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What's new in the uk nsc

Presentation by Dr Anne Mackie

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Part of Public Health England
What’s new and coming up in
the UK NSC
December 2015
Dr Anne Mackie, Director of Screening PHE and
UK National Screening Committee
The UK NSC
• UK governments set systematic screening programme policy (not
NICE, not PHE, not Royal Colleges, not clinical bodies, not the
press)
• The UK NSC is the body set out in the NHS constitution that
provides that advice based on a set of internationally accepted
criteria.
• It is a scientific advisory committee bringing together experts on the
science, acceptability, feasibility, acceptability and cost effectiveness
of systematic population screening programmes.
• This includes
• Starting a programme
• Stopping a programme
• Making big changes to a programme
• Piloting a programme
2 BCS2
Why the separate governance/ fuss. Why not let
NICE or clinical bodies just get on?
Because systematic population screening is different
• The invitees didn’t necessarily want to be informed they are at risk
• They may be worried about something (that they may not want to have to
worry about)
• They will receive tests which have false positives/ negatives
• They will be advised to have further tests or treatments for a false positive
• Or be reassured by a false negative (and keep up their risky behaviours or
ignore symptoms)
• The tests will find things that they weren't being screened for (SWANs)
• They may be harmed in the course of being investigated or treated for
something that would never have hurt them
• A systematic screening programme is expensive. The money may be spent
on something better (clinicians diverted).
3
Ayear of reflection and change
STC
Three yearly review
Consultation
PHE and cancer/non cancer division
QA
4
Science and Technology Committee
5 BCS
6 BCS

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What's new in the uk nsc

  • 1. Part of Public Health England What’s new and coming up in the UK NSC December 2015 Dr Anne Mackie, Director of Screening PHE and UK National Screening Committee
  • 2. The UK NSC • UK governments set systematic screening programme policy (not NICE, not PHE, not Royal Colleges, not clinical bodies, not the press) • The UK NSC is the body set out in the NHS constitution that provides that advice based on a set of internationally accepted criteria. • It is a scientific advisory committee bringing together experts on the science, acceptability, feasibility, acceptability and cost effectiveness of systematic population screening programmes. • This includes • Starting a programme • Stopping a programme • Making big changes to a programme • Piloting a programme 2 BCS2
  • 3. Why the separate governance/ fuss. Why not let NICE or clinical bodies just get on? Because systematic population screening is different • The invitees didn’t necessarily want to be informed they are at risk • They may be worried about something (that they may not want to have to worry about) • They will receive tests which have false positives/ negatives • They will be advised to have further tests or treatments for a false positive • Or be reassured by a false negative (and keep up their risky behaviours or ignore symptoms) • The tests will find things that they weren't being screened for (SWANs) • They may be harmed in the course of being investigated or treated for something that would never have hurt them • A systematic screening programme is expensive. The money may be spent on something better (clinicians diverted). 3
  • 4. Ayear of reflection and change STC Three yearly review Consultation PHE and cancer/non cancer division QA 4
  • 5. Science and Technology Committee 5 BCS
  • 7. Challenges Governance Membership What’s a screening programme (versus large public health programmes) Criteria fit for purpose? Rare diseases? Evidence: thresholds, new programmes, big changes Stakeholders/transparency/ easy read Ethics Health economics Horizon scanning Informed Choice; meaning and data 7
  • 8. Governance Scientific Advisory Committee Code of practice Membership • Increased PPV • Ethics • Training 8
  • 10. What’s a screening programme (versus large (public) health programme) The review group has considered the scope of screening that should be within the remit of the UK NSC and recommends that topics should be considered on a case by case basis using the following characteristics as a guide: • The target population to be screened should be large (ie sufficiently large enough to enable safe, clinically and cost effective screening) • The cohort to be offered screening would regard themselves as not necessarily having symptoms of the disease or to be at risk of the disease – ie the business of the committee should be apparently healthy people • There should be an effective means of identifying and holding a list of the whole cohort to be offered screening • The population should be proactively approached (eg by written invitation, verbal invitation at the time of the contact with the health service, encouraging attendance for screening) among other things this would ensure that those offered screening would be properly informed of the potential benefits and risks in order to help make an informed choice • The primary purpose of screening should be to offer benefit to the person being screened. If there is no possibility of benefit to the person 10
  • 11. Criteria/Evidence STC, the evidence threshold should remain high (WHO) criteria for screening stood the test 1. The condition 2. The test 3. The treatment 4. The programme Rare disease/genetic disease/ diagnostic odyssey ? RCT? Major changes to programmes 11
  • 12. Evidence cont. Consistent evidence review process 1.Open call 2.Triage 3.Rapid review 4.Systematic review 5.Other products (models) 12 BCS12
  • 13. Developing new evidence 1. Research on NIPT with NIHR 2. RCT on extending age for breast screening with Oxford 3. Pilot pulse Ox. RCT evidence that PO finds babies with critical heart disease. Unknowns about other conditions so pilot 4. Pilot HPV:RCT evidence, feasibility issues tested 5. Pilot FIT: evidence, feasibility issues tested 6. Interval cancer 7. Congenital anomalies and rare disease register 8. BGS rapid test 9. Pre-eclampsia 13
  • 14. Informed choice Single definition and description Share good practice Make sure data is accurate and OK to be quoted 14 BCS
  • 15. Stakeholders plain English summaries and more concise review documents – now implemented monthly alerts on current consultations on way evidence process manual – published UK-wide definition of informed choice and sharing best practice in public info – reviewing how we use stats in public info annual call for topics – being taken forward next year annual meeting – happening! We’re very active and open on social media (Twitter and blog) and that these are great ways for stakeholders to see what we’re up to and engage with us. 15
  • 16. Continually improving programmes 1. Roll out bowelscope 2. Assessment of new technology for sickle cell and thalassaemia 3. Audit of HIV positive babies 4. DES IT and grading 5. Training for extra views of babies hearts 6. IT for NIPE 7. Failsafe for bloodspot 8. Vascular surgical outcomes 16 BCS
  • 17. New programmes 2014-15 Approved first trimester screen for T13 and 18 Expansion of the NHS Newborn Blood Spot Screening Programme following the UK NSC’s recommendation to introduce screening for 4 additional rare but serious conditions – GA1, HCU, IVA and MSUD. 17 BCS
  • 18. Evidence coming up Ovary cancer Lung cancer Prostate cancer Atrial Fibrillation Intervals for cervix 18 BCS