Health diabetes

458 views

Published on

Published in: Health & Medicine
0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
458
On SlideShare
0
From Embeds
0
Number of Embeds
2
Actions
Shares
0
Downloads
7
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Health diabetes

  1. 1. CAM Project  Diabetes overview  Chromium - Non-herbal dietary supplement  Insulin - Allopathic Treatment  Clinical Research
  2. 2. Diabetes Group of diseases that affect how your body uses glucose (Blood sugar) Diabetes means too much glucose in your blood Important source of energy for the cells that make up your muscles and tissues Brains main source of fuel
  3. 3. Diabetes How Insulin Works Hormone that comes from the pancreas and secrets insulin into bloodstream. Insulin circulates enabling sugar to enter cells. Insulin lowers amount of sugar in bloodstream. As blood sugar level drops, so does the secretion of insulin from pancreas
  4. 4. Diabetes Role of glucose  Comes from two major sources – food and your liver. Sugar absorbed into bloodstream where it enters cells with the help of insulin. Liver stores and makes glucose  When insulin levels low – liver metabolizes stored glycogen into glucose to keep level within normal range.
  5. 5. Diabetes TYPE 1 Your immune system attacks and destroys the insulin producing cells in the pancreas leaving you with little or no insulin. Caused by genetic susceptibility and environmental factors TYPE 2 Your cells become resistant to the action of insulin and your pancreas is unable to make enough insulin to overcome. Sugar builds in bloodstream. Caused by genetic and environmental factors. Being overweight may be a factor Diabetes, Mayo Clinic, www.mayoclinic.org/diseases-conditions/diabetes/basics/causes/con-20033091
  6. 6. Chromium  Mineral humans require in trace amounts  Mechanisms of action in the body and the amounts needed for optimal health not well defined  Found two forms − Trivalent – biologically active and found in food − Hexavalent - toxic form that results from industrial pollution
  7. 7. Chromium  Known to enhance the action of insulin  Critical to the metabolism and storage of carbohydrate, fat and protein in the body  In 1957 a compound in brewers' yeast was found to prevent an age-related decline in the ability of rats to maintain normal levels of glucose in their blood. That compound was chromium  Found naturally in foods such as broccoli, grape juice, English muffins and potatoes
  8. 8. Chromium  Chromium deficiency impairs the bodies ability to use glucose to meet its energy needs and raises insulin requirements  May help control type 2 diabetes or the glucose and insulin responses in persons at high risk of developing diabetes “Chromium”, National Institutes of Health – Office of Dietary Supplements, www.ods.od.nih.gov/factsheets/Chromium-HealthProfessional/
  9. 9. Insulin – Allopathic Treatment  FDA first approved insulin in 1939.  Derived from beef and pork pancreas as well as recombinant technology (From humans -FDA approved in 1982)  Administered by injection under the skin  Preferable injection site under the skin of the abdomen because absorption of the insulin is most consistent from this location
  10. 10. Insulin HOW DOES INSULIN WORK?  Since glucose is a problem with diabetics – increase in the uptake of glucose by cells and reducing the concentration of glucose in the blood – insulin prevents or reduces the long- term complications of diabetes  Complications include damage to blood vessels, eyes, kidneys and nerves Marks, Jay W. & Ogbru, Omudhome, “Insulin”, www.medicinenet.com/insulin/article.htm
  11. 11. Insulin  The following video details how insulin works in the body
  12. 12. Clinical research study 1  Hypothesis - elevated intake of supplemental chromium is involved with the control of type 2 diabetes  180 subjects all with type 2 diabetes – between age 36-65 − 60 received placebo − 60 received 3.85 umol Cr (chromium picolinate) − 60 received 19.2 umol Cr
  13. 13. Clinical research study 1 Fasting Results − At 0 months  Placebo 9.5, 3.85 @ 10.5, 19.2 @9.3 − At 2 months  Placebo @ 9.2, 3.85 @ 9, 19.2 @ 6.8 − At 4 months  Placebo @ 8.6, 3.85 @ 8.4, 19.2 @ 6.7  2 Hr Glucose Results − At 0 months  Placebo 14.6, 3.85 @ 16.3, 19.2 @ 14.7 − At 2 months  Placebo @ 13.2, 3.85 @ 13.6, 19.2 @ 10.9 − At 4 months  Placebo @ 12.2, 3.85 @ 12.4, 19.2 @ 10.3
  14. 14. Clinical research study 1  Fasting blood glucose concentrations significantly lower in the group receiving the highest dosage after 2 & 4 months  Significant effects both statistically and clinically of supplemental chromium at 19.2 umol/day  Fasting glucose and insulin concentration document elevated intakes of supplemental chromium
  15. 15. Clinical research study 2  Objective – To investigate the effects of daily chromium picolinate supplementation on serum measures of glucose tolerance and insulin sensitivity to patient at high risk for type 2 diabetes  59 participants
  16. 16. Clinical research study 2  Randomized, double-blind, placebo-controlled, modified cross-var clinical trial  6 months sequences of intervention and placebo followed by 6 month post intervention assessment  Adult patients with impaired fasting glucose, impaired glucose tolerance or metabolic syndrome  Chromium (500 or 100 mcg per day) or placebo
  17. 17. Clinical research study 2 RESULTS  No changes in glucose level, insulin level or HOMA-IR after 6 months at either dosage level when compared with placebo  Does not appear to ameliorate insulin resistance or impaired glucose metabolism in patients at risk for type 2 diabetes. Unlikely to attenuate diabetes risk
  18. 18. Research Works Cited  Anderson, Richard A, Cheny, Nanzheng, Bryden, Noella A., Polansjy, Marilyn M., Cheng, Nanping, Chi, Jiaming, Feng, Jinguang, “Elevated intake of supplemental chromium improves glucose and insulin variables in individuals with type 2 diabetes”, Available: www.diabetes.diabetesjournals.org/content/46/11/1786.full.pdf+htm  Ali A, Ma Y, Reynolds H, Wise JP Sr, Inzucchi SE, Katz DL, “Chromium effects on glucose tolerance and insulin sensitivity in persons at risk for diabetes mellitus”, Endocr Pract, 2011, Jan-Feb; 17(1):16-+25, Available: www.ncbi.nlm.nih.gov/pubmed/20634174l

×