Cancer Biology Training Program
Washington University School of
Medicine
Siteman Cancer Center
Lee Ratner MD PhD
Program D...
Objectives
• To train graduate and postgraduate students in
interdisciplinary research relevant to cancer biology
• To pro...
Rationale
• In light of the rapid pace and complexity of basic, translational, and
clinical research, it is imperative to ...
Program History
• Initiated at Washington University with institutional funds in 2002 as a
program for training graduate s...
Cancer Biology Graduates
Student Advisor Dept Program Thesis
2002
Andy Bredemeyer Ley Medicine Immunology GzmB & CTL
Maris...
Cancer Biology Trainees
Student Advisor Dept Program Thesis
2004
Gunjan Choudhary Ratner Medicine Mol Genetics HTLV recept...
Key recent program projects to
SCC members
• The Genomics of Acute Myelogenous Leukemia” (PI:
T Ley), funded by the NCI as...
Factors instrumental to the success
of this training program
• Superb and rapidly expanding medical school
• An outstandin...
Administrative Structure of Training
Program
Theresa Waldhoff
Journal Clubs Participating in
Molecular Oncology Training
Program
• Molecular & Developmental Journal Club K Kroll
• Expe...
Clinical Mentoring
Session
Clinical Mentors Goals
Medical Oncology
– Breast Cancer
Research
Matthew Ellis MD PhD
Katherine...
Steering Committee Meetings
• Aug:
– Review and select students and postdocs for the program
– Review plans of journal clu...
Didactic Course
Proposed Schedule for 2006 Course
Jan 17 – Lee Ratner - Introduction
Jan 24 – Jason Weber – Translational ...
Trainee Schedule
Average Number of
Hours/Week
Fall Semester Year 1 Journal Club
Clinical Mentoring Program
Other Lectures
...
Other Educational Programs
• 7 SCC research programs have regular internal seminars or discussion
groups, including
– Canc...
Upcoming SlideShare
Loading in …5
×

Slide 1

397 views

Published on

0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
397
On SlideShare
0
From Embeds
0
Number of Embeds
1
Actions
Shares
0
Downloads
2
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Slide 1

  1. 1. Cancer Biology Training Program Washington University School of Medicine Siteman Cancer Center Lee Ratner MD PhD Program Director Director, Molecular Oncology
  2. 2. Objectives • To train graduate and postgraduate students in interdisciplinary research relevant to cancer biology • To provide basic scientists in depth training in diverse aspects of basic, translational, and clinical cancer research • To foster the development of interdisciplinary collaborative undertakings • Program is devoted entirely to training students in the PhD program or postdoctoral fellows with a PhD, not those training for or have received MD or MD PhD degrees who have other sources of support our institution and other avenues of obtaining a background in broad issues of cancer biology.
  3. 3. Rationale • In light of the rapid pace and complexity of basic, translational, and clinical research, it is imperative to provide graduate and post-graduate trainees the necessary armamentarium of experimental skills and intellectual background to undertake cutting edge cancer research • Success in an academic career pathway requires proficiency in research skills and mentored training. • This program is closely integrated with and supported by the Siteman Cancer Center. • Specific didactic courses and journal clubs integrates these fields with other areas of cancer research in providing trainees a broad and in- depth understanding of important issues in oncology. • A clinical mentoring program is provided to give graduate students and post-doctoral fellows exposure to translational and clinical research approaches. • This is the only training program at our university completed dedicated to research in cancer biology.
  4. 4. Program History • Initiated at Washington University with institutional funds in 2002 as a program for training graduate students. • The program may be expanded to include postdoctoral students with funding of the T32 application • The Siteman Cancer Center (SCC) at Washington University funded at 50% stipend level for 2 yrs each: – 8 students in 2002 – 6 additional students in 2003 – 5 additional students in 2004 – 5 additional students in 2005 – In 2006, will provide full stipend to 3 postdocs & 4 students • The didactic courses associated with the program have been ongoing since 1999 • The program has been interdisciplinary since its inception with students and postdoctoral fellows participating in cancer research in a wide range of fields in multiple different departments.
  5. 5. Cancer Biology Graduates Student Advisor Dept Program Thesis 2002 Andy Bredemeyer Ley Medicine Immunology GzmB & CTL Marisa Ponpuak Weber Medicine Mol Gen ARF nucleolar dynamics Sage Berg-Cross Marshall Biochem Chem Biology Modeling beta-turn mimetics Suzanne Brady Weber Medicine Mol Genetics Nucleophosmin in cell cycle progression Hiliary Luderer Longmore Medicine Mol Cell Bio Ajuba & Zyxin in mets Jane Knisely Bu Radiology Mol Cell Bio LDL receptor protein in tumor invasion Holly Epple Longmore Medicine Mol Cell Bio Ajuba in motility and polarity Ellen Langer Longmore Medicine Mol Cell Bio Epithelial mesenchymal transition 2003 Julia Cordero Cagan Cell Bio Mol Cell Bio EGFR/Ras/MAPK in Drosophila So Hee Dho Weintraub Surgery Mol Cell Bio Na-H exchanger in antineoplastic activity Jaehong Kim Parks Medicine Mol Cell Bio Synovial sarcoma translocation in adhesion Gwanghee Lee H Piwnica-Worms Cell Bio Mol Cell Bio CDC25 in breast cancer Julie O’Neal Tomasson Medicine Mol Cell Bio Myc in myeloid leukemia Jennifer Sprague Anderson Radiology Chem Biology Cu-ligands and metalloproteinases
  6. 6. Cancer Biology Trainees Student Advisor Dept Program Thesis 2004 Gunjan Choudhary Ratner Medicine Mol Genetics HTLV receptor Rachel Delston Harbour Opthamol Mol Cell Bio Ink4a and melanoma Snehal Naik D Piwnica-Worms Radiology Mol Genetics Imaging beta catenin interactions Ozge Uluckan Weilbaecher Medicine Mol Genetics Beta3 integrin and bone mets Bin Zhang Milbrandt Pathology Mol Genetics Nkx3.1 target genes in prostate Ca 2005 Meghna Das Thakur Longmore Medicine Mol Genetics Lim proteins and epithelia adhesion Shugaku Takeda Hsieh Medicine Dev Biol Taspase 1 and tumorigenesis Yat Tang Marshall Biochem Comp Biol p53-Mdm2 peptide antagonists Ho-Chou Tu Cheng Medicine Mol Cell Bio Regulation of Bcl2 proteins Robert Yang Marshall Biochem Comp Biol Inhbitors of Erb signaling
  7. 7. Key recent program projects to SCC members • The Genomics of Acute Myelogenous Leukemia” (PI: T Ley), funded by the NCI as a P01 project in 9/03 • “Functional Polymorphism Analysis in Drug Pathways” (PI: H McLeod) awarded by GM as a U01 project in 2001 • Washington University Molecular Imaging Center (ICMIC)” (PI: D Piwnica-Worms) was awarded by NCI in 5/02 • Biomed 21 is a 250,000 sq ft translational research facility to be located in the heart of the medical school that will add 50 new faculty members, funded by donations to the university, and to be completed 2005. The project will include a Center for Genomics and Human Genetics led by RK Wilson PhD, a Division of Clinical Sciences led by KS Polonsky MD, and a Center for Biological Imaging led by RJ Jost MD.
  8. 8. Factors instrumental to the success of this training program • Superb and rapidly expanding medical school • An outstanding cancer center • Broad coverage of areas of modern cancer research • A vigorous and enthusiastic research-oriented faculty • Dedicated administrative staff • A program committee that is actively involved in student and postdoctoral selection, mentoring, and policy formulation • A sound financial base • A flexible, but defined program • Collegial atmosphere that support collaborative research • Outstanding students
  9. 9. Administrative Structure of Training Program Theresa Waldhoff
  10. 10. Journal Clubs Participating in Molecular Oncology Training Program • Molecular & Developmental Journal Club K Kroll • Experimental Hematopoiesis Journal Club D Link • Cancer Biology Journal Club J Weber • Genetics Journal Club S Dutcher • Molecular Virology Journal Club A Pekosz • Hematology & Oncology Journal Club P Majerus
  11. 11. Clinical Mentoring Session Clinical Mentors Goals Medical Oncology – Breast Cancer Research Matthew Ellis MD PhD Katherine Weilbaecher MD 1. Half day session in comprehensive breast cancer clinic 2. Educate students on screening for breast cancer 3. Discuss chemoprevention for breast cancer 4. Understand genetic risk factors for breast cancer 5. Review the molecular basis of breast cancer 6. Review breast cancer endocrine treatment 7. Review breast cancer targeted therapies Radiation Oncology Jeffrey Bradley MD Jeff Michalski MD MBA 1. Introduce students to technical aspects of radiation therapy treatment planning and delivery. 2. Students will have the opportunity to witness the clinical care of patients receiving radiotherapy for a variety of malignancies 3. Students will be introduced to multidisciplinary aspects of cancer management 4. Students will participate in interdepartmental patient management conferences and tumor boards Gynecologic Oncology Janet Rader MD Matthew Powell MD 1. Educate the students on the screening and treatment of gynecologic malignancies 2. They will see many integrated therapies particularly in the treatment of ovarian cancer. 3. The students will have exposure to the operating room, clinics and in-patient service. 4. They can participate in the weekly tumor board and evaluation of patients for clinical trials. Oncologic Surgical Pathology John Pfeiffer MD PhD Richard Burack MD 1. Review slides of cancer cancers with students to highlight pathologic basis of diagnosing and staging cancer 2. Review immunohistochemical, FACS, gene rearrangement studies used by the pathologist Oncologic Radiology & Nuclear Medicine Dennis Balfe MD Barry Siegel MD 1. Review techniques of radiology, including CT, MRI, and PET scans, and nuclear medicine approaches to diagnosis and staging of cancer 2. Review examples in which radiological techniques are used in monitoring therapeutic responses Bone Marrow Transplantation John DiPersio MD PhD Ravi Vij MD 1. Clinical care and follow-up of autologous and allogeneic stem cell transplant recipients 2. Molecular basis of tracking patients with hematologic malignancies 3. Molecular basis of tracking chimerism, minimal residual disease and GvHD after allogeneic stem cell transplantation. 4. Biology and clinical methods for stem cell mobilization and ex-vivo manipulation. 5. Assessing risk of relapse, treatment related mortality and GvHD in patients who are planning allogeneic stem cell transplantation. Surgical Oncology Jeffrey Moley MD David Linehan MD 1. Introduce student to concepts and approaches in surgical oncology 2. The students will have exposure to the operating room, clinics, and in-patient service 3. The students will participate in the weekly tumor board and evaluation of patients for clinical trials Genomics & Proteomics Reid Townsend MDPhD Purpose, methodology, instrumentation, and clinical sample preparation and analysis for genomic expression, SNP, and proteomics analyses
  12. 12. Steering Committee Meetings • Aug: – Review and select students and postdocs for the program – Review plans of journal clubs and clinical and translational mentoring groups, and review plans for annual program retreat – Review internal advisory board and trainees’ evaluations of the program • Jan: – Review content and student critiques of journal clubs and clinical and translational mentoring groups, and plans for didactic course – Review research progress forms for each pre- and post-doctoral student • May: – Review content and student critiques of didactic courses – Pre- and post-doctoral student advising
  13. 13. Didactic Course Proposed Schedule for 2006 Course Jan 17 – Lee Ratner - Introduction Jan 24 – Jason Weber – Translational control in cancer Jan 31 – Sheila Stewart – Senescence and Tumorigenesis Feb 7 - Loren Michel – Mitotic Checkpoints Feb 14 - Simon Powell – Radiation Repair Feb 21 Emily Cheng – Apoptosis and Cancer Feb 28 – Ming You – Molecular Basis of Cancer Prevention Mar 7 – Suzanne Pontow – Cytoskeleton and cancer Mar 14 – Jeffrey Moley - Familial Cancer and Pre-emptive Surgery Mar 21 - James Hsieh – Proteases and Cancer Mar 28 – Michael Tomasson – Tyrosine kinase inhibitors for cancer Apr 4 – Matthew Walters – Chromosomal Abnormalities and Cancer Apr 11 - Tim Graubert – Stem cell transplantation Apr 18- Jerry Linette – Cancer Vaccines Apr 25 – Student sponsored speaker Courses started in 1999 Alternating years – D Wilson & L Ratner (emphasis on pediatric vs adult oncology
  14. 14. Trainee Schedule Average Number of Hours/Week Fall Semester Year 1 Journal Club Clinical Mentoring Program Other Lectures Laboratory Research 1 1 (4 hrs once per month) 1-2 36 Spring Semester Year 1 Molecular Basis of Cancer Course (even years) Other Lectures Laboratory Research 1.5 1-2 36 Fall Semester Year 2 Journal Club Clinical Mentoring Program Other Lectures Laboratory Research 1 1 (4 hrs once per month) 1-2 36 Spring Semester Year 2 Special Emphasis Pathway in Cancer Biology (odd years) Other Lectures Laboratory Research 1.5 1-2 36
  15. 15. Other Educational Programs • 7 SCC research programs have regular internal seminars or discussion groups, including – Cancer Genetics Lunchtime Seminar Series – Molecular and Development Biology Journal Club – Cancer Center Research Talks – Weekly Immunology Seminar – Weekly Signaling/Cell Cycle Series – Prevention and Control Seminar – Oncologic Imaging Seminar Series • SCC has sponsored two major conferences in 2003 that have had national and international participation, including – Small Animal Imaging Resource Advanced Symposium – Stem Cell Symposium • Division of Biology and Biomedical Sciences has extensive graduate training programs • Siteman Cancer Center Basic Science Symposia

×