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Low dose vs high-dose

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Low dose vs high-dose

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Why Low-dose is more efficient than High-dose when it comes to iron .A Heme-Iron tablet with a dose of 18 mg will yield up to 4 mgs for bodily needs, whereas a non-heme tablet of 100 mg will yield 2 mg. The rest is reactive and remains in the gut.
The body will absorb no more than it needs of Heme-Iron and the rest is completely inert – no stomach problems.

Why Low-dose is more efficient than High-dose when it comes to iron .A Heme-Iron tablet with a dose of 18 mg will yield up to 4 mgs for bodily needs, whereas a non-heme tablet of 100 mg will yield 2 mg. The rest is reactive and remains in the gut.
The body will absorb no more than it needs of Heme-Iron and the rest is completely inert – no stomach problems.

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Low dose vs high-dose

  1. 1. Why Low-dose is more efficient than High-dose when it comes to iron
  2. 2. Restoring iron counts • Restoring iron values takes a while, just like the onset and development of iron deficiency doesn't happen overnight. It is a question of balance where the uptake of iron needs to match the losses. • Natural losses include for instance loss of blood through menstruation and natural intake is based on the diet.
  3. 3. Natural dose • The regular amount of iron we need in a mixed diet is 12 - 18 mg in total per day. • In healthy individuals the average iron demand is 1 mg daily for men, 1.5 - 2.5 mg daily for women and during pregnancy 2-3 mg daily. • A heme iron tablet with a dose of 18 mg will yield up to 4 mgs for bodily needs, whereas a non-heme tablet of 100 mg will yield 2 mg. The rest is reactive and remains in the gut. • The body will absorb no more than it needs of heme iron and the rest is completely inert – no stomach problems.
  4. 4. Iron absorption • Most of the daily iron will be in non-heme form, which is bound in plants or bound chemically in the regular syntethic supplements. Non-heme iron is not very bioavailable, so more than 95 % will not be absorbed. • Heme-Iron is taken up at a significantly higher rate, 20 -40 % and will not produce side-effects like the syntethic supplements. It is also not affected by other simultaneously ingested food or drink.
  5. 5. Uptake of non-heme iron • 30 days of supplementation with 100 mg Fe++ non-heme iron at a bio-availablity of 2 % theoretically gives 60 mg absorbed iron. At 4 %, which is unusual, the amount is 120 mg. • Non-heme supplements at 100 mg Fe++ per dose regularly have an incidence of side-effects leading to termination of the therapy of around 30 %.
  6. 6. Uptake of Heme-iron • Supplementation with 18 mg of heme iron for thirty days with a bio-availability/uptake of 20 % gives 108 mg of absorbed iron. • Heme iron is very well tolerated and is known to have a side-effects ratio as placebo. This means a higher therapy success rate. This is why heme iron tablets with a dose of 18 mg Fe++ can compete with non-heme tablets of 100 mg Fe++.
  7. 7. More than 60 mg non-heme stops zinc uptake • A dose of more than 60 mg of non-heme iron per day will block the uptake of Zinc, which is an essential trace element vital for many biological functions and that has a crucial role in the enzyme system in the body. • Heme-Iron will not affect the uptake of Zinc.
  8. 8. Syntethic supplements with high doses • There is a clear tendency to use non-heme iron supplements in very large doses because many believe a strong deficiency situation should be cured as quickly as possible. • However there is a large risk for therapy-ruining side- effects and a normal uptake will not permit a large change quickly. • A steady therapy with an efficient and well tolerated iron, such as Heme-Iron in tablet form, is therefore always preferable.
  9. 9. The OptiFer® Series is the nr. 1 Heme-Iron formula available internationally -The OptiFer® series is safe. No reported cases of serious side-effects or poisonings after long-time massive use of heme iron in Scandinavia.

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