Dr. Sudhakar Kokate
Director PPRC, India
Circadian rhythms .…
Also known as the “Body clock”
Physical, mental and behavioural changes that
follow a roughly 24 hrs. cycle responding to light
and darkness in the organism
Found in living things, plants, animals and even
among tiny microbes
Circadian rhythms ….
Related to biological cycle
Study of Circadian rhythms and health is known
Biological cycle controls Circadian rhythms –
governing of interacting molecules in cells
throughout the body
Master clock ….
Master clock: Brain
A group of nerve cells ‘Suprachiasmatic nucleus’
(SCN) containing 20,000 nerve cells are located
Location: above optic nerves from eyes cross
About CR ….
CR tells our body when to sleep and regulate
many other physiological processes
This internal body clock is affected by
environmental cues like sunlight and
When CR is disrupted, sleeping & eating
patterns can run amok
Physiological disruption leads to ….
A growing body of research is examining the
adverse health effects like increasing cardio-
vascular events, observing neurological problems
like depression and bipolar disorders.
It also affects immune and metabolic systems
Scientists are looking into:
1. How brain-neuro system works in disorder?
2. What are effective remedies without side effects
with minimum duration of time span?
3. Behaviour of Human being in disrupted CR
4. Treatment of sleep disorders, Jet lag and other
health related issues
5. Do Ayurvedic plants control Circadian rhythms
in plants, animals and microbes? If so how and
at what level of output?
6. Are there any natural control for strengthening
nerves and muscle? If so how and what
mechanism does it possess?
Change or modify lifestyle
Ideal diet plan – implementation
Yoga, exercises and meditation
Use of herbal technology
Well disciplinary actions in exact time
Strengthen and calm – nerves and muscles
Organic molecules participating in Neural activity
Dopamine: Function of the limbic system,
emotional function and control
Serotonin: Mood, sleep and alertness, sensation