The Space LaboratoryPast Experience and Future PerspectivesJörn RittwegerGerman Aerospace Center (DLR)                    ...
STS-9                   First SpaceLab Payload (28th Nov to 8th Dec 1983)Source: ESA/NASA                                 ...
D1Spacelab:German AstronautsSTS-9                                Reinhard Furrer                                          ...
Life Science Experiments on STS-9PI           Experiment                     Discipline     Country       Publicatio      ...
Caloric Nystagmus:  a standard test in medicine• Warm fluid evokes typical sequence of  rapid and slow eye movements• Expl...
Salt & blood pressure:                             Space Medicine fosters                             Medicine on EarthExc...
MARS500                24h Diastolic Blood Pressure           85           80           75p (mmHg)                        ...
Flight experiment SOLO:SOdium LOad in MicrogravityPI: Petra Frings-Meuthen                              Bicarbonate mmol/L...
Lessons learnt   Life Science in Space is possible and often fruitful   More experiments, and greater samples are  desirab...
:envihab   A new DLR facility for ground-basedparallel research into the human organism                   Partners: Space ...
Folie 11Vortrag > Autor > Dokumentname > Datum
:enviGeneration – Matrix organisation                                                                              Topics ...
Thank you for your attention !    :envihab - Current status (functional in 2013)                                          ...
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2012 02-22 rittweger orlando ipmc

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2012 02-22 rittweger orlando ipmc

  1. 1. The Space LaboratoryPast Experience and Future PerspectivesJörn RittwegerGerman Aerospace Center (DLR) Folie 1
  2. 2. STS-9 First SpaceLab Payload (28th Nov to 8th Dec 1983)Source: ESA/NASA Source: NASA Preparing Spacelab 1 at KSC Launch of STS-9 Folie 2 Vortrag > Autor > Dokumentname > Datum
  3. 3. D1Spacelab:German AstronautsSTS-9 Reinhard Furrer Ernst Messerschmid D2 Ulf Merbold Hans Schlegel Ulrich Walter Folie 3
  4. 4. Life Science Experiments on STS-9PI Experiment Discipline Country Publicatio nA Scano Ballistocardiography in Cardio- Italy weightlessness vascular PhysiologyRJ von Effects of Rectilinear Vestibular Germany ScienceBaumgarten Acceleration, Optokinetic and Physiology 225:208-12 Caloric Stimulation on (1984) Human Vestibular Reactions and SensationsO Quadens Eye movements during sleep Neuroscience Belgium Science 225:221- 222 (1984)A Cogoli Effects of weightlessness on Cell and Switzerland Science lymphocyte proliferation Molecular 225:228- Biology 230 (1984)HE Ross Mass discrimination during Neuroscience United Science weightlessness Kingdom 225:219- 221 (1984)KA Kirsch Measurement of central Cardio- Germany Science venous pressure and vascular 225:218- hormones in blood serum Physiology 219 (1984) during weightlessness Folie 4
  5. 5. Caloric Nystagmus: a standard test in medicine• Warm fluid evokes typical sequence of rapid and slow eye movements• Explained by density-related fluid flow by Robert Bárány (Nobel prize in 1915)• However, caloric nystagmus can also be elicited in the absence of gravity 3D-ETD• So, the mechanisms are still unclear…. Clarke & Scherer (1988) after 100 years of research on Earth! Folie 5
  6. 6. Salt & blood pressure: Space Medicine fosters Medicine on EarthExcess sodium is Lymphatic vessel Macrophages arestored in the skin! formation in response to salt-sensitive salty diet Folie 6 Machnik et al., Nature Medicine, 15:545-552 (2009) Vortrag > Autor > Dokumentname > Datum
  7. 7. MARS500 24h Diastolic Blood Pressure 85 80 75p (mmHg) * 70 ‡ ‡ 65 60 0 BDC ISO-1 ISO-2 ISO-3 R+6 R+13 *: p < 0.05 ‡: p < 0.001Renin, mineralocorticoids, glucocorticoids, androgens, and sodium excretion can explain 80% oflong-term blood pressure variance during confinement. Folie 7
  8. 8. Flight experiment SOLO:SOdium LOad in MicrogravityPI: Petra Frings-Meuthen Bicarbonate mmol/L 28.5 Hypothesis 28 27.5 Salt Intake 27 26.5 Low NaCl 26 Acidosis High NaCl 25.5 25 24.5 Bone Loss 24 Astro 1 Astro 2 Folie 8
  9. 9. Lessons learnt Life Science in Space is possible and often fruitful More experiments, and greater samples are desirable Solution: International Space Station Complicated mechanisms often difficult to unravel in Space Solution: Ground based parallel research Folie 9 Vortrag > Autor > Dokumentname > Datum
  10. 10. :envihab A new DLR facility for ground-basedparallel research into the human organism Partners: Space Community+Acad. Industry Health Insurers Hospital Chains Military „Green Industry“ Outreach Stakeholders Folie 10 Gerzer Passing the Torch 110421 10
  11. 11. Folie 11Vortrag > Autor > Dokumentname > Datum
  12. 12. :enviGeneration – Matrix organisation Topics e.g. Eye problems in astronauts Gender e.g. Centrifuge Training e.g. Pharmacological Countermeasures Age Themes … Prevention & Rehabilitation Genetics / omics Musculoskeletal, cardiovascular, psychological well-being Folie 12 Vortrag > Autor > Dokumentname > Datum
  13. 13. Thank you for your attention ! :envihab - Current status (functional in 2013) Folie 13 Vortrag > Autor > Dokumentname > Datum

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