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03 vaccinationstrategieslast herin

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03 vaccinationstrategieslast herin

  1. 1. PCV2 vaccination strategies Jean-Bernard HERIN, Merial France
  2. 2. Agenda <ul><li>PCV2 characteristics </li></ul><ul><li>PCVD: the disease has changed over time </li></ul><ul><li>PCV2 control strategies </li></ul><ul><li>« How to optimize PCVD control according to what we currently know and the available tools? » </li></ul>
  3. 3. PCV2 characteristics and image <ul><li>PMWS raised in 1995 </li></ul><ul><li>PCV2 : a worrying virus… </li></ul><ul><ul><li>Stable and resistant virus / disinfection difficult </li></ul></ul><ul><ul><li>Found everywhere / unlikely to eradicate </li></ul></ul><ul><ul><li>Impact on piglet immunity and farmer’s revenue </li></ul></ul><ul><li>Still considered as a major threat by pig farmers </li></ul>« What we currently know »
  4. 4. PCVD: 3 risk factors <ul><li>High PCV2 pressure in the herd </li></ul><ul><li>Poor passive immunity </li></ul><ul><li>Young age of piglets at exposure </li></ul><ul><li>Will lead to PCVD any time in the life of the pigs due to triggering co-factors </li></ul>Courtesy: Dr K. Mc Cullough Immunostimulation « What we currently know »
  5. 5. Evolution of the disease Sporadic Acute Chronic In France Very rare ≈ 80% Quite all 1995-2002 Mortality PCVD < 1 % Up to 35 % 5 to 15 % Control measures None Management Medication Genetic Before 1995 Since 2002 Vaccination: sow/piglets Management Medication Genetic « What we currently know »
  6. 6. PMWS in 1995-2000 « What we currently know »
  7. 7. PCVD in 2005-2010 « What we currently know »
  8. 8. In pigs, has the disease changed? Yes <ul><li>Later </li></ul><ul><ul><li>Move from postweaning to finishing period </li></ul></ul><ul><ul><li>Extended period for clinical signs </li></ul></ul><ul><ul><li>Mixed with other diseases </li></ul></ul><ul><li>Milder </li></ul><ul><ul><li>Lower mortality, sometimes at a “residual” level </li></ul></ul><ul><ul><li>Less typical acute forms </li></ul></ul><ul><ul><li>Increased impact on performances (growth, homogeneity) </li></ul></ul><ul><li>Influenced by control measures applied since late 90’s </li></ul><ul><ul><li>Management and hygiene improvement (MADEC’s rules) </li></ul></ul><ul><ul><li>Pig genetic lines(?) </li></ul></ul><ul><ul><li>Massive vaccination (sows and/or piglets) </li></ul></ul>« What we currently know »
  9. 9. Mortality rate in Brittany Zootechnical measures, genetic changes and vaccination allowed to control PCVD Data from GTE –GTTT : source IFIP- EDE Bretagne 2010 Sow vaccination Piglet/Sow vaccination Madec’s rules Genetic «How to control this changing disease»
  10. 10. ADWG (8 to 115 kg) Growth performance improved with PCV2 vaccination Sow vaccination Piglet/Sow vaccination Madec’s rules Genetic Data from GTE –GTTT : source IFIP- EDE Bretagne 2010 «How to control this changing disease»
  11. 11. PCV2 vaccination challenges <ul><li>Limiting the impact of environmental risk factors and co infections (E.Coli,Lawsonia,Flu ,PRRS) </li></ul><ul><li>Assessing the infectious dynamics at herd level (necropsy, IHC, serology, PCR) </li></ul><ul><li>Optimizing the vaccination strategy </li></ul>«How to control this changing disease»
  12. 12. PCV2 Vaccination options <ul><li>Sow vaccination </li></ul><ul><ul><li>Transmission of passive immunity to offspring </li></ul></ul><ul><ul><li>Viral pressure decreased: herd stabilization </li></ul></ul><ul><ul><li>Best ROI </li></ul></ul><ul><ul><li>Benefits on reproductive parameters </li></ul></ul><ul><ul><li>Long term impact: booster vaccination needed </li></ul></ul><ul><ul><li>Passive immunity related to colostrum intake </li></ul></ul><ul><ul><li>Interference between passive and active immunity </li></ul></ul><ul><li>Piglet vaccination </li></ul><ul><ul><li>Active immunization before clinical signs </li></ul></ul><ul><ul><li>Fast answer </li></ul></ul><ul><ul><li>« Demonstrative » vaccination </li></ul></ul><ul><ul><li>Herd stabilization ? </li></ul></ul><ul><ul><li>One injection more </li></ul></ul><ul><ul><li>Cost </li></ul></ul><ul><ul><li>Need for combined vaccination with Myco hyo </li></ul></ul>«Optimizing the vaccination strategy» Possible synergy ?
  13. 13. « Assault program » : piglets vaccination <ul><li>Objective: </li></ul><ul><ul><li>Fast protection of the piglets after 3 weeks of age </li></ul></ul><ul><li>Active immunization of piglets. </li></ul><ul><li>Target herds : </li></ul><ul><ul><ul><li>post-weaning or fattening units with piglets from multi-origines, </li></ul></ul></ul><ul><ul><ul><li>Farrowing units with bad colostral intake management. </li></ul></ul></ul>«Optimizing the vaccination strategy»
  14. 14. « Complete program »: sow and piglets <ul><li>Objective: </li></ul><ul><ul><li>Maximum security for the whole herd. </li></ul></ul><ul><li>Sow active immunization and passive of piglets, then relay with active immunization of piglets. </li></ul><ul><li>Target situations : </li></ul><ul><ul><li>Large size farm with management at risk, </li></ul></ul><ul><ul><li>Multiple co-infections, high pig density, </li></ul></ul><ul><ul><li>Stabilization needed during sow herd repopulation, </li></ul></ul><ul><ul><li>Optimization of reproductives performance </li></ul></ul>«Optimizing the vaccination strategy»
  15. 15. « Basic program » : sows <ul><li>Objective: </li></ul><ul><ul><li>PCV2 herd protection with the best ROI of vaccination </li></ul></ul><ul><li>Active immunization of sows and passive of piglets. </li></ul><ul><li>Target situations : </li></ul><ul><ul><li>Improvement of piglet viability, </li></ul></ul><ul><ul><li>Good colostral intake management, </li></ul></ul><ul><ul><li>Introduction of naïves gilts, </li></ul></ul><ul><ul><li>Optimisation of reproductive performances, </li></ul></ul><ul><ul><li>Early form of PMWS, </li></ul></ul><ul><ul><li>Multiple co-infections in farrowing units. </li></ul></ul>«Optimizing the vaccination strategy»
  16. 16. Dynamics of the programs Choice of the program COMPLETE program : Sow + piglets No vaccination BASIC program: Sow + gilts ASSAULT program : piglets Clinical PMWS Subclinical PMWS Demonstrative? (Show) vaccination Coinfections Bad colostrum intake The best security Better coinfections management To reduce vaccination cost Optimal colotrum intake «Optimizing the vaccination strategy»
  17. 17. Slaughter age (115 kg) /PCV2 vaccination program 18 herds, 63 500 piglets «Field results of Circovac programs »
  18. 18. Mortality rate / PCV2 vaccination program *** ** ***p<0,001 **p<0,05 18 herds, 63 500 piglets «Field results of Circovac programs »
  19. 19. Baromètre 2010 de la Evolution of the PCV2 vaccination
  20. 20. Evolution of the vaccination rate PCV2 Vaccination farmer phone survey : 301 FTF herds PCV2– July – Aug 2010 33 35 21 15 19 21 16 14 2 2 0 5 10 15 20 25 30 35 40 2010 (301 herds) 2009 (313 herds) 2007 (304 herds) % of herds Vaccination rate (%) Sow vaccination only (%) Piglet vaccination only (%) Sow and/or piglet vaccination (%)
  21. 21. (*) technical level evaluated by the number of weaned piglets/sow/year: bottom group less than 23 piglets, Average group between 23 and 27, top group more than 27. PCV2 Vaccination farmer phone survey : 301 FTF herds PCV2– July – Aug 2010 Evolution of the vaccination rate 33,2 27 34,8 61,5 31 36,1 44 26,2 32 0 10 20 30 40 50 60 70 Top group (*) Average group (*) Bottom group (*) Other areas Brittany 300 sows and + 200-299 sows 100-199 sows Farrow-to-finish farms Fréquence en % des éleveurs de chaque classe
  22. 22. Expected benefits of the different programs Basic (Sow) Assault (Piglets) Complete (Sow+Piglets) Gilts acclimatization ++ 0 ++(+) Sow reproduction ++ 0 ++(+) Post weaning ++ + ++(+) Fattening +(+) ++ ++(+) Vaccination cost 100 250-300 350-400 ROI 9 4 (3 or more !)
  23. 23. Possible herd segmentation* in 2015 * Source : C Roguet IFIP – JRP 09 French example CIRCOVAC Programs Brittany (Density,PRRSV and SIV +++) Other regions (Low density,PRRS and FLU -) 300 sows FTF farms (1-2 FTE) <ul><li>Assault </li></ul><ul><li>Basic </li></ul>Basic Large multisite herds (600 to 2000 sows, FTF or FTW) (2-7 FTE, excellent performances needed, security +++) Complete (sow + piglets) Basic Collectives farrowing units(< 860 sows) (2-3 FTE, excellent performances needed, security +++) Assault (piglets) Or Complete if reproductive problems Basic if possible
  24. 24. Conclusion <ul><li>It is essential to adapt the vaccinal program </li></ul><ul><ul><li>epidemiology, </li></ul></ul><ul><ul><li>Farm by farm </li></ul></ul><ul><li>CIRCOVAC ® , 1 st sow and piglet PCV2 vaccine: for a tailor-made protection in pigs farms </li></ul>
  25. 25. CIRCOVAC benefits… <ul><li>Thank you for your attention. </li></ul>

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