Developing Cures with Less Time & Capital:A New Research Model to Accelerate Drug Development

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Rising Drug Costs & Lack of New Treatments

As the U.S. deals with spiraling drug costs and an urgent need for new treatments, the Myelin Repair Foundation has pioneered a holistic approach to multiple sclerosis drug development that bridges the gap between the promising discoveries made in academic laboratories and big pharmaceutical drug research and development. The approach shows early promise in cutting development costs and shaving years off of the time it takes to develop a drug from basic science to patient therapy.

The Myelin Repair Foundation’s approach will not only benefit the millions living with MS but also provides a new source of high-quality drug targets for the dwindling biopharma pipelines.
Investing in Innovation

The Ewing Marion Kauffman Foundation, Pioneer Portfolio of the Robert Wood Johnson Foundation, and the Scott Cook & Signe Ostby Foundation are investing in MRF’s unique approach, its potential to accelerate the drug development process.
Online Webinar: March 25, 2010

All three organizations held a webinar on March 25, 2010 session to discuss why they support the MRF model and why attention should be paid to this new research paradigm.

Contact info@myelinrepair.org with questions or media requests.

Published in: Health & Medicine
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Developing Cures with Less Time & Capital:A New Research Model to Accelerate Drug Development

  1. 1. Developing Cures with Less Time & Capital: A New Research Model to Accelerate Drug Development March 25, 2010
  2. 2. Margaret Anderson Executive Director, FasterCures Catalyzing efforts across sectors to improve the effectiveness and efficiency of the medical research enterprise Committed to analyzing barriers to progress and overcoming them through action
  3. 3. Agenda Overview of Research Development Process Panel Discussion Open Questions
  4. 4. Participants • Scott Johnson, President and Founder, Myelin Repair Foundation • Lesa Mitchell, Vice President, Advancing Innovation, Kauffman Foundation • Nancy Barrand, Special Adviser for Program Development, Robert Wood Johnson Foundation • Scott Cook, Co-founder of the Scott Cook & Signe Ostby Foundation and co-founder of Intuit Inc. • Host: Margaret Anderson, Executive Director of FasterCures
  5. 5. Scott Johnson Founder and President, Myelin Repair Foundation Waiting for a cure for MS since 1976 Leading the way toward faster development of new treatments and cures for ALL diseases
  6. 6. Crisis in Health Care Effective new treatments for difficult diseases are far too slow in reaching patients who can’t afford to wait. The economic impact in the U.S. of these untreated diseases is estimated at $1.3 trillion annually. Shrinking pharma pipeline threatens industry. Shrinking venture capital funding for biotech startups.
  7. 7. Increasing R&D Spend, but Flat Results R&D spending has grown steadily… …but NME approvals relatively flat No. of approvals ($B) 140 45 CAGR 11.3% 30 70 INDs R&D abroad CAGR 10.5% 15 Domestic R&D NMEs 0 0 ’91 ’92 ’93 ’94 ’95 ’96 ’97 ’98 ’99 ’00 ’01 ’02 ’03 ’04 ’05 ’91 ’92 ’93 ’94 ’95 ’96 ’97 ’98 ’99 ’00 ’01 ’02 ’03 ’04 ’05 1. IMDs (Incrementally Modified Drugs) are new derivatives, formulations and combinations 2. NME (New Molecular Entities) include both chemical and biological therapeutic agents, excludes contrast agents and diagnostics Source: FDA, PhRMA 2005 Yearbook
  8. 8. Evolution of the Medical Research Enterprise Paradigm 1940 2010 shift
  9. 9. Holistic Approach Manages to Milestones: Accelerating Basic Science
  10. 10. Holistic Approach Manages to Milestones: Building a Network of CROs
  11. 11. Holistic Approach Manages to Milestones: Building Partnerships with Biopharma
  12. 12. Holistic Approach Manages to Milestones MRF ARC Model
  13. 13. Shifting the Paradigm: Rapid Results at Far Lower Cost Published > 75 peer-reviewed scientific articles. Established first partnership with pharmaceutical company to review and validate academic discoveries. • Demonstrated that myelin can be repaired in animal models of MS. • Identified 144 discoveries that have the potential to repair myelin; prioritized top 20 discoveries to develop further. • Developed 24 new research tools. • Created significant intellectual property; 20 patentable inventions
  14. 14. Panelists • Scott Johnson, President and Founder, Myelin Repair Foundation • Lesa Mitchell, Vice President, Advancing Innovation, Kauffman Foundation • Nancy Barrand, Special Adviser for Program Development, Robert Wood Johnson Foundation • Scott Cook, Co-founder of the Scott Cook & Signe Ostby Foundation and co-founder of Intuit Inc.
  15. 15. Nancy Barrand Special Adviser for Program Development, Robert Wood Johnson Foundation Works to ensure health coverage for all Americans, improve the social factors that shape health for vulnerable populations, and support innovative ideas that can transform the future of health and health care Wants to make the research enterprise work faster and more openly to accelerate treatment discoveries and cures
  16. 16. Lesa Mitchell Vice President of Advancing Innovation, Ewing Marion Kauffman Foundation 20 years experience in biotech and pharmaceutical entrepreneurship Committed to improving pathways that shepherd research from universities and labs through commercialization
  17. 17. Scott Cook Founder & Chairman of the Executive Committee - Intuit Board Member – Procter & Gamble, eBay, Intuit Catalyst of paradigm change in health care, education, and Internet access for the developing world
  18. 18. Panelists • Scott Johnson, President and Founder, Myelin Repair Foundation • Lesa Mitchell, Vice President, Advancing Innovation, Kauffman Foundation • Nancy Barrand, Special Adviser for Program Development, Robert Wood Johnson Foundation • Scott Cook, Co-founder of the Scott Cook & Signe Ostby Foundation and co-founder of Intuit Inc. • Host: Margaret Anderson, Executive Director of FasterCures
  19. 19. For More Information Carol Menaker carol@myelinrepair.org 408-871-2410 Myelin Repair Foundation http://myelinrepair.org http://wherearethecures.org Kelly Rohrs kelly.rohrs@edelman.com 212-819-4852 Edelman

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