Mesotheluima is the malignant disease of the pleural , is an aggressive <br />Disease , arising from the serosal lining of the chest . Characterized by <br />Poor survival rate .<br />Aetiology ;-<br />Strongly associated with cigarette smoking .<br />Caused by asbestose exposure ( perlonged latent peroid after exposure ) <br />Erionite fibers <br />Thorium dioxide .<br />Pathology ;-<br />Mesothelioma arise from the parietal or visceral pleural and grow diffusely <br />Within the pleural space , commony associated with pleural effusion and <br />Encasement of the lunge by sold mass .<br />Tumour spread directly to the lunge , mediastinum & may cross the diaphragm<br />To involve peritoneum . Other organs which may involve e .g liver <br />Histological subtypes ;-<br /><ul><li>Epithelial (about 50 % ) .
ascites due to involvement of the peritoneum</li></li></ul><li>Workuo ;-<br />H & P , CXR , CT / MRI chest , PET / CT chest , P F T . ….. Looking for pleural<br />Thickening , effusion , contraction of ipsilateralhemithorax<br />Histological diagnosis ;- <br />Using least invasive tech - ;-<br /><ul><li>aspiration cytology .