I created this 4-page product brochure to serve as a sales tool for NuSoothe™, a compounded transdermal pain cream. The target audience is orthopedic and podiatric surgeons. Imagery is used throughout to give the impression of a fast, full return to an active lifestyle. Text highlights the various NuSoothe formulations, benefits of using the product, and the ways in which the Lipoderm® base makes NuSoothe uniquely effective. The back page briefly describes the company's value proposition and the other therapies in its "Continuum of Care".

1. Personalized Solutions for Pain Management
Distributed by

2. Benefits of the
NuSoothe Series
Faster, More
Complete Relief
Uses the only
base proven to
bring 4 drugs
simultaneously
through the skin for
faster, more effective
pain management.
Faster Return to
Daily Living
May reduce the
need for oral pain
medications that
affect the entire
body. This puts
patients back on their
feet faster, completing
daily activities sooner
(like driving).
Prolonged Patient
Relief
Anesthetic
bupivacaine lasts
longer than the
more commonly
used tetracaine and
lidocaine. 1
Fewer Side Effects
Avoids the side
effects of oral pain
medications, like
digestive issues,
drowsiness, loss
of driving ability,
addiction and
overdose.
Safer And Avoids
Patient Error
Tube dispenses
the appropriate,
premeasured
amount of cream
for a single dose.
Can be used up to 5
times per day.
Tube contains UV protection to
prevent chemical breakdown.
NuSoothe Series
The NuSoothe series consists of three transdermal
creams formulated in a Lipoderm® base that
drives multiple drugs simultaneously through the
skin. NuSoothe achieves faster drug delivery and
better absorption for improved pain relief.
plantar fasciitis
NuSoothe PF is designed to alleviate pain caused by
plantar fasciitis and other inflammatory conditions of the
foot. The drug combination helps loosen the tight bundle
of fascia at or near the site of the patient’s pain.
NuSoothe™ PF
Flurbiprofen
Gabapentin
Diphenhydramine
Cyclobenzaprine
Bupivacaine
10%
6%
5%
2%
1%
pain, inflammation & muscle spasms
The original NuSoothe formulation treats pain,
inflammation and muscle spasms locally. It contains four
drugs with different mechanisms of action to quickly and
effectively alleviate discomfort.
NuSoothe™
Flurbiprofen
Gabapentin
Cyclobenzaprine
Bupivacaine
10%
6%
2%
1%
30%
neuropathic pain
NuSoothe Plus is used to treat neuropathic pain, such as
that caused by diabetic neuropathy. It can be prescribed
in addition to NuSoothe and NuSoothe PF to help with
difficult-to-treat nerve pain.
NuSoothe™ Plus
Ketamine

3. Breakthrough Studies of Lipoderm®
The First Transdermal Base to Undergo Rigorous Testing
According to the latest competitive studies, NuSoothe’s Lipoderm transdermal base
delivers ketoprofen (NSAID) more quickly and with better absorption. In addition,
Lipoderm is the only base proven to bring 4 drugs simultaneously through the skin.
This means faster relief and the potential for better outcomes.
Delivers Ketoprofen Better and Faster
Percutaneous Absorption Flux Profile
of Ketoprofen
Mean from 3 Donors as µg/cm2
/hr
• This formulation delivered ketoprofen more
rapidly than all other formulations.
Flux(µg/cm2
/hr)
Mid Time (hr)
Competitor
Lipoderm®
14.5%
Lipoderm®
5.5%
PLO
• Percent of ketoprofen dose delivered completely through
human skin in vitro was significantly better with Lipoderm
versus PLO.
Percent Permeation of Ketoprofen Through Human Skin and
Into Receptor Solution
Using human skin in vitro
Only Base Proven to Deliver 4 Drugs Simultaneously
Percent Permeation of Multiple Drugs Beyond
Stratum Corneum
Through ex vivo human skin
• Lipoderm delivered ketamine HCl, gabapentin,
clonidine HCl and baclofen simultaneously and
intact.
• Drugs were selected due to their frequent use in
topical pain formulations.
Ketamine Clonidine Baclofen Gabapentin
4% 4%
45%
21%

4. NuPulse®
Provides iceless cold
compression, DVT prophylaxis
and thermal contrast therapy
to ease pain, reduce swelling
and speed healing.
iCPM™
“Smart” continuous passive
motion improves range of
motion for knees, shoulders,
hips, elbows and more.
Our Continuum of Care
NuLife Med’s Continuum of Care consists of a range of cutting-edge, robust therapies
that work together to improve patient outcomes after surgery or injury.
All therapies are provided with in-home, concierge service, 7 days per week, with no
unexpected cost to the patient.
WARNING: If patient is allergic to any of the ingredients in NuSoothe™, patient should not use the medication. Patient should contact the pharmacy/physician
immediately. SIDE EFFECTS: If allergic, patients may respond negatively to any of the medications represented in this therapy. Although absorption of an
appreciable amount of the active ingredients is uncommon, some can occur in rare situations. Absorption, if it does occur, will typically result in stomach upset
(anti-inflammatory) and drowsiness (muscle relaxant, nerve pain suppressant or anesthetics). If patient experiences any of these side effects (or other events
that they feel are abnormal), patient should contact clinical staff. OVERDOSE: If an overdose is identified, please contact the pharmacy toll-free at 800-850-
2101. Poison control can also be reached at 1-800-222-1222. MISSED DOSE: The patient may apply a missed dose as soon as he/she recognizes that is has been
missed. Please allow a minimum of 4 hours between applications unless otherwise directed by a healthcare professional. STORAGE: Store this medication in a
cool, dry place. Avoid exposure to excessive heat, sunlight or dampness.
250 North Commercial Street, Suite 3003, Manchester, NH 03101 • info@nulifemed.net
1. Annals of Emergency Medicine. 1987, 16(7); 752-757
NuSoothe™
Transdermal analgesic
cream treats pain, swelling
and muscle spasms locally
without the side effects of
oral medications.
Bone Growth Stimulator
30-minute daily treatment
with combined magnetic
fields helps heal persistent
fractures and non-unions.
Additional Therapies
NuLife Med also offers transcutaneous
electrical nerve stimulation (TENS),
muscle stimulation and select
immobilizing braces.