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Fostering Translational Doctoral Programmes in health Sciences

Presentation form ORPHEUS conference 2017 in Klaipeda

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Fostering Translational Doctoral Programmes in health Sciences

  1. 1. Fostering Translational Doctoral Programmes in Health Sciences Opportunities and Challenges at Nova Medical School, Lisbon PAULO PEREIRA
  2. 2. Prevention Diagnosis Treatment The Cycle of Biomedical Research Transla0onal Research Individual Popula>on Genes & environment Cell Animal
  3. 3. Strategy Educa>on products Mechanisms Drugs Devices T1 T2 Transla0onal Research 19 years Basic Science Cells & molecules Clinical Research Humans/ trials Health community & popula0on “Transla)onal research fosters the mul)direc)onal and mul)disciplinary integra)on of basic research, pa)ent-oriented research, and popula)on-based research, with the long-term aim of improving the health of the public”. Rubio et al. Acad Med. 2010 - Evalua0on CommiDee of the Associa0on for Clinical Research Training (ACRT)
  4. 4. The “valley of death” Tomorrow’s Medicine, 2015 Facts & Figures •  800.000 medical Res papers, 2008 •  21 new drugs approved by FDA, 2011 •  Time to market: 10-15 Yrs •  Average Cost: 1000 M€ •  Failure Rate: 90%
  5. 5. Changes to Portuguese scientific production by scientific area The Landscape FCT, 2013
  6. 6. The Landscape: Medical and Health FCT, 2013
  7. 7. A PhD programme in medical sciences @ NOVA MEDICAL SCHOOL CEDOC IBET IPOLF4 Research center for Chronic Diseases Nova Medical School Private non for profit SME in Biotechnology Ins0tute for Chemical and Biological . Technology . Portuguese Oncology Ins0tute ITQB iNOVA 4 Health
  8. 8. The research and teaching ecosystem for PhD training Pa)ent Applica)on Student Molecules & cells Theory principles Prac)ce industry TRANSLATIONAL BASIC TRANSLATIONAL POLICIES CLINICAL IPO/ ITQB Hospitals IBET/ITQB CEDOC Toxomics CEDOC Popula0on studies Funding to compe00ve transla0onal projects
  9. 9. Admission Degree Core courses CSRT* Elec0ve courses CP1: Project Defense Research Work Elec0ve courses CP2: Mee>ng with thesis commiQee Research Work Elec0ve courses CP2: Mee>ng with thesis commiQee Research Work Submit PhD thesis Viva Voce *CSRT: Clinical Scholars Research Training Program – Designed and implemented in collabora0on with Harvard Medical School Curricular Structure and Milestones
  10. 10. Programs and Speciali0es New policies for funding From PhD programs to individual studentship Programmes Ageing and Chronic Diseases Bioengineering and Cell Therapies Regenera0ng Medicine Medicine PhD in Medical Sciences All students All areas Degree in Medical Sciences Chronic diseases Oncobiology Neurobiology Regenera0ve Medicine Speciali>es: Transla0onal •  Clinical oriented Medical speciali0es
  11. 11. The way forward: form discovery to delivery Ins0tu0onal strategies & Public Policies ¤  Facilitate communica0on: Forum basic, transla0onal, clinical ¤  Facilitate access to resources and facili0es ¤  Nurture people and groups – do not punish failure ¤  Train new genera0on of clinicians in Research ¤  Mo0vate basic researchers ¤  Develop Infrastructures (e.g. Clinical Trials, Biobanks) ¤  Iden0fy Research navigators & Sherpa ¤  Implement Incubator Programs and Accelerators
  12. 12. The way forward Trainning a new genera0on of scien0sts that can “walk the walk” From discovery to delivery The goal is becoming competent to interpret, evaluate, and discuss different types of research, rather than conduc)ng it all yourself D. Rubio, 2011