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Tell it straight: How Selenium helps prevent Cancer

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This slidedeck was submitted to the DCU-run "Telling It Straight" (TIS) competition by NICB scientist Ali Coyle.
A video clip of Ali's pitch is available here: https://www.youtube.com/watch?v=PrxbPuNjSgs
TIS challenges post-graduates to communicate their research to an audience and panel of judges that have no prior knowledge of their research

Published in: Health & Medicine
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Tell it straight: How Selenium helps prevent Cancer

  1. 1. Overview 1. What is Selenium? 2. A model for cancer in the lab 3. ‘The big experiment’
  2. 2. N a t i o n a l I n s t i t u t e F o r C e l l u l a r B i o t e c h n o l o g yN a t i o n a l I n s t i t u t e F o r C e l l u l a r B i o t e c h n o l o g yNational Institute for Cellular Biotechnology
  3. 3. Selenium in the diet http://www.teagasc.ie/soil/trace/grassland/selenium.asp http://www.microfeeder.com/news/en_selen.asp (modified after Hasselberger, 2006)
  4. 4. BenefitRisk Narrow range for protective effects ‘Just right.’ One key function of selenium-containing proteins is anti-oxidant protection Too little Se- oxidative damage Too much Se- oxidative damage
  5. 5. Selenium and cancer • Selenium's role as a protector against oxidative damage has gained interest in cancer research Image from http://www.bluemountainorganics.com/_blog/Health_and_Nutrition
  6. 6. Selenium and cancer• Studies in various populations worldwide have found a link between low selenium levels and certain types of cancer • Results inconclusive- back to the drawing board Skin Lung Colon and prostate
  7. 7. Cell culture • We can grow cells in the lab from virtually any organ in the body to study what’s happening at the level of the cell
  8. 8. The big experiment Cell will die CellCells will repair Attempt repair- ineffective, causing the incorporation of mistakes, can lead to cancer
  9. 9. The big experiment Cell will die CellCells will repair Attempt repair- ineffective, causing the incorporation of mistakes, can lead to cancer
  10. 10. • Understand more about the role selenium is playing in cancer prevention • How much selenium should we be getting from our diets to maximise protection Potential impact of this research
  11. 11. Questions? N a t i o n a l I n s t i t u t e f o r C e l l u l a r B i o t e c h n o l o g y D u b l i n C i t y U n i v e r s i t y, G l a s n e v i n , D u b l i n 9 , I r e l a n d . + 3 5 3 1 7 0 0 5 7 0 0 w w w. n i c b . i e n i c b @ d c u . i e T h a n k y o u !

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