palliative treatment usually is conducted to improve quality of life and to achieve a
longer survival time. It includes surgery, radiation therapy, and chemotherapy. A
maximally feasible resection with maximal tumor-free margins is usually performed

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along with external beam radiation and chemotherapy. Gross total resection of tumor is
associated with a better prognosis.
• Surgery
Surgery is the first stage of treatment of glioblastoma. An average GBM tumor
contains cells, which is on average reduced to cells after surgery (a reduction of
99%). Benefits of surgery include resection for a pathological diagnosis,
alleviation of symptoms related to mass effect, and potentially removing disease
before secondary resistance to radiotherapy and chemotherapy occurs.
• Radiotherapy
Subsequent to surgery, radiotherapy becomes the mainstay of treatment for
people with glioblastoma. It is typically performed along with giving temozolomide
(TMZ).A pivotal clinical trial carried out in the early 1970s showed that among ,
GBM patients randomized to radiation or nonradiation therapy, those who
received radiation had a median survival more than double those who did not.
Subsequent clinical research has attempted to build on the backbone of surgery
followed by radiation. On average, radiotherapy after surgery can reduce the
tumor size to cells. Whole-brain radiotherapy does not improve when compared

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to the more precise and targeted three-dimensional conformal radiotherapy. A
total radiation dose of 60–65 Gy has been found to be optimal for treatment.
• Chemotherapy
Most studies show no benefit from the addition of chemotherapy. However, a
large clinical trial of 575 participants randomized to standard radiation versus
radiation plus temozolomide chemotherapy showed that the group receiving
temozolomide survived a median of 14.6 months as opposed to 12.1 months for
the group receiving radiation alone.
This treatment regime is now standard for most cases of glioblastoma where the
person is not enrolled in a clinical trial.Temozolomide seems to work by
sensitizing the tumor cells to radiation.
Ayurvedic Medicine For Glioblastoma
Multiforme At Central India
• In Ayurveda, There are various Medicine availble to treat Glioblastoma
Multiforme.
• But We have to Discuss here four Important Medicine i.e
1. Varanadi Kashayam
2. Gorochanadi Gulika
3. Brahma Rasayana
4. Guggulu Tikta Ghrita

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• Varanadi Kashayam is herbal formulation used in Ayurveda for the treatment
of urinary disorders, skin diseases, and obesity
• Varanadi Kashayam has the capacity to correct the digestion and metabolism.
• It helps in fatty liver, belly fat and central obesity.
• In skin diseases, it is beneficial to reduce itching. Therefore, it can be helpful in
eczema and dermatitis.
Varanadi Kashayam contains following ingredients.
1. Crataeva nurvala (Varuna)
2. Asparagus racemosus (Shatavari)
3. Plumbago zeylanica (Chitrak)
4. Strobilanthes ciliatus (Sairyaka)
5. Chonemorpha fragrans (Moorva)
6. Aegle marmelos (Bael or Bilva or golden apple)
7. Aristolochia bracteolate (Vishanika, Kiramar)

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8. Solanum melongena (Brihati)
9. Aerua lanata (Bhadra)
10. Pongamia glabra (Karanja)
11. Holoptelia integrifolia (Pootikaranja)
12. Premna corymbosa (Jaya)
13. Terminalia chebula (Hareetki)
14. Moringa oleifera (Sahijan, Bahalapallava)
15. Desmostachya bipinnata (Kush, Darbha)
16. Semecarpus anacardium (Agnimukh, Rujakara, Marking Nut)
Dosage: 30 ml two times a day before food
• Gorochanadi Gulika is a tablet, used in the Ayurvedic treatment of fever,
pneumonia, cough, cold etc.
• It contains nonveg and heavy metal ingredients.
• This product is formulated based on Kerala Ayurveda principle.

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Gorochanadi contains following ingredients
10 g of each of
• Gorochana – Cow bile
• Mrigashringa – Horn of Deer, made into Bhasma
• Rudraksha – utrasum-bead tree – Elaeocarpus sphaericus
• Chandana – Sandalwood – Santalum album
• Vacha – Sweet flag (rhizome) – Acorus calamus
• Aklari
• Usheera – Vetiveria zizanioides
• Kamala – Lotus – Nelumbium speciosum
• Puzuku – Ceveat cat semen
• Naga Bhasma – Lead Bhasma
• Krishnamrigashrunga – Deer Horn Bhasma
• Goshrunga – Cow horn
• Varahadanta
• Mahishashrunga
• Kiratatikta – Swertia chirata
• Swarna Bhasma – Gold Bhasma
• Pravala Bhasma – Corel Bhasma
• Anjana – Aqueous extract of Berberis aristata
• Karpoora – Camphor – Cinnamomum camphora
• Jiraka – Cumin seed – Cuminum cyminum
• Dronapushpi – Leucas cephalotes
• Karpasa – Indian cotton plant – Gossypium herbaceum
• Apamarga – Prickly Chaff Flower – Achyranthes aspera
• Lashuna – Garlic – Alium sativum
• Chirabilwa – Holoptelea integrifolia
• Shunti – Ginger (rhizome) – Zingiber officinalis
• Maricha – Black pepper – Piper nigrum
• Pippali – Long pepper – Piper longum
• Agnimantha – Premna corymbosa / mucronata Root
• Ishwari – Aristolochia indica
• Pata – Cyclea peltata
• Shankhapushpi – Clitorea ternatea
• Neelini – Indigofera tinctorea
• Haritaki – Chebulic Myrobalan (fruit rind) – Terminalia chebula
• Vibhitaki – Belliric Myrobalan – Terminalia bellirica
• Amalaki -Indian Gooseberry- Emblica officinalis / Phyllanthus emblica
• Jatiphala – Nutmeg (fruit) – Myristica fragrans
• Tankana – Borax Mayakka
• Shatapushpa – Indian Dill (fruit) 0 Anethum sowa / Peucedanum graveolens
• Ajaji – Cumin – Cuminum cyminum

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• Musta – Nut grass (root) – Cyperus rotundus
• Krishajiraka – Nigella sativa Ambara
• Ardraka – Ginger (rhizome) – Zingiber officinalis – juice extract – quantity sufficient.
Reference: Vaidyayoga Ratnavali Gutika prakarana – 77, AFI vol. I
Dosage: 1 nos two times a day before food.
• There are many Ayurvedic herbal products explained for natural rejuvenation.
• Among them, Brahma rasayana stands as the choicest natural remedy for stress
and tiredness chronic.

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Brahma Rasayan contains following ingredients
• Pathya – Chebulic Myrobalan fruit rind – Terminalia chebula – 1000 fruits
• Amalaki – Indian gooseberry fruit – Emblica officinalis Gaertn. – 3000 fruits
• 480 g coarse powder of each of
• Bilwa – Bael (root) – Aegle marmelos
• Shyonaka – Oroxylum indicum
• Gambhari – Coomb Teak (root) – Gmelina arboera
• Patala – Trumpet (root) – Stereospermum suaveolens
• Agnimantha – Premna corymbosa (Burm.f) Merr
• Shalaparni – Desmodium gangeticum
• Prishniparni – Uraria picta
• Brihati – Indian Nightshade (root) – Solanum indicum
• Kantakari – Yellow berried nightshade (whole plant) – Solanum xanthcarpum
• Bala – Country mallow (root) – Sida cordifolia
• Punarnava – Spreading Hogweed – Boerhaavia diffusa
• Eranda – Castor – Ricinus communis
• Mashaparni – Teramnus labialis / Vigna radiata
• Mudgaparni – Green gram – Phaseolus trilobus
• Shatavari – Asparagus racemosus root
• Meda – Litsea monopetala
• Jivanti – Leptadenia reticulata
• Jivaka – Malaxis acuminata
• Rishabhaka – Manilkara hexandra (Roxb.) Dubard / Mimusoops hexandra Roxb.

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• Shali – Rice – Oryza sativa
• Kasha – Saccharum spontaneum
• Shara – Serratophyllum submersom
• Darbha – Saccharum spontaneum
• Ikshu – Sugarcanne – Saccharum officinarum
• Water for decoction – 120 liters, boiled and reduced to 12 liters, filtered.
• 192 g of fine powder of each of –
• Twak – Cinnamon – Cinnamomum zeylanicum
• Ela – Cardamom – Elettaria cardamomum
• Musta – Nut grass (root) – Cyperus rotundus
• Rajani – Turmeric (rhizome) – Curcuma longa
• Pippali – Long pepper fruit – Piper longum
• Agaru – Aquilaria agallocha
• Chandana – Sandalwood – Santalum album
• Mandukaparni – Gotu Kola – Centella asiatica
• Nagakeshara – Mesua ferrea
• Shankhapushpi – Clitoria ternatea
• Vacha – Acorus calamus
• Plava – Nyctanthes arbor-tristis
• Yashti – Licorice – Glycyrrhiza glabra
• Vidanga – False black pepper – Embelia ribes
• Sitopala – Sugar candy – 48 kg
• Sarpi – Cow ghee – 9.219 kg

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• Taila – Sesame oil – Sesamum indicum – 6.144 kg
• Kshaudra – Honey – 15.360 kg
Reference: Ashtanga Hrudayam Uttarasthana, 39/15-23
Dosage: 2.5gm once daily after food
• Guggulu Tikta Ghrita (Guggulutiktaka Ghritam) is an Ayurvedic formula used in
treating inflammatory conditions of skin, joints and bones.
• It is in herbal ghee form.
It is also available in Kashayam (Herbal Decoction) form.
Guggulu Tikta Ghrita contains following ingredients
• Nimba – neem – Azadirachta indica

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• Patola – Trichosanthes dioica
• Vyaghri / Kantakari – Solanum xanthocarpum
• Guduchi – Tinospora cordifolia
• Vasaka – Adhatoda vasica
• Shuddha Guggulu – Purified Commiphora mukul
• Ghrita (Ghee)
• Patha – Cyclea peltata / Cissampelos pariera
• Vidanga – Embelia ribes
• Suradaru – Cedrus deodara
• Gajopakulya – Piper chaba
• Yavakshara – Hordeum vulgare
• Sarjikshara
• Nagara – Zingiber officinalis
• Nisha – Turmeric
• Mishreya – Anethum sowa
• Chavya – Piper chaba
• Kushta – Saussurea lappa
• Tejovati – Zanthoxylum alatum
• Maricha – Black pepper
• Vatsaka – Holarrhena antidysenterica
• Deepyaka – Trachyspermum ammi
• Agni – Plumbago zeylanica
• Rohini – Picrorrhiza kurroa

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• Arushkara – Purified Semecarpus anacardium
• Vacha – Acorus calamus
• Kanamoola – Piper longum – root
• Yukta – Pluchea lanceolata
• Manjishta – Rubia cordifolia
• Ativisha – Aconitum heterophyllum
• Vishani – Aconitum species
• Yavani – Trachyspermum ammi
The above combination is heated till herbal ghee is prepared.
Dosage: 2.5 ml at night with milk
Summary:
• Parijatak Ayurveda has become one of the most renowned brain specialist
hospitals in Nagpur which can provide Best Brain Treatment Center India.
• Ayurvedic treatment for brain tumor, glioblastoma Ayurvedic treatment and
brain cancer immunotherapy for those of us who believe in Ayurveda.
• You can get the best of Ayurvedic remedies; Shankhpushpi is one of the most
trusted Ayurvedic formulation used for memory loss.
• The neuropharmacological effect of Shankhpushpi may be attributed due to the
presence of steroids.

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Refference:
1. parijatak.com
2. Wikipedia
3. Vaidyayoga Ratnavali Gutika prakarana – 77, AFI vol. I
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Contact Us:
Dr. Nitesh Khonde
Parijatak Ayurveda Treatment Center Nagpur
Shankar Branch :
154, Shankar Nagar, Near Garden,
Nagpur-440010(INDIA)
Phone No :- +91-9607957777, 7263807777
+91-9923200007
info@parijatak.com , ayurveda@parijatak.com
Khamla Branch :
19, Kotwal Nagar, Khamla Square,
Nagpur-440010(INDIA)
Phone No :- +91-9607187777
info@parijatak.com, ayurveda@parijatak.com
!!Thank you!!