5. The early colonial settlers planted
marijuana because they recognized its
medicinal value.
A. True
B. False
True
False
0%0%
6. 1. Charas, also known as hashish
2. Ganja, also known as sinsemilla
From Spanish sin semilla, “without seeds”
3. Bhang
Preparations
7.
8. The use of marijuana by high
school students has
increased in the last five
years while alcohol
consumption has decreased.
A. True
B. False
True
False
0%0%
9. 1900s little use or interest
1926 newspaper articles linked marijuana to crime
1936 all state had laws regulating use
Early perceptions
Marijuana Tax Act
Declared unconstitutional in 1969
Reefer Madness
http://digital.films.com/PortalViewVideo.aspx?xtid=5863&loid=1217
8&psid=0&sid=0&State=&title=Altered%20States:%20A%20History%
20of%20Drug%20Use%20in%20America&IsSearch=Y&parentSeriesI
D=
History
10. The federal government
owns a farm in
Mississippi where it grows
marijuana to be used for
research purposes.
A. True
B. False
True
False
0%0%
11. Mouse Party
http://digital.films.com/PortalViewVideo.aspx?xtid=39495&lo
id=70444&psid=0&sid=0&State=&title=Marijuana&IsSearch=
Y&parentSeriesID=#
Pharmacology
12. Review: The neurotransmitter affected
by THC:
A. Dopamine
B. Serotonin
C. Cannabinoids
D. GABA
Dopam
ine
Serotonin
Cannabinoids
GABA
0% 0%0%0% Response
13. Most young people who try marijuana for
the first time do so during the winter
months.
A. True
B. False
True
False
0%0%
14.
15.
16. Anandamide
THC binds to two receptors
CB1
Primarily in brain
CB2
Primarily outside brain in
immune cells
Mechanism of Action
17.
18. Cardiovascular
Pulmonary
Reddening of eyes
Dryness of
mouth/throat
http://digital.films.co
m/PortalViewVideo.as
px?xtid=39495
Physiological Effects
21. The federal government
allows the medical use
of marijuana only to
treat the side effects of
chemotherapy on cancer
patients.
A. True
B. False
True
False
0%0%
22. Declined even before Marijuana Tax Act
Dropped from National Formulary & US Pharmacopia 1941
Uses:
Anticonvulsant
Headaches
Glaucoma
Reduces nausea
Increases appetite
https://www.youtube.com/watch?v=qQzyfYfq1WY
Medical Uses
23. EC Review: The neurotransmitter directly
affected by THC is:
A. Anandamide
B. GABA
C. Serotonin
D. Dopamine
Anandam
ide
GABA
Serotonin
Dopam
ine
0% 0%0%0% Response
24. EC Review: Medical uses for marijuana
do not include:
A. To increase
appetite
B. To control
convulsions
C. To fight infection
D. To reduce nausea
To
increase
appetite
To
controlconvulsionsTo
fightinfectionTo
reducenausea
0% 0%0%0%
Response
http://www.drugabuse.gov/publication
s/drugfacts/marijuana-medicine
26. EC: Do marijuana users experience
withdrawal?
A. Yes
B. No
C. No, but they do
experience mild
symptoms when
they abstain
Yes
No
No,butthey
do
experi...
0% 0%0%
Response
27. EC: Does tolerance develop with
marijuana use?
A. No
B. Yes, rapidly and
immediately
C. Yes, with regular
use
D. Yes, but
unevenly, (not to
all effects)
No
Yes,rapidlyand
im
m
edia...
Yes,with
regularuse
Yes,butunevenly,(notto...
0% 0%0%0%
Response
28. Public opinion polls reveal that the
majority of Americans favor legalizing
marijuana.
A. True
B. False
True
False
0%0%
http://www.gallup.com/poll/165539/
first-time-americans-favor-legalizing-
marijuana.aspx
29. Acute
No recorded human overdoses
Chronic
Lungs
Anxiety
Reproductive Effects
Immune System Effects
Toxicity
31. EC: The negative effects of marijuana
include:
A. Increased
violence
B. Problems with
memory
C. Problems with
learning
D. Respiratory
problems Increasedviolence
Problemswithmemory
Problemswithlearning
Respiratoryproblems
0% 0%0%0%
Response
32. Opinion: Do you believe amotivational
syndrome occurs in marijuana users?
A. Yes
B. No
Yes
No
0%0%
Response
34. Opinion: I think legalization of
marijuana was a good idea.
A. Yes
B. No
Yes
No
0%0%
Response
Editor's Notes
Cannabis sativa
Most widespread; used primarily to make rope
Has a tall, woody stem and can reach a height of 20 feet
Cannabis indica
Grown for its psychoactive properties
Grows to a height of 3 to 4 feet
Cannabis ruderalis
Found mainly in northern Europe and Asia
Has a short growing season and low potency
The primary mood-altering, psychoactive agent in marijuana is delta-9-tetrahydrocannabinol, or THC
Several factors influence THC levels:
The plant’s sex
Soil and climate conditions
The part of the plant that is used
How the plant is harvested, prepared, and stored
Female plants produce more resin and flowers, which contain higher THC concentrations
Marijuana is a preparation of leafy material from the Cannabis plant that is smoked
Marijuana is classified separately because its effects are varied and complex
Sedation
Pain relief
Hallucinations (in large doses)
Effects it produces in most users are sufficiently different from the effects of depressants, narcotics, and hallucinogens to merit its separate classification
Cannabis sativa
Originated in Asia but now grown worldwide
Grown primarily for its fibers,from which hemp rope is made
Grows as a weed in the U.S. and Canada
A lanky plant up to 18 feet high
Cannabis indica
Grown for its psychoactive resins
Cultivated in many areas of the world
A compact plant 2 to 3 feet high
Potency varies depending on plant genetics and environmental conditions
Cannabis ruderalis
Grown primarily in Russia
The cannabis plant can be grown almost anywhere
Production is especially high in Colombia and Mexico
Other countries in Latin America, and in Asia and the Caribbean, also produce marijuana
Lebanon, Morocco, Pakistan, and Thailand are particularly known for producing much marijuana
Indoor cultivation of marijuana makes it easier to avoid federal, state, and local law enforcement
Indoor cultivation has allowed for production of marijuana with a higher THC content
The profits of indoor cultivation are higher because marijuana plants can be harvested four to six times per year
Not used for medicinal purposes until early 1990s.
Ganja, consisting of the top leaves and flowers of the female cannabis plant, is considered the best quality marijuana
Bhang consists of the lower leaves, stems, and seeds of the cannabis plant and is regarded as poor quality marijuana
Sinsemilla (“without seeds”) is derived from the unfertilized female cannabis plant, and has higher THC levels
Two other forms are hashish (charas) and hash oil
These forms of marijuana have a higher THC content than Cannabis sativa
Hashish, taken from the resin of the cannabis plant, is usually smoked in a pipe
Hash oil is made by boiling resin in alcohol, and has a THC content of 60% – it is mixed with tobacco and smoked
Hashish
Consists of pure resin that has been carefully removed from the surface of leaves and stems
May be less than pure depending on how carefully the resin has been separated from the plant material
Rare in the U.S.
Average THC content of U.S. hashish ranges from 3 to 8 percent
A few batches have tested as high as 20 percent THC
Production methods
Traditional production involves manual scraping of exuded resin from the plant
More efficient recent production method involves boiling the plants in alcohol and evaporating the resulting liquid down to thick, dark hash oil
Potency of hash oil varies but can contain more than 50 percent THC
Sinsemilla
Consists of dried flowering tops of plantswith pistillate flowers (female plants)
Male plants are removed from the fields before the female plants are pollinated
Female plants don’t put their energy into seed production, thus increasing their potency
Average THC content of U.S. sinsemilla samples is about 7 to 12 percent
Bhang
Consists of the remainder of the Cannabis plant after the top has been picked
Plant material is dried, ground into a powder, and mixed into drinks or candies
Rare in the U.S., but about equivalent to low-grade marijuana consisting of leaves
Average THC content of less than1 percent
Potency varies widely
Low-grade products (less than 1 percent THC)
High-grade sinsemilla (9 percent or more THC)
Typical range of potency is 2 to 8 percent THC
Proportion of confiscated marijuana samples of higher-potency has increased since the 1980s but is still only about 15 percent
Annual marijuana use increased from 22% to 25% in 2011, while annual alcohol use decreased 51% in 2006 to 45% in 2011.
NEED TO FACT CHECK…TWO TEXTS SAY TWO DIFFERENT THINGS>>>>>>>>
Marijuana (cannabis) is one of the world’s oldest known drugs
Early settlers in Jamestown, Virginia, planted marijuana (hemp) for its fiber, which also was used during World War II
People started smoking it for its euphoric effect during the 1920s, coinciding with alcohol prohibition
Marijuana use was banned after the Marijuana Tax Act was enacted in 1937
Earliest mention: Chinese pharmacy book (2737 BC)
Social use of the plant had spread to the Muslim world and North Africa by AD 1000
“Hashishiyya” religious cult carried out political murders
Story of cult spread in works by Marco Polo (1299) and Boccaccio (1350s)
Origin of the term assassin
Hashish use mentioned frequently in The Arabian Nights
Early 1900s: Little public interest or use
1926: Series of newspaper articles linked marijuana and crime
Other reports by police and in popular literature followed
1936: All states had laws regulating the use, sale, and/or possession of marijuana
Most early regulation efforts
Based on concerns about use and resultant behavior
Not based on direct evidence linking marijuana use with crime or violence
Contributing factors to “pyramid of prejudice” against marijuana
Marijuana use associated with lower-class groups and recent immigrants
Regular references made in popular literature to the murdering cult of assassins as suggestive of the characteristics of the drug
Shaky factual ground of the stories
Individuals in the legends did NOT commit murder under the influence of hashish but rather received hashish as a reward for their actions
MARIJUANA TAX ACT
Act followed the regulation-by-taxation theme of the 1914 Harrison Act
Grower, distributor, seller, and buyer were taxed
Administratively almost impossible to deal in Cannabis
Bureau of Narcotics uniform law specifically named Cannabis sativa
Current federal and uniform laws refer more generally to the genus Cannabis
State laws made possession and use of Cannabis illegal per se
1969: U.S. Supreme Court declared the Marijuana Tax Act unconstitutional
AFTER MARIJUANA TAX ACT
Cost of marijuana increased significantly
Reports continued to be published that marijuana use had less serious effects than commonly believed BUT
Substantial disagreement over the interpretation of research findings
1950s and ‘60s
Little scientific research done on Cannabis
Use of Cannabis continued to increase
A common symbol of youthful rejection of authority
Identification with a new era of personal freedom
Usage rose around 1980, declined until the mid-1990s, and then peaked in the late 1990s, although never reaching the levels in the 1970s.
Worldwide, marijuana is the fourth most commonly used drug, after nicotine, caffeine, and alcohol
Marijuana is the most common illegal drug in the US, with an annual prevalence of 13.7%
The most important reasons that students significantly increased use of marijuana relate to reduced perception of risk and less disapproval of its use
Chemistry of Cannabis is complex and unique
Active agent contains no nitrogen and thus is not an alkaloid like other psychoactive plant materials
Cannabinoids are 66 chemicals unique to the Cannabis plant
Delta-9-tetrahydrocannabinol (THC)
Isolated and synthesized in 1964
The most pharmacologically active cannabinoid
There may be several other active agents in Cannabis
Smoked marijuana
THC is absorbed rapidly by the blood and travels to the brain and then the rest of the body
Within 30 minutes, most THC is gone from the brain
Peak psychological and cardiovascular effects occur together within 5 to 10 minutes
Oral THC
THC is absorbed more slowly and the liver transforms it into 11-hydroxy-delta-9-THC
Less THC reaches the brain
Peak effects occur about 90 minutes following ingestion
Metabolites have different half-lives
After one week, 25 to 30 percent of the THC and its metabolites might remain in the body
Two or three weeks may be required to completely eliminate a large dose of THC and its metabolites
High lipid solubility of THC and its metabolites
Selectively taken up and stored in fatty tissue, to be released slowly
No easy way to monitor THC and metabolite levels and relate them to effects
Long-lasting low concentrations of THC and metabolites may have effects on the brain and other organs that have not yet been determined
Marijuana contains more than 500 chemicals – 60 are unique to the cannabis plant (cannabinoids)
Marijuana smoke contains 70% more carcinogenic benzopyrene and 50% more tar than tobacco smoke
Marijuana releases five times as much tar into the lungs as cigarettes
Marijuana can be smoked or ingested
Smoked THC is three times more potent than ingested THC
If ingested, marijuana’s actions last longer
Most smokers roll marijuana into a cigarette – an alternative is to roll it into a blunt, a type of cigar in which some of the tobacco is removed and replaced with marijuana
When marijuana is smoked, THC reaches the brain within a few seconds – peak effects are felt in about 30 minutes
When smoked, about half of the THC is absorbed by way of the lungs into the bloodstream
If ingested, the effects may not be felt for a couple of hours because less THC is absorbed
Marijuana is fat soluble, and its metabolites can remain in the fatty tissue of heavy users for two to three weeks after use
In studies, pharmacological tolerance was more likely to develop among daily users
One indication of tolerance is that heavy users are still capable of doing cognitive tasks
Many users claim they get high from decreasing doses, though no evidence of reverse tolerance exists
Frequent users also experience less loss of memory, coordination, and concentration
June & July – lack of supervision.
Anandamide
Endogenous substance isolated from brain tissue with marijuana-like effects
From ananda, Sanskrit for “bliss”
THC and other cannabinoids bind to two receptors
CB1 receptor
CB2 receptor
CB1 receptor found primarily in the brain but also unusually widespread throughout the body
Potential actions of cannabinoids are widespread
High density of CB1 receptors in specific brain regions
Basal ganglia (movement coordination)
Cerebellum (fine body movement coordination)
Hippocampus (memory storage)
Cerebral cortex (higher cognitive functions)
Nucleus accumbens (reward)
CB2 receptor found mainly outside the brain in immune cells
Potential role of cannabinoids in the modulation of the immune system
Rimonabant, a selective CB1 receptor antagonist, is being tested
Shows promise in reducing food intake and helping people quit smoking
Concerns raised over use of the drug due to concerns about side effects such as depression and anxiety
When marijuana is smoked, THC reaches the brain within a few seconds – peak effects are felt in about 30 minutes
When smoked, about half of the THC is absorbed by way of the lungs into the bloodstream
If ingested, the effects may not be felt for a couple of hours because less THC is absorbed
Marijuana is fat soluble, and its metabolites can remain in the fatty tissue of heavy users for two to three weeks after use
Cardiovascular effects
Increased heart rate occurs after smoking marijuana and ingesting oral THC
Time course differs substantially following the two different methods of administration
Research findings on the effects of cannabinoids on blood pressure have been mixed
Cardiovascular risks of marijuana use haven’t been shown in young, healthy users
People with cardiovascular disease should probably avoid marijuana and oral THC due to effects on heart rate
Pulmonary effects
Bronchodilation is seen following acute exposure to marijuana
Heavy marijuana smoking over a long period could lead to clinically significant impairment of pulmonary function
Reddening of the eyes
Dryness of the mouth and throat
52%
Abuse potential has been shown
Studies show both animals and humans willself-administer the drug
Marijuana cigarettes with higher THC content are preferred
Oral THC does not have high abuse potential, likely due to its different time course
Less rapid onset of effects is usually associated with reduced risk of abuse
Effects include euphoria, “high,” mellowness, hunger, and stimulation
Peak effects occur within 5 to 10 minutes and last for about two hours
Oral THC has similar effects but a different time course
Magnitude of effects is greater with increasing THC concentrations
Regular marijuana smokers can recognize the effects and distinguish between real and placebo marijuana cigarettes
Infrequent smokers
Experience similar but more intense effects compared with experienced smokers due to lower tolerance
At high THC concentrations, may report negative effects such as mild paranoia and hallucinations
Acute administration of marijuana to infrequent users disrupts cognitive performance
Slowed cognitive processing
Impaired short-term memory
Impaired inhibitory control
Loss of sustained concentration or vigilance
Impaired visuospatial processing
Acute administration of marijuana to frequent users
Causes less dramatic effects, implying they are tolerant to some (but not all) cognitive effects
Slowed cognitive processing consistently seen
Impairment during certain workplace tasks and the operation of machinery and automobiles can have significant effects
Effects on long-term cognitive functioning are more difficult to predict
Studies have had divergent findings and interpretations
Current evidence suggests that after abstaining for more than a month, regular marijuana use produces few effects on cognition
Additional (and better) research may change current thinking
Food intake: Marijuana and oral THC significantly increase total daily calorie intake
Clinical use of cannabis-based drugs for appetite stimulation
Unclear if average chronic marijuana users are overweight
Verbal behavior: Verbal exchanges decrease, nonverbal social interactions increase
Marijuana increases the release of dopamine, a neurotransmitter involved in the experience of euphoria
Numerous studies support the connection between marijuana use and mental illness
Detrimental psychological reactions to marijuana are unusual, although high doses can induce anxiety, delusions, disorientation, hallucinations, and paranoia
Marijuana alters perceptions of time and space
Mood changes are marked by anxiety, sadness, laughter, and paranoia
Some people experience panic reactions, which tend to be temporary and triggered by a feeling of not being in control
One reported cognitive effect of marijuana is impairment of short-term memory
Learning and remembering new information become more arduous when using marijuana
Heavy users were impaired in skills involving expression but not in vocabulary, mathematics, and reading comprehension
Cognitive deficits persist up to 28 days after a person last smoked marijuana
U.S. medical use declined even before the 1937 Marijuana Tax Act
New and better drugs were developed to treat most illnesses
Variability of product (also a problem for research)
Active ingredient insoluble in water (can’t be injected)
Oral dose has delayed onset of action
1941: Cannabis dropped from The National Formulary and The U.S. Pharmacopoeia
Renewed interest in potential medical uses led to a review of older reports
May be effective as an anticonvulsant in some cases when preferred medication is ineffective
May relieve tension and migraine headaches
Reduces fluid pressure in the eyes
May be useful in glaucoma patients
Limited program in which NIDA supplied medical-grade marijuana cigarettes to certain patients on a “compassionate use” protocol
Reduces severe nausea caused by certain drugs used to treat cancer
1985: Oral TCH (dronabinol; brand name Marinol) licensed for sale to cancer patients experiencing nausea from chemotherapy
1993: Approved to stimulate appetite in AIDS patients
State and federal action
1996: Arizona and California ballot initiatives pass
Physicians can recommend marijuana
Patients can use marijuana if recommended
Currently, 14 states have some form of similar legislation
State and federal action
U.S. government announced plans to prevent medical marijuana use
Closure of Cannabis buyers’ clubs
Revocation of the DEA registration of any physician who advised a patient to use marijuana
Prosecution of physicians and patients
2005: U.S. Supreme Court ruled that patients could be prosecuted for possessing marijuana even if their physicians recommended its use for a serious illness
In 2009, US Attorney General Eric Holder said that the government would end its raids on state-approved marijuana dispensaries.
Findings from Institute of Medicine report
Marijuana is a relatively safe and effective medicine for patients suffering from certain chronic conditions
More research is needed on marijuana and synthetic cannabinoids
An effective inhaler should be developed to solve the problem of poor oral absorption of THC
Compassionate use of smoked marijuana cigarettes should be allowed for no more than six months in certain patients with debilitating, intractable pain or vomiting under certain conditions
In the late 1800s, marijuana was used medically to treat convulsions, chronic cough, sleeplessness, gastrointestinal disorders, gonorrhea, and pain
Recently, marijuana has been used for treating glaucoma, asthma, nausea and vomiting during cancer chemotherapy, and pain associated with multiple sclerosis
It also has been used to alleviate withdrawal symptoms related to barbiturates, narcotics, and alcohol
Glaucoma
Marijuana reduces pressure behind the eye
Nausea and Vomiting
Marijuana is an effective anti-emetic to counteract nausea and vomiting associated with chemotherapy for cancer
Marinol (THC formulated in sesame oil)
Cesamet (a synthetic cannabinoid)
More than 40% of oncologists recommended marijuana to their cancer patients to control nausea and vomiting
Asthma
THC dilates the bronchial tubes
Additional Medical Uses
Appetite stimulant
Pain relief
Muscle relaxant
Recommended for epilepsy, insomnia, rheumatoid arthritis, chronic pain conditions, premenstrual syndrome and menstrual cramps
DSM-IV: No listing of cannabis withdrawal, BUT
Research suggests an abstinence syndrome does exist
Not life threatening but unpleasant
Symptoms
Negative mood states–anxiety, irritability
Disrupted sleep
Decreased food intake
Aggressive behavior (in some cases)
Begins about 1 day after the last dose
Lasts 4 to 12 days
Tolerance to many marijuana effects develops after regular use of high levels
Tolerance may not develop uniformly to all effects
Marijuana has abuse potential
A significant minority of current marijuana users may be abusing or dependent on the drug
Although most experts agree that physical dependence on marijuana does not occur – it might depend on how dependency is defined
One-fourth of adolescents who use marijuana frequently meet the criteria for marijuana abuse or dependency
60% of regular marijuana smokers experienced significant withdrawal symptoms, including irritability, nausea, vomiting, diarrhea, sweating, anxiety, and insomnia
Marijuana can result in psychological dependence
If dependency develops, it is more likely to be motivated by psychosocial than by physiological factors
The perceived need for the drug is believed to be responsible for compulsive use and dependency
Factors influencing effects of marijuana:
Whether it is smoked or ingested
Dosage
THC content
Interval between puffs
Depth of inhalation
Length of time in one’s lungs
Set and setting
Previous experiences
Acute physiological effects
Increased heart rate, possibly risky for someone with preexisting cardiovascular disease
No human overdose deaths have been reported
Chronic lung exposure from marijuana smoking
Daily smoking impairs air flow in and out of the lungs
Long-term implications for health are unclear
Marijuana smoke contains many—but not all—the chemicals found in tobacco smoke
Tar
Carbon monoxide
Hydrogen cyanide
Nitrosamines
Benzopyrene
Carcinogen found in higher levels in marijuana cigarettes than in tobacco cigarettes
Marijuana cigarettes are not filtered
Chronic lung exposure from marijuana smoking
Smoking behavior among regular marijuana users
Smoke fewer marijuana cigarettes than tobacco users smoke standard cigarettes
Hold smoke deep in their lungs longer than do cigarette smokers
No direct evidence that marijuana smoking causes lung cancer
More time may be required to show the link
Anxiety
Characterized by fear of loss of control and fear that things won’t return to normal
Some people require a medical sedative or tranquilizer but the best method to remind a person everything will go back to normal is a “talking down.”
Reproductive effects
Reduced testosterone levels in men
Diminished sperm counts and abnormal sperm in men
A growing number of studies show that marijuana use by pregnant mothers does not appear to be associated with low birth weight or premature birth.
The amounts of marijuana used by the women in these studies were relatively low.
Immune system effects
Findings have been mixed
Some evidence that marijuana use reduces immunity to infection
Mortality data do NOT show a relationship between marijuana use and overall death rate
In a study of first-year college students, over 9% had a cannabis use disorder that resulted in concentration problems or missing a number of classes
Adolescents who smoked at least once a week had increased thoughts of suicide, felt more lonely and unloved, and were more likely to run away from home, cut classes, or steal
Marijuana impairs perceptual and motor skills and the ability to stay awake – skills necessary for driving
Appetite
Marijuana users consistently report increase in appetite
The Respiratory System
THC acts as a bronchodilator
Smoke contains many respiratory irritants and carcinogens
One marijuana cigarette equals 20 regular cigarettes in terms of bronchial damage
Marijuana contains 20 times as much ammonia and 5 times as much hydrogen cyanide as tobacco smoke
The Immune System
Studies with animals demonstrate that marijuana affects the immune system adversely
The Reproductive System
In males, marijuana decreases testosterone levels, sperm count, and libido
In women, it may inhibit ovulation
The Brain
Chronic marijuana users experience cognitive deficits
Marijuana reduces acetylcholine in the hippocampus, the portion of the brain that affects memory
Marijuana affects the activity of the neurotransmitters norepinephrine and dopamine
Anticholinergic drugs such as marijuana are related to schizophrenia
Amotivational syndrome
Concern has been expressed about the effect of regular marijuana use on behavior and motivation.
Laboratory data do not support the hypothesis that frequent marijuana smokers exhibit diminished motivation.
Heavy marijuana users reportedly are unable to concentrate and are unmotivated, apathetic, lacking ambition, and not achievement-oriented (amotivational syndrome)
Amotivational syndrome is more likely to develop in adolescents than in older people
However, people who smoke a great deal might also be predisposed to these problems initially
Marijuana Madness
Some researchers are collecting data that they claim shows that marijuana causes psychosis
Some studies have found a correlation between marijuana use and psychotic symptoms.
Participants admitted to having at least one psychotic symptoms.
It is possible the people had psychotic symptoms prior to using marijuana.
Since marijuana users typically use other psychoactive drugs, it is difficult to disentangle the influence of other drug use on the psychotic symptoms
There is evidence that marijuana can increase the liklihood of psychotic episodes in individuals with a history of psychiatric problems.
Driving ability: Research findings mixed
Laboratory studies of computer-controlled driving simulations
Marijuana produces significant impairment
Epidemiological studies
Little evidence that drivers who use marijuana alone are more likely to be involved in an accident
Effects may be more severe in infrequent users
In 1972, the Presidential Commission on Marijuana and Drug Abuse recommended the decriminalization of marijuana
11 states decriminalized marijuana, making possession a minor offense punishable by a $100 fine
In 2008, Michigan became the 13th state to approve the medical use of marijuana
An argument against marijuana is that it is a gateway drug, leading to the use of more dangerous drugs
However, most marijuana smokers do not proceed to use other drugs
Steppingstone theory
Hypothesis that use of soft drugs such as marijuana and alcohol leads to use of harder drugs such as heroin and cocaine
Which is the greater problem—marijuana or laws against marijuana?
The National Organization for the Reform of Marijuana Laws (NORML) contends that the quality of marijuana would be controlled more effectively if it were legal
Legalization of marijuana is compared to tobacco and alcohol, which have known medical and social consequences
In 2011, the Dutch government reversed its tolerance policies and reclassified marijuana so that it is now comparable to cocaine and Ecstasy
The Dutch government believe that better control over marijuana use reduces the risks
It is estimated that 13% of Dutch high school students have used marijuana, compared to 28% of American students
Marijuana has a long history of medical use and is reasonably safe
Opponents believe that if marijuana were available for medical use, its nonmedical use would increase dramatically
In states that legalized medical marijuana, rates of marijuana use, abuse, and dependence are higher
One concern is that medical marijuana may be illegally diverted for substance abuse
In November 1996, California voters eliminated state penalties for medical uses of marijuana
Fifteen states, including the District of Columbia, have now passed medical marijuana laws
The Institute of Medicine (IOM) found that marijuana has “potential for therapeutic use”
In 2006, the FDA reaffirmed that marijuana should remain a Schedule I drug, and has no currently accepted medical use
Drug reform advocates:
Treating drug offenders is much cheaper than incarcerating them
Legalizing marijuana and other drugs would stem the rise in violence and criminal activity
Opponents of drug reform:
Marijuana is unhealthy and the only viable option is elimination of its use
Advertising and marketing would increase drug problems dramatically
Hassan, an Arabian politico who lived during the Middle Ages, and his cult, purportedly used hashish in preparation for aggressive acts against others
Legalization might reduce criminal and violent behavior, but interpersonal and intrapersonal problems might escalate
When alcohol was prohibited, organized crime increased – legalization would remove much of the profit motive
Marijuana has become the single most important drug issue in the United States.
Today 14 states have legalized medical marijuana and a dozen others will consider this in late 2010
In the 1960s and 1970s, there was a shift in attitude about marijuana
Marijuana was found to be pretty innocuous
Young people found out the government had been lying about drugs and it led to broad rejections of government information.
Seniors who smoked marijuana peaked at 60% in the 1970s.
Changing attitudes toward decriminalization
1972 report recommended decriminalizing possession of small amounts for personal use and casual distribution of small amounts without monetary profit
Beginning in 1973, several states altered laws
Possession of small amounts of marijuana became a civil offense rather than a criminal offense
Changing marijuana possession from a felony to a misdemeanor saved money on court costs, juries, and jails
Usage rates went up, but not substantially
In 2009, the AMA called upon the Federal government to rethink its classification of marijuana as a Schedule I drug.
Changing attitudes toward decriminalization
There are four factors toward the recent push
Increasing amount of scientific evidence that marijuana is not as toxic as once thought
While the economy in 2007 was crashing, billions of dollars were spent to stop illicit drug use.
A growing number of Americans believe the government could tax the growth, transportation and sale of marijuana if it were legal.
Reports of violence in Mexico due to the illicit drug trade.