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  1. 2. Four Mitotic Stages <ul><li>Pro phase </li></ul><ul><li>Meta phase </li></ul><ul><li>Ana phase </li></ul><ul><li>Telo phase </li></ul>
  2. 3. Prophase
  3. 4. Steps in Prophase <ul><li>DNA coils tightly & becomes visible as chromosomes </li></ul>
  4. 5. Prophase continued <ul><li>2. Membrane around nucleus disappears </li></ul><ul><li>3. Nuceolus disappears </li></ul><ul><li>4. Centrioles migrate to poles </li></ul><ul><li>5. Spindle begins to form </li></ul><ul><li>* the job of the spindle is to attach to the middle of each chromosome and pull the chromatids apart </li></ul><ul><li>* (see next slide for image of spindle) </li></ul>
  5. 6. Mitotic Spindle
  6. 7. Eukaryotic Chromosome At the point in the center of the chromosome, labeled kinetochore, fibers attach in order to pull the two halves apart.
  7. 9. Human Chromosomes
  8. 10. Steps in Metaphase <ul><li>Spindle fibers from centrioles attach to each chromosome </li></ul><ul><li>Cell preparing to separate its chromosomes </li></ul><ul><li>Cell aligns its chromosomes in the middle of the cell </li></ul><ul><li>Remember: meta = middle </li></ul>
  9. 11. Metaphase Chromosomes lined up at the equator Asters at the poles Spindle Fibers
  10. 12. Metaphase
  11. 13. Steps in Anaphase <ul><li>Cell chromosomes are separated </li></ul><ul><li>Spindle fibers shorten so chromosomes pulled to ends of cell </li></ul>
  12. 14. Anaphase
  13. 15. Anaphase Sister chromatids being separated
  14. 16. Steps in Telophase <ul><li>Separation of chromosomes completed </li></ul><ul><li>Cell Plate forms (plants) </li></ul><ul><li>Cleavage furrow forms (animals) </li></ul><ul><li>Nucleus & nucleolus reform </li></ul><ul><li>Chromosomes uncoil </li></ul>
  15. 17. Telophase         Plant              Animal
  16. 18. Cytokinesis <ul><li>Means division of cytoplasm and all organelles within </li></ul><ul><li>Occurs after chromosomes separate </li></ul><ul><li>Forms two, identical daughter cells </li></ul>
  17. 19. Cytokinesis Cell Plate Forming in Plant Cells
  18. 20. Cytokinesis Cleavage furrow in animal cell Cell plate in animal cell
  19. 21. Stages of M phase of cell cycle
  20. 22. Put the following in the correct order: