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Phytodrugs curing Tuberculosis

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Recent investigations of Phytodrugs curing tuberculosis are essential for further Research & Development. Tuberculosis is mostly a latent and asymptomatic infection, typically attacks lungs and other parts of the body.

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Phytodrugs curing Tuberculosis

  1. 1. Recent Investigations of Phyto-drugs curing TUBERCULOSIS Presented by Dr. Sudhakar Kokate Director PPRC, India
  2. 2. Tuberculosis (TB) 1. Globally TB continues to be a major cause of disability and death 2. 1/3 of world’s population is affected by Mycobacterium tuberculosis (MBT) PPRC/INDIA 01
  3. 3. Tuberculosis (TB) 3. 2 million deaths are caused / year in the world 4. TB is responsible for more human deaths than any other single infectious agent 5. 26% of all preventable deaths, 7% all deaths PPRC/INDIA 02
  4. 4. Tuberculosis (TB) 6. WHO 1993 declared TB – a global emergency 7. In developing countries the impact of TB has intensified with the spread of HIV infection 8. Earlier therapy was costlier and longer duration treatment PPRC/INDIA 03
  5. 5. Tuberculosis (TB) 9. Multi-drug resistant TB evolved that’s why documented in many countries 10. Herbs are rich sources of therapeutic agents for Prevention and treatment of TB PPRC/INDIA 04
  6. 6. Plant extracts exhibiting anti-TB activity PLANT PART TYPE OF EXTRACT MIN. CONC AT WHICH NO GROWTH Punica granatum Fruit peelings Methanolic 5 mg / ml Punica granatum Fruit peelings Ethanolic 3 mg / ml Fruits Ethanolic 2 mg / ml Fruits Ethanolic 3 mg / ml Buds Methanolic 1.5 mg / ml Rhizome Ethanolic 1.5 mg / ml Coriandrum sativum Myristica fragrans Syzygium aromaticum Zingiber officinale PPRC/INDIA 05
  7. 7. Punica granatum PPRC/INDIA 06
  8. 8. Punica granatum  A shrub or small tree native of Iran, Afghanistan and Baluchistan  Cultivated throughout India  Seeds along with the fleshy portions are dried and commercially marketed as Anar dana  Edible portion 68% contain 78% moisture, protein 4.6, fat 0.1, fibre 5.1, carbohydrate 14.5 and minerals PPRC/INDIA 07
  9. 9. Punica granatum  Fruit: good source of sugars, Vitamin C and iron  Fresh rind of fruit contains: ___% Wax 0.8 Inulin 1.0 Resins 4.5 Mucilage 0.6 Mannitol 1.8 Rannin 10.4 Gums 3.2 Gallic acid 4.0 Non-crystallized sugars 2.7 Pectin 2-4 Calcium oxalate 4.0 Tannin upto 26% in dried rind Dr. Thorpe 1958 PPRC/INDIA 08
  10. 10. Punica granatum  Rind of pomegranate….source of a dye (yellowish, brown shades)  Fruit peelings used for diarrhoea & respiratory infections  Extracts of fruits effective against:  Micrococcus pyogenes  Escherichia coli  Pseudomonas aeruginosa  Intestinal pathogenic bacilli PPRC/INDIA 09
  11. 11. Coriandrum sativum PPRC/INDIA 10
  12. 12. Coriandrum sativum  Annual herb from Apiaceae family  Native to south-western Asia to North Africa  Medicinal plant is used as domestic remedy  Culinary properties and used in preparations of Indian food items PPRC/INDIA 11
  13. 13. Coriandrum sativum It has several pharmacological effects such as anti-fertility, anti-hyperglycaemic, anti-oxidant, anti-proliferative and hypo-tensive activities  Chemicals: quercetin-3-glucuronide, linalool, camphor, geranyl acetate, geraniol and coumarins PPRC/INDIA 12
  14. 14. Myristica fragrans PPRC/INDIA 13
  15. 15. Myristica fragrans Family: Myristicaceae  Evergreen, aromatic tree  Fruit is yellow, broadly pyriform orglobose, 6.9 cm long, often drooping pericarp, fleshy, splitting into 2 halves at maturity PPRC/INDIA 14
  16. 16. Myristica fragrans Imported from South-east Asian countries & consumed in India for culinary and medical purpose  Traditionally Myristica fragnans is used as anti- inflammatory, hypolipidemic, hypocholesterolemic agent  Anti-cancer, anti-diabetic activities are also known PPRC/INDIA 15
  17. 17. Syzygium aromaticum PPRC/INDIA 16
  18. 18. Syzygium aromaticum Family: Myrtaceae Buds of Syzygium aromaticum are used as spice and flavouring agents.  It’s oil (clove oil) is traditionally used in toothache, mouth sores, rheumatism and arthritis PPRC/INDIA 17
  19. 19. Syzygium aromaticum Used as carminative, to increase hydrochloric acid and improve peristalsis  Said to be natural anthelmintic  Used in aromatherapy where stimulation and warming is needed, especially for digestive tract PPRC/INDIA 18
  20. 20. Zingiber officinale PPRC/INDIA 19
  21. 21. Zingiber officinale 10-gingerol is the main component of Ethanolic extract of dried rhizome of ginger  Exhibits anti-bacterial, anti-fungal activity, anti-oxidant, anti-inflammatory activity  Used as a stimulant & carminative for curing gastrointestinal disorders PPRC/INDIA 20
  22. 22. Thank You!! “BE WITH US”

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