Production of insulin from microbial culture

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Production of insulin from microbial culture

  1. 1. PRODUCTION OF INSULIN FROM MICROBIAL CULTURE RUI BAI MUHAMMAD AKLIL BIN AYOB YANGJIE CUI CHEN 60351 : CORE BIOTECHNOLOGY 1
  2. 2. CONTENT 1. 2. 3. 4. 5. Abstract Introduction Main process of insulin production Significance of human insulin Conclusion
  3. 3. Abstract     Hormone secreted by pancreas Control blood sugar level Lack of insulin caused diabetes mellitus Industrial production by manipulating genetic engineering and microbial
  4. 4. Introduction    Protein generated by beta cell of pancreas (islet of Langerhans) Exist in animal: porcine and bovine Build up of 51 amino acids    30 amino acids form chain B 21 amino acids form chain A 2 chain linked by disulfide bonds
  5. 5. (Introduction)…cont www.bio.davidson.edu www.depositphotos.com
  6. 6. (Introduction)…cont   Diabetes mellitus (DM) lack of insulin to control blood sugar level Need to insulin therapy to keep healthy www.som.uq.edu.au
  7. 7. Main process of insulin production Microorganisms Fungi Yeast
  8. 8. Microorganisms Kinds of bacteria E. coli www.google.com.hk
  9. 9. Genetic Engineering http://blogs.swa-
  10. 10. Microbial Fermentation
  11. 11. Significance of human insulin   1978: insulin from animal; pig and cow Switch to microbial culture. Why?  Quantity & quality is better   E. coli culture is convenient   No allergy and side effect Cheaper for commercial Predictable  Problems easily solved
  12. 12. Conclusion     Insulin market grown at 7% annual rate Company: Novo Nordisk, Eli Lilly & Sanofi Aventis Cost : £75 – 200 per vial Different delivery ways www.novonordisk.com
  13. 13. Thank you! http://www.bd.com

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