Novel drugs from Plants
approved by
German Commission E.
for UTI
(UTI – III)
- Ref: Bluementhal et. al. (1998)
Presented b...
Angelica archangelica – Fruit
Asparagus officinalis – Rhizome root
Phaseolus vulgaris – Bean pod
Taraxacum officinale
...
Angelica archangelica
Asparagus officinalis
Phaseolus vulgaris
Taraxacum officinale
Armoracia rusticana
Orthosiphon spicatus
Levisticum officinale
Tropaeolum majus
Santalum album – Sandalwood
Ononis spinosa
Agropyron repens
…. Above phyto drugs are approved by
Germ...
Tropaeolum majus
Santalum album
Ononis spinosa
Agropyron repens
Botanicals
with
anti-nephrotoxic activity
Rheum palmatum
Rheum palmatum
(Chinese rhubarb)
Used for treatment of chronic renal failure in ancient times
Active compounds: tannins
...
In rats with diabetic nephropathy showed that this extract
speeded nitrogen excretion and alleviated hyper lipidemia
(Yok...
Findings – effect on symptoms blood urea nitrogen serum
creatinine levels in chronic renal failure patients
(Yarnell E. 2...
Lespedeza capitata
Lespedeza capitata
Chemicals:
 Flavonoids
 Procyanidins
 Pentacosane
n-hexacosane
 n-hentriacontane
 n-tritriacontane
Lespedeza capitata
Preliminary clinical trials in patients with renal failure of
various types suggest that extracts redu...
 Phytosterols
 Terpenoids
 Lectins
 Plant oils
 Phytoestrogens
 Flavonoids
 Polysaccharides
 Aliphatic alcohols
 ...
Serenoa repens, Sabal serrulata
Serenoa repens, Sabal serrulata
(Saw palmetto) fruit
Used in the treatment of genitourinary tract disturbances
since 1899...
Serenoa repens, Sabal serrulata
(Saw palmetto) fruit
Compounds: Carpic, Captylic, Lauric, Cis-linoleic, Myristic,
Palmiti...
Serenoa repens, Sabal serrulata
(Saw palmetto) fruit
Aliphatic alcohols, polyprenic compounds (Arabinose,
flavonoids, gal...
Serenoa repens, Sabal serrulata
(Saw palmetto) fruit
Liposterolic extract of Serenoa repens showed:
 Anti-androgenic
 An...
Pygeum africanum
Pygeum africanum
Bark extract (Tadenan®) is widely used in France and
throughout Europe
Other formulations like prostate...
Pygeum africanum
Bark contains waxes, triterpenes, fatty acids and their
esters and ferulic acid
Known to be anti-inflam...
Effects of Pygeum extracts
Reduction in Nocturia
Improve peak flow rate
Decrease residual urine and symptoms
Inhibit a...
Effects of Pygeum extracts
Suppresses prostatic growth factors
Inflammation & cholesterol accumulation (McClure 2002)
Urtica dioica
Urtica dioica
Root extracts widely used in Germany 16 different
preparations available
Major components:
 Phenols
 Lig...
Utrica dioica
Inhibits 5-alpha-reductase and aromatase activity
(McQueen & Shields 2001)
Extracts evaluated numerous mul...
Curcubita pepo
Curcubita pepo
Pumpkin seed oil for treating BPH kidney inflammation
since 19th century
Extracts have anti-androgenic, a...
Hypoxis rooperi
Hypoxis rooperi
(Harzol®) – extract of African star grass used in Germany
Product contain > 70% Beta sitosterol dry weig...
Secale cereale
Secale cereale
(Cernilton®) Rye grass pollen reported to be effective in
symptoms of BPH
Experimental studies suggest th...
Secale cereale
No significant adverse effect
It lowers urethral pressure, relax external muscles,
decrease swelling in p...
Opuntia ficus-indica
Opuntia ficus-indica
Cactus flower extract for treatment of Prostatic
hypertrophy
…. British Herbal pharmacopoeia
Anti-o...
Epilobium sp.
Epilobium sp.
Historically used to treat prostate disorders, cancer,
hypertrophy, prostatis, gastro-intestinal disorders
...
Lepidium latifolium
Lepidium latifolium
This plant used as anti-escrobte stomach tonic, aperitif
and diuretic
Anti-inflammatory, anti-oxidan...
Botanical derivatives
for
Prostate cancer
Camellia sinensis
Camellia sinensis (Green tea)
Effective compound: Epigallocatechin-3-gallate (Eaca)
Prevent the initiation, promotion an...
Camellia sinensis (Green tea)
Inhibit cell proliferation, decrease contact of carcinogenic
with cells, blocking cancer in...
Silybum marianum
Silybum marianum (Milk thistle)
Seeds contain Silymarin inhibit prostate tumour growth in
animal models
In lab, Silibini...
Curcuma longa
Curcuma longa
“Curcumin” major active anti-oxidant component
Effects: Inhibition of prostate cancer cell growth
Inducti...
Allium sativum
Allium sativum
Garlic diminishes LNcap cell growth on human prostate
carcinoma (Pinto et. al. 1997)
Active compound: S-a...
Thank You!!
“BE WITH US”
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UTI - III

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This presentation is a continuation of UTI - Part I and Part II. It discusses Novel drugs from plants approved by German Commission E. for Urinary Tract Infections.

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UTI - III

  1. 1. Novel drugs from Plants approved by German Commission E. for UTI (UTI – III) - Ref: Bluementhal et. al. (1998) Presented by Dr. Sudhakar Kokate Director PPRC, India
  2. 2. Angelica archangelica – Fruit Asparagus officinalis – Rhizome root Phaseolus vulgaris – Bean pod Taraxacum officinale Armoracia rusticana Orthosiphon spicatus Levisticum officinale
  3. 3. Angelica archangelica
  4. 4. Asparagus officinalis
  5. 5. Phaseolus vulgaris
  6. 6. Taraxacum officinale
  7. 7. Armoracia rusticana
  8. 8. Orthosiphon spicatus
  9. 9. Levisticum officinale
  10. 10. Tropaeolum majus Santalum album – Sandalwood Ononis spinosa Agropyron repens …. Above phyto drugs are approved by German Commission E. for UTI Ref: (Blumenthal et. al. 1998)
  11. 11. Tropaeolum majus
  12. 12. Santalum album
  13. 13. Ononis spinosa
  14. 14. Agropyron repens
  15. 15. Botanicals with anti-nephrotoxic activity
  16. 16. Rheum palmatum
  17. 17. Rheum palmatum (Chinese rhubarb) Used for treatment of chronic renal failure in ancient times Active compounds: tannins Tannins reduce levels of uremic toxins and to improve glomercular filtration and blood flow to the kidneys (Yokozawa et. al. 1991)
  18. 18. In rats with diabetic nephropathy showed that this extract speeded nitrogen excretion and alleviated hyper lipidemia (Yokozawa et. al. 1997) Several clinical trials in China Rheum palmatum (Chinese rhubarb)
  19. 19. Findings – effect on symptoms blood urea nitrogen serum creatinine levels in chronic renal failure patients (Yarnell E. 2000) Rheum palmatum (Chinese rhubarb)
  20. 20. Lespedeza capitata
  21. 21. Lespedeza capitata Chemicals:  Flavonoids  Procyanidins  Pentacosane n-hexacosane  n-hentriacontane  n-tritriacontane
  22. 22. Lespedeza capitata Preliminary clinical trials in patients with renal failure of various types suggest that extracts reduce azotemia uremia and cholesterol Procyanidins inhibited angiotension: converting enzyme (Wagner & Elbl. 1992) Phytoingredients to relieve the symptoms of benign prostatic hyperplasia (BPH)
  23. 23.  Phytosterols  Terpenoids  Lectins  Plant oils  Phytoestrogens  Flavonoids  Polysaccharides  Aliphatic alcohols  Fatty acids (Lowe et. al. 1998)
  24. 24. Serenoa repens, Sabal serrulata
  25. 25. Serenoa repens, Sabal serrulata (Saw palmetto) fruit Used in the treatment of genitourinary tract disturbances since 1899 It increases the function of the testicles and relieves irritation in mucous membranes of genitourinary tract and prostate (D’elos et. al. 1994)
  26. 26. Serenoa repens, Sabal serrulata (Saw palmetto) fruit Compounds: Carpic, Captylic, Lauric, Cis-linoleic, Myristic, Palmitic and Stearic acid Steroids: Beta-sitosterol, Campestrol, Cycloartenol, Lupeol, Lupenone, Stigmasterol
  27. 27. Serenoa repens, Sabal serrulata (Saw palmetto) fruit Aliphatic alcohols, polyprenic compounds (Arabinose, flavonoids, galactose, uronic acid, antranilic acid, carotenes, lipase and tannins (Van Coppenolle et. al. 2000)
  28. 28. Serenoa repens, Sabal serrulata (Saw palmetto) fruit Liposterolic extract of Serenoa repens showed:  Anti-androgenic  Anti-estrogenic  Anti-inflammatory effects (Lowe & Fagelman 1999)
  29. 29. Pygeum africanum
  30. 30. Pygeum africanum Bark extract (Tadenan®) is widely used in France and throughout Europe Other formulations like prostate are available in health food and nutrition shops in US (Lowe and Fagelman 1999)
  31. 31. Pygeum africanum Bark contains waxes, triterpenes, fatty acids and their esters and ferulic acid Known to be anti-inflammatory and anti-edematous (Miller 1996)
  32. 32. Effects of Pygeum extracts Reduction in Nocturia Improve peak flow rate Decrease residual urine and symptoms Inhibit androgen stimulation
  33. 33. Effects of Pygeum extracts Suppresses prostatic growth factors Inflammation & cholesterol accumulation (McClure 2002)
  34. 34. Urtica dioica
  35. 35. Urtica dioica Root extracts widely used in Germany 16 different preparations available Major components:  Phenols  Lignans  Sterols  Polysaccharides  Lectins  Triterpene acids
  36. 36. Utrica dioica Inhibits 5-alpha-reductase and aromatase activity (McQueen & Shields 2001) Extracts evaluated numerous multi-center open label and double-blind studies Significant improvement in peak flow rate & residual urinary volumes (Wagner et. al. 1994)
  37. 37. Curcubita pepo
  38. 38. Curcubita pepo Pumpkin seed oil for treating BPH kidney inflammation since 19th century Extracts have anti-androgenic, anti-inflammatory effects (Steenkamp 2003) Chemical: Phytosterols, Selen, Magnesium, Carotenoid
  39. 39. Hypoxis rooperi
  40. 40. Hypoxis rooperi (Harzol®) – extract of African star grass used in Germany Product contain > 70% Beta sitosterol dry weight (Lowe et. al. 1998) Effects: anti-inflammatory, stimulating Improved peak flow rate, residual urine volume (Dreikorn 2002)
  41. 41. Secale cereale
  42. 42. Secale cereale (Cernilton®) Rye grass pollen reported to be effective in symptoms of BPH Experimental studies suggest that the product contains: anti-inflammatory, inhibiting 5-ɑ-reductase activity
  43. 43. Secale cereale No significant adverse effect It lowers urethral pressure, relax external muscles, decrease swelling in prostate
  44. 44. Opuntia ficus-indica
  45. 45. Opuntia ficus-indica Cactus flower extract for treatment of Prostatic hypertrophy …. British Herbal pharmacopoeia Anti-oxidant activity Inhibits reductase, aromatase activity (Jonas et. al. 1998)
  46. 46. Epilobium sp.
  47. 47. Epilobium sp. Historically used to treat prostate disorders, cancer, hypertrophy, prostatis, gastro-intestinal disorders Active compound – Oenotheis B
  48. 48. Lepidium latifolium
  49. 49. Lepidium latifolium This plant used as anti-escrobte stomach tonic, aperitif and diuretic Anti-inflammatory, anti-oxidant Steroid activity and inhibition of aromatase due to presence of flavonoids (Martinez caballero et. al. 2004)
  50. 50. Botanical derivatives for Prostate cancer
  51. 51. Camellia sinensis
  52. 52. Camellia sinensis (Green tea) Effective compound: Epigallocatechin-3-gallate (Eaca) Prevent the initiation, promotion and progression of Prostate cancer
  53. 53. Camellia sinensis (Green tea) Inhibit cell proliferation, decrease contact of carcinogenic with cells, blocking cancer initiation, slowing cancer progression Prevent DNA strand breaks (Liao et. al. 1995, Ahmad 1997)
  54. 54. Silybum marianum
  55. 55. Silybum marianum (Milk thistle) Seeds contain Silymarin inhibit prostate tumour growth in animal models In lab, Silibinin prevents cancer initiation, promotion, progression by altering signalling mols. & adaptor factor receptor (Zi et. al. 1998)
  56. 56. Curcuma longa
  57. 57. Curcuma longa “Curcumin” major active anti-oxidant component Effects: Inhibition of prostate cancer cell growth Induction of apoptosis (McClure 2002)
  58. 58. Allium sativum
  59. 59. Allium sativum Garlic diminishes LNcap cell growth on human prostate carcinoma (Pinto et. al. 1997) Active compound: S-allylmercaptocysteine Decrease prostate: specific antigen (PSA) Secretions & decreasing trophic effects (Steenkamp 2003)
  60. 60. Thank You!! “BE WITH US”

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