What is celiac disease


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What is celiac disease

  1. 1. What is Celiac Disease?(Pronounced: SEE-lee-ack disease)Celiac disease (CD), also known as celiac sprue or gluten-sensitive enteropathy, is a geneticallylinked autoimmune disorder that can affect both children and adults. In people with CD, eatingcertain types of grain-based products set off an immune response that causes damage to thesmall intestine. This, in turn, interferes with the small intestine’s ability to absorb nutrients foundin food, leading to malnutrition and a variety of other complications. The offending amino acidsequences are collectively called “gluten” and are found in wheat, barley, rye, and to a lesserextent, oats* (WBRO). Related proteins are found in triticale, spelt, kamut. Refer to the grainsand flours glossary for a more extensive classification of grains.In people with CD, eating certain types of protein fractions, collectively called gluten, set offan immune mediated response at the site of the epithelial cells. This abnormal, cellular levelimmune activity evokes damage to the lining of the small intestine. The damaged small intestinelining, mucosa and villi, interferes with the ability to absorb the nutrients available in food.Without adequate nutritients available, malnutrition and a variety of other related complicationsbecome apparent.Celiac Disease is: an inherited disease. Celiac disease effects those with a geneticpredisposition. ● COMMON. Approximately 1 in 133 people have CD, however, most have yet to be diagnosed. ● This number is based upon a milestone multi-center study of blood samples collected from 13,145 people from ● February 1996 to May of 2001. This means that there were over 2.1 million undiagnosed people with celiac ● disease in the United States in 2001. ● characterized by (IgA mediated) damage to the mucosal lining of the small intestine known as villous atrophy. ● responsible for the malabsorption of nutrients resulting in malnutrition. ● linked to skin blisters known as dermatitis herpetiformis (DH). ● linked to gluten ataxia. ● not age-dependent. It may become active at any age. ● linked to genetically transmitted histocompatibility cell antigens (HLA DR3-DQ2, DR5/7 DQ2, and DR4-DQ8). ● Other genetic links have been identified.Celiac Disease is NOT: ● simply a food allergy (IgE). ● an idiosyncratic reaction to food proteins (mediated by IgE). ● typified by a rapid histamine-type reaction (such as bronchospasm, urticaria, etc.). ● an intolerance, a non-immune system response to food.The Damaging Protein FractionsThe term "gluten" is, in a sense, a generic term for the storage proteins that are found ingrains. In reality, each type of protein - glutenin and gliadin in wheat, secalin in rye, hordeinin barley, avenin in oats, zein in corn and oryzenin in rice - is slightly different from the others.The "gluten" in wheat, rye, barley, and in a much lower amount, oats, contains particular aminoacid sequences that are harmful to persons with celiac disease. The damaging proteins areparticularly rich in proline and glutamine (especially the amino acid sequences which are in thefollowing orders: Pro-Ser-Gln-Gln and Gln-Gln-Gln-Pro). As peptides, some such as 33-MER,cannot be broken down any further. In people with celiac disease, 33-MER stimulates T-cells toproduce antibodies. Sequences containing as few as 7 amino acids can be toxic to those withceliac disease. The antibodies, in turn, attack the villi in the small intestine, reducing their abilityto absorb nutrients.
  2. 2. It is important to note that these sequences are NOT found in the proteins of corn and rice.The Nature of the InjuryThe damage to the small intestine (the jejunum) caused by this disease is very slow to developand is insidious. It is: ● almost certainly mediated by the immune system. ● associated with ANTIBODIES to glutenin, gliadin, reticulin and/or endomysial (smooth muscle) proteins. ● probably not directly caused by the antibodies, though they may be signals for cell- mediated immunity. ● probably produced by the cellular immune system (T and B cells) - but only when gluten- type prolamins are present. ● reversible, in most cases, to completely normal bowel function, if the injurious protein is excluded from the diet. ● normal bowel function, diarrhea, constipation or irritable bowel symptoms may be present.How Do You Get Celiac Disease?Celiac disease cannot be "caught," but rather the potential for CD may be in the body frombirth. Its onset is not confined to a particular age range or gender, although more women arediagnosed than men. It is not known exactly what activates the disease, however three thingsare required for a person to develop CD: ● A genetic disposition: being born with the necessary genes. The Human Leukocyte Antigen (HLA) genes specifically linked to celiac disease are DR3, DQ2 and DQ8...and others. ● A trigger: some environmental, emotional or physical event in one’s life. While triggering factors are not fully understood, possibilities include, but are not limited to adding solids to a baby’s diet, going through puberty, enduring a surgery or pregnancy, experiencing a stressful situation, catching a virus, increasing WBRO products in the diet, or developing a bacterial infection to which the immune system responds inappropriately. ● A diet: containing WBRO, or any of their derivatives.SummaryCeliac disease is life-long and currently incurable. The only known treatment at this time is strictadherence to a gluten-free lifestyle, free of WBRO. Oats are not a risk free choice for those withceliac disease and not reccommended during the first year. There is no way to determine inadvance whether or not a person will be able to tolerate uncontaminated oats. Contact CSA forassistance and guidance on beginning a gluten-free lifestyle. What is the prevelance of celiacdisease in the United States?The National Health and Nutrition Examination Survey (NHANES) is a program of studiesdesigned to assess the health and nutritional status of adults and children in the United States.The survey is unique in that it combines interviews and physical examinations. Two newquestions added to include celiac disease. MCQ082 - Ever been told you have celiac disease? MCQ086 - Are you on a gluten-free diet? NHANES Statement.