Addgene

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Addgene is a non-profit plasmid repository dedicated to helping scientists around the world share high-quality plasmids.

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Addgene

  1. 1. Joanne Kamens, PhD Executive DirectorADDGENEA UNIQUE NON-PROFIT BIOTECH
  2. 2. How I Got Here Couple of Kids BASF/Abbott Addgene• Advisor with (Pharma) • Director of Research (Non-profit) strong ties to • RNAi early adoptor • Business Dev industry • Executive • Good at managing • HBA leadership role Director and all• Collaborations • Alliances that entails • Incensed by lack of diversity in science •? • Collaborations RXi Harvard PhD (Biotech)
  3. 3. Addgene Helps Scientists Share Plasmids Non-profit, mission driven company dedicated to facilitating collaboration and sharing in the scientific community We fund this mission by making it easy to share plasmids!
  4. 4. Digression—What is a Plasmid?• Plasmids are fragments of double-stranded DNA that can replicate independently of chromosomal DNA, and usually carry genes• Scientists can easily study and manipulate genes and other genetic elements using specifically engineered plasmids which have become possibly the most ubiquitous tools in the molecular biologist’s toolbox• Types of Plasmids • Cloning • Expression • Gene knock-down • Reporter • Viral
  5. 5. Addgene Statistics >20,000 plasmids stored From >1,360 contributing labs, 270 institutions worldwide >250,000 plasmids shipped (not including kits), 1,400/week 45% shipped to scientists outside the United States  Samples shipped within 2 business days of MTA approval “I do science differently because I can use the Addgene library to find ¼ Million Milestone reagents”
  6. 6. Sharing Plasmids with AddgeneIt’s free to deposit plasmids• Addgene’s PhD Scientists help store plasmid data and take care of the quality control sequencingWe work with the Tech Transfer Offices• To establish MTAs for each plasmidWhat plasmids to we solicit for deposit?• Published Plasmids• Soon to be published plasmids—Addgene can hold plasmids until publication, once the paper is published, we can associate the deposit with the appropriate PubMed ID and make them available online• Full length genes, Reporters, Plasmid tools /collections useful to the community
  7. 7. Why is this Working?• Tenacious and talented founders• First adopters were respected scientists, prestigious institutions, leading TTOs• Plasmids were getting less “valuable” in potential licensing terms• Everybody was getting fed up with how long it takes to get an MTA in place• Addgene created a “Win-Win-Win” service
  8. 8. Creating a Win-Win-Win SituationDepositor Wins – Save time by not having to answer requests for published reagents – Gain exposure with searchable database – Increase citations of depositor publications – Protection against usual lab turnover, archiving of key reagents – Never have to figure out how to ship to QatarRequestor Wins – Gain access to many laboratories’ plasmids through one order – Find things you didn’t know you needed in the database – Actually receive the plasmids requested, usually within days, and no reminder emails need to be sent to a busy lab tech – International access – Rigorous QC and curationTechnology Transfer Office Wins – Scientists actually use MTAs to exchange plasmids – “Credit” for clearing MTAs rapidly – Get a list of who has plasmids any time (for grants or legal record keeping)
  9. 9. Addgene’s Electronic MTA System • You want it, you sign it—no red lining • Based on the Universal Biological MTA • Each plasmid exchange has a signed MTA • Addgene maintains close relationships with the Tech Transfer Offices to make this as easy as possible 15% 3% Very dissatisfiedHow would you rate your 9% Somewhat dissatisfiedlevel of satisfaction with NeutralAddgene’s MTA services? 74% Somewhat satisfied Very satisfied
  10. 10. New Initiative – Therapeutic Area Collaborationswww.addgene.org/PD• Addgene is collaborating with The Michael J. Fox Foundation for Parkinson’s Research (MJFF) to assemble a collection of plasmid DNA samples useful for researchers studying this disease• MJFF has provided a set of 200 plasmids available for both academic and industry requestors
  11. 11. Pilot Initiative—Distribution to Industry• Two collections (~1,000 plasmids) now available to industry requestors• Only slightly modified MTA (very similar to the UBMTA)• Addgene actually has some industry depositors-still working on ways to continue to bridge the gap

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