1. Understanding Bile
Ducts Cancer
(Cholangiocarcinoma)
Dr. Valeria Simone MD,
Southlake General Surgery,
Texas, USA

2. Overview
Cholangiocarcinoma, often known as
bile ducts cancer, is a life-threatening
condition. Despite its rarity,
understanding its risks and
symptoms is crucial for early
detection and effective treatment.
Early detection is difficult because
symptoms usually don’t appear until
the later stages. In the following
paragraphs, we will discuss
cholangiocarcinoma and its
associated factors, diagnostics, and
treatments.

3. What is Bile Ducts Cancer (Cholangiocarcinoma)?
Cholangiocarcinoma is a type of cancer that affects the bile ducts, which are small tubes that convey bile from
the liver to the small intestine. Cholangiocarcinoma can also affect other organs in the digestive system.
There are two primary subtypes of cholangiocarcinoma, intrahepatic and extrahepatic. Intrahepatic
cholangiocarcinoma develops inside the liver, while extrahepatic cholangiocarcinoma develops outside of the
liver.
There are several factors that can increase the risk of developing cholangiocarcinomas, such as age, gender,
exposure to toxins, chronic inflammation of the bile ducts, infection with parasites, and a family history of liver
disease.
The exact causes of cholangiocarcinoma are not completely understood; however, there are several factors
that can increase the risk of developing the disease. Those who are diagnosed with cholangiocarcinoma can
considerably enhance their chances of survival if they receive a diagnosis and treatment as soon as possible,
despite the difficulties associated with early identification.

4. Types of Bile Ducts Cancer (Cholangiocarcinoma)
• Intrahepatic Cholangiocarcinoma
An Intrahepatic Cholangiocarcinoma is a rare form of primary liver tumor that develops within the liver and
accounts for just a small portion of all primary liver tumors.
As a result of the absence of early signs, it is frequently misdiagnosed until a later stage, which might make
treatment more challenging if cancer has spread beyond the liver.
Depending on the stage of the disease and the location of the tumor, intrahepatic cholangiocarcinoma may be
treated with surgery, radiation therapy, chemotherapy, or targeted therapy.
These treatment methods are all possible. It is essential for persons who are at risk to have a conversation
with their healthcare practitioner about the many screening and monitoring options available to them. This
will assist in the early discovery of a condition and maximize treatment possibilities.

5. • Extrahepatic Cholangiocarcinoma
Extrahepatic cholangiocarcinoma, on the other hand, develops outside of the liver and affects the bile ducts that are
in the region that is intermediate between the liver and the small intestine.
It is more prevalent than intrahepatic cholangiocarcinoma and carries a larger risk of spreading to other organs as a
result. Pain in the stomach region, jaundice, a decrease in body weight, and itching are all possible symptoms of
extrahepatic cholangiocarcinoma.
Depending on the stage of the disease and the location of the tumor, extrahepatic cholangiocarcinoma may be
treated with surgery, radiation, chemotherapy, or targeted therapy, just like intrahepatic cholangiocarcinoma does.
• Gallbladder Cancer
Cholangiocarcinoma, which is another name for gallbladder cancer, is an extremely uncommon form of cancer that
can involve both the gallbladder and the bile ducts.
It is quite like cholangiocarcinoma in many ways, including its risk factors and the treatment options that are
available for it. In fact, the gallbladder has been linked to the development of cholangiocarcinoma in some
individuals.
Because gallbladder cancer, like cholangiocarcinoma, often does not exhibit any symptoms in its early stages, it can
be difficult to diagnose; thus, those who are at risk should undergo routine screening and monitoring.

6. Who is most likely to get cholangiocarcinoma and why?
Cholangiocarcinoma has been discovered to be more prevalent in people over the age of 50, with those between the
ages of 60 and 70 having the highest risk.
In addition, men are more likely to be impacted by the disease than women are, with the risk being two times higher
for men.
There are some underlying health factors that have been linked to an increased chance of developing
cholangiocarcinoma. Such as:
• chronic liver disease
• an infection with the hepatitis C virus (HCV)
• cirrhosis
• primary sclerosing cholangitis (PSC)
• chronic ulcerative colitis
• infection with the Chinese liver fluke parasite, known medically as clonorchiasis.
• Inflammatory bowel disease (IBD)
• HIV

7. Asbestos, radon, and nitrosamines are just some of the chemicals that may play a part in the development
of the condition. Other lifestyle factors that may also contribute to the disease, such as:
• smoking
• high alcohol intake
• diabetes
• obesity

8. Bile Ducts Cancer (Cholangiocarcinoma): how prevalent
is it?
Cholangiocarcinoma is a form of cancer that is not very common. In Western countries, it accounts
for just 3% of all cases of gastrointestinal cancer.
On the other hand, its prevalence has been growing over the course of the last few decades. In
fact, some studies reveal that the prevalence of intrahepatic cholangiocarcinoma has increased by
about a factor of two since the 1990s.
Although the causes for this increase are not completely known, some hypotheses imply that there
may be a connection to the rising prevalence of risk factors such as hepatitis C virus infection and
obesity.
Cholangiocarcinoma is a relatively uncommon kind of cancer; nonetheless, due to its dismal
outlook and limited availability of curative therapies, it continues to be a major problem for the
public’s health.

9. Causes of Bile Ducts Cancer (Cholangiocarcinoma)
There are many potential causes of cholangiocarcinoma, including genetic changes,
anomalies in the biliary tract, and long-term inflammation.
An important risk factor for the development of cholangiocarcinoma is chronic inflammation,
which can be the result of disorders like primary sclerosing cholangitis and inflammatory
bowel disease.
Increased risk of cholangiocarcinoma is also associated with anomalies in the biliary tract,
such as cysts and choledochal malformations. Lastly, mutations in some genes, such as KRAS
and TP53, have been linked to an increased risk of cholangiocarcinoma.

10. Symptoms of Cholangiocarcinoma
Cholangiocarcinoma is frequently referred to as a “silent disease,” as its early stages are frequently
symptomless. On the other hand, if the tumor expands, it could bring on several symptoms, such as:
• abdominal pain
• nausea
• vomiting
• jaundice.
Additionally, fever, exhaustion, and unexplained weight loss may be symptoms of cholangiocarcinoma in
certain patients.
It is essential to keep in mind that these symptoms may be suggestive of a wide variety of different
illnesses and that cholangiocarcinoma should be identified by a qualified medical practitioner using
imaging and laboratory tests.

11. How to diagnose cholangiocarcinoma?
The presence of cholangiocarcinoma can be determined using a variety of imaging and laboratory
procedures, such as an ultrasound, CT scan, MRI, and blood test.
It is also possible to acquire pictures of the biliary tract using the procedures of endoscopic retrograde
cholangiopancreatography (ERCP) and percutaneous transhepatic cholangiography (PTC).
Either an endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) or a surgical procedure can be
utilized to collect a tissue biopsy, which may be required for the development of a conclusive diagnosis.
It is essential to discover and diagnose cholangiocarcinoma at an early stage to maximize the efficacy of
treatment and the prognosis for patients.

12. Stages of cholangiocarcinoma
The TNM staging approach is used to stage cholangiocarcinoma. This technique considers the size and extent
of the tumor (T), whether cancer has spread to adjacent lymph nodes (N), and whether the disease has
metastasized to other areas of the body (M).
It is essential to determine the patient’s prognosis and appropriate treatment options based on the staging of
the cholangiocarcinoma.
Early cases of cholangiocarcinoma are often treated with surgery, but more advanced cases may require a
combination of chemotherapy, radiation therapy, and targeted therapy. In most cases, surgical intervention is
the best course of treatment.
Despite the difficulties that are inherent in the treatment of cholangiocarcinoma, the research that is now
being conducted helps us understand the disease better and leads to the development of novel and original
treatment strategies.

13. Treatment of cholangiocarcinoma (bile ducts cancer)
According to Dr. Valeria Simone MD, an experienced general surgeon at Southlake General
Surgery, Texas, USA, the stage of cancer determines the range of treatment choices available
for cholangiocarcinoma, which may include surgery, radiation therapy, chemotherapy, or any
combination of these three treatments.
Chemotherapy and radiation therapy may be used to decrease tumors before surgery or to
treat tumors that cannot be removed surgically. Surgery is typically suggested for tumors that
are in an early stage and have not migrated to other parts of the body.
Let’s explore more: Understanding Bile Ducts Cancer (Cholangiocarcinoma) - Southlake
General Surgery

14. Appointment
• For more information on “Bile Ducts Cancer (Cholangiocarcinoma)” and consultation with
Dr. Valeria Simone MD, at Southlake General Surgery, Texas, USA. Please contact our
healthcare expert today at +1(817) 748-0200. You can also make an online
appointment with us.
• Follow us on Facebook and YouTube.
• Source: Understanding Bile Ducts Cancer (Cholangiocarcinoma) - Southlake General
Surgery

15. THANK YOU!
SOUTHLAKE GENERAL SURGERY
1545 E. Southlake Blvd, Suite 270 Southlake, TX 76092
EMAIL: info@southlakegeneralsurgery.com
VISIT US AT: www.southlakegeneralsurgery.com