The complex internal structure of cells depends to a large extend on active transport by molecular motors. These molecular motors are 'nano-trucks' that transport various cargoes, like vesicles, organelles or mRNA, along cytoskeletal filaments, the 'roads'.
Many cargoes are transported by small teams of about 1-10 motors. Some cargoes make use of just one team of motors of the same kind, while other cargoes are propelled by two different motor teams. These teams might move into opposite directions on the same filament, or move on different types of filaments.
In this talk, we will describe systematic stochastic models for cargo transport by one or two small teams of molecular motors. These models are based on single motor properties as determined in single molecule experiments, and can be used to explain and predict various properties of the movements of cargoes inside of cells. By providing a direct connection between the behavior of single motors and†intracellular transport, the models lead to an improved understanding of this transport†and†its biological functions.