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Presentation: Developing Science-Informed Policy Responses to Curb Endocrine Disruption in Freshwater, Astrid Wester - Norway

This document outlines how SDG indicators could be used to identify areas for action to reduce human health risks from endocrine disruptor compounds in freshwater where data is limited. It discusses which SDG indicators related to water, sanitation, waste, and housing may act as proxies for sources of and exposure to EDCs. While SDG data has good statistical robustness and global coverage, validity at local levels varies. The document concludes SDG indicators could provide more information than single studies and help guide cross-sectoral action, though methods to apply the data need development.

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Astrid Louise Wester, MD, PhD, specialist in clinical microbiology
SDG 6 indicators (and others) to
identify hotspots for action
To reduce human health risks from endocrine disruptor
compounds in freshwater
Outlines of presentation
Part I – high-level introductions
Overview of souces and exposure routes
Groups of endocrine disruptor compounds (EDCs)
human health effects
Sources of EDCs linked to freshwater
Exposure routes (via freshwater) to humans
Part II
Global perspective of EDC concentrations
When EDC data is limited – apply SDG indicator data?
https://doi.org/10.1016/j.watres.2016.02.047
EDC groups, by source
linked to freshwater:
1. In human, animal and production wastes:
• Natural hormones and metabolites (17-β- estradiol, estriol,
estrone)
• Artificial hormones (contraceptive pill) + drugs with
hormonal side effects (beta-blockers, antibiotics, anti-
inflammatory drugs)
• Phyto- and mycoestrogens (isoflavones, lignans, stilbenes
etc)
2. Pesticides and metabolites (DDT,
methoxycholor, kepone, tosaphene)
3. Chemicals used in houshoulds and
industry (PCBs, paints, plasticiziers)
https://www.researchgate.net/publication/248997531_Endocrine_Disruptors_and_Water_Quality_A_State-of-the-Art_Review https://www.sciencedirect.com/science/article/pii/S0160412016310182?via%3Dihub
Human health effects from EDCs
Fetal development + later in life
https://www.sciencedirect.com/science/article/pii/S0160412016310182?via%3Dihub/
Water-associated sources for EDCs
https://doi.org/10.1016/j.watres.2016.02.047
Sources
Routes/exposure
- EDC removal efficacy
- WWTPs not present?

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Presentation: Developing Science-Informed Policy Responses to Curb Endocrine Disruption in Freshwater, Astrid Wester - Norway

  • 1. Astrid Louise Wester, MD, PhD, specialist in clinical microbiology SDG 6 indicators (and others) to identify hotspots for action To reduce human health risks from endocrine disruptor compounds in freshwater
  • 2. Outlines of presentation Part I – high-level introductions Overview of souces and exposure routes Groups of endocrine disruptor compounds (EDCs) human health effects Sources of EDCs linked to freshwater Exposure routes (via freshwater) to humans Part II Global perspective of EDC concentrations When EDC data is limited – apply SDG indicator data?
  • 4. EDC groups, by source linked to freshwater: 1. In human, animal and production wastes: • Natural hormones and metabolites (17-β- estradiol, estriol, estrone) • Artificial hormones (contraceptive pill) + drugs with hormonal side effects (beta-blockers, antibiotics, anti- inflammatory drugs) • Phyto- and mycoestrogens (isoflavones, lignans, stilbenes etc) 2. Pesticides and metabolites (DDT, methoxycholor, kepone, tosaphene) 3. Chemicals used in houshoulds and industry (PCBs, paints, plasticiziers) https://www.researchgate.net/publication/248997531_Endocrine_Disruptors_and_Water_Quality_A_State-of-the-Art_Review https://www.sciencedirect.com/science/article/pii/S0160412016310182?via%3Dihub
  • 5. Human health effects from EDCs Fetal development + later in life https://www.sciencedirect.com/science/article/pii/S0160412016310182?via%3Dihub/
  • 6. Water-associated sources for EDCs https://doi.org/10.1016/j.watres.2016.02.047 Sources Routes/exposure - EDC removal efficacy - WWTPs not present?
  • 7. https://doi.org/10.1016/j.watres.2016.02.047 - EDC removal effectivity - DWTPs not present? Water-related routes for human exposure for EDCs Sources Routes/exposure
  • 9. EDCs in freshwater – data coverage and data robustness
  • 12. Point-prevalence studies! WHAT TO DO WHEN THERE IS LITTLE OR NO DATA?
  • 13. What SDG indicators could be relevant as proxies/surrogate markers – and for what?
  • 15. SDG6 indicators relevant to sources and human exposure to EDCs SDG 6.1.1: Safely managed drinking water (WHO/UNICEF JMP) SDG 6.1.2: Safely managed sanitation (WHO/UNICEF JMP) SDG 6.1.3: Safely treated wastewater* (WHO, UN- Habitat) *Wastewater from households and industry https://washdata.org/monitoring/drinking-water/water-quality-monitoring MIC survey of drinking water quality
  • 16. SDG 6.3.2: Good ambient water quality (UNEP:GEMS Water) SDG 6 indicators relevant to sources and human exposure to EDCs, cont. SDG 6.b.1: Local community participation in WASH management (WHO, UNEP, OECD: GLAAS)
  • 17. 11.1.1 Proportion of urban population living in slums, informal settlements or inadequate housing 11.6.1 Proportion of municipal solid waste collected and managed in controlled facilities out of total municipal waste generated, by cities 12.2.2 Material consumption per capita 12.4.2 Hazardous waste generated per capita Other SDGs relevant to sources and human exposure to EDCs
  • 18. Relevant SDGs – data robustness and coverage
  • 19. Statistical robustness and Coverage Validity, reliability and representativeness of SDG country estimates SDG indicator measurement: longstanding work across statisticians and relevant other sectors Validity, reliability Representative country estimates Countries have subnational data => if no country level data, may have local data Different SDG indicators at different level of ‘maturity’ (coverage) https://washdata.org/how-we-work/about-jmp
  • 21. SDG 6 SDG 11 SDG 12 https://washdata.org/sites/default/files/2022-01/jmp-2021-wash-households_3.pdf https://www.sdg6data.org/indicator/6.3.1 https://ourworldindata.org/grapher/share-of-urban-population-living-in-slums Drinking water Sanitation Wastewater treatment Ambient water quality Hazardous waste Urban slums https://unstats.un.org/unsd/environment/municipalwaste.htm Solid waste management https://ourworldindata.org/grapher/domestic-material-consumption-per-capita https://ourworldindata.org/grapher/hazardous-waste-generated-per-capita?country=KGZ~KAZ~BTN~LUX https://www.unwater.org/sites/default/files/app/uploads/2021/09/SDG6_Indicator_Report_632_Progress-on-Ambient-Water-Quality_2021_Executive-Summary_EN.pdf Material consumption
  • 22. Conclusions & thoughts SDG indicators May add information, or act as proxies More robust than syntheses of single point-prevalence studies Locally generated data – preferable to samples shipped for sentralized analyses Needs coverage analysis by country and subnational levels For what? Proxies for EDC concentration in different water matrices? Proxies for risk to humans? Guiding cross-sectoral action as needed? How?: apply average level? Add into 3D topographic maps? Develop an OECD-tool?
  • 23. Thank you for your attention!