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38 baeker diplomarbeit_plasma needle for biomedical applications_enzo palmieri

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38 baeker diplomarbeit_plasma needle for biomedical applications_enzo palmieri

  1. 1. For this and much more material, visit the free download area on: http:// www.surfacetreatments.it / http://www.slideshare.net/PalmieriProfEnzo
  2. 2. Development and characterization of a plasma needle for biomedical applications Student: Matthias Bäcker Advisors: prof. M. Mueller Veggian prof V. Palmieri
  3. 3. Prospective applications of atmospheric plasmas <ul><li>Treatment of skin ailments </li></ul><ul><li>Hair growth restauration </li></ul><ul><li>Cleaning of dental cavities </li></ul><ul><li>Induce apoptosis in (cancer) cells </li></ul><ul><li>Atherosclerosis treatment </li></ul>
  4. 4. Plasma generation solid gaseous + Energy liquid + Energy + Energy PLASMA
  5. 5. What is a plasma? <ul><li>Electrical conductive gas </li></ul><ul><li>Fourth state of matter </li></ul><ul><li>Unique physical properties due to the presence of active species such as radicals, ions, electrons, (UV)-photons </li></ul>
  6. 6. Plasma interaction with surfaces
  7. 7. Medical applications of plasma technology <ul><ul><li>Carbon film deposition </li></ul></ul><ul><ul><ul><ul><ul><li>Diamond-like carbon films </li></ul></ul></ul></ul></ul><ul><ul><li>Sterilization purposes </li></ul></ul><ul><ul><ul><ul><ul><li>Surgical instruments </li></ul></ul></ul></ul></ul><ul><ul><li>Surface modifications </li></ul></ul><ul><ul><ul><ul><ul><li>Adhesion promotion, improved biocompatibility, enhanced surface wettability </li></ul></ul></ul></ul></ul>
  8. 8. Thermal and non-thermal plasmas
  9. 9. Different atmospheric plasmas 1 2 3 4 3) J. Goree, Biomedical applications of plasma treatment 4) G. Fridman, Bio-Medical Applications of Non-thermal Atmospheric Pressure Plasmas 2) Atomflo™ 225C, www.surfxtechnologies.com 1) I. E. Kieft, Electrical and optical characterization of the plasma needle
  10. 10. (Safety) requirements <ul><li>Cause no damage to biological tissue due to an electric shock, thermal damage, UV-radiation or any other yet unknown effect </li></ul><ul><li>Stable, reliable, and controllable plasma generation </li></ul><ul><li>Sufficient active plasma species production </li></ul><ul><li>Low dimensions </li></ul><ul><li>Operable at atmospheric pressure/open air </li></ul>
  11. 11. Helium plasma RF- excitation at 13.56 MHz Helium
  12. 12. Diagnostic procedures <ul><li>Electrical characterization </li></ul><ul><ul><ul><ul><ul><li>Measurement of current and voltage </li></ul></ul></ul></ul></ul><ul><ul><ul><ul><ul><li>Determination of breakdown voltage </li></ul></ul></ul></ul></ul><ul><ul><ul><ul><ul><li>Calculation of power consumption </li></ul></ul></ul></ul></ul><ul><li>Temperature measurements </li></ul><ul><ul><ul><ul><ul><li>Pure helium plasma </li></ul></ul></ul></ul></ul><ul><li>Optical characterization </li></ul><ul><ul><ul><ul><ul><li>Optical emission spectroscopy </li></ul></ul></ul></ul></ul>
  13. 13. U-I-characteristic Breakdown voltage U=274 V
  14. 14. Measured current and voltage Calculated Power: P = 15,8 ± 3,1 W Consumed in plasma: P = 4,6 W
  15. 15. Temperature helium plasma
  16. 16. OES helium plasma .
  17. 17. I. Surface modification
  18. 18. Contact angle measurements 45° Copper 32° Quartz Untreated 13° 7° Treated
  19. 19. Contact angle measurements 21° 40° Silicon Silicon with PLCH Untreated 18° 29° Treated
  20. 20. Contact angle measurements 20° Treated 71° Polystyrene Untreated
  21. 21. Multi-well titerplate treatment
  22. 22. ELISA results Run# Time in s Power in W I 0 --- II 60 10 III 120 10 IV 60 15 V 120 15 VI 10 20
  23. 23. II. Thin film deposition Pictures taken from Kwang-Ryeol Lee, Diamon-Like Carbon Coatings for Bio-medical Implant Materials
  24. 24. Cyclohexane bypass <ul><li>Under standard conditions liquid </li></ul><ul><li>Vapour pressure of cyclohexane at 20°: 104hPa </li></ul><ul><li>Hydrogen to carbon ratio: 2:1 </li></ul>
  25. 25. Plasma with admixture of cyclohexane
  26. 26. Deposition rate <ul><li>35 sccm cyclohexane </li></ul><ul><li>Estimated deposition rate: 550 nm/min </li></ul>
  27. 27. FTIR spectra comparison
  28. 28. FTIR peak comparison
  29. 29. Thank you for your attention
  30. 30. Temperature with cyclohexane admixture
  31. 31. Temperature vs. distance
  32. 32. OES cyclohexane plasma
  33. 33. Measured voltage and current
  34. 34. Deposition rate <ul><li>7 sccm cyclohexane </li></ul><ul><li>Estimated deposition rate: 1000nm/min </li></ul>
  35. 35. FTIR spectrum
  36. 36. For this and much more material, visit the free download area on: http:// www.surfacetreatments.it / http://www.slideshare.net/PalmieriProfEnzo

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