Anti ulcer

2,105 views

Published on

Many drugs are available in the market which cure various types of ulcer. These drugs also leave many side-effects on the human body. Natural anti-ulcer drugs are needed for cure. This presentation gives an introduction to plant research for curing ULCER.

0 Comments
4 Likes
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total views
2,105
On SlideShare
0
From Embeds
0
Number of Embeds
14
Actions
Shares
0
Downloads
87
Comments
0
Likes
4
Embeds 0
No embeds

No notes for slide

Anti ulcer

  1. 1. Plant Research for curing U L C E R Presented by Dr. Sudhakar Kokate Director PPRC, India
  2. 2. Ulcer  Ulcer is a sore which means it is an open painful wound  A break in a bodily membrane  Peptic ulcer is one of the most common gastrointestinal diseases  More common in adult males PPRC/INDIA 01
  3. 3. causes  Stress  Hormones  Synthetic drugs  Alcohol  Smoking  Bacterial infection (Helicobacter pylori)  Sepsis PPRC/INDIA 02
  4. 4. symptoms  Loss of appetite  Stomach pain  Nausea  Weight loss  Vomiting  Blackish bowel movements PPRC/INDIA 03
  5. 5. diagnosis  Observing upper gastrointestinal (GT) series  Endoscopy PPRC/INDIA 04
  6. 6. Types of ulcer PPRC/INDIA 05 Peptic Ulcer – Gastrointestinal mucosa (Stomach ulcer) It is most common type of Peptic ulcer Venous Ulcer – Wound in functioning of valves in the veins Stress Ulcer – Anywhere within stomach Can be in Proximal duodenum Ulcerative sarcoidosis – A cutaneous condition affecting people within Sarcoidosis
  7. 7. Types of ulcer PPRC/INDIA 06 Ulcerative iiche planus – Rare variant of Lichen planus Ulcerative colitis – Inflammatory bowel disease (IBD) Ulcerative disposition – Abnormal distress associated with gastritis
  8. 8. Common forms of ulcer Ulcer dermatology Break in skin Pressure ulcers Bedsores Genital ulcers Genital area Ulcerative dermatitis Skin disorder Corneal ulcer Cornea infective condition Mouth ulcer Open sore in mouth Aphthous ulcer Canker sore PPRC/INDIA 07
  9. 9. Drugs presently available PPRC/INDIA 08  There are number of modern anti- ulcer drugs commercially available in the market  But many drugs show various side- effects evoking an urgent need for alternative medicine
  10. 10. Common side-effects PPRC/INDIA 09  Diarrhoea  Abdominal pain  Headache  Nausea  Vomiting  Dizziness  Depression  Constipation
  11. 11. First effective phyto-drug on ulcer PPRC/INDIA 10
  12. 12. carbenoxolone PPRC/INDIA 11  Plant: Glycyrrhiza glabra  Ref: Brown H.M., Christie E., Colin Jones, R.S.H. Finney, W.G. MacGregor, J.M. Smith, W.G. Smith, F.M. Sullivan, A.L. Tornoy and E.E. Turner 1959, Lancet 2:492
  13. 13. Glycyrrhiza glabra PPRC/INDIA 12
  14. 14. One more phyto-drug for u on ulcer PPRC/INDIA 13
  15. 15. gefarnate PPRC/INDIA 14  Plant: Brassica oleraceae  Ref: 1. Adami E.E. Marzzi-Uberti & C. Turba 1964 Arch. Int. Pharmacodyn. Ther. 147, 113-145 2. Barbara L. Coriandesi M. Giorge – Conciata L. Luchelta & G. Busca 1974, Current Medical Research and opinion 2, 399-410
  16. 16. Brassica oleraceae PPRC/INDIA 15
  17. 17. Abies pindrow PPRC/INDIA 16
  18. 18. Abies pindrow PPRC/INDIA 17  Family: Pinaceae  Leaf: Pet. Ether, benzene, chloroform extract  Protective role to aspirin induced Ulcer in Rat  Chemicals: Glycosides and steroid
  19. 19. Aegle marmelos PPRC/INDIA 18
  20. 20. Aegle marmelos PPRC/INDIA 19  Family: Rutaceae  Seeds: Chemical Luvangetin  Significant protection in Gastric ulcers in Rats and Guinea pigs
  21. 21. Aloe barbadensis PPRC/INDIA 20
  22. 22. Aloe barbadensis PPRC/INDIA 21  Family: Liliaceae  Leaf extract: Reduced gastric lesions and lesion index in experimental rats
  23. 23. Alpinia galanga PPRC/INDIA 22
  24. 24. Alpinia galanga PPRC/INDIA 23  Family: Zingiberaceae  Ethanolic extract of rhizomes exhibited gastric antisecretory, anti-ulcer and cytoprotective activities in rats
  25. 25. Althaea rosea PPRC/INDIA 24
  26. 26. Althaea rosea PPRC/INDIA 25  Family: Malvaceae  Stem decreased ulcer in rats  Chemicals: Polysaccharides
  27. 27. Amomum subulatum PPRC/INDIA 26
  28. 28. Amomum subulatum PPRC/INDIA 27  Family: Zingiberaceae  Methanolic extract reduced the gastric motility
  29. 29. Anchusa strigosa PPRC/INDIA 28
  30. 30. Anchusa strigosa PPRC/INDIA 29  Family: Boraginaceae  Root extract showed significant protection
  31. 31. Andrographis paniculata PPRC/INDIA 30
  32. 32. Andrographis paniculata PPRC/INDIA 31  Family: Acanthaceae  A flavone produced significant reduction in rats and guinea pigs
  33. 33. Aparisthmium cordatum PPRC/INDIA 32
  34. 34. Aparisthmium cordatum PPRC/INDIA 33  Family: Euphorbiaceae  Aparisthman, a diterpene showed effect in different ulcer models
  35. 35. Asarum europaeum PPRC/INDIA 34
  36. 36. Asarum europaeum PPRC/INDIA 35  Family: Aristolochiaceae  Compound isolated from roots  Roots: showed anti-ulcer activity
  37. 37. Asparagus pubescens PPRC/INDIA 36
  38. 38. Asparagus pubescens PPRC/INDIA 37  Family: Liliaceae  Methanolic extract reduces ulcer
  39. 39. Asparagus racemosus PPRC/INDIA 38
  40. 40. Asparagus racemosus PPRC/INDIA 39  Family: Liliaceae  Dry roots prevented the formation of duodenal ulcer in rats
  41. 41. Azadirachta indica PPRC/INDIA 40
  42. 42. Azadirachta indica PPRC/INDIA 41  Family: Meliaceae  The extracts of bark, leaves and nimbidin – oil from seeds showed anti-ulcer activity in male rats
  43. 43. Bacopa monnieri PPRC/INDIA 42
  44. 44. Bacopa monnieri PPRC/INDIA 43  Family: Scrophulariaceae  Juice produced significant anti-ulcer activity
  45. 45. Benincasa hispida PPRC/INDIA 44
  46. 46. Benincasa hispida PPRC/INDIA 45  Family: Cucurbitaceae  Different extracts are effective
  47. 47. Bidens pilosa PPRC/INDIA 46
  48. 48. Bidens pilosa PPRC/INDIA 47  Family: Asteraceae  Ethanolic, methylene chloride extracts showed significant activity in rats
  49. 49. Brassica oleraceae PPRC/INDIA 48
  50. 50. Brassica oleraceae PPRC/INDIA 49  Family: Brassicaceae  Aqueous extract of leaves is significant
  51. 51. Bupleurum falcatum PPRC/INDIA 50
  52. 52. Bupleurum falcatum PPRC/INDIA 51  Family: Apiaceae  Polysaccharides fraction active against ulcer in rats
  53. 53. Caesalpinia ferrea PPRC/INDIA 52
  54. 54. Caesalpinia ferrea PPRC/INDIA 53  Family: Caesalpiniaceae  Stem extract is effective
  55. 55. Calotropis procera PPRC/INDIA 54
  56. 56. Calotropis procera PPRC/INDIA 55  Family: Asclepidaceae  Chloroform extract is effective
  57. 57. Calligonum comosum PPRC/INDIA 56
  58. 58. Calligonum comosum PPRC/INDIA 57  Family: Polygonaceae  Ethanolic extracts of aerial parts is active
  59. 59. Camellia sinensis PPRC/INDIA 58
  60. 60. Camellia sinensis PPRC/INDIA 59  Family: Theaceae  Extract reduced the incidence
  61. 61. Cassia nigricans PPRC/INDIA 60
  62. 62. Cassia nigricans PPRC/INDIA 61  Family: Fabaceae  Extract of leaves is active
  63. 63. Catha edulis PPRC/INDIA 62
  64. 64. Catha edulis PPRC/INDIA 63  Family: Celastraceae  Extract of aerial parts produced anti-ulcer activity
  65. 65. Centella asiatica PPRC/INDIA 64
  66. 66. Centella asiatica PPRC/INDIA 65  Family: Apiaceae  Leaf extract inhibited ulcer
  67. 67. Cinnamomum cassia PPRC/INDIA 66
  68. 68. Cinnamomum cassia PPRC/INDIA 67  Family: Lauraceae  Compounds from bark produced anti-ulcer activity
  69. 69. Cistus incanus PPRC/INDIA 68
  70. 70. Cistus incanus PPRC/INDIA 69  Family: Cistaceae  Aqueous extract of aerial parts showed the anti-ulcer activity in rats
  71. 71. Convolvulus pluricaulis PPRC/INDIA 70
  72. 72. Convolvulus pluricaulis PPRC/INDIA 71  Family: Convolvulaceae  Juice of fresh whole plant showed ulcerogenic effects
  73. 73. Capaifera langsdorfii PPRC/INDIA 72
  74. 74. Capaifera langsdorfii PPRC/INDIA 73  Family: Fabaceae  Product obtained from stem bark protected against gastric damage
  75. 75. Croton cajucara PPRC/INDIA 74
  76. 76. Croton cajucara PPRC/INDIA 75  Family: Euphorbiaceae  The essential oil significantly reduced gastric lesions in different experimental models
  77. 77. Cryptomeria japonica PPRC/INDIA 76
  78. 78. Cryptomeria japonica PPRC/INDIA 77  Family: Cupressaceae  Essential oil from leaves exhibited strong inhibitory activity
  79. 79. Curcuma longa PPRC/INDIA 78
  80. 80. Curcuma longa PPRC/INDIA 79  Family: Zingiberaceae  Ethanol extract produced significant results in rats
  81. 81. Curcuma zedoaria PPRC/INDIA 80
  82. 82. Curcuma zedoaria PPRC/INDIA 81  Family: Zingiberaceae  Extract of rhizomes inhibited gastric ulcer
  83. 83. Diodia sarmentosa PPRC/INDIA 82
  84. 84. Diodia sarmentosa PPRC/INDIA 83  Family: Rubiaceae  Extract of whole plant is effective
  85. 85. Dombeya buettneri PPRC/INDIA 84
  86. 86. Dombeya buettneri PPRC/INDIA 85  Family: Sterculiaceae  Aqueous extract of leaves is effective
  87. 87. Emblica officinalis PPRC/INDIA 86
  88. 88. Emblica officinalis PPRC/INDIA 87  Family: Euphorbiaceae  Alcohol extract significantly inhibited the development of gastric lesions in all test models
  89. 89. Evodia rutaecarpa PPRC/INDIA 88
  90. 90. Evodia rutaecarpa PPRC/INDIA 89  Family: Rutaceae  Eight compounds synthesized from this plant showed significant activity
  91. 91. Ferula species PPRC/INDIA 90
  92. 92. Ferula species PPRC/INDIA 91  Family: Apiaceae  Colloidal solution of Ferula species showed significant protection
  93. 93. Ficus exasperata PPRC/INDIA 92
  94. 94. Ficus exasperata PPRC/INDIA 93  Family: Moraceae  Extracts of leaves produced effect in rats
  95. 95. Ficus racemosa PPRC/INDIA 94
  96. 96. Ficus racemosa PPRC/INDIA 95  Family: Moraceae  Aqueous extract of dried bark produced effect in rats
  97. 97. Gingko biloba PPRC/INDIA 96
  98. 98. Gingko biloba PPRC/INDIA 97  Family: Gingkoaceae  Extracts are effective
  99. 99. Hippocratea excelsa PPRC/INDIA 98
  100. 100. Hippocratea excelsa PPRC/INDIA 99  Family: Hippocrataceae  Aqueous and ethanol extract of root, bark showed an important gastroprotective effect in rats
  101. 101. Iris germanica PPRC/INDIA
  102. 102. Iris germanica PPRC/INDIA  Family: Iruaceae  Terpene derivatives inhibited ulcer
  103. 103. Lippia alba PPRC/INDIA
  104. 104. Lippia alba PPRC/INDIA  Family: Verbenaceae  Oral administration prevented ulcer
  105. 105. Maytenus aquifolium PPRC/INDIA
  106. 106. Maytenus aquifolium PPRC/INDIA  Family: Celastraceae  Aqueous infusion reduced ulcer
  107. 107. Melia azedarachta PPRC/INDIA
  108. 108. Melia azedarachta PPRC/INDIA  Family: Meliaceae  Lipid components from fruits showed significant activity
  109. 109. Microgramma squamulosa PPRC/INDIA
  110. 110. Microgramma squamulosa PPRC/INDIA  Family: Polypodiaceae  Extract of plant rhizome showed significant activity
  111. 111. Momordica charantia PPRC/INDIA
  112. 112. Momordica charantia PPRC/INDIA  Family: Cucurbitaceae  The olive oil extract and dried powder of fruits in filtered honey showed significant and dose dependent anti-ulcerogenic activity
  113. 113. Musa paradisiaca PPRC/INDIA
  114. 114. Musa paradisiaca PPRC/INDIA  Family: Musaceae  Compounds from fruits reported to be active in rats  Methanolic extract showed activity in rats
  115. 115. Myristica fragrans PPRC/INDIA
  116. 116. Myristica fragrans PPRC/INDIA  Family: Myristicaceae  Eugenol: Active principle of Nutmeg seeds significantly reduced the gravity of gastric ulcer
  117. 117. Nigella sativa PPRC/INDIA
  118. 118. Nigella sativa PPRC/INDIA  Family: Ranunculaceae  Oil significantly reduced ulcers in rats
  119. 119. Ocimum basilicum PPRC/INDIA
  120. 120. Ocimum basilicum PPRC/INDIA  Family: Laminaceae  Flavonoid and glycosides of leaves decreased the ulcer index
  121. 121. Ocimum sanctum PPRC/INDIA
  122. 122. Ocimum sanctum PPRC/INDIA  Family: Laminaceae  Aqueous extract of leaves reduced ulcer in rats
  123. 123. Opuntia ficus-indica PPRC/INDIA
  124. 124. Opuntia ficus-indica PPRC/INDIA  Family: Cactaceae  Showed significant action in rats
  125. 125. Paedaria foetida PPRC/INDIA
  126. 126. Paedaria foetida PPRC/INDIA  Family: Rubiaceae  Aqueous extract, ethanol extract and leaf juice revealed significant anti-ulcer activity
  127. 127. Panax ginseng PPRC/INDIA
  128. 128. Panax ginseng PPRC/INDIA  Family: Araliaceae  Polysaccharides obtained from leaves produced anti-ulcer activity
  129. 129. Parkia biglandulosa PPRC/INDIA
  130. 130. Parkia biglandulosa PPRC/INDIA  Family: Fabiaceae  Ethanol extract of leaves is active
  131. 131. Phyllanthus emblica PPRC/INDIA
  132. 132. Phyllanthus emblica PPRC/INDIA  Family: Euphorbiaceae  Butanol extract of water fraction of fruits active
  133. 133. Picrorrhiza kurroa PPRC/INDIA
  134. 134. Picrorrhiza kurroa PPRC/INDIA  Family: Scrophulariaceae  Ethanol extract of rhizomes and roots prevented ulcer
  135. 135. Piper betle PPRC/INDIA
  136. 136. Piper betle PPRC/INDIA  Family: Piperaceae  Alcoholic extract of leaves prevented
  137. 137. Stachytarpheta cayennensis PPRC/INDIA
  138. 138. Stachytarpheta cayennensis PPRC/INDIA  Family: Verbenaceae  Aqueous extract of whole plant inhibited ulcerogenic activity
  139. 139. Strychnos nux-vomica PPRC/INDIA
  140. 140. Strychnos nux-vomica PPRC/INDIA  Family: Loganiaceae  Oral administration of seed powder produced anti-ulcer activity
  141. 141. Styrax camporum PPRC/INDIA
  142. 142. Styrax camporum PPRC/INDIA  Family: Styracaceae  Stem extract prevented ulcerogenic activity
  143. 143. Tectona grandis PPRC/INDIA
  144. 144. Tectona grandis PPRC/INDIA  Family: Verbenaceae  Ethanol extract of bark and wood chips waas found to have significant activity
  145. 145. Teucrium buxifolium PPRC/INDIA
  146. 146. Teucrium buxifolium PPRC/INDIA  Family: Lamiaceae  Significant ulcerogenic activity noted in addition to other anti-inflammatory properties
  147. 147. Theobroma cacao PPRC/INDIA
  148. 148. Theobroma cacao PPRC/INDIA  Family: Sterculiaceae  Compound prevented ulcer
  149. 149. Trigonella foenum-graenum PPRC/INDIA
  150. 150. Trigonella foenum-graenum PPRC/INDIA  Family: Fabaceae  Aqueous extract of seeds show significant ulcer protective effects
  151. 151. Turnea ulmifolia PPRC/INDIA
  152. 152. Turnea ulmifolia PPRC/INDIA  Family: Turneraceae  Ethanolic extract of aerial parts showed activity in rats
  153. 153. Viburnum dilatatum PPRC/INDIA
  154. 154. Viburnum dilatatum PPRC/INDIA  Family: Caprifoliaceae  Effective against ulcerogenic activity
  155. 155. Voacanga africana PPRC/INDIA
  156. 156. Voacanga africana PPRC/INDIA  Family: Apocynaceae  Methanolic extract exhibited activity
  157. 157. Wilbrandia ebracteata PPRC/INDIA
  158. 158. Wilbrandia ebracteata PPRC/INDIA  Family: Cucurbitaceae  Leaf extract reduced gastric damage
  159. 159. Withania somnifera PPRC/INDIA
  160. 160. Withania somnifera PPRC/INDIA  Family: Solanaceae  Oral administration prevented ulcer
  161. 161. Zingiber officinale PPRC/INDIA
  162. 162. Zingiber officinale PPRC/INDIA  Family: Zingiberaceae  Acetone extract of rhizome showed activity
  163. 163. Thank You!! “BE WITH US”

×