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EtG EtS Chem Quant App Note

Novel method for EtG/EtS using same mobile phase as Chem quant drug tox method.

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3 minute injection to injection LCMSMS ETG/ETS method
CQ Application Note 2:
Individually Customized Solutions for Laboratories
Data Support Consulting Methodology Training Validation Support Financing Service
EIC of all compounds eluting in 3.2 minutes.
ETG/ETS – run within
the same batch on the
same instrument as your
toxicology method
ETS
ETG
3 minute injection to injection LCMSMS ETG/ETS method
Individually Customized Solutions for Laboratories
Data Support Consulting Methodology Training Validation Support Financing Service
EIC of all compounds eluting in 3.2 minutes.
The toxicology and ETG/S method have the same
mobile phase - no manual switching or buying extra
pumps. It’s an elegant solution for alcohol metabolites.
Obtain excellent baseline separation of both
metabolites.
Clearly baseline separate the sulfate qualifying ion
from urinary matrix.
Matrix interference
ETS
CQ Application Note 2: ETG/ETS
Blank 1/2 of cutoff
Data Support Consulting Methodology Training Validation Support Financing Service
Regression
E
T
S
E
T
G
RETENTION
TIME
BLANK
Intensity
1/2 CUTOFF
Intensity
CUTOFF
Signal to
Noise
ETG 2.117 473 6005 316.12
ETS 1.688 741 43681 513.66
Individually Customized Solutions for Laboratories
Data Support Consulting Methodology Training Validation Support Financing Service
Contact a Quant to improve performance and the bottom line:
michaelquant@chemquant.com
rickyquant@chemquant.com
admin@chemquant.com
CQ- Making an
Art of
Science and Data
Support
by helping labs stand out
from the competition
Ad

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EtG EtS Chem Quant App Note

  • 1. 3 minute injection to injection LCMSMS ETG/ETS method CQ Application Note 2: Individually Customized Solutions for Laboratories Data Support Consulting Methodology Training Validation Support Financing Service EIC of all compounds eluting in 3.2 minutes. ETG/ETS – run within the same batch on the same instrument as your toxicology method ETS ETG
  • 2. 3 minute injection to injection LCMSMS ETG/ETS method Individually Customized Solutions for Laboratories Data Support Consulting Methodology Training Validation Support Financing Service EIC of all compounds eluting in 3.2 minutes. The toxicology and ETG/S method have the same mobile phase - no manual switching or buying extra pumps. It’s an elegant solution for alcohol metabolites. Obtain excellent baseline separation of both metabolites. Clearly baseline separate the sulfate qualifying ion from urinary matrix. Matrix interference ETS
  • 3. CQ Application Note 2: ETG/ETS Blank 1/2 of cutoff Data Support Consulting Methodology Training Validation Support Financing Service Regression E T S E T G RETENTION TIME BLANK Intensity 1/2 CUTOFF Intensity CUTOFF Signal to Noise ETG 2.117 473 6005 316.12 ETS 1.688 741 43681 513.66
  • 4. Individually Customized Solutions for Laboratories Data Support Consulting Methodology Training Validation Support Financing Service Contact a Quant to improve performance and the bottom line: michaelquant@chemquant.com rickyquant@chemquant.com admin@chemquant.com CQ- Making an Art of Science and Data Support by helping labs stand out from the competition